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The map label for this gene is kdpD [H]

Identifier: 119870325

GI number: 119870325

Start: 4518002

End: 4520512

Strand: Direct

Name: kdpD [H]

Synonym: Mkms_4295

Alternate gene names: 119870325

Gene position: 4518002-4520512 (Clockwise)

Preceding gene: 119870324

Following gene: 119870326

Centisome position: 78.75

GC content: 72.12

Gene sequence:

>2511_bases
GTGACGGTGGCCAACGGCCCGAAACGCGGGGAGCTGCGCATCTACCTGGGCGCAGCTCCCGGCGTCGGCAAGACCTACGC
GATGCTCGGCGAAGCACACCGGCGCCTGGCGCGCGGCACCGACGTGGTCGCCGCCGTCGTCGAGACCCACGGCCGCGCCA
AGACCGCCGAACTGCTCGACGGCATCGAGGTGCTCCCCCCGCGTCACGTCACCTACCGGGGCGGCCGGTTCCCCGAACTC
GACGTCGACGCCGTCCTCGCCCGCCGCCCCGAGGTCGTCCTCGTCGACGAACTCGCGCACACCAACACCCCGGGCAGCCG
CAACGCCAAACGCTGGCAGGACGTCGAAGCGCTTCTGGCCGCGGGGATCACGGTGATCTCGACGGTCAACGTCCAGCACC
TCGAGAGCCTCAACGACGTCGTCACCCAGATCACCGGTATCGAACAGCGCGAGACGGTCCCCGACGAGGTCGTCCGGTCC
GCCGATCAGGTCGAGCTGGTCGACATCACCCCTGAGGCGTTGCGCCGCAGGCTTTCTCACGGCAACGTCTACGCCCCCGA
ACGCATCGACGCGGCGCTGTCCAACTACTTCCGGCGCGGCAACCTCACCGCGCTGCGCGAGCTGGCGCTGCTGTGGCTGG
CCGATCAGGTCGACGCCGCGCTGGCGAAGTACCGGGCCGACAACCGGATCACCGACACGTGGGAGGCGCGTGAACGGGTC
GTCGTCGCGGTCACCGGTGGACCCGAATCCGAGACGCTGGTGCGCCGCGCCTCACGTATCGCATCGAAGTCGAGCGCCGA
ACTGATGGTCGTACACGTCGTGCGCGGCGACGGTCTGACCGGTGTCTCGGCACCCGAGATGGGCCGGGTGCGCGAACTCG
CGGCCAGTCTGGGCGCCACCCTGCACACCGTCACCGGTGACGACGTGCCCACGGCGCTGCTGGATTTCGCGCGCGAACGC
AACGCCACCCAGCTCGTACTCGGCACCTCCCGGCGGTCCCGCTGGGCACGCATCCTCGACGAGGGCATCGGCGCGGCCGT
CGTCCAGCGGTCCGGCAAGATCGACGTCCACATGGTCACCCATGACGAGGCGCACCGAAGCCCGACGGCGTCGCCCCGCA
CCCGGCGTGCGGCGTCGTGGCTGGCCGCTCTGGCCGTACCCGCCGCGATCTGCGCGCTGACGGTGCTGCTGCTCGACCCG
CTGCTCGGCGTGGCCGGCGAGAGCGCGGTGTTCTTCGTCGGGGTCCTGCTCGTCGCACTGCTCGGCGGCGTGGCGCCGGC
GGCGCTGTCGGCCGTGCTGTCCGGTCTGCTCCTCAACTACTTCCTCATCAACCCCCGCCACACCTTCACCATCGCCGAAC
CCGACAGCGCACTGACGATCGTGGTGATGCTCGCCGTCGCGGTGGCCGTCGCGGCCCTGGTCGACGGTGCCGCCAGCCGG
CGCCGCGAGGCGCGCCATGCCGCGCGGGAAGCCGAACTGCTCGCCCTGTTCGCCGGCGCCGTCCTCCGGGGCGCGGACCT
GACCGTCCTGCTCGAGCGGGTCCGCGAGACCTACGGCCAACGGGCGGTCAGCCTGCTGCGCGAGAAGGCCGGGGTCGTCG
CCTGCGTCGGTGCGGACCCGTGCGTCGACGTCAACACCGCCGACACCGCCATCGAAGTCGGCGACGACGAGTTCTGGCTG
CTGCTGGCCGGGCGCAAACTCGCCGCCCