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The map label for this gene is yeaP [H]

Identifier: 119871324

GI number: 119871324

Start: 5534585

End: 5535706

Strand: Direct

Name: yeaP [H]

Synonym: Mkms_5298

Alternate gene names: 119871324

Gene position: 5534585-5535706 (Clockwise)

Preceding gene: 119871323

Following gene: 119871326

Centisome position: 96.47

GC content: 69.7

Gene sequence:

>1122_bases
GTGGACAATCGGAGTGTGACGTCGCGCATGGACTCGGTGCGGCGGTGGTGGATGTTGCCCGATCACTTCGACTGGGTGAC
CGGCTATCTGCGCAGCCGCGGGATGATGGTTGCTGCACGCACCATCCTGTCCGTGATGGTCGGTTCGCTCGCCCTGGTCC
CGATCCTGTTGGTGTTCAGCAATTTCGGGCCGAAGTCGACGATCGGTGTGGTGGTGTCGTGGCTCGCGGGCATCGGCGGG
TGGGCGACCATGCTCCCCTACGTCCAGCGCTGGCCGACCCGCGTGCAGTCATTGGTGGTGTCGTACATCGCGACCGCCTG
CGTCGCCGCGATCTGCCTGGTCCAGTCCGATCCGACGATCGCCTTGGTGGGCTGCTTCGGCTTCGTGACGCCGGCGGCCT
ACGTCGCATTCCTGCACACCTCCCGCTACACCGCCTACGTCTTCGCGGCGGCGGTGGCGGTGGGCGCGATCGCCGCGACC
CGGTTGGCGTCGAGCGGCCAACTGGTCGGCGCGCTCGCGCTGCTCTGGTTCGTCATCGTGCTCAACGCGGTCATCCCGTT
CGGCGTCCAGACGATCGTGCACGCGCTCGGTGTGGACGTGGTGCGCTCGGAATGGGACCCGCTGACGGGTCTGCTGACCC
GGCGGGCGTTCTACCAACGGCTGTCCACCCTGGTCGCCGGTGACCAGCCGGCCGACCGCAACCTGCTGGTCGCCGTGATC
GACCTCGACAGGTTCAAGAACCTCAACGACACCCAGGGCCACGCCGCCGGTGACCGGGCGCTGATCGCGGTGGGGCGGGC
GCTGTCGCGCAGTTCCGACGACGACGCGCTGGTGGGCCGCACCGGCGGTGAGGAGTTCGTCGTCGCCACGGTGTCGGCCT
CCGCCAACCCGACCCAGCCGGCGATGCGGTTGCTGTCCGCCATCGAGAAGGCGGCGCCGCTGACGGCCAGCGTCGGGACC
GCGAGCGTGCCGCTGATGCGACTCCGTGTCACGGGCTGGCGGGCGGGCATCGACGAGGCGATCACCGCCGCCGACGCGGC
GATGTACGACGCGAAACGCGCAGGCGGCAACCAGGTCCGGCACCGGGAGCTGCCGATGACGGCGGACGACGACCCGTCCT
GA

Upstream 100 bases:

>100_bases
GACCGCCATTCCGGCGGTGGCCGGAGTACTCACCGAGTTCTTCCTGCACCCGGCGGCATAGTGGTCCAACACCCCGCGTG
ACAACGGGATTTGCAGGGCC

Downstream 100 bases:

>100_bases
CCCGGCCGCTCAGAGCCCGGGCTGGTCCTCGATGATCCCGAGCCAGATCTGCGCCGCGTCGATGGCCACCTTCTCCGAGA
TGAATGCGTGCTGGGTGCCG

Product: diguanylate cyclase

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MDNRSVTSRMDSVRRWWMLPDHFDWVTGYLRSRGMMVAARTILSVMVGSLALVPILLVFSNFGPKSTIGVVVSWLAGIGG
WATMLPYVQRWPTRVQSLVVSYIATACVAAICLVQSDPTIALVGCFGFVTPAAYVAFLHTSRYTAYVFAAAVAVGAIAAT
RLASSGQLVGALALLWFVIVLNAVIPFGVQTIVHALGVDVVRSEWDPLTGLLTRRAFYQRLSTLVAGDQPADRNLLVAVI
DLDRFKNLNDTQGHAAGDRALIAVGRALSRSSDDDALVGRTGGEEFVVATVSASANPTQPAMRLLSAIEKAAPLTASVGT
ASVPLMRLRVTGWRAGIDEAITAADAAMYDAKRAGGNQVRHRELPMTADDDPS

Sequences:

>Translated_373_residues
MDNRSVTSRMDSVRRWWMLPDHFDWVTGYLRSRGMMVAARTILSVMVGSLALVPILLVFSNFGPKSTIGVVVSWLAGIGG
WATMLPYVQRWPTRVQSLVVSYIATACVAAICLVQSDPTIALVGCFGFVTPAAYVAFLHTSRYTAYVFAAAVAVGAIAAT
RLASSGQLVGALALLWFVIVLNAVIPFGVQTIVHALGVDVVRSEWDPLTGLLTRRAFYQRLSTLVAGDQPADRNLLVAVI
DLDRFKNLNDTQGHAAGDRALIAVGRALSRSSDDDALVGRTGGEEFVVATVSASANPTQPAMRLLSAIEKAAPLTASVGT
ASVPLMRLRVTGWRAGIDEAITAADAAMYDAKRAGGNQVRHRELPMTADDDPS
>Mature_373_residues
MDNRSVTSRMDSVRRWWMLPDHFDWVTGYLRSRGMMVAARTILSVMVGSLALVPILLVFSNFGPKSTIGVVVSWLAGIGG
WATMLPYVQRWPTRVQSLVVSYIATACVAAICLVQSDPTIALVGCFGFVTPAAYVAFLHTSRYTAYVFAAAVAVGAIAAT
RLASSGQLVGALALLWFVIVLNAVIPFGVQTIVHALGVDVVRSEWDPLTGLLTRRAFYQRLSTLVAGDQPADRNLLVAVI
DLDRFKNLNDTQGHAAGDRALIAVGRALSRSSDDDALVGRTGGEEFVVATVSASANPTQPAMRLLSAIEKAAPLTASVGT
ASVPLMRLRVTGWRAGIDEAITAADAAMYDAKRAGGNQVRHRELPMTADDDPS

Specific function: Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger (Probable). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: COG2199

COG function: function code T; FOG: GGDEF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI87081977, Length=159, Percent_Identity=32.7044025157233, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI145693134, Length=184, Percent_Identity=34.7826086956522, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787802, Length=186, Percent_Identity=29.0322580645161, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787262, Length=169, Percent_Identity=31.3609467455621, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87081881, Length=166, Percent_Identity=34.3373493975904, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786584, Length=165, Percent_Identity=30.3030303030303, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788085, Length=187, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1787816, Length=161, Percent_Identity=31.055900621118, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082007, Length=204, Percent_Identity=30.8823529411765, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788956, Length=159, Percent_Identity=30.8176100628931, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR003018 [H]

Pfam domain/function: PF01590 GAF; PF00990 GGDEF [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 39845; Mature: 39845

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCC
>Mature Secondary Structure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CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]