Click here to switch to the map view.

The map label for this gene is selB [H]

Identifier: 119871330

GI number: 119871330

Start: 5540931

End: 5542628

Strand: Direct

Name: selB [H]

Synonym: Mkms_5304

Alternate gene names: 119871330

Gene position: 5540931-5542628 (Clockwise)

Preceding gene: 119871329

Following gene: 119871331

Centisome position: 96.58

GC content: 74.15

Gene sequence:

>1698_bases
ATGTACGTAGTCGCCACCGCCGGACACGTCGACCACGGCAAGTCGACGCTGGTGCAGCGGCTCACCGGGATGTGGCCCGA
CCGGCTCGCCGAGGAGCAGCGCCGCGGCCTGACGATCGACCTCGGATTCGCCTGGGCCGACATCGGCGGACGCGAGATGG
CGTTCGTCGACGTACCGGGACATGAGCGGTTCGTCGCGAACATGCTTGCGGGTGTGGGCCCGGTGCCGGCGGTGATGTTC
GTCGTCGCCGCGACCGAGGGGTGGATGCCGCAGTCCGAGGAGCATCTGGCCGCCCTCGATGCGCTCGGTGTGCGACACGC
GCTGCTGGTCGTCACGAAGGCCGATCTCACCGACCCCGCGCCGGCCGTCGAACAGGCGCTGCACGCCTTCGCCGACACCG
GCCTGGCCGCGCCGCCGGTCGCCGTCAGCACGGATCTGGATCACGTCCGCGCCGAGCTGGTGGACCTCGTCGACCGGTTG
CCCGCACCGGACGCCGGCGCCGACGTCCGGCTCTGGGTCGACCGCTCCTTCTCGGTGCGCGGTGCGGGCACCGTCGTCAC
CGGCACGCTCACCGCGGGAACCCTCGGGGTGGGTGACGAACTCGACCACGCCGGACGCCGCGTCACCGTGCGCGGACTGC
AGTCGCTGGGGCAGCAGCGCAGCGCCGTCGGCCCGGTGGCGCGCGTGGCGGTGAACCTGCGCGGAGTCGACCGGCGCGAG
ATCGGCCGCGGCGACGCACTGCGCACCGCTGGGGCATGGCTGGACACCGACGAGGTGGACGTCGCGCTGCGCGCCGCCGA
CGGTGTGCACCGCCAACTCGTGTTGCACATCGGATCGGCCGCGGTGCCGGTGCATGTCCGCCCCCTTGGCGCCGCCGCCC
GCCTGCGGTTGTCACATCCGCTGCCGCTGCGGGTCGGGGACGTCGGGTTGTTGCGCGACCCGGGACAGCACCGCATCGCC
GCCGGGGTCGAGGTGCTCGACGTGCGGCCACCGCCGCTGCGGCGCCGGGGCGCGGCACGCGAGCGCGCCGCGGAGCTGGC
CGAGGGACGGATACGTCCACCGGTGTGCGCCCGCGCATCGGATCTGCGTGCGATGGGGTTACCGCAGACCGGCCGGCGCA
TCGGCGCATGGGTGGTCGACGAGACGTGGTGGGCACAGCGGCGCGAGCAGGCGGTGGCCGCCGTGCGGCGGTGGTCGGCC
GACCATGACGTGGCCGCCGGGATGCCGCTGGAGACGCTGCGCCGGGAAACCGGTCTGCCCGCAGCCGAACTCGTCACCCC
GCTGTTGGCGGGCACCACCCTCGAGGTGTCGGACGGCCGGGTTCGCCGGCCCGGGATGACGCTGCCGACCAGGATCGACG
AGGCGGTCCGCGCGGTCGAGAAGTCCTTGGCCGACGACCCGTTCCGCGCACCGGACGCGGACACCCTCGGGCAGTTGGGG
CTCGGCACACCGGAACTGGCCGCGGCGGTGCGGTCCGGGCGGCTGACCCGGATCGCCGAGGGAGTCGTCCTCGGTGCCGA
CGCACTCGAGCGCGCCGCGGAGATCCTCACCGCGCTCCCCCAGCCGTTCACCGTCGCCGAGGCCAAACGCGCACTGGGCA
CCACCCGCCGCGTCGCGGTGCCACTGCTCGAGCAACTCGACGCGCAGCGGATCACCCGCCGCGACGCCGACGGCACCCGC
ACTGTCGCGAAACGCTGA

Upstream 100 bases:

>100_bases
CACCACCGGTGGTGGGCCGCGTCGAATCCGGCCGCTGCGTCCTCGACCTGCGCACGGTCGATCCGGAGGAGGATGCGCGG
CTGCTCGAGGCCATCAGCAG

Downstream 100 bases:

>100_bases
CGACGTCATACCTAGCGCTGCTAGGGTAGAGGCGCTATGCATATCGACAAGGACCTCGTGGCGGCCACCGCGACCCCACT
CGTCCTCGGCATCCTCGCCG

Product: selenocysteine-specific translation elongation factor SelB

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MYVVATAGHVDHGKSTLVQRLTGMWPDRLAEEQRRGLTIDLGFAWADIGGREMAFVDVPGHERFVANMLAGVGPVPAVMF
VVAATEGWMPQSEEHLAALDALGVRHALLVVTKADLTDPAPAVEQALHAFADTGLAAPPVAVSTDLDHVRAELVDLVDRL
PAPDAGADVRLWVDRSFSVRGAGTVVTGTLTAGTLGVGDELDHAGRRVTVRGLQSLGQQRSAVGPVARVAVNLRGVDRRE
IGRGDALRTAGAWLDTDEVDVALRAADGVHRQLVLHIGSAAVPVHVRPLGAAARLRLSHPLPLRVGDVGLLRDPGQHRIA
AGVEVLDVRPPPLRRRGAARERAAELAEGRIRPPVCARASDLRAMGLPQTGRRIGAWVVDETWWAQRREQAVAAVRRWSA
DHDVAAGMPLETLRRETGLPAAELVTPLLAGTTLEVSDGRVRRPGMTLPTRIDEAVRAVEKSLADDPFRAPDADTLGQLG
LGTPELAAAVRSGRLTRIAEGVVLGADALERAAEILTALPQPFTVAEAKRALGTTRRVAVPLLEQLDAQRITRRDADGTR
TVAKR

Sequences:

>Translated_565_residues
MYVVATAGHVDHGKSTLVQRLTGMWPDRLAEEQRRGLTIDLGFAWADIGGREMAFVDVPGHERFVANMLAGVGPVPAVMF
VVAATEGWMPQSEEHLAALDALGVRHALLVVTKADLTDPAPAVEQALHAFADTGLAAPPVAVSTDLDHVRAELVDLVDRL
PAPDAGADVRLWVDRSFSVRGAGTVVTGTLTAGTLGVGDELDHAGRRVTVRGLQSLGQQRSAVGPVARVAVNLRGVDRRE
IGRGDALRTAGAWLDTDEVDVALRAADGVHRQLVLHIGSAAVPVHVRPLGAAARLRLSHPLPLRVGDVGLLRDPGQHRIA
AGVEVLDVRPPPLRRRGAARERAAELAEGRIRPPVCARASDLRAMGLPQTGRRIGAWVVDETWWAQRREQAVAAVRRWSA
DHDVAAGMPLETLRRETGLPAAELVTPLLAGTTLEVSDGRVRRPGMTLPTRIDEAVRAVEKSLADDPFRAPDADTLGQLG
LGTPELAAAVRSGRLTRIAEGVVLGADALERAAEILTALPQPFTVAEAKRALGTTRRVAVPLLEQLDAQRITRRDADGTR
TVAKR
>Mature_565_residues
MYVVATAGHVDHGKSTLVQRLTGMWPDRLAEEQRRGLTIDLGFAWADIGGREMAFVDVPGHERFVANMLAGVGPVPAVMF
VVAATEGWMPQSEEHLAALDALGVRHALLVVTKADLTDPAPAVEQALHAFADTGLAAPPVAVSTDLDHVRAELVDLVDRL
PAPDAGADVRLWVDRSFSVRGAGTVVTGTLTAGTLGVGDELDHAGRRVTVRGLQSLGQQRSAVGPVARVAVNLRGVDRRE
IGRGDALRTAGAWLDTDEVDVALRAADGVHRQLVLHIGSAAVPVHVRPLGAAARLRLSHPLPLRVGDVGLLRDPGQHRIA
AGVEVLDVRPPPLRRRGAARERAAELAEGRIRPPVCARASDLRAMGLPQTGRRIGAWVVDETWWAQRREQAVAAVRRWSA
DHDVAAGMPLETLRRETGLPAAELVTPLLAGTTLEVSDGRVRRPGMTLPTRIDEAVRAVEKSLADDPFRAPDADTLGQLG
LGTPELAAAVRSGRLTRIAEGVVLGADALERAAEILTALPQPFTVAEAKRALGTTRRVAVPLLEQLDAQRITRRDADGTR
TVAKR

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=316, Percent_Identity=30.6962025316456, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI4503507, Length=252, Percent_Identity=30.952380952381, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI194018522, Length=356, Percent_Identity=23.5955056179775, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI194097354, Length=356, Percent_Identity=23.5955056179775, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI194018520, Length=356, Percent_Identity=23.5955056179775, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI46094014, Length=356, Percent_Identity=23.5955056179775, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI2367247, Length=614, Percent_Identity=31.2703583061889, Blast_Score=178, Evalue=1e-45,
Organism=Escherichia coli, GI1790412, Length=284, Percent_Identity=30.9859154929577, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1789737, Length=284, Percent_Identity=30.9859154929577, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1789108, Length=145, Percent_Identity=26.2068965517241, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI25141371, Length=370, Percent_Identity=28.3783783783784, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17509919, Length=253, Percent_Identity=31.2252964426877, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17556456, Length=303, Percent_Identity=27.0627062706271, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17506081, Length=247, Percent_Identity=25.9109311740891, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115532067, Length=249, Percent_Identity=26.9076305220884, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532065, Length=249, Percent_Identity=26.1044176706827, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324761, Length=286, Percent_Identity=30.4195804195804, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6320863, Length=252, Percent_Identity=28.968253968254, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI281363316, Length=408, Percent_Identity=28.4313725490196, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17864358, Length=408, Percent_Identity=28.4313725490196, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI19921738, Length=285, Percent_Identity=29.4736842105263, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24647046, Length=252, Percent_Identity=30.1587301587302, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24647048, Length=252, Percent_Identity=30.1587301587302, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19922690, Length=271, Percent_Identity=25.4612546125461, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015189
- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09105 SelB-wing_1; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 60259; Mature: 60259

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVVATAGHVDHGKSTLVQRLTGMWPDRLAEEQRRGLTIDLGFAWADIGGREMAFVDVPG
CEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEECEEEECCCCCEEEEEECCC
HERFVANMLAGVGPVPAVMFVVAATEGWMPQSEEHLAALDALGVRHALLVVTKADLTDPA
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEEECCCCCCC
PAVEQALHAFADTGLAAPPVAVSTDLDHVRAELVDLVDRLPAPDAGADVRLWVDRSFSVR
HHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCEEEC
GAGTVVTGTLTAGTLGVGDELDHAGRRVTVRGLQSLGQQRSAVGPVARVAVNLRGVDRRE
CCCEEEEEEEECCCCCCCCCHHHCCCEEEHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHH
IGRGDALRTAGAWLDTDEVDVALRAADGVHRQLVLHIGSAAVPVHVRPLGAAARLRLSHP
CCCCCHHHHCCCCCCCCCHHEEEECCCCHHHHHHHHCCCCCCEEEEECCCHHHHEEECCC
LPLRVGDVGLLRDPGQHRIAAGVEVLDVRPPPLRRRGAARERAAELAEGRIRPPVCARAS
CCEEECCCCCCCCCCCCHHHCCCEEEECCCCCHHHCCCHHHHHHHHHCCCCCCCHHCCCH
DLRAMGLPQTGRRIGAWVVDETWWAQRREQAVAAVRRWSADHDVAAGMPLETLRRETGLP
HHHHCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCC
AAELVTPLLAGTTLEVSDGRVRRPGMTLPTRIDEAVRAVEKSLADDPFRAPDADTLGQLG
HHHHHHHHHCCCEEEECCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCC
LGTPELAAAVRSGRLTRIAEGVVLGADALERAAEILTALPQPFTVAEAKRALGTTRRVAV
CCCHHHHHHHHCCCHHHHHCCEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHH
PLLEQLDAQRITRRDADGTRTVAKR
HHHHHHHHHHHHHCCCCCCHHHHCC
>Mature Secondary Structure
MYVVATAGHVDHGKSTLVQRLTGMWPDRLAEEQRRGLTIDLGFAWADIGGREMAFVDVPG
CEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEECEEEECCCCCEEEEEECCC
HERFVANMLAGVGPVPAVMFVVAATEGWMPQSEEHLAALDALGVRHALLVVTKADLTDPA
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEEECCCCCCC
PAVEQALHAFADTGLAAPPVAVSTDLDHVRAELVDLVDRLPAPDAGADVRLWVDRSFSVR
HHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCEEEC
GAGTVVTGTLTAGTLGVGDELDHAGRRVTVRGLQSLGQQRSAVGPVARVAVNLRGVDRRE
CCCEEEEEEEECCCCCCCCCHHHCCCEEEHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHH
IGRGDALRTAGAWLDTDEVDVALRAADGVHRQLVLHIGSAAVPVHVRPLGAAARLRLSHP
CCCCCHHHHCCCCCCCCCHHEEEECCCCHHHHHHHHCCCCCCEEEEECCCHHHHEEECCC
LPLRVGDVGLLRDPGQHRIAAGVEVLDVRPPPLRRRGAARERAAELAEGRIRPPVCARAS
CCEEECCCCCCCCCCCCHHHCCCEEEECCCCCHHHCCCHHHHHHHHHCCCCCCCHHCCCH
DLRAMGLPQTGRRIGAWVVDETWWAQRREQAVAAVRRWSADHDVAAGMPLETLRRETGLP
HHHHCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCC
AAELVTPLLAGTTLEVSDGRVRRPGMTLPTRIDEAVRAVEKSLADDPFRAPDADTLGQLG
HHHHHHHHHCCCEEEECCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCC
LGTPELAAAVRSGRLTRIAEGVVLGADALERAAEILTALPQPFTVAEAKRALGTTRRVAV
CCCHHHHHHHHCCCHHHHHCCEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHH
PLLEQLDAQRITRRDADGTRTVAKR
HHHHHHHHHHHHHCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8893853 [H]