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The map label for this gene is prrB [H]

Identifier: 119870565

GI number: 119870565

Start: 4771543

End: 4772889

Strand: Direct

Name: prrB [H]

Synonym: Mkms_4536

Alternate gene names: 119870565

Gene position: 4771543-4772889 (Clockwise)

Preceding gene: 119870564

Following gene: 119870567

Centisome position: 83.17

GC content: 70.45

Gene sequence:

>1347_bases
ATGAGCGCGCTGTCGCGGATCTTCCGCCGCACCCCGTCCCTGCGGACCAGGGTGGCCTTCGCGACAGCGATCGGCGCGGC
GATCGTCGTGGTGATCGTCGGCACCGTGGTGTGGGTCGGCATCACCAACGACCGCAAGGAGCGCCTCGACCGGCGCCTCG
ACGAGGCGGCCGGTTTCGCGATCCCGTTCCTGCCGCGCGGCCTGGACACCATCCCGAAGTCGCCGAACAACCAGGACGTC
GTCATCACCGTGCGCCTACCCAGCGGTGAGGTCACCTCGAACTCCGACGTGGTGCTGCCGGAGTCGCAGCCCGGGTACGC
CGACACGTATGTCGACGGTGTGCGCTACCGGGTGCGCACCGTCGACATCCGCTACCCCGAACCGATGTCGGTGGAAGTCG
GCGCCACCTACGACGCCACCGTCGCCGACACCAACAACCTGCACCGACGGGTGATCATCATCTGCGCGTTGGCGGTCGGG
GCGGCCACCCTGCTGGGCTGGCTGCTGGCGGCGTTCGCGGTGCGCCCGCTCAAACGCCTCGCCGAACAGACCCGCCAGAT
CGACGCCGGTGACGAAGCCCCCGACGTCGAAGTGCGCGGCGCCTCCGAGGCCGTCGAGATCGCCGAAGCCGTCAAGGGCA
TGCTCGAACGCATCTGGTCCGAACAGGACCGCACGAAGGCCGCGCTCGCGTCGGCGCGCGACTTCGCGTCGGTCTCCGCG
CACGAACTGCGCACGCCGCTGACCGCGATGCGGACCAACCTCGAGGTGCTGGCCACCCTGGACCTCGCCGACGAACAGCG
CAAAGAGGTGATCAACGACGTCATCCGGACCCAGTCGCGTATCGAGGCGACGCTGTCCGCGCTGGAACGCCTGGCCCAGG
GTGAACTGTCGACCGCCGCCGACCATGTGCCCGTCGACATCACCGAACTGCTCGACCGCGCCGCCCACGACGCGATGCGC
GTGTATCCGGACCTGGAGGTGACGCTGGTGCCTGCGCCGACGGTGATCATCGTCGGACTGCCCGCCGGGTTGCGACTCGC
CGTCGACAACGCGATCGCCAACGCCGTCAAACACGGCGGCGCCACGCGGGTGCAGCTGTCGGCGGTCAGTTCCCGCGCGG
GTGTGGAGATCGCGATCGACGACGACGGCGTCGGCGTGCCCGAGGAGGAACGTACGCGGGTGTTCGAGCGGTTCTCCCGC
GGGTCGACCGCGTCGCACTCCGGCTCCGGGCTGGGGCTGGCGCTGGTCGCTCAGCAGGCCGAATTGCACGGCGGGACGGC
GACACTGGAGTCCAGCCCGCTCGGCGGGGCACGGCTGCTGCTGCGGCTACCCGGGCCCCGCGGCTGA

Upstream 100 bases:

>100_bases
TGTTCATCGGATACCTGCGCCGCAAGCTCGAGGCGGGCGGCGCGCCCCGCCTGCTGCACACCGTGCGGGGTGTGGGATTC
GTCCTCCGGACCCAATAGCC

Downstream 100 bases:

>100_bases
CCCTGCGCGAACGTGAGCTTGTGCGTGAGTCGCGGGCGCTTTCTCGCTCACGGGCTCACGTTCGGCGGACCTTATCGGGT
GGCCAGCAGGTCGATGACGA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSALSRIFRRTPSLRTRVAFATAIGAAIVVVIVGTVVWVGITNDRKERLDRRLDEAAGFAIPFLPRGLDTIPKSPNNQDV
VITVRLPSGEVTSNSDVVLPESQPGYADTYVDGVRYRVRTVDIRYPEPMSVEVGATYDATVADTNNLHRRVIIICALAVG
AATLLGWLLAAFAVRPLKRLAEQTRQIDAGDEAPDVEVRGASEAVEIAEAVKGMLERIWSEQDRTKAALASARDFASVSA
HELRTPLTAMRTNLEVLATLDLADEQRKEVINDVIRTQSRIEATLSALERLAQGELSTAADHVPVDITELLDRAAHDAMR
VYPDLEVTLVPAPTVIIVGLPAGLRLAVDNAIANAVKHGGATRVQLSAVSSRAGVEIAIDDDGVGVPEEERTRVFERFSR
GSTASHSGSGLGLALVAQQAELHGGTATLESSPLGGARLLLRLPGPRG

Sequences:

