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The map label for this gene is pbpA [H]

Identifier: 119871070

GI number: 119871070

Start: 5285428

End: 5287188

Strand: Direct

Name: pbpA [H]

Synonym: Mkms_5043

Alternate gene names: 119871070

Gene position: 5285428-5287188 (Clockwise)

Preceding gene: 119871066

Following gene: 119871071

Centisome position: 92.13

GC content: 72.23

Gene sequence:

>1761_bases
GTGAAACGACTCGTTCTCGCACTCGTCGGCGCACTCGTTCTCACGCTGACGGCCTGTTCGTCGCCGAGCCCGGCCGACCC
CTTCCGGGCCTTCGCCGAGGCCCTCGGCCGCCGGGATGCGAAGGCGGCCGCACAGCAGACCGACGACCCGGGCGCCGCCG
AACCGGTCATCGCGGCCATGTTCGACGGGATGGGCGCCGACGCCGGTGTGCGCGTCGAGACGGCGCCGGTCGACGGTGCG
GACACCGATCAGACGCTGGCCTACCGGTGGACCCTGGCTCCCGGTCGCGAATTCGGGTACGAGGCGACGGGCACCGCCGA
GCAGAGCGGCGACGCCTGGCGGTTGGGGTGGTCACCGGCGCTGCTGCACCCGGACCTGAAACCCGGGATGAAGTTCCAGT
ACAGCGAGGACAGCGAGCTGCAGACACCGGTGCTCGACCGCACCGGCCAACCGTTGATGACGTGGCAGACCGTCGCTCTG
GTCAACCTGGACCGCGCCCACCGGGAGTCGGCGGCCGCGCTCGCCGCACTGCTGGCCCCGATCGAGCCGACCATCACACC
CGAATCCATCCAGGCGCAGTTCGACACCGGCGACGACCAGGTGGTCACCGTGATCCGGTTGCGCGAGGCCGACTTCACGC
CGATCGCCGACCAGCTGCGCGCCGTGCCCGGCGTCGCGGTCGCCGAACAGGGCGACCTGCTGACCGCCGACCGGGCGCTG
TCCTCACCGGCGATGGCCGAGCTGCCGAAGGTCTGGCACGACCGCATCACCCGGACCGCCGGCTGGTCGGTGTATCTGGT
CGACGGCGACGGGGCGGCCGCACAACGGCTGACCGCCACCCCGCCCGCACCGACCGACCCCGTCCGCACCTCACTGGACC
TGCGGCTGCAGCTGCTGGCCCAGTCCGCCGTCGCCGCCGAGCCGCGGCCCACGATGCTCGTCGCAATCTCGCCATCGGAC
GGTGGCATCCTCGCGGCCGCGCAGAACGAGGCGGCCGACGCGCAGGGCGCCATCGCGTTCAACGGGCTCTACCCGCCCGG
GTCGACGTTCAAGACGATCACCACCGCCGCGGCGCTGGAGGCGGGGCTGGCGACTCCCCAGACGCCGGTGGCCTGTCCGG
GACGGCTGACGATCGAGAACCGCACGATCCCCAACGACGACGAATTCGACCTCGGGACCGTGCCGCTGACCACCGCGTTC
GCCCGGTCCTGCAACACCTCGATGGCAGCGCTGGCCGACCGGTTACCCGCCGATGCGCTGTCCACCACGGCGCGCGCGTT
CGGGATCGGCGTCGACTACGTGATCCCGGGTCTGACCACCGTGACCGGCCGGGTGCCCGCGGCCGACACCGCGGCCCAGC
GCGTGGAGAACGGCATCGGCCAGGGCACGGTCACGGTCAGCCCGTTCGGGCTCGCGGTCGCCGAGGCCAGCCTCGCGCAC
GGCTCGACGATCACCCCCGCGCTCGTCCTCGGCGAGAAGACCACCGCCGACACCCCGCCCGAAACGCTGCCTCCCGGTGT
CGTCGAAGAACTCCGGACGATGATGCGCGCGACGGTCACCGAGGGCACCGCCGCCGAATTGGCCGACATCGCCGACCTGG
GCGGCAAGACCGGAACGGCCGAGTTCGGCGACAATACCCACTCCCACGGATGGTTCGCCGGGATCGCCGGCGACATCGCG
TTCGCGACGCTGGTGGTCGGCGGCGATTCGTCGGCGCCGGCGATCACGGTCTCGGGCAACTTCCTGCGGCCGGCGGGGTG
A

Upstream 100 bases:

>100_bases
GTTCCGTCACGGCGACGATCCTGCCGCCTCGGAACCCGACACGCGAAACGATTACCGGTCGGCGTTTCTGGCCCTTTTCG
GACACTGCCACGATGGGGTC

Downstream 100 bases:

>100_bases
ATCGGGCAAGCTGAGTTCATGAAACTGGTGGCTGTTCTGGCACTGGCCGGCGGTGTTCTCGCCGCGCCGCTCGTCACCGC
CTCGCCGGCCGCGGCGGTCC

Product: penicillin-binding protein, transpeptidase

Products: NA

Alternate protein names: PBPA [H]

Number of amino acids: Translated: 586; Mature: 586

Protein sequence:

>586_residues
MKRLVLALVGALVLTLTACSSPSPADPFRAFAEALGRRDAKAAAQQTDDPGAAEPVIAAMFDGMGADAGVRVETAPVDGA
DTDQTLAYRWTLAPGREFGYEATGTAEQSGDAWRLGWSPALLHPDLKPGMKFQYSEDSELQTPVLDRTGQPLMTWQTVAL
VNLDRAHRESAAALAALLAPIEPTITPESIQAQFDTGDDQVVTVIRLREADFTPIADQLRAVPGVAVAEQGDLLTADRAL
SSPAMAELPKVWHDRITRTAGWSVYLVDGDGAAAQRLTATPPAPTDPVRTSLDLRLQLLAQSAVAAEPRPTMLVAISPSD
GGILAAAQNEAADAQGAIAFNGLYPPGSTFKTITTAAALEAGLATPQTPVACPGRLTIENRTIPNDDEFDLGTVPLTTAF
ARSCNTSMAALADRLPADALSTTARAFGIGVDYVIPGLTTVTGRVPAADTAAQRVENGIGQGTVTVSPFGLAVAEASLAH
GSTITPALVLGEKTTADTPPETLPPGVVEELRTMMRATVTEGTAAELADIADLGGKTGTAEFGDNTHSHGWFAGIAGDIA
FATLVVGGDSSAPAITVSGNFLRPAG

Sequences:

>Translated_586_residues
MKRLVLALVGALVLTLTACSSPSPADPFRAFAEALGRRDAKAAAQQTDDPGAAEPVIAAMFDGMGADAGVRVETAPVDGA
DTDQTLAYRWTLAPGREFGYEATGTAEQSGDAWRLGWSPALLHPDLKPGMKFQYSEDSELQTPVLDRTGQPLMTWQTVAL
VNLDRAHRESAAALAALLAPIEPTITPESIQAQFDTGDDQVVTVIRLREADFTPIADQLRAVPGVAVAEQGDLLTADRAL
SSPAMAELPKVWHDRITRTAGWSVYLVDGDGAAAQRLTATPPAPTDPVRTSLDLRLQLLAQSAVAAEPRPTMLVAISPSD
GGILAAAQNEAADAQGAIAFNGLYPPGSTFKTITTAAALEAGLATPQTPVACPGRLTIENRTIPNDDEFDLGTVPLTTAF
ARSCNTSMAALADRLPADALSTTARAFGIGVDYVIPGLTTVTGRVPAADTAAQRVENGIGQGTVTVSPFGLAVAEASLAH
GSTITPALVLGEKTTADTPPETLPPGVVEELRTMMRATVTEGTAAELADIADLGGKTGTAEFGDNTHSHGWFAGIAGDIA
FATLVVGGDSSAPAITVSGNFLRPAG
>Mature_586_residues
MKRLVLALVGALVLTLTACSSPSPADPFRAFAEALGRRDAKAAAQQTDDPGAAEPVIAAMFDGMGADAGVRVETAPVDGA
DTDQTLAYRWTLAPGREFGYEATGTAEQSGDAWRLGWSPALLHPDLKPGMKFQYSEDSELQTPVLDRTGQPLMTWQTVAL
VNLDRAHRESAAALAALLAPIEPTITPESIQAQFDTGDDQVVTVIRLREADFTPIADQLRAVPGVAVAEQGDLLTADRAL
SSPAMAELPKVWHDRITRTAGWSVYLVDGDGAAAQRLTATPPAPTDPVRTSLDLRLQLLAQSAVAAEPRPTMLVAISPSD
GGILAAAQNEAADAQGAIAFNGLYPPGSTFKTITTAAALEAGLATPQTPVACPGRLTIENRTIPNDDEFDLGTVPLTTAF
ARSCNTSMAALADRLPADALSTTARAFGIGVDYVIPGLTTVTGRVPAADTAAQRVENGIGQGTVTVSPFGLAVAEASLAH
GSTITPALVLGEKTTADTPPETLPPGVVEELRTMMRATVTEGTAAELADIADLGGKTGTAEFGDNTHSHGWFAGIAGDIA
FATLVVGGDSSAPAITVSGNFLRPAG

Specific function: Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Probable). Note=Localized to the division site (septum) along with newly synthesized peptidoglycan, between segregated nucleoids (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 60554; Mature: 60554

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLVLALVGALVLTLTACSSPSPADPFRAFAEALGRRDAKAAAQQTDDPGAAEPVIAAM
CHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHH
FDGMGADAGVRVETAPVDGADTDQTLAYRWTLAPGREFGYEATGTAEQSGDAWRLGWSPA
HCCCCCCCCCEEEECCCCCCCCCCEEEEEEEECCCHHCCCCCCCCCCCCCCEEEECCCCC
LLHPDLKPGMKFQYSEDSELQTPVLDRTGQPLMTWQTVALVNLDRAHRESAAALAALLAP
EECCCCCCCCEEEECCCCCCCCCHHHCCCCCCEEEEEEEEEECHHHHHHHHHHHHHHHHC
IEPTITPESIQAQFDTGDDQVVTVIRLREADFTPIADQLRAVPGVAVAEQGDLLTADRAL
CCCCCCHHHHEEEECCCCCEEEEEEEEECCCCCCHHHHHHHCCCEEEECCCCEEEHHHHH
SSPAMAELPKVWHDRITRTAGWSVYLVDGDGAAAQRLTATPPAPTDPVRTSLDLRLQLLA
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHCCEECCCCCCCCCCCCCHHHHHHHHH
QSAVAAEPRPTMLVAISPSDGGILAAAQNEAADAQGAIAFNGLYPPGSTFKTITTAAALE
HHHHCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHH
AGLATPQTPVACPGRLTIENRTIPNDDEFDLGTVPLTTAFARSCNTSMAALADRLPADAL
HCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCHHHH
STTARAFGIGVDYVIPGLTTVTGRVPAADTAAQRVENGIGQGTVTVSPFGLAVAEASLAH
HHHHHHHHCCHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCC
GSTITPALVLGEKTTADTPPETLPPGVVEELRTMMRATVTEGTAAELADIADLGGKTGTA
CCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCC
EFGDNTHSHGWFAGIAGDIAFATLVVGGDSSAPAITVSGNFLRPAG
CCCCCCCCCCEEEHHHHHHEEEEEEECCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MKRLVLALVGALVLTLTACSSPSPADPFRAFAEALGRRDAKAAAQQTDDPGAAEPVIAAM
CHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHH
FDGMGADAGVRVETAPVDGADTDQTLAYRWTLAPGREFGYEATGTAEQSGDAWRLGWSPA
HCCCCCCCCCEEEECCCCCCCCCCEEEEEEEECCCHHCCCCCCCCCCCCCCEEEECCCCC
LLHPDLKPGMKFQYSEDSELQTPVLDRTGQPLMTWQTVALVNLDRAHRESAAALAALLAP
EECCCCCCCCEEEECCCCCCCCCHHHCCCCCCEEEEEEEEEECHHHHHHHHHHHHHHHHC
IEPTITPESIQAQFDTGDDQVVTVIRLREADFTPIADQLRAVPGVAVAEQGDLLTADRAL
CCCCCCHHHHEEEECCCCCEEEEEEEEECCCCCCHHHHHHHCCCEEEECCCCEEEHHHHH
SSPAMAELPKVWHDRITRTAGWSVYLVDGDGAAAQRLTATPPAPTDPVRTSLDLRLQLLA
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHCCEECCCCCCCCCCCCCHHHHHHHHH
QSAVAAEPRPTMLVAISPSDGGILAAAQNEAADAQGAIAFNGLYPPGSTFKTITTAAALE
HHHHCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHH
AGLATPQTPVACPGRLTIENRTIPNDDEFDLGTVPLTTAFARSCNTSMAALADRLPADAL
HCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCHHHH
STTARAFGIGVDYVIPGLTTVTGRVPAADTAAQRVENGIGQGTVTVSPFGLAVAEASLAH
HHHHHHHHCCHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCC
GSTITPALVLGEKTTADTPPETLPPGVVEELRTMMRATVTEGTAAELADIADLGGKTGTA
CCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCC
EFGDNTHSHGWFAGIAGDIAFATLVVGGDSSAPAITVSGNFLRPAG
CCCCCCCCCCEEEHHHHHHEEEEEEECCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA