| Definition | Mycobacterium sp. KMS chromosome, complete genome. |
|---|---|
| Accession | NC_008705 |
| Length | 5,737,227 |
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The map label for this gene is hdhA [H]
Identifier: 119870477
GI number: 119870477
Start: 4682116
End: 4682907
Strand: Direct
Name: hdhA [H]
Synonym: Mkms_4448
Alternate gene names: 119870477
Gene position: 4682116-4682907 (Clockwise)
Preceding gene: 119870476
Following gene: 119870478
Centisome position: 81.61
GC content: 71.21
Gene sequence:
>792_bases GTGATCCTGGACAGATTCCGGCTCGACGGACAGGTCGCCACCGTCACCGGCGCGGGCCGAGGACTGGGCGCCGCCATCGC GGTGGCGTTCGCGGAAGCCGGTGCGGACGTGGTGATCGCGGCCCGCACCGAATCGCAACTCGACGAGGTCGCCGAGCGGA TCCGGGCGACCGGACGGCGCGCCCACGTCGTCGTCGCCGACCTCGCCCACCCCGAGTCGACGGCCGGGCTCGCACCGGCC GCGGTGGAGGCCTTCGGAAAACTAGACATCGTCGTCAACAACGTCGGCGGCACCATGCCGGCCGCCCTGACCGACACCTC CGCGAAGGATCTCAAGGACGCGTTCACCTTCAACGTCGCCACCGCCCACGCGCTGACCACGGCCGCGGTTCCGTTGATGC TCGAGCACTCCGGCGGCGGCAGCGTCATCAACATCACCTCGACGATGGGCCGCCTCGCCGGCCGCGGCTTCGCCGCCTAC GGCACCGCGAAAGCCGCGCTCGCGCACTACACCCGGCTCGCCGCGCTCGACCTCTGCCCGCGGATCCGGGTCAACGCGAT CGCGCCCGGTTCCATCCTCACCTCCGCGCTCGACATCGTCGCCAGCAACGACGACCTTCGCGAGCCCATGGAGAAGGCGA CGCCGATGCGCCGGCTCGGCGATCCCGAGGACATCGCCGCCGCTGCGGTCTACCTGGCCTCGCCGGCGGCGAGCTACCTG ACCGGTAAGACCCTCGAGGTCGACGGCGGGCTGACGTTCCCCAACCTCGACATGCCCTTCCCGGACCTCTAG
Upstream 100 bases:
>100_bases CGACACCGACCGTGACCGAATTAGAACGTGTTTCAGAAACCCCTCTCCCCGCGAAGCGTGCCTTGCTACGGTGACGCCGG TCGAAGGGAGTGAGGCACAC
Downstream 100 bases:
>100_bases GAGATTCGATGGCGATACGCGTCGCGCAGATCGGCACCGGCAACGTCGGCAGTCACGCGCTCACCCAGCTGATCATCGAC CCGCAGTTCGAGCTGACCGG
Product: short chain dehydrogenase
Products: NA
Alternate protein names: 7-alpha-HSDH [H]
Number of amino acids: Translated: 263; Mature: 263
Protein sequence:
>263_residues MILDRFRLDGQVATVTGAGRGLGAAIAVAFAEAGADVVIAARTESQLDEVAERIRATGRRAHVVVADLAHPESTAGLAPA AVEAFGKLDIVVNNVGGTMPAALTDTSAKDLKDAFTFNVATAHALTTAAVPLMLEHSGGGSVINITSTMGRLAGRGFAAY GTAKAALAHYTRLAALDLCPRIRVNAIAPGSILTSALDIVASNDDLREPMEKATPMRRLGDPEDIAAAAVYLASPAASYL TGKTLEVDGGLTFPNLDMPFPDL
Sequences:
>Translated_263_residues MILDRFRLDGQVATVTGAGRGLGAAIAVAFAEAGADVVIAARTESQLDEVAERIRATGRRAHVVVADLAHPESTAGLAPA AVEAFGKLDIVVNNVGGTMPAALTDTSAKDLKDAFTFNVATAHALTTAAVPLMLEHSGGGSVINITSTMGRLAGRGFAAY GTAKAALAHYTRLAALDLCPRIRVNAIAPGSILTSALDIVASNDDLREPMEKATPMRRLGDPEDIAAAAVYLASPAASYL TGKTLEVDGGLTFPNLDMPFPDL >Mature_263_residues MILDRFRLDGQVATVTGAGRGLGAAIAVAFAEAGADVVIAARTESQLDEVAERIRATGRRAHVVVADLAHPESTAGLAPA AVEAFGKLDIVVNNVGGTMPAALTDTSAKDLKDAFTFNVATAHALTTAAVPLMLEHSGGGSVINITSTMGRLAGRGFAAY GTAKAALAHYTRLAALDLCPRIRVNAIAPGSILTSALDIVASNDDLREPMEKATPMRRLGDPEDIAAAAVYLASPAASYL TGKTLEVDGGLTFPNLDMPFPDL
Specific function: 7-alpha-dehydroxylation of cholic acid, yielding deoxycholic acid and lithocholic acid, respectively. Highest affinity with taurochenodeoxycholic acid [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=245, Percent_Identity=34.6938775510204, Blast_Score=129, Evalue=2e-30, Organism=Homo sapiens, GI19923817, Length=265, Percent_Identity=31.6981132075472, Blast_Score=124, Evalue=6e-29, Organism=Homo sapiens, GI10190704, Length=268, Percent_Identity=36.1940298507463, Blast_Score=119, Evalue=4e-27, Organism=Homo sapiens, GI126723750, Length=248, Percent_Identity=31.8548387096774, Blast_Score=107, Evalue=7e-24, Organism=Homo sapiens, GI5031737, Length=244, Percent_Identity=30.327868852459, Blast_Score=105, Evalue=3e-23, Organism=Homo sapiens, GI59889578, Length=229, Percent_Identity=33.1877729257642, Blast_Score=100, Evalue=2e-21, Organism=Homo sapiens, GI15277342, Length=259, Percent_Identity=31.6602316602317, Blast_Score=93, Evalue=3e-19, Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=26.9387755102041, Blast_Score=88, Evalue=8e-18, Organism=Homo