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The map label for this gene is prrA [H]

Identifier: 119870564

GI number: 119870564

Start: 4770839

End: 4771540

Strand: Direct

Name: prrA [H]

Synonym: Mkms_4535

Alternate gene names: 119870564

Gene position: 4770839-4771540 (Clockwise)

Preceding gene: 119870563

Following gene: 119870565

Centisome position: 83.16

GC content: 69.52

Gene sequence:

>702_bases
ATGGACAGTGGTGTGGGATCGCCCCGGGTACTGGTCGTCGACGACGACCCCGACGTGCTGGCGTCGCTGGAACGCGGGTT
GCGGCTGTCCGGGTTCGACGTGTCCACCGCGGTGGACGGCGCCGAGGCGCTGCGCAGCGCCACCGAGACGCGCCCCGATG
CGATCGTCCTCGACATCAACATGCCGGTGCTCGACGGCGTCAGCGTGGTCACGGCGTTGCGCGCGATGGACAACGACGTG
CCGGTCTGCGTGCTGAGCGCGCGCAGCAGTGTCGACGACCGGGTGGCCGGTCTGGAGGCGGGCGCCGACGACTACCTCGT
CAAACCCTTCGTGCTGGCCGAGCTGGTGGCCCGGGTCAAGGCACTGTTGCGTCGGCGGGGTTCGTCGGCGACCTTCTCGT
CGGAGACCATCCAGGTCGGCCCGCTCGAGGTCGACATCCCCGGCCGGCGGGCCCGTGTCAACGGCGTCGACGTCGACCTG
ACCAAACGTGAATTCGACCTGCTGGCGGTGCTGGCCGAGCACAAGACCGCGGTGCTCTCCCGCGCCCAGTTGCTCGAACT
GGTCTGGGGTTACGACTTCGCCGCCGACACCAACGTCGTCGACGTGTTCATCGGATACCTGCGCCGCAAGCTCGAGGCGG
GCGGCGCGCCCCGCCTGCTGCACACCGTGCGGGGTGTGGGATTCGTCCTCCGGACCCAATAG

Upstream 100 bases:

>100_bases
CGGATCTGCGCGGGGAGATCGCACAGATGCGTGAGGAGGGACGGCGATCCGGCGGGCAGCCTCCCCCAGCCTGACCTCTG
TATCAGGCAAGATTGCTCCC

Downstream 100 bases:

>100_bases
CCATGAGCGCGCTGTCGCGGATCTTCCGCCGCACCCCGTCCCTGCGGACCAGGGTGGCCTTCGCGACAGCGATCGGCGCG
GCGATCGTCGTGGTGATCGT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MDSGVGSPRVLVVDDDPDVLASLERGLRLSGFDVSTAVDGAEALRSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDV
PVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGSSATFSSETIQVGPLEVDIPGRRARVNGVDVDL
TKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGAPRLLHTVRGVGFVLRTQ

Sequences:

>Translated_233_residues
MDSGVGSPRVLVVDDDPDVLASLERGLRLSGFDVSTAVDGAEALRSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDV
PVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGSSATFSSETIQVGPLEVDIPGRRARVNGVDVDL
TKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGAPRLLHTVRGVGFVLRTQ
>Mature_233_residues
MDSGVGSPRVLVVDDDPDVLASLERGLRLSGFDVSTAVDGAEALRSATETRPDAIVLDINMPVLDGVSVVTALRAMDNDV
PVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGSSATFSSETIQVGPLEVDIPGRRARVNGVDVDL
TKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGAPRLLHTVRGVGFVLRTQ

Specific function: Member of the two-component regulatory system prrB/prrA. Involved specifically in early intracellular multiplication of Mycobacterium [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=40.0900900900901, Blast_Score=160, Evalue=7e-41,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=38.3259911894273, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=35.4545454545455, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=38.6363636363636, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=35.6828193832599, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=36.7256637168142, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=40.174672489083, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=34.6846846846847, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=35.1111111111111, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=37.6106194690265, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=31.0043668122271, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=32.8947368421053, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=36.4485981308411, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=37.8378378378378, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1790437, Length=119, Percent_Identity=34.453781512605, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=26.7241379310345, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788713, Length=113, Percent_Identity=33.6283185840708, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788905, Length=101, Percent_Identity=34.6534653465347, Blast_Score=61, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=118, Percent_Identity=30.5084745762712, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25007; Mature: 25007

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSGVGSPRVLVVDDDPDVLASLERGLRLSGFDVSTAVDGAEALRSATETRPDAIVLDIN
CCCCCCCCEEEEECCCHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEEC
MPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVK
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ALLRRRGSSATFSSETIQVGPLEVDIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLS
HHHHHCCCCCCCCCCEEEECCEEEECCCCEEEECCCCEEECHHHHHHHHHHHHHHHHHHH
RAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGAPRLLHTVRGVGFVLRTQ
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEECC
>Mature Secondary Structure
MDSGVGSPRVLVVDDDPDVLASLERGLRLSGFDVSTAVDGAEALRSATETRPDAIVLDIN
CCCCCCCCEEEEECCCHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEEC
MPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVK
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ALLRRRGSSATFSSETIQVGPLEVDIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLS
HHHHHCCCCCCCCCCEEEECCEEEECCCCEEEECCCCEEECHHHHHHHHHHHHHHHHHHH
RAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGAPRLLHTVRGVGFVLRTQ
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]