| Definition | Mycobacterium sp. KMS chromosome, complete genome. |
|---|---|
| Accession | NC_008705 |
| Length | 5,737,227 |
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The map label for this gene is xecD [H]
Identifier: 119870527
GI number: 119870527
Start: 4731274
End: 4732044
Strand: Direct
Name: xecD [H]
Synonym: Mkms_4498
Alternate gene names: 119870527
Gene position: 4731274-4732044 (Clockwise)
Preceding gene: 119870526
Following gene: 119870528
Centisome position: 82.47
GC content: 68.22
Gene sequence:
>771_bases GTGCAGGTAGCGATCGTCACGGGTGCCAGCAGCGGCATCGGGTTCGGTTGTGCCACAACGCTGGCCGAGCAGGGTATGGC GGTGCTGGGCACCGGACGAGACGAGGAACGGCTCGCCGAACTGGAGAAGGCCGTCGGCTCCGACCGGATCGCCACGGTCG CGGTGGATCTGACCGACGACGACGGTCCCGCCCGGGTCGTCGCGGCCGCACTGGAGCGGTGGGGGCGGATCGACTTCCTG GTCAACAACGCCGGGGTGGGCAGTCCCAAACCCCTGCACGAGACCGACGACGAATCGCTGGACTATTTCCTGAACCTGAT GCTGCGGGCGCCGTTCCGGTTGTCGCGCGACGTGATCCCGCACATGCAGCCGGGCTCGGCGATCATCAACGTGACGTCCA CGTTCGCGGTCGTCGGTGGGCTGCGCGGCGGCGCGTACTCGGCGGCCAAGGGCGGGCTGACCGCACTGACCGCCCACATC GCGTGCCAATACGGTGCGCAGGGCATCCGGTGCAACGCGGTGGCGCCCGGCGTCACGCTCACCCCCATGGTGGCGACGCG GCTCGAGGACGAGCGGTTCCGCAAGATCAACACCGAGATGACACCGCACCAGCGGTTGGGCCGGGTCGAGGACATCGCCG CCACCGTGGCGTTCCTCTGCTCCGAGGGCGGCAGTTTCATCAACGGCCAGACCATCGTCGTCGACGGTGGCTGGAGTTCG ACGAAGTACCTGTCCGATTTCGCGCTGAACTCCGACTGGGTGCCCAGGTGA
Upstream 100 bases:
>100_bases GTGCCCGAACAGGTGGTGCTGGTGGAGGCGTTGCCGAAGAACGATGCGGGCAAGGTGCTCAAGCACAAGATCAGGGCATC GCTGACGGAAGGTGGATGAC
Downstream 100 bases:
>100_bases ACCTGTTCGCACTGCTCGACCAGACCGCGGCGCGCCACGCCGACCGCGGCGCGGTGTATCACGGTGAGCGCCAGGTGCAC ACGTGGTCGTCGCTGCGGGA
Product: short-chain dehydrogenase/reductase SDR
Products: NA
Alternate protein names: R-HPCDH; Aliphatic epoxide carboxylation component III [H]
Number of amino acids: Translated: 256; Mature: 256
Protein sequence:
>256_residues MQVAIVTGASSGIGFGCATTLAEQGMAVLGTGRDEERLAELEKAVGSDRIATVAVDLTDDDGPARVVAAALERWGRIDFL VNNAGVGSPKPLHETDDESLDYFLNLMLRAPFRLSRDVIPHMQPGSAIINVTSTFAVVGGLRGGAYSAAKGGLTALTAHI ACQYGAQGIRCNAVAPGVTLTPMVATRLEDERFRKINTEMTPHQRLGRVEDIAATVAFLCSEGGSFINGQTIVVDGGWSS TKYLSDFALNSDWVPR
Sequences:
>Translated_256_residues MQVAIVTGASSGIGFGCATTLAEQGMAVLGTGRDEERLAELEKAVGSDRIATVAVDLTDDDGPARVVAAALERWGRIDFL VNNAGVGSPKPLHETDDESLDYFLNLMLRAPFRLSRDVIPHMQPGSAIINVTSTFAVVGGLRGGAYSAAKGGLTALTAHI ACQYGAQGIRCNAVAPGVTLTPMVATRLEDERFRKINTEMTPHQRLGRVEDIAATVAFLCSEGGSFINGQTIVVDGGWSS TKYLSDFALNSDWVPR >Mature_256_residues MQVAIVTGASSGIGFGCATTLAEQGMAVLGTGRDEERLAELEKAVGSDRIATVAVDLTDDDGPARVVAAALERWGRIDFL VNNAGVGSPKPLHETDDESLDYFLNLMLRAPFRLSRDVIPHMQPGSAIINVTSTFAVVGGLRGGAYSAAKGGLTALTAHI ACQYGAQGIRCNAVAPGVTLTPMVATRLEDERFRKINTEMTPHQRLGRVEDIAATVAFLCSEGGSFINGQTIVVDGGWSS TKYLSDFALNSDWVPR
Specific function: Catalyzes the oxidation of 2-(R)-hydroxyalkyl thioesters of CoM to 2-oxoalkyl thioesters of CoM. The enzyme highly specific for the R enantiomers [H]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI5031737, Length=242, Percent_Identity=33.0578512396694, Blast_Score=108, Evalue=7e-24, Organism=Homo sapiens, GI32483357, Length=247, Percent_Identity=30.7692307692308, Blast_Score=106, Evalue=2e-23, Organism=Homo sapiens, GI19923817, Length=267, Percent_Identity=28.4644194756554, Blast_Score=101, Evalue=7e-22, Organism=Homo sapiens, GI66933014, Length=245, Percent_Identity=30.2040816326531, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI7705925, Length=238, Percent_Identity=32.7731092436975, Blast_Score=98, Evalue=9e-21, Organism=Homo sapiens, GI10190704, Length=263, Percent_Identity=30.7984790874525, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=29.9610894941634, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI59889578, Length=193, Percent_Identity=30.5699481865285, Blast_Score=86, Evalue=4e-17, Organism=Homo sapiens, GI40254992, Length=240, Percent_Identity=29.5833333333333, Blast_Score=86, Evalue=5e-17, Organism=Homo sapiens, GI126723750, Length=247, Percent_Identity=27.5303643724696, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI4504505, Length=251, Percent_Identity=28.6852589641434, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI4503301, Length=227, Percent_Identity=25.9911894273128, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI33667109, Length=187, Percent_Identity=32.0855614973262, Blast_Score=75, Evalue=4e-14, Organism=Homo sapiens, GI4758504, Length=248, Percent_Identity=29.4354838709677, Blast_Score=73, Evalue=3e-13, Organism=Escherichia coli, GI1789208, Length=241, Percent_Identity=32.3651452282158, Blast_Score=117, Evalue=7e-28, Organism=Escherichia coli, GI87082160, Length=242, Percent_Identity=31.8181818181818, Blast_Score=116, Evalue=2e-27, Organism=Escherichia coli, GI1788459, Length=244, Percent_Identity=34.4262295081967, Blast_Score=113, Evalue=1e-26, Organism=Escherichia coli, GI1787335, Length=239, Percent_Identity=33.0543933054393, Blast_Score=113, Evalue=1e-26, Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=30.9803921568627, Blast_Score=109, Evalue=1e-25, Organism=Escherichia coli, GI1787905, Length=242, Percent_Identity=32.2314049586777, Blast_Score=99, Evalue=4e-22, Organism=Escherichia coli, GI1790717, Length=237, Percent_Identity=29.1139240506329, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI1786812, Length=242, Percent_Identity=31.404958677686, Blast_Score=89, Evalue=2e-19, Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=28.5140562248996, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI1787545, Length=259, Percent_Identity=26.2548262548263, Blast_Score=73, Evalue=2e-14, Organism=Escherichia coli, GI1787820, Length=195, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=3e-14, Organism=Escherichia coli, GI1789378, Length=239, Percent_Identity=25.5230125523013, Blast_Score=65, Evalue=3e-12, Organism=Escherichia coli, GI2367365, Length=246, Percent_Identity=26.0162601626016, Blast_Score=64, Evalue=1e-11, Organism=Caenorhabditis elegans, GI71994600, Length=248, Percent_Identity=33.8709677419355, Blast_Score=129, Evalue=1e-30, Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=34.412955465587, Blast_Score=125, Evalue=2e-29, Organism=Caenorhabditis elegans, GI17559104, Length=271, Percent_Identity=33.5793357933579, Blast_Score=122, Evalue=1e-28, Organism=Caenorhabditis elegans, GI17562904, Length=260, Percent_Identity=33.8461538461538, Blast_Score=119, Evalue=1e-27, Organism=Caenorhabditis