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The map label for this gene is 119870753

Identifier: 119870753

GI number: 119870753

Start: 4948441

End: 4949619

Strand: Direct

Name: 119870753

Synonym: Mkms_4724

Alternate gene names: NA

Gene position: 4948441-4949619 (Clockwise)

Preceding gene: 119870752

Following gene: 119870754

Centisome position: 86.25

GC content: 69.38

Gene sequence:

>1179_bases
ATGGCGAAGAACATGGCAGCGGTGCTGGGCACCGGGCAGACCAAGTACGTCGCCAAGCGCCAGGACGTGTCGATGAACGG
CCTGGTGCGCGAGGCCATCGACCGCGCGCTCGCCGACGCCGGCGCCACGATGGACGACATCGACGCCGTGGTGGTGGGCA
AGGCGCCGGACTTCTTCGAAGGCGTCATGATGCCCGAACTGTTCCTCGCCGACGCCGTCGGCGCCACCAACAAGCCGATG
ATCCGCGTGCACACCGCAGGATCGGTCGGCGGGTCCACCGCGGTGGTGGCCGCCAGCCTGGTGCAGTCCGGCAAGTACCG
CCGCGTGCTGGCGATGGCGTGGGAGAAGCAGTCCGAATCGAACGCCATGTGGGCGTTGAGCATTCCGGTGCCGTTCACCA
AGCCGGTCGGCGCCGGCGCCGGCGGCTACTTCGCACCGCACGTGCGGGCCTACATCCGCCGGTCGGGTGCGCCGACGCAC
ATCGGGGCGATGGTGGCCGTCAAGGACCGGCTCAACGGTGCGAAGAACCCGCTGGCCCACCTGCATCAGCCCGACATCAC
GCTGGAGAAGGTGCTGTCCTCGCAGATGCTGTGGGACCCGATCCGTTTCGACGAGACCTGCCCGTCCTCCGACGGTGCCT
GCGCGCTGGTGATCGGCGACGAGGAGGCCGCGGACAGCCGTGTCGCCGAGGGCCATCCGGTGGCGTGGATCCACGCCACC
GCGCTGCGCACCGAACCGCTGGCCTATGCGGGCCGCGATCAGGTGAACCCGCAGGCCGGCCGCGACGCCGCCAAGGCGCT
GTGGGCGGCGGCCGGGATCAACAGCCCGATCGACGAGATCGACGTGGCGGAGATCTACGTCCCCTTCTCCTGGTTCGAAC
CGATGTGGCTGGAGAACCTCGGGTTCGCCGCCGAGGGCGAGGGTTGGAAACTCACCGAGGCCGGTGAGACGGCGATCGGC
GGGCGGCTGCCGGTCAACCCGTCCGGTGGTGTGCTCTCGTCGAACCCGATCGGCGCGTCGGGGATGATCCGCTTCGCCGA
GGCCGCCATCCAGGTGATGGGCAAGGCCGGCGAACATCAGGTGGAGGGCGCCCGCAAAGCCCTCGGACATGCGTACGGCG
GTGGCTCGCAGTACTACTCGATGTGGGTGGTGAGCTCCGACAAGCGGACGCAGCCGTGA

Upstream 100 bases:

>100_bases
TCGACGGCTCGGCGCAGCGGGTGCTCGCGCACGCCACCAGTGGCCCTGCGCTGCAACAGAACCTGGTCGCGGTCCTCGAG
GGAAGGGACGGCAAGAACTG

Downstream 100 bases:

>100_bases
CCATGAAGTACACGGTCAGCATCGCGATGGGTCCCGTCGACGAGTTGACCGAGCTCGCGAGATGCGCCGAAGAGGTCGGG
TTCGACGCTATCGCGCTGCC

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MAKNMAAVLGTGQTKYVAKRQDVSMNGLVREAIDRALADAGATMDDIDAVVVGKAPDFFEGVMMPELFLADAVGATNKPM
IRVHTAGSVGGSTAVVAASLVQSGKYRRVLAMAWEKQSESNAMWALSIPVPFTKPVGAGAGGYFAPHVRAYIRRSGAPTH
IGAMVAVKDRLNGAKNPLAHLHQPDITLEKVLSSQMLWDPIRFDETCPSSDGACALVIGDEEAADSRVAEGHPVAWIHAT
ALRTEPLAYAGRDQVNPQAGRDAAKALWAAAGINSPIDEIDVAEIYVPFSWFEPMWLENLGFAAEGEGWKLTEAGETAIG
GRLPVNPSGGVLSSNPIGASGMIRFAEAAIQVMGKAGEHQVEGARKALGHAYGGGSQYYSMWVVSSDKRTQP

Sequences:

>Translated_392_residues
MAKNMAAVLGTGQTKYVAKRQDVSMNGLVREAIDRALADAGATMDDIDAVVVGKAPDFFEGVMMPELFLADAVGATNKPM
IRVHTAGSVGGSTAVVAASLVQSGKYRRVLAMAWEKQSESNAMWALSIPVPFTKPVGAGAGGYFAPHVRAYIRRSGAPTH
IGAMVAVKDRLNGAKNPLAHLHQPDITLEKVLSSQMLWDPIRFDETCPSSDGACALVIGDEEAADSRVAEGHPVAWIHAT
ALRTEPLAYAGRDQVNPQAGRDAAKALWAAAGINSPIDEIDVAEIYVPFSWFEPMWLENLGFAAEGEGWKLTEAGETAIG
GRLPVNPSGGVLSSNPIGASGMIRFAEAAIQVMGKAGEHQVEGARKALGHAYGGGSQYYSMWVVSSDKRTQP
>Mature_391_residues
AKNMAAVLGTGQTKYVAKRQDVSMNGLVREAIDRALADAGATMDDIDAVVVGKAPDFFEGVMMPELFLADAVGATNKPMI
RVHTAGSVGGSTAVVAASLVQSGKYRRVLAMAWEKQSESNAMWALSIPVPFTKPVGAGAGGYFAPHVRAYIRRSGAPTHI
GAMVAVKDRLNGAKNPLAHLHQPDITLEKVLSSQMLWDPIRFDETCPSSDGACALVIGDEEAADSRVAEGHPVAWIHATA
LRTEPLAYAGRDQVNPQAGRDAAKALWAAAGINSPIDEIDVAEIYVPFSWFEPMWLENLGFAAEGEGWKLTEAGETAIGG
RLPVNPSGGVLSSNPIGASGMIRFAEAAIQVMGKAGEHQVEGARKALGHAYGGGSQYYSMWVVSSDKRTQP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=394, Percent_Identity=27.9187817258883, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI302344760, Length=328, Percent_Identity=27.7439024390244, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI302344767, Length=324, Percent_Identity=27.7777777777778, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI302344762, Length=283, Percent_Identity=28.2685512367491, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI55956775, Length=249, Percent_Identity=26.1044176706827, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17537653, Length=390, Percent_Identity=25.3846153846154, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI19921506, Length=396, Percent_Identity=28.7878787878788, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24585051, Length=396, Percent_Identity=29.040404040404, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 41438; Mature: 41307

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKNMAAVLGTGQTKYVAKRQDVSMNGLVREAIDRALADAGATMDDIDAVVVGKAPDFFE
CCCCCEEECCCCCCCEEHHCCCCCHHHHHHHHHHHHHHHCCCCHHHCCEEEECCCCHHHH
GVMMPELFLADAVGATNKPMIRVHTAGSVGGSTAVVAASLVQSGKYRRVLAMAWEKQSES
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEHHHHHHCCCCC
NAMWALSIPVPFTKPVGAGAGGYFAPHVRAYIRRSGAPTHIGAMVAVKDRLNGAKNPLAH
CCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHEEEEHHHCCCCCCCHHH
LHQPDITLEKVLSSQMLWDPIRFDETCPSSDGACALVIGDEEAADSRVAEGHPVAWIHAT
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEE
ALRTEPLAYAGRDQVNPQAGRDAAKALWAAAGINSPIDEIDVAEIYVPFSWFEPMWLENL
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHCCCHHHHHC
GFAAEGEGWKLTEAGETAIGGRLPVNPSGGVLSSNPIGASGMIRFAEAAIQVMGKAGEHQ
CCCCCCCCEEEECCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCHH
VEGARKALGHAYGGGSQYYSMWVVSSDKRTQP
HHHHHHHHHHCCCCCCEEEEEEEEECCCCCCC
>Mature Secondary Structure 
AKNMAAVLGTGQTKYVAKRQDVSMNGLVREAIDRALADAGATMDDIDAVVVGKAPDFFE
CCCCEEECCCCCCCEEHHCCCCCHHHHHHHHHHHHHHHCCCCHHHCCEEEECCCCHHHH
GVMMPELFLADAVGATNKPMIRVHTAGSVGGSTAVVAASLVQSGKYRRVLAMAWEKQSES
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEHHHHHHCCCCC
NAMWALSIPVPFTKPVGAGAGGYFAPHVRAYIRRSGAPTHIGAMVAVKDRLNGAKNPLAH
CCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHEEEEHHHCCCCCCCHHH
LHQPDITLEKVLSSQMLWDPIRFDETCPSSDGACALVIGDEEAADSRVAEGHPVAWIHAT
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEE
ALRTEPLAYAGRDQVNPQAGRDAAKALWAAAGINSPIDEIDVAEIYVPFSWFEPMWLENL
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHCCCHHHHHC
GFAAEGEGWKLTEAGETAIGGRLPVNPSGGVLSSNPIGASGMIRFAEAAIQVMGKAGEHQ
CCCCCCCCEEEECCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCHH
VEGARKALGHAYGGGSQYYSMWVVSSDKRTQP
HHHHHHHHHHCCCCCCEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]