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The map label for this gene is yngE [H]

Identifier: 119870421

GI number: 119870421

Start: 4612569

End: 4614161

Strand: Direct

Name: yngE [H]

Synonym: Mkms_4392

Alternate gene names: 119870421

Gene position: 4612569-4614161 (Clockwise)

Preceding gene: 119870420

Following gene: 119870422

Centisome position: 80.4

GC content: 68.61

Gene sequence:

>1593_bases
ATGGCGCTGAAGTCCACGCTCGATCCGTCGTCGCCGGGATACGCCGCGGCCGCCGACGCCATGGCCGCCAAGCTGGCCGA
ACTGGAGACCGAACACGCCAAGGCGCTCGCCGGCGGCGGCGCCAAGTACGTCGAACGTCACCACGCCCGCGGCAAACTCA
CCGCCCGCGAACGCATCGAACTGCTCCTCGACCCCGACTCCCCCTTCCTCGAACTGAGCCCGCTGGCCGCCTGGGGCAGC
GAGTTCACCGTCGGCGCCAGCGTGGTCACCGGGATCGGCGCGGTCAGCGGTGTGGAATGCCTGCTCGTCGCCAACGACCC
CACCGTGAAGGGCGGCACCAGCAATCCGTGGACGCTGCGGAAAATCCTGCGCGCCAACCAGATCGCGCTCCAGAACCCGC
TCCCGGTGATCTCGCTGGTCGAGTCCGGCGGCGCGGACCTGCCCACGCAGAAGGAGGTGTTCATCCCCGGCGGGCAGATG
TTCCGCGACCTCACCCGGTTGTCCGCGGCCGGGATCCCGACGATCGCCCTGGTCTTCGGCAACTCCACCGCGGGCGGCGC
GTACGTGCCGGGCATGTCCGATCACGTCGTGATGATCAAGGAACGCTCGAAGGTGTTCCTGGCCGGGCCGCCGCTGGTGA
AGATGGCCACCGGTGAGGAATCCGACGACGAATCGCTCGGCGGCGCCGAGATGCACGCCCGCACATCGGGTCTCGCCGAC
TACTTCGCGCTCGACGAACTCGACGCCCTGCGGATCGGCCGACGCATCGTCGGACGGCTCAACTGGCGCAAGCAGGGACC
CGCTCCGGCCCCGGTGACCGAGCCGCTGTTCGACAGCGAGGAACTGCTCGGCATCGTCCCGGCCGATCTGCGGATCCCGT
TCGATCCGCGTGACGTCGTCGCGCGCATCGTCGACGGTTCGGAGTTCGACGAGTTCAAGGCGCTCTACGGGTCGTCGCTG
GTGACCGGCTGGGCGCGGCTGCACGGCTATCCGATCGGCATCCTGGCCAACGCCCGCGGTGTGCTGTTCAGCGAGGAGTC
GCAGAAGGCCACCCAGTTCATCCAGCTGGCGAACCGCTCGAACACCCCACTTCTGTTCCTGCACAACACGACCGGATACA
TGGTCGGAAGGCAGTACGAAGAGGGCGGGATGATCAAACACGGCTCGATGATGATCAACGCCGTGTCGAACTCGACGGTG
CCGCACCTGTCGCTGCTGATCGGCGCCTCCTACGGCGCCGGCCACTACGGTATGTGCGGACGGGCCTACGACCCCCGCTT
CCTGTTCGCCTGGCCCAGCGCGAAGGCCGCGGTGATGGGCGGTACGCAACTGGCCGGCGTCATCTCGATCGTCGGCCGCG
CGGCCGCCGAAGCGCGTGGCCAGGTGGTGGACGAGGACGCCGACGCCGCGCTGAGGGCGGCGATCGAGGCGCAGATCGAG
GCGGAGTCGCTGCCGATGTTCCTGTCCGGCCGGCTCTACGACGACGGGGTGATCGACCCGCGCGACACCCGCACCGTGCT
GGGGATGTGCCTGTCCGCCATCGCCAACGGTCCGATCGAGGGGACGTCGAACTTCGGCGTCTTCCGGATGTGA

Upstream 100 bases:

>100_bases
ACGTTGGGATATCAGGGATGAACATGCCGAATGTGCACTCAGCGCGAGAATCGGCCGCGAAAATCGCGGTGGCTTCACAC
TCGGCGACGGAGGCGGCGAT

Downstream 100 bases:

>100_bases
GGCCGTCGATGCTTGCGATTTCGGCGTGCACGGTCGCGGTGAGCGCAACTGCGCACGCCGAAATCGCCGAGGAGGGGGCA
CGATGATCACCAGAGTCCTC

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MALKSTLDPSSPGYAAAADAMAAKLAELETEHAKALAGGGAKYVERHHARGKLTARERIELLLDPDSPFLELSPLAAWGS
EFTVGASVVTGIGAVSGVECLLVANDPTVKGGTSNPWTLRKILRANQIALQNPLPVISLVESGGADLPTQKEVFIPGGQM
FRDLTRLSAAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARTSGLAD
YFALDELDALRIGRRIVGRLNWRKQGPAPAPVTEPLFDSEELLGIVPADLRIPFDPRDVVARIVDGSEFDEFKALYGSSL
VTGWARLHGYPIGILANARGVLFSEESQKATQFIQLANRSNTPLLFLHNTTGYMVGRQYEEGGMIKHGSMMINAVSNSTV
PHLSLLIGASYGAGHYGMCGRAYDPRFLFAWPSAKAAVMGGTQLAGVISIVGRAAAEARGQVVDEDADAALRAAIEAQIE
AESLPMFLSGRLYDDGVIDPRDTRTVLGMCLSAIANGPIEGTSNFGVFRM

Sequences:

>Translated_530_residues
MALKSTLDPSSPGYAAAADAMAAKLAELETEHAKALAGGGAKYVERHHARGKLTARERIELLLDPDSPFLELSPLAAWGS
EFTVGASVVTGIGAVSGVECLLVANDPTVKGGTSNPWTLRKILRANQIALQNPLPVISLVESGGADLPTQKEVFIPGGQM
FRDLTRLSAAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARTSGLAD
YFALDELDALRIGRRIVGRLNWRKQGPAPAPVTEPLFDSEELLGIVPADLRIPFDPRDVVARIVDGSEFDEFKALYGSSL
VTGWARLHGYPIGILANARGVLFSEESQKATQFIQLANRSNTPLLFLHNTTGYMVGRQYEEGGMIKHGSMMINAVSNSTV
PHLSLLIGASYGAGHYGMCGRAYDPRFLFAWPSAKAAVMGGTQLAGVISIVGRAAAEARGQVVDEDADAALRAAIEAQIE
AESLPMFLSGRLYDDGVIDPRDTRTVLGMCLSAIANGPIEGTSNFGVFRM
>Mature_529_residues
ALKSTLDPSSPGYAAAADAMAAKLAELETEHAKALAGGGAKYVERHHARGKLTARERIELLLDPDSPFLELSPLAAWGSE
FTVGASVVTGIGAVSGVECLLVANDPTVKGGTSNPWTLRKILRANQIALQNPLPVISLVESGGADLPTQKEVFIPGGQMF
RDLTRLSAAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARTSGLADY
FALDELDALRIGRRIVGRLNWRKQGPAPAPVTEPLFDSEELLGIVPADLRIPFDPRDVVARIVDGSEFDEFKALYGSSLV
TGWARLHGYPIGILANARGVLFSEESQKATQFIQLANRSNTPLLFLHNTTGYMVGRQYEEGGMIKHGSMMINAVSNSTVP
HLSLLIGASYGAGHYGMCGRAYDPRFLFAWPSAKAAVMGGTQLAGVISIVGRAAAEARGQVVDEDADAALRAAIEAQIEA
ESLPMFLSGRLYDDGVIDPRDTRTVLGMCLSAIANGPIEGTSNFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=539, Percent_Identity=50.278293135436, Blast_Score=498, Evalue=1e-141,
Organism=Homo sapiens, GI119943100, Length=511, Percent_Identity=31.8982387475538, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI295821216, Length=531, Percent_Identity=31.0734463276836, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI310133460, Length=146, Percent_Identity=47.2602739726027, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17552936, Length=535, Percent_Identity=46.9158878504673, Blast_Score=487, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI25147362, Length=512, Percent_Identity=31.640625, Blast_Score=228, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=31.9526627218935, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI24586065, Length=551, Percent_Identity=48.6388384754991, Blast_Score=517, Evalue=1e-147,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 56189; Mature: 56058

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKSTLDPSSPGYAAAADAMAAKLAELETEHAKALAGGGAKYVERHHARGKLTARERIE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEE
LLLDPDSPFLELSPLAAWGSEFTVGASVVTGIGAVSGVECLLVANDPTVKGGTSNPWTLR
EEECCCCCCEEECCHHHCCCCEEEHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHH
KILRANQIALQNPLPVISLVESGGADLPTQKEVFIPGGQMFRDLTRLSAAGIPTIALVFG
HHHHHCHHHHCCCCCEEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCEEEEEEC
NSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARTSGLAD
CCCCCCEECCCCCCCEEEEEECCEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHCCCHH
YFALDELDALRIGRRIVGRLNWRKQGPAPAPVTEPLFDSEELLGIVPADLRIPFDPRDVV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHEEECCCCCCCCCCHHHHH
ARIVDGSEFDEFKALYGSSLVTGWARLHGYPIGILANARGVLFSEESQKATQFIQLANRS
HHHHCCCCHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCEEEEECCHHHHHHHHHHHCCC
NTPLLFLHNTTGYMVGRQYEEGGMIKHGSMMINAVSNSTVPHLSLLIGASYGAGHYGMCG
CCCEEEEECCCCEEEEEEECCCCEEEECCEEEEECCCCCCCEEEEEEECCCCCCCCCCCC
RAYDPRFLFAWPSAKAAVMGGTQLAGVISIVGRAAAEARGQVVDEDADAALRAAIEAQIE
CCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
AESLPMFLSGRLYDDGVIDPRDTRTVLGMCLSAIANGPIEGTSNFGVFRM
CCCCCEEEECEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEC
>Mature Secondary Structure 
ALKSTLDPSSPGYAAAADAMAAKLAELETEHAKALAGGGAKYVERHHARGKLTARERIE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEE
LLLDPDSPFLELSPLAAWGSEFTVGASVVTGIGAVSGVECLLVANDPTVKGGTSNPWTLR
EEECCCCCCEEECCHHHCCCCEEEHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHH
KILRANQIALQNPLPVISLVESGGADLPTQKEVFIPGGQMFRDLTRLSAAGIPTIALVFG
HHHHHCHHHHCCCCCEEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCEEEEEEC
NSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARTSGLAD
CCCCCCEECCCCCCCEEEEEECCEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHCCCHH
YFALDELDALRIGRRIVGRLNWRKQGPAPAPVTEPLFDSEELLGIVPADLRIPFDPRDVV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHEEECCCCCCCCCCHHHHH
ARIVDGSEFDEFKALYGSSLVTGWARLHGYPIGILANARGVLFSEESQKATQFIQLANRS
HHHHCCCCHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCEEEEECCHHHHHHHHHHHCCC
NTPLLFLHNTTGYMVGRQYEEGGMIKHGSMMINAVSNSTVPHLSLLIGASYGAGHYGMCG
CCCEEEEECCCCEEEEEEECCCCEEEECCEEEEECCCCCCCEEEEEEECCCCCCCCCCCC
RAYDPRFLFAWPSAKAAVMGGTQLAGVISIVGRAAAEARGQVVDEDADAALRAAIEAQIE
CCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
AESLPMFLSGRLYDDGVIDPRDTRTVLGMCLSAIANGPIEGTSNFGVFRM
CCCCCEEEECEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]