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The map label for this gene is accA1 [H]

Identifier: 119870422

GI number: 119870422

Start: 4614244

End: 4616181

Strand: Direct

Name: accA1 [H]

Synonym: Mkms_4393

Alternate gene names: 119870422

Gene position: 4614244-4616181 (Clockwise)

Preceding gene: 119870421

Following gene: 119870423

Centisome position: 80.43

GC content: 70.49

Gene sequence:

>1938_bases
ATGATCACCAGAGTCCTCGTCGCCAACCGCGGGGAGATCGCCCGCCGCGTGTTCTCCACCTGCCGCCGCCTCGGCATCGG
CACCGTCGCCGTCTACACCGAACCCGATGCGCAGTCTCCGCATGTCGCGGAGGCCGACGCCCGGGTTCGGCTGCAGGGCA
ACAACGGTTACCTCGACAGCGCCCAACTGATCGCCGCCGCACGCGCCGCCGGCGCCGATGCGATACATCCCGGATACGGA
TTCCTCTCGGAGAACGCCGAATTCGCCGCAGCGGTGTGCGACGCCGGGTTGACGTGGATCGGGCCGCCTGCCGCGGCGGT
CGCGGCGATGGGCAGCAAGATCGAGGCCAAGAAGATGATGGCCGCGGCCGGGGTGCCGGTGCTCGACGAACTCGACCCGG
CCACCGTGACGGCCGACCGGTTACCGGTCCTGGTGAAGGCCTCCGCCGGTGGCGGCGGACGCGGCATGCGGGTGGTCCGC
GACCTCGACGCGCTGGCCGGTGAAGTCCAGGCTGCGCAGCGCGAGGCACAGTCGGCGTTCGGCGACCCGACGGTGTTCTG
TGAGCGGTACCTCGCCGCCGGCCACCACATCGAGGTGCAGGTGATGGCCGACGTCCACGGCACCGTGTGGGCGGTCGGCG
AACGCGAGTGCTCGATCCAGCGCAGGCACCAGAAGATCATCGAGGAGGCGCCGTCGCCTCTGGTCGAGCGCACACCGGGC
ATGCGCGCCAAGCTGTTCGACGCGGCGAGACTGGCGGCCGAAGCCATCGGTTACACCGGGGCGGGCACCGTCGAGTTCAT
GGCGGACGACACGGGCGAGTTCTTCTTCCTCGAGATGAACACCCGACTGCAGGTCGAGCACCCCGTCACCGAGGCCACCA
CCGGACTCGACCTCGTCGAGTTGCAACTGCTGGTCGCCGACGGCGGTCGGCTCGACGCCGAACCCCCACCGTCACGCGGA
TCGTCCGTCGAGGCGAGGCTCTACGCCGAGGACCCCGCGAAGAACTGGCAGCCGCAGGCGGGCACGGTGCACCGCTTCCA
CGTGCCGCCGACGGTGCGGGTTGACTCCGGCGTCGAAGACGGTTCGGTGGTGTCGATCTTCTACGATCCGATGCTCGCCA
AGGTCATCTCGTACGCACCGACCCGAAGACAGGCCGCGGCGATCCTGGCCGACGCGCTGGTGCGCACGCGGTTGCACGGG
GTCCGGACCAACCGCGACCTGCTGGTCAACGTGCTGCGGCATCCGGCCTTCCTCGACGGGGCGACCGATACGGCGTTCTT
CGACACCCACGGCCTGGCCGAACTCGCCGCGCCGATCGGCGACGCCCGGGCAGGCGAACTGTCGGTCCTCGCCGCCGCAC
TCGCCGATGCCGCCCGGAACCGCAGTGACGCAACGGTGTTCGCGGCCGCACCGAGCGGCTGGCGCAACCTGGCCTCCGGC
TACCAGACCAAGCGGTACCGCGACGCCGCGGGCGACGAACACGAGGTGCGCTACCGATTCACCCGCGCGGGTGTGCAATT
CGGCGACCACGACGACGTGCGCCTGATGTCCGCGACCCCGCAGCGGGTGGTGCTGGCCTCCGGGGGCGTCGAGTTCCCGT
TCGACGTCGCCCGCCACGGTGATGCGGTGTTCGTCGACTCACCGCTCGGGGCCGTGGAATTCGTTGCGCTGCCCCGCTTC
CCCGACCCGGAGTCCGCCGTCGCGCAGGGATCGTTGATCGCGCCGATGCCCGGTGCGGTGGTGCGGGTCGGCGCCGCCGT
CGGGGACACCGTCAGCGCCGGCCAACCGCTGGTGTGGCTCGAGGCGATGAAGATGGAACACATCCTGACCGCACCCGGTG
ACGGTGTGCTCGCCGAACTGACCGTCGCACCCGGCCAGCAGGTCGAGGTCGGCACGGTCCTGGCCCGGGTGGAGAGCCCA
GAAGGAGACGACACATGA

Upstream 100 bases:

>100_bases
GGCGTCTTCCGGATGTGAGGCCGTCGATGCTTGCGATTTCGGCGTGCACGGTCGCGGTGAGCGCAACTGCGCACGCCGAA
ATCGCCGAGGAGGGGGCACG

Downstream 100 bases:

>100_bases
CCGGATTCGTGGAGACCGACGAACAACAGGCGCTGCGGCAGGCGGTGGCGGCGATGGCCGCCAACTACGGGCAGGACTAC
TACCTCGAGAAGGCCCGCGC

Product: pyruvate carboxylase

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 645; Mature: 645

Protein sequence:

>645_residues
MITRVLVANRGEIARRVFSTCRRLGIGTVAVYTEPDAQSPHVAEADARVRLQGNNGYLDSAQLIAAARAAGADAIHPGYG
FLSENAEFAAAVCDAGLTWIGPPAAAVAAMGSKIEAKKMMAAAGVPVLDELDPATVTADRLPVLVKASAGGGGRGMRVVR
DLDALAGEVQAAQREAQSAFGDPTVFCERYLAAGHHIEVQVMADVHGTVWAVGERECSIQRRHQKIIEEAPSPLVERTPG
MRAKLFDAARLAAEAIGYTGAGTVEFMADDTGEFFFLEMNTRLQVEHPVTEATTGLDLVELQLLVADGGRLDAEPPPSRG
SSVEARLYAEDPAKNWQPQAGTVHRFHVPPTVRVDSGVEDGSVVSIFYDPMLAKVISYAPTRRQAAAILADALVRTRLHG
VRTNRDLLVNVLRHPAFLDGATDTAFFDTHGLAELAAPIGDARAGELSVLAAALADAARNRSDATVFAAAPSGWRNLASG
YQTKRYRDAAGDEHEVRYRFTRAGVQFGDHDDVRLMSATPQRVVLASGGVEFPFDVARHGDAVFVDSPLGAVEFVALPRF
PDPESAVAQGSLIAPMPGAVVRVGAAVGDTVSAGQPLVWLEAMKMEHILTAPGDGVLAELTVAPGQQVEVGTVLARVESP
EGDDT

Sequences:

>Translated_645_residues
MITRVLVANRGEIARRVFSTCRRLGIGTVAVYTEPDAQSPHVAEADARVRLQGNNGYLDSAQLIAAARAAGADAIHPGYG
FLSENAEFAAAVCDAGLTWIGPPAAAVAAMGSKIEAKKMMAAAGVPVLDELDPATVTADRLPVLVKASAGGGGRGMRVVR
DLDALAGEVQAAQREAQSAFGDPTVFCERYLAAGHHIEVQVMADVHGTVWAVGERECSIQRRHQKIIEEAPSPLVERTPG
MRAKLFDAARLAAEAIGYTGAGTVEFMADDTGEFFFLEMNTRLQVEHPVTEATTGLDLVELQLLVADGGRLDAEPPPSRG
SSVEARLYAEDPAKNWQPQAGTVHRFHVPPTVRVDSGVEDGSVVSIFYDPMLAKVISYAPTRRQAAAILADALVRTRLHG
VRTNRDLLVNVLRHPAFLDGATDTAFFDTHGLAELAAPIGDARAGELSVLAAALADAARNRSDATVFAAAPSGWRNLASG
YQTKRYRDAAGDEHEVRYRFTRAGVQFGDHDDVRLMSATPQRVVLASGGVEFPFDVARHGDAVFVDSPLGAVEFVALPRF
PDPESAVAQGSLIAPMPGAVVRVGAAVGDTVSAGQPLVWLEAMKMEHILTAPGDGVLAELTVAPGQQVEVGTVLARVESP
EGDDT
>Mature_645_residues
MITRVLVANRGEIARRVFSTCRRLGIGTVAVYTEPDAQSPHVAEADARVRLQGNNGYLDSAQLIAAARAAGADAIHPGYG
FLSENAEFAAAVCDAGLTWIGPPAAAVAAMGSKIEAKKMMAAAGVPVLDELDPATVTADRLPVLVKASAGGGGRGMRVVR
DLDALAGEVQAAQREAQSAFGDPTVFCERYLAAGHHIEVQVMADVHGTVWAVGERECSIQRRHQKIIEEAPSPLVERTPG
MRAKLFDAARLAAEAIGYTGAGTVEFMADDTGEFFFLEMNTRLQVEHPVTEATTGLDLVELQLLVADGGRLDAEPPPSRG
SSVEARLYAEDPAKNWQPQAGTVHRFHVPPTVRVDSGVEDGSVVSIFYDPMLAKVISYAPTRRQAAAILADALVRTRLHG
VRTNRDLLVNVLRHPAFLDGATDTAFFDTHGLAELAAPIGDARAGELSVLAAALADAARNRSDATVFAAAPSGWRNLASG
YQTKRYRDAAGDEHEVRYRFTRAGVQFGDHDDVRLMSATPQRVVLASGGVEFPFDVARHGDAVFVDSPLGAVEFVALPRF
PDPESAVAQGSLIAPMPGAVVRVGAAVGDTVSAGQPLVWLEAMKMEHILTAPGDGVLAELTVAPGQQVEVGTVLARVESP
EGDDT

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=685, Percent_Identity=37.5182481751825, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI65506442, Length=670, Percent_Identity=36.5671641791045, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI189095269, Length=670, Percent_Identity=36.5671641791045, Blast_Score=346, Evalue=4e-95,
Organism=Homo sapiens, GI295821183, Length=665, Percent_Identity=35.9398496240602, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=41.4253897550111, Blast_Score=306, Evalue=4e-83,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=41.4253897550111, Blast_Score=306, Evalue=4e-83,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=41.4253897550111, Blast_Score=306, Evalue=4e-83,
Organism=Homo sapiens, GI38679971, Length=730, Percent_Identity=26.4383561643836, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI38679960, Length=730, Percent_Identity=26.4383561643836, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI38679977, Length=730, Percent_Identity=26.4383561643836, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI38679967, Length=730, Percent_Identity=26.4383561643836, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI38679974, Length=730, Percent_Identity=26.4383561643836, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI134142062, Length=729, Percent_Identity=26.0631001371742, Blast_Score=190, Evalue=4e-48,
Organism=Escherichia coli, GI1789654, Length=452, Percent_Identity=42.9203539823009, Blast_Score=313, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI71987519, Length=663, Percent_Identity=40.1206636500754, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17567343, Length=692, Percent_Identity=36.1271676300578, Blast_Score=350, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17562816, Length=452, Percent_Identity=43.141592920354, Blast_Score=318, Evalue=5e-87,
Organism=Caenorhabditis elegans, GI133931226, Length=710, Percent_Identity=26.1971830985915, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71997168, Length=538, Percent_Identity=28.0669144981413, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=28.3757338551859, Blast_Score=174, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=42.0224719101124, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6319695, Length=526, Percent_Identity=38.9733840304183, Blast_Score=296, Evalue=5e-81,
Organism=Saccharomyces cerevisiae, GI6321376, Length=524, Percent_Identity=39.1221374045802, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6324343, Length=738, Percent_Identity=26.5582655826558, Blast_Score=188, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6323863, Length=479, Percent_Identity=27.9749478079332, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24651757, Length=671, Percent_Identity=38.5991058122206, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24651759, Length=613, Percent_Identity=38.0097879282219, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI281363050, Length=453, Percent_Identity=43.7086092715232, Blast_Score=318, Evalue=7e-87,
Organism=Drosophila melanogaster, GI24652224, Length=453, Percent_Identity=43.7086092715232, Blast_Score=318, Evalue=7e-87,
Organism=Drosophila melanogaster, GI24652222, Length=453, Percent_Identity=43.7086092715232, Blast_Score=318, Evalue=7e-87,
Organism=Drosophila melanogaster, GI24652220, Length=453, Percent_Identity=43.7086092715232, Blast_Score=318, Evalue=7e-87,
Organism=Drosophila melanogaster, GI24652218, Length=453, Percent_Identity=43.7086092715232, Blast_Score=318, Evalue=7e-87,
Organism=Drosophila melanogaster, GI24652212, Length=453, Percent_Identity=43.7086092715232, Blast_Score=318, Evalue=8e-87,
Organism=Drosophila melanogaster, GI24652210, Length=453, Percent_Identity=43.7086092715232, Blast_Score=318, Evalue=8e-87,
Organism=Drosophila melanogaster, GI24652214, Length=453, Percent_Identity=43.7086092715232, Blast_Score=318, Evalue=8e-87,
Organism=Drosophila melanogaster, GI19921944, Length=453, Percent_Identity=43.7086092715232, Blast_Score=318, Evalue=8e-87,
Organism=Drosophila melanogaster, GI24652216, Length=453, Percent_Identity=43.7086092715232, Blast_Score=318, Evalue=8e-87,
Organism=Drosophila melanogaster, GI161076409, Length=714, Percent_Identity=26.890756302521, Blast_Score=203, Evalue=3e-52,
Organism=Drosophila melanogaster, GI161076407, Length=713, Percent_Identity=27.2089761570827, Blast_Score=203, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24586460, Length=713, Percent_Identity=27.2089761570827, Blast_Score=203, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24586458, Length=713, Percent_Identity=27.2089761570827, Blast_Score=202, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 68228; Mature: 68228

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITRVLVANRGEIARRVFSTCRRLGIGTVAVYTEPDAQSPHVAEADARVRLQGNNGYLDS
CCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCCEEEEECCCCCCCH
AQLIAAARAAGADAIHPGYGFLSENAEFAAAVCDAGLTWIGPPAAAVAAMGSKIEAKKMM
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHH
AAAGVPVLDELDPATVTADRLPVLVKASAGGGGRGMRVVRDLDALAGEVQAAQREAQSAF
HHCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GDPTVFCERYLAAGHHIEVQVMADVHGTVWAVGERECSIQRRHQKIIEEAPSPLVERTPG
CCHHHHHHHHHHCCCEEEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHCCCC
MRAKLFDAARLAAEAIGYTGAGTVEFMADDTGEFFFLEMNTRLQVEHPVTEATTGLDLVE
CHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCEEEEECCCHHHHCCCEEEE
LQLLVADGGRLDAEPPPSRGSSVEARLYAEDPAKNWQPQAGTVHRFHVPPTVRVDSGVED
EEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCEEEECCCCCC
GSVVSIFYDPMLAKVISYAPTRRQAAAILADALVRTRLHGVRTNRDLLVNVLRHPAFLDG
CCEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEECC
ATDTAFFDTHGLAELAAPIGDARAGELSVLAAALADAARNRSDATVFAAAPSGWRNLASG
CCCCEEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHCC
YQTKRYRDAAGDEHEVRYRFTRAGVQFGDHDDVRLMSATPQRVVLASGGVEFPFDVARHG
HHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCEEEEECCCCCCCHHHHCCC
DAVFVDSPLGAVEFVALPRFPDPESAVAQGSLIAPMPGAVVRVGAAVGDTVSAGQPLVWL
CEEEEECCCCCEEEEECCCCCCCHHHHHCCCEECCCCCHHEEECHHHCCCCCCCCCEEEH
EAMKMEHILTAPGDGVLAELTVAPGQQVEVGTVLARVESPEGDDT
HHHHHHHEEECCCCCEEEEEEECCCCCEEHHEEEEEECCCCCCCC
>Mature Secondary Structure
MITRVLVANRGEIARRVFSTCRRLGIGTVAVYTEPDAQSPHVAEADARVRLQGNNGYLDS
CCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCCEEEEECCCCCCCH
AQLIAAARAAGADAIHPGYGFLSENAEFAAAVCDAGLTWIGPPAAAVAAMGSKIEAKKMM
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHH
AAAGVPVLDELDPATVTADRLPVLVKASAGGGGRGMRVVRDLDALAGEVQAAQREAQSAF
HHCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GDPTVFCERYLAAGHHIEVQVMADVHGTVWAVGERECSIQRRHQKIIEEAPSPLVERTPG
CCHHHHHHHHHHCCCEEEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHCCCC
MRAKLFDAARLAAEAIGYTGAGTVEFMADDTGEFFFLEMNTRLQVEHPVTEATTGLDLVE
CHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCEEEEECCCHHHHCCCEEEE
LQLLVADGGRLDAEPPPSRGSSVEARLYAEDPAKNWQPQAGTVHRFHVPPTVRVDSGVED
EEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCEEEECCCCCC
GSVVSIFYDPMLAKVISYAPTRRQAAAILADALVRTRLHGVRTNRDLLVNVLRHPAFLDG
CCEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEECC
ATDTAFFDTHGLAELAAPIGDARAGELSVLAAALADAARNRSDATVFAAAPSGWRNLASG
CCCCEEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHCC
YQTKRYRDAAGDEHEVRYRFTRAGVQFGDHDDVRLMSATPQRVVLASGGVEFPFDVARHG
HHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCEEEEECCCCCCCHHHHCCC
DAVFVDSPLGAVEFVALPRFPDPESAVAQGSLIAPMPGAVVRVGAAVGDTVSAGQPLVWL
CEEEEECCCCCEEEEECCCCCCCHHHHHCCCEECCCCCHHEEECHHHCCCCCCCCCEEEH
EAMKMEHILTAPGDGVLAELTVAPGQQVEVGTVLARVESPEGDDT
HHHHHHHEEECCCCCEEEEEEECCCCCEEHHEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]