sapiens, GI66933014, Length=253, Percent_Identity=31.6205533596838, Blast_Score=88, Evalue=8e-18, Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=27.7551020408163, Blast_Score=84, Evalue=2e-16, Organism=Homo sapiens, GI40254986, Length=210, Percent_Identity=29.5238095238095, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI109715829, Length=245, Percent_Identity=29.3877551020408, Blast_Score=78, Evalue=7e-15, Organism=Homo sapiens, GI4504505, Length=258, Percent_Identity=30.6201550387597, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI126723191, Length=182, Percent_Identity=31.3186813186813, Blast_Score=75, Evalue=7e-14, Organism=Homo sapiens, GI7706318, Length=229, Percent_Identity=24.8908296943231, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI33667109, Length=195, Percent_Identity=30.2564102564103, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI31542939, Length=276, Percent_Identity=25.7246376811594, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI210032110, Length=208, Percent_Identity=25.9615384615385, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI20149619, Length=195, Percent_Identity=29.7435897435897, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI142976729, Length=191, Percent_Identity=26.7015706806283, Blast_Score=68, Evalue=8e-12, Organism=Homo sapiens, GI4503301, Length=251, Percent_Identity=27.8884462151394, Blast_Score=68, Evalue=1e-11, Organism=Homo sapiens, GI38348362, Length=162, Percent_Identity=30.2469135802469, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI38424085, Length=162, Percent_Identity=30.2469135802469, Blast_Score=65, Evalue=5e-11, Organism=Homo sapiens, GI31543615, Length=198, Percent_Identity=29.2929292929293, Blast_Score=65, Evalue=6e-11, Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=40.7258064516129, Blast_Score=164, Evalue=7e-42, Organism=Escherichia coli, GI1789208, Length=252, Percent_Identity=34.5238095238095, Blast_Score=133, Evalue=1e-32, Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=34.375, Blast_Score=130, Evalue=9e-32, Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=34.136546184739, Blast_Score=127, Evalue=9e-31, Organism=Escherichia coli, GI1788459, Length=250, Percent_Identity=33.2, Blast_Score=122, Evalue=3e-29, Organism=Escherichia coli, GI1787335, Length=250, Percent_Identity=35.2, Blast_Score=118, Evalue=4e-28, Organism=Escherichia coli, GI1789378, Length=249, Percent_Identity=33.7349397590361, Blast_Score=108, Evalue=5e-25, Organism=Escherichia coli, GI1790717, Length=249, Percent_Identity=28.5140562248996, Blast_Score=105, Evalue=2e-24, Organism=Escherichia coli, GI2367365, Length=243, Percent_Identity=32.0987654320988, Blast_Score=86, Evalue=2e-18, Organism=Escherichia coli, GI1786812, Length=257, Percent_Identity=29.1828793774319, Blast_Score=86, Evalue=3e-18, Organism=Escherichia coli, GI1789057, Length=253, Percent_Identity=26.8774703557312, Blast_Score=81, Evalue=6e-17, Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=29.5275590551181, Blast_Score=81, Evalue=7e-17, Organism=Escherichia coli, GI1787526, Length=249, Percent_Identity=28.9156626506024, Blast_Score=79, Evalue=3e-16, Organism=Escherichia coli, GI1786701, Length=191, Percent_Identity=31.413612565445, Blast_Score=63, Evalue=2e-11, Organism=Escherichia coli, GI1787820, Length=241, Percent_Identity=28.6307053941909, Blast_Score=63, Evalue=3e-11, Organism=Caenorhabditis elegans, GI17560676, Length=251, Percent_Identity=34.6613545816733, Blast_Score=125, Evalue=2e-29, Organism=Caenorhabditis elegans, GI17560150, Length=262, Percent_Identity=30.9160305343511, Blast_Score=120, Evalue=8e-28, Organism=Caenorhabditis elegans, GI17559104, Length=261, Percent_Identity=34.4827586206897, Blast_Score=119, Evalue=2e-27, Organism=Caenorhabditis elegans, GI17562910, Length=278, Percent_Identity=31.294964028777, Blast_Score=119, Evalue=2e-27, Organism=Caenorhabditis elegans, GI17531453, Length=265, Percent_Identity=32.0754716981132, Blast_Score=116, Evalue=1e-26, Organism=Caenorhabditis elegans, GI17562906, Length=268, Percent_Identity=32.4626865671642, Blast_Score=113, Evalue=1e-25, Organism=Caenorhabditis elegans, GI17561402, Length=252, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=2e-25, Organism=Caenorhabditis elegans, GI17555706, Length=245, Percent_Identity=31.8367346938775, Blast_Score=110, Evalue=6e-25, Organism=Caenorhabditis elegans, GI17562904, Length=264, Percent_Identity=28.7878787878788, Blast_Score=110, Evalue=7e-25, Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=30.5343511450382, Blast_Score=109, Evalue=2e-24, Organism=Caenorhabditis elegans, GI17560332, Length=268, Percent_Identity=32.8358208955224, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI72000259, Length=262, Percent_Identity=29.3893129770992, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI17562908, Length=268, Percent_Identity=31.3432835820896, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI193204405, Length=264, Percent_Identity=31.0606060606061, Blast_Score=105, Evalue=3e-23, Organism=Caenorhabditis elegans, GI17563726, Length=262, Percent_Identity=30.5343511450382, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17538486, Length=262, Percent_Identity=30.5343511450382, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17560220, Length=264, Percent_Identity=30.6818181818182, Blast_Score=101, Evalue=3e-22, Organism=Caenorhabditis elegans, GI71994604, Length=248, Percent_Identity=29.8387096774194, Blast_Score=100, Evalue=5e-22, Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=31.3253012048193, Blast_Score=100, Evalue=5e-22, Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=28.9156626506024, Blast_Score=100, Evalue=8e-22, Organism=Caenorhabditis elegans, GI17551412, Length=265, Percent_Identity=30.188679245283, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17565030, Length=266, Percent_Identity=31.9548872180451, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17538480, Length=269, Percent_Identity=30.4832713754647, Blast_Score=94, Evalue=6e-20, Organism=Caenorhabditis elegans, GI17536025, Length=254, Percent_Identity=30.7086614173228, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17536651, Length=260, Percent_Identity=30.3846153846154, Blast_Score=87, Evalue=7e-18, Organism=Caenorhabditis elegans, GI17544670, Length=273, Percent_Identity=25.2747252747253, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI115534694, Length=239, Percent_Identity=28.4518828451883, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI17508895, Length=188, Percent_Identity=28.1914893617021, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17568967, Length=204, Percent_Identity=32.3529411764706, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17508651, Length=254, Percent_Identity=29.5275590551181, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI17561272, Length=249, Percent_Identity=31.3253012048193, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI17564282, Length=163, Percent_Identity=27.6073619631902, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI71982365, Length=210, Percent_Identity=28.0952380952381, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17538182, Length=258, Percent_Identity=29.8449612403101, Blast_Score=65, Evalue=4e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=255, Percent_Identity=30.1960784313725, Blast_Score=87, Evalue=3e-18, Organism=Saccharomyces cerevisiae, GI6323882, Length=248, Percent_Identity=26.2096774193548, Blast_Score=72, Evalue=1e-13, Organism=Saccharomyces cerevisiae, GI6322226, Length=188, Percent_Identity=28.7234042553192, Blast_Score=69, Evalue=7e-13, Organism=Saccharomyces cerevisiae, GI6322861, Length=190, Percent_Identity=27.8947368421053, Blast_Score=65, Evalue=1e-11, Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=34.9397590361446, Blast_Score=129, Evalue=2e-30, Organism=Drosophila melanogaster, GI23397609, Length=248, Percent_Identity=31.8548387096774, Blast_Score=120, Evalue=8e-28, Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=33.6, Blast_Score=118, Evalue=5e-27, Organism=Drosophila melanogaster, GI28571526, Length=246, Percent_Identity=33.3333333333333, Blast_Score=115, Evalue=2e-26, Organism=Drosophila melanogaster, GI24644339, Length=248, Percent_Identity=31.4516129032258, Blast_Score=114, Evalue=7e-26, Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=32.258064516129, Blast_Score=112, Evalue=4e-25, Organism=Drosophila melanogaster, GI24644337, Length=250, Percent_Identity=35.2, Blast_Score=103, Evalue=2e-22, Organism=Drosophila melanogaster, GI24643142, Length=247, Percent_Identity=29.1497975708502, Blast_Score=91, Evalue=8e-19, Organism=Drosophila melanogaster, GI18859837, Length=200, Percent_Identity=32.5, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI21358495, Length=197, Percent_Identity=31.4720812182741, Blast_Score=74, Evalue=7e-14, Organism=Drosophila melanogaster, GI24641232, Length=241, Percent_Identity=28.6307053941909, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI24580925, Length=198, Percent_Identity=28.2828282828283, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI17737361, Length=266, Percent_Identity=30.0751879699248, Blast_Score=68, Evalue=5e-12, Organism=Drosophila melanogaster, GI21357673, Length=215, Percent_Identity=28.8372093023256, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI116007236, Length=240, Percent_Identity=27.5, Blast_Score=66, Evalue=3e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.159 [H]
Molecular weight: Translated: 27047; Mature: 27047
Theoretical pI: Translated: 5.08; Mature: 5.08
Prosite motif: PS00061 ADH_SHORT ; PS00184 GARS
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 3.0 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 3.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MILDRFRLDGQVATVTGAGRGLGAAIAVAFAEAGADVVIAARTESQLDEVAERIRATGRR CCCCCEECCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCE AHVVVADLAHPESTAGLAPAAVEAFGKLDIVVNNVGGTMPAALTDTSAKDLKDAFTFNVA EEEEEEECCCCCCCCCCCHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHEECHH TAHALTTAAVPLMLEHSGGGSVINITSTMGRLAGRGFAAYGTAKAALAHYTRLAALDLCP HHHHHHHHHHEEEEEECCCCCEEEEHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHCCC RIRVNAIAPGSILTSALDIVASNDDLREPMEKATPMRRLGDPEDIAAAAVYLASPAASYL CCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCHHHHH TGKTLEVDGGLTFPNLDMPFPDL CCCEEEECCCCCCCCCCCCCCCC >Mature Secondary Structure MILDRFRLDGQVATVTGAGRGLGAAIAVAFAEAGADVVIAARTESQLDEVAERIRATGRR CCCCCEECCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCE AHVVVADLAHPESTAGLAPAAVEAFGKLDIVVNNVGGTMPAALTDTSAKDLKDAFTFNVA EEEEEEECCCCCCCCCCCHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHEECHH TAHALTTAAVPLMLEHSGGGSVINITSTMGRLAGRGFAAYGTAKAALAHYTRLAALDLCP HHHHHHHHHHEEEEEECCCCCEEEEHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHCCC RIRVNAIAPGSILTSALDIVASNDDLREPMEKATPMRRLGDPEDIAAAAVYLASPAASYL CCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCHHHHH TGKTLEVDGGLTFPNLDMPFPDL CCCEEEECCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]