>Translated_448_residues
MSALSRIFRRTPSLRTRVAFATAIGAAIVVVIVGTVVWVGITNDRKERLDRRLDEAAGFAIPFLPRGLDTIPKSPNNQDV
VITVRLPSGEVTSNSDVVLPESQPGYADTYVDGVRYRVRTVDIRYPEPMSVEVGATYDATVADTNNLHRRVIIICALAVG
AATLLGWLLAAFAVRPLKRLAEQTRQIDAGDEAPDVEVRGASEAVEIAEAVKGMLERIWSEQDRTKAALASARDFASVSA
HELRTPLTAMRTNLEVLATLDLADEQRKEVINDVIRTQSRIEATLSALERLAQGELSTAADHVPVDITELLDRAAHDAMR
VYPDLEVTLVPAPTVIIVGLPAGLRLAVDNAIANAVKHGGATRVQLSAVSSRAGVEIAIDDDGVGVPEEERTRVFERFSR
GSTASHSGSGLGLALVAQQAELHGGTATLESSPLGGARLLLRLPGPRG
>Mature_447_residues
SALSRIFRRTPSLRTRVAFATAIGAAIVVVIVGTVVWVGITNDRKERLDRRLDEAAGFAIPFLPRGLDTIPKSPNNQDVV
ITVRLPSGEVTSNSDVVLPESQPGYADTYVDGVRYRVRTVDIRYPEPMSVEVGATYDATVADTNNLHRRVIIICALAVGA
ATLLGWLLAAFAVRPLKRLAEQTRQIDAGDEAPDVEVRGASEAVEIAEAVKGMLERIWSEQDRTKAALASARDFASVSAH
ELRTPLTAMRTNLEVLATLDLADEQRKEVINDVIRTQSRIEATLSALERLAQGELSTAADHVPVDITELLDRAAHDAMRV
YPDLEVTLVPAPTVIIVGLPAGLRLAVDNAIANAVKHGGATRVQLSAVSSRAGVEIAIDDDGVGVPEEERTRVFERFSRG
STASHSGSGLGLALVAQQAELHGGTATLESSPLGGARLLLRLPGPRG

Specific function: Member of the two-component regulatory system prrB/prrA. Involved specifically in early intracellular multiplication of Mycobacterium. Probably phosphorylates prrA [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=278, Percent_Identity=28.4172661870504, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789808, Length=309, Percent_Identity=28.1553398058252, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1789403, Length=471, Percent_Identity=26.3269639065817, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787894, Length=232, Percent_Identity=31.8965517241379, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788279, Length=286, Percent_Identity=26.9230769230769, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=27.7580071174377, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790861, Length=298, Percent_Identity=26.510067114094, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786912, Length=252, Percent_Identity=30.1587301587302, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788713, Length=237, Percent_Identity=24.8945147679325, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=27.7272727272727, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787374, Length=277, Percent_Identity=25.2707581227437, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789149, Length=266, Percent_Identity=24.4360902255639, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI145693157, Length=258, Percent_Identity=25.5813953488372, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082128, Length=266, Percent_Identity=26.6917293233083, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790551, Length=288, Percent_Identity=25.3472222222222, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786783, Length=368, Percent_Identity=22.8260869565217, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI48994928, Length=258, Percent_Identity=27.5193798449612, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47948; Mature: 47817

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALSRIFRRTPSLRTRVAFATAIGAAIVVVIVGTVVWVGITNDRKERLDRRLDEAAGFA
CHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHCCCC
IPFLPRGLDTIPKSPNNQDVVITVRLPSGEVTSNSDVVLPESQPGYADTYVDGVRYRVRT
CCCCCCCCHHCCCCCCCCEEEEEEECCCCCCCCCCCEEECCCCCCCCHHHHHCCEEEEEE
VDIRYPEPMSVEVGATYDATVADTNNLHRRVIIICALAVGAATLLGWLLAAFAVRPLKRL
EEEECCCCCEEEECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEQTRQIDAGDEAPDVEVRGASEAVEIAEAVKGMLERIWSEQDRTKAALASARDFASVSA
HHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
HELRTPLTAMRTNLEVLATLDLADEQRKEVINDVIRTQSRIEATLSALERLAQGELSTAA
HHHHCCHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCC
DHVPVDITELLDRAAHDAMRVYPDLEVTLVPAPTVIIVGLPAGLRLAVDNAIANAVKHGG
CCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCEEHHHHHHHHHHHCCC
ATRVQLSAVSSRAGVEIAIDDDGVGVPEEERTRVFERFSRGSTASHSGSGLGLALVAQQA
CCEEEEEEHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEHHH
ELHGGTATLESSPLGGARLLLRLPGPRG
HHCCCEEEECCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
SALSRIFRRTPSLRTRVAFATAIGAAIVVVIVGTVVWVGITNDRKERLDRRLDEAAGFA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHCCCC
IPFLPRGLDTIPKSPNNQDVVITVRLPSGEVTSNSDVVLPESQPGYADTYVDGVRYRVRT
CCCCCCCCHHCCCCCCCCEEEEEEECCCCCCCCCCCEEECCCCCCCCHHHHHCCEEEEEE
VDIRYPEPMSVEVGATYDATVADTNNLHRRVIIICALAVGAATLLGWLLAAFAVRPLKRL
EEEECCCCCEEEECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEQTRQIDAGDEAPDVEVRGASEAVEIAEAVKGMLERIWSEQDRTKAALASARDFASVSA
HHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
HELRTPLTAMRTNLEVLATLDLADEQRKEVINDVIRTQSRIEATLSALERLAQGELSTAA
HHHHCCHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCC
DHVPVDITELLDRAAHDAMRVYPDLEVTLVPAPTVIIVGLPAGLRLAVDNAIANAVKHGG
CCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCEEHHHHHHHHHHHCCC
ATRVQLSAVSSRAGVEIAIDDDGVGVPEEERTRVFERFSRGSTASHSGSGLGLALVAQQA
CCEEEEEEHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEHHH
ELHGGTATLESSPLGGARLLLRLPGPRG
HHCCCEEEECCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]