Click here to switch to the map view.

The map label for this gene is mas [H]

Identifier: 119871103

GI number: 119871103

Start: 5311866

End: 5312849

Strand: Direct

Name: mas [H]

Synonym: Mkms_5076

Alternate gene names: 119871103

Gene position: 5311866-5312849 (Clockwise)

Preceding gene: 119871101

Following gene: 119871105

Centisome position: 92.59

GC content: 69.0

Gene sequence:

>984_bases
ATGCAAGCGATCGTCGCGGAGTCCCCGGCAAAGCTGATCTGGACGGAAGTACCTGAACGCCCACTTCAATCGGGTGATGT
GCGAATCGATGTGGTTGCCGCAGGAATCAACCGGGCCGACCTGTTACAGGCCGCAGGCAAGTATCCGCCGCCGAAGGGCG
CCAGCGACATCATGGGCCTCGAGGTATCGGGCGTCATCAGCGACGTCGCCGACGACGTCTCCGGGTGGGCCGTGGGGCAA
CCGGTCTGCGCTTTGCTGGCAGGCGGCGGGTACGCAGAAAACGTCACCGTCCCGGCCGGCCAGGTCATGCCCGTCCCCGA
GTCGGTGGACCTCGCCCATGCGGCCGCGCTACCGGAAGTGGCGTGCACGGTCTGGTCCAACGTCGTGATGACCGCCGCCC
TGGCCGCCGGCGAGGTGCTGCTGATCCACGGCGGCGCCAGCGGGATCGGGACCCACGCCATCCAGGTGGCCAACGCGCTC
GGCTGCCGGGTCGCCGTCACCGCGGGTTCGGCCAACAAGCTCGACCTGTGCCGGGAACTGGGCGCCGAGGTGGCGATCAA
CTATCGCGACGAGGATTTCGTCGAGCGGTTGCGCGCCGAGACCGACGGCGCGGGCGCCGACGTGATCCTCGACATCATGG
GAGCGGCCTACCTCGACCGCAACGTCGACGCCCTGGCCACCGGCGGGCGGCTCGCCATCATCGGGATGCAGGGTGGCGTC
AAGGCCGAACTCAACATCGGCAAGCTGCTCGCCAAACGCGCGAGTGTCACGGCGACCGCGTTGCGGTCGCGCCCCGTCAG
CGGACCGGGCAGTAAGAGCGACATCGTCGCCGAGGTGGTGGCCAACGTCTGGCCGATGGTCGCCGACGGCCGGGTGCGCC
CGATCATCGGCGCGGAATTCCCGGTACAGGAGGCGCAGGCCGCGCAGGAGATGCTCGACTCCGGTGAGGTGTCGGGCAAG
GTGCTGCTGCGGGTACGCGACTGA

Upstream 100 bases:

>100_bases
CGCTCGCCGTACGCCCCCCAATCATCCCCTCCATCCGCTCATGGTAGAGCACGAAGCCGTCCCCGGGAAGCGAACTGAAC
CCAGGAGTAGGGTTTTGTTG

Downstream 100 bases:

>100_bases
GTCAGCCCAGCGACGCCAGTGCGCGCACCAGCTGGTCGACCTCGGCGGTGGTGGTGTAGTGCGCAAGCCCGATCGTCACG
GCTCCGCCGATGTCGTCGAC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MQAIVAESPAKLIWTEVPERPLQSGDVRIDVVAAGINRADLLQAAGKYPPPKGASDIMGLEVSGVISDVADDVSGWAVGQ
PVCALLAGGGYAENVTVPAGQVMPVPESVDLAHAAALPEVACTVWSNVVMTAALAAGEVLLIHGGASGIGTHAIQVANAL
GCRVAVTAGSANKLDLCRELGAEVAINYRDEDFVERLRAETDGAGADVILDIMGAAYLDRNVDALATGGRLAIIGMQGGV
KAELNIGKLLAKRASVTATALRSRPVSGPGSKSDIVAEVVANVWPMVADGRVRPIIGAEFPVQEAQAAQEMLDSGEVSGK
VLLRVRD

Sequences:

>Translated_327_residues
MQAIVAESPAKLIWTEVPERPLQSGDVRIDVVAAGINRADLLQAAGKYPPPKGASDIMGLEVSGVISDVADDVSGWAVGQ
PVCALLAGGGYAENVTVPAGQVMPVPESVDLAHAAALPEVACTVWSNVVMTAALAAGEVLLIHGGASGIGTHAIQVANAL
GCRVAVTAGSANKLDLCRELGAEVAINYRDEDFVERLRAETDGAGADVILDIMGAAYLDRNVDALATGGRLAIIGMQGGV
KAELNIGKLLAKRASVTATALRSRPVSGPGSKSDIVAEVVANVWPMVADGRVRPIIGAEFPVQEAQAAQEMLDSGEVSGK
VLLRVRD
>Mature_327_residues
MQAIVAESPAKLIWTEVPERPLQSGDVRIDVVAAGINRADLLQAAGKYPPPKGASDIMGLEVSGVISDVADDVSGWAVGQ
PVCALLAGGGYAENVTVPAGQVMPVPESVDLAHAAALPEVACTVWSNVVMTAALAAGEVLLIHGGASGIGTHAIQVANAL
GCRVAVTAGSANKLDLCRELGAEVAINYRDEDFVERLRAETDGAGADVILDIMGAAYLDRNVDALATGGRLAIIGMQGGV
KAELNIGKLLAKRASVTATALRSRPVSGPGSKSDIVAEVVANVWPMVADGRVRPIIGAEFPVQEAQAAQEMLDSGEVSGK
VLLRVRD

Specific function: Catalyzes the elongation of N-fatty acyl-CoA with methylamalonyl-CoA (not malonyl-CoA) as the elongating agent to form mycocerosyl lipids [H]

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 acyl carrier domain [H]

Homologues:

Organism=Homo sapiens, GI22538446, Length=324, Percent_Identity=38.5802469135802, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI22538444, Length=324, Percent_Identity=38.5802469135802, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI194239674, Length=300, Percent_Identity=26.6666666666667, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI13236495, Length=300, Percent_Identity=26.6666666666667, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI41872631, Length=324, Percent_Identity=29.320987654321, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI18379349, Length=304, Percent_Identity=27.3026315789474, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI28557745, Length=247, Percent_Identity=33.1983805668016, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI194239676, Length=300, Percent_Identity=24, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI197927207, Length=198, Percent_Identity=25.2525252525253, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI24308257, Length=330, Percent_Identity=22.1212121212121, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI47519420, Length=294, Percent_Identity=27.891156462585, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1790485, Length=302, Percent_Identity=30.1324503311258, Blast_Score=118, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI212642053, Length=336, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17507255, Length=305, Percent_Identity=23.9344262295082, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=290, Percent_Identity=26.551724137931, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=290, Percent_Identity=25.8620689655172, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=290, Percent_Identity=24.1379310344828, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=290, Percent_Identity=23.7931034482759, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319520, Length=318, Percent_Identity=22.9559748427673, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24581345, Length=329, Percent_Identity=28.8753799392097, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI19920632, Length=320, Percent_Identity=27.1875, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221330659, Length=320, Percent_Identity=27.1875, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR009081
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR000794
- InterPro:   IPR011032
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016036
- InterPro:   IPR016040
- InterPro:   IPR006163
- InterPro:   IPR020842
- InterPro:   IPR020801
- InterPro:   IPR020841
- InterPro:   IPR020807
- InterPro:   IPR020843
- InterPro:   IPR013968
- InterPro:   IPR006162
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF08240 ADH_N; PF00107 ADH_zinc_N; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF08659 KR; PF00550 PP-binding [H]

EC number: =2.3.1.111 [H]

Molecular weight: Translated: 33535; Mature: 33535

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAIVAESPAKLIWTEVPERPLQSGDVRIDVVAAGINRADLLQAAGKYPPPKGASDIMGL
CCCCCCCCCCCEEEECCCCCCCCCCCEEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCE
EVSGVISDVADDVSGWAVGQPVCALLAGGGYAENVTVPAGQVMPVPESVDLAHAAALPEV
EHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEECCCCCEECCCCCCCHHHHHHHHHH
ACTVWSNVVMTAALAAGEVLLIHGGASGIGTHAIQVANALGCRVAVTAGSANKLDLCREL
HHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHC
GAEVAINYRDEDFVERLRAETDGAGADVILDIMGAAYLDRNVDALATGGRLAIIGMQGGV
CCCEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHEECCCEEEEEEECCCC
KAELNIGKLLAKRASVTATALRSRPVSGPGSKSDIVAEVVANVWPMVADGRVRPIIGAEF
EEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCC
PVQEAQAAQEMLDSGEVSGKVLLRVRD
CHHHHHHHHHHHHCCCCCCEEEEEEEC
>Mature Secondary Structure
MQAIVAESPAKLIWTEVPERPLQSGDVRIDVVAAGINRADLLQAAGKYPPPKGASDIMGL
CCCCCCCCCCCEEEECCCCCCCCCCCEEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCE
EVSGVISDVADDVSGWAVGQPVCALLAGGGYAENVTVPAGQVMPVPESVDLAHAAALPEV
EHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEECCCCCEECCCCCCCHHHHHHHHHH
ACTVWSNVVMTAALAAGEVLLIHGGASGIGTHAIQVANALGCRVAVTAGSANKLDLCREL
HHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHC
GAEVAINYRDEDFVERLRAETDGAGADVILDIMGAAYLDRNVDALATGGRLAIIGMQGGV
CCCEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHEECCCEEEEEEECCCC
KAELNIGKLLAKRASVTATALRSRPVSGPGSKSDIVAEVVANVWPMVADGRVRPIIGAEF
EEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCC
PVQEAQAAQEMLDSGEVSGKVLLRVRD
CHHHHHHHHHHHHCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1527058; 12788972 [H]