elegans, GI17551412, Length=258, Percent_Identity=34.1085271317829, Blast_Score=115, Evalue=2e-26, Organism=Caenorhabditis elegans, GI17562910, Length=260, Percent_Identity=32.3076923076923, Blast_Score=113, Evalue=1e-25, Organism=Caenorhabditis elegans, GI17538480, Length=258, Percent_Identity=32.9457364341085, Blast_Score=110, Evalue=8e-25, Organism=Caenorhabditis elegans, GI17560676, Length=244, Percent_Identity=29.0983606557377, Blast_Score=107, Evalue=5e-24, Organism=Caenorhabditis elegans, GI72000259, Length=254, Percent_Identity=34.251968503937, Blast_Score=107, Evalue=5e-24, Organism=Caenorhabditis elegans, GI17560332, Length=258, Percent_Identity=32.9457364341085, Blast_Score=107, Evalue=6e-24, Organism=Caenorhabditis elegans, GI17561402, Length=246, Percent_Identity=32.1138211382114, Blast_Score=106, Evalue=1e-23, Organism=Caenorhabditis elegans, GI17565030, Length=258, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=30.5660377358491, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI193204405, Length=262, Percent_Identity=31.2977099236641, Blast_Score=101, Evalue=4e-22, Organism=Caenorhabditis elegans, GI17560150, Length=252, Percent_Identity=31.7460317460317, Blast_Score=101, Evalue=4e-22, Organism=Caenorhabditis elegans, GI115534694, Length=240, Percent_Identity=29.5833333333333, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17563726, Length=253, Percent_Identity=30.8300395256917, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17538486, Length=258, Percent_Identity=31.3953488372093, Blast_Score=99, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17562908, Length=255, Percent_Identity=31.3725490196078, Blast_Score=99, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17560220, Length=261, Percent_Identity=29.5019157088123, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17562990, Length=253, Percent_Identity=31.2252964426877, Blast_Score=94, Evalue=6e-20, Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=30, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17544670, Length=259, Percent_Identity=29.3436293436293, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI25147288, Length=244, Percent_Identity=29.0983606557377, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17555706, Length=249, Percent_Identity=28.5140562248996, Blast_Score=84, Evalue=8e-17, Organism=Caenorhabditis elegans, GI17538182, Length=250, Percent_Identity=29.2, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17536651, Length=259, Percent_Identity=25.8687258687259, Blast_Score=77, Evalue=6e-15, Organism=Caenorhabditis elegans, GI17508651, Length=255, Percent_Identity=30.1960784313725, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17536025, Length=260, Percent_Identity=26.5384615384615, Blast_Score=75, Evalue=4e-14, Organism=Caenorhabditis elegans, GI25152911, Length=190, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17555612, Length=217, Percent_Identity=31.7972350230415, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17561272, Length=233, Percent_Identity=26.6094420600858, Blast_Score=65, Evalue=3e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=256, Percent_Identity=27.34375, Blast_Score=94, Evalue=2e-20, Organism=Saccharomyces cerevisiae, GI6322861, Length=244, Percent_Identity=27.0491803278689, Blast_Score=72, Evalue=1e-13, Organism=Drosophila melanogaster, GI23397609, Length=243, Percent_Identity=34.9794238683128, Blast_Score=122, Evalue=2e-28, Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=35.7429718875502, Blast_Score=122, Evalue=3e-28, Organism=Drosophila melanogaster, GI24643142, Length=238, Percent_Identity=31.9327731092437, Blast_Score=117, Evalue=5e-27, Organism=Drosophila melanogaster, GI24644339, Length=249, Percent_Identity=34.136546184739, Blast_Score=117, Evalue=6e-27, Organism=Drosophila melanogaster, GI21357041, Length=248, Percent_Identity=34.2741935483871, Blast_Score=115, Evalue=2e-26, Organism=Drosophila melanogaster, GI21355319, Length=246, Percent_Identity=29.6747967479675, Blast_Score=108, Evalue=4e-24, Organism=Drosophila melanogaster, GI24639444, Length=243, Percent_Identity=30.4526748971193, Blast_Score=104, Evalue=6e-23, Organism=Drosophila melanogaster, GI17737361, Length=251, Percent_Identity=29.4820717131474, Blast_Score=87, Evalue=7e-18, Organism=Drosophila melanogaster, GI18859837, Length=254, Percent_Identity=27.1653543307087, Blast_Score=82, Evalue=5e-16, Organism=Drosophila melanogaster, GI24644337, Length=176, Percent_Identity=32.3863636363636, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI21356301, Length=187, Percent_Identity=28.8770053475936, Blast_Score=66, Evalue=2e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.268 [H]
Molecular weight: Translated: 27069; Mature: 27069
Theoretical pI: Translated: 4.93; Mature: 4.93
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.6 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 3.9 %Cys+Met (Translated Protein) 1.6 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 3.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQVAIVTGASSGIGFGCATTLAEQGMAVLGTGRDEERLAELEKAVGSDRIATVAVDLTDD CEEEEEECCCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEEEEECC DGPARVVAAALERWGRIDFLVNNAGVGSPKPLHETDDESLDYFLNLMLRAPFRLSRDVIP CCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCC HMQPGSAIINVTSTFAVVGGLRGGAYSAAKGGLTALTAHIACQYGAQGIRCNAVAPGVTL CCCCCCEEEEHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEE TPMVATRLEDERFRKINTEMTPHQRLGRVEDIAATVAFLCSEGGSFINGQTIVVDGGWSS HHHHHHHCCHHHHHHHCCCCCCHHHHCHHHHHHHHHHHHHHCCCCEECCCEEEEECCCCC TKYLSDFALNSDWVPR HHHHHHHCCCCCCCCC >Mature Secondary Structure MQVAIVTGASSGIGFGCATTLAEQGMAVLGTGRDEERLAELEKAVGSDRIATVAVDLTDD CEEEEEECCCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEEEEECC DGPARVVAAALERWGRIDFLVNNAGVGSPKPLHETDDESLDYFLNLMLRAPFRLSRDVIP CCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCC HMQPGSAIINVTSTFAVVGGLRGGAYSAAKGGLTALTAHIACQYGAQGIRCNAVAPGVTL CCCCCCEEEEHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEE TPMVATRLEDERFRKINTEMTPHQRLGRVEDIAATVAFLCSEGGSFINGQTIVVDGGWSS HHHHHHHCCHHHHHHHCCCCCCHHHHCHHHHHHHHHHHHHHCCCCEECCCEEEEECCCCC TKYLSDFALNSDWVPR HHHHHHHCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 7704278; 9405410; 12524213 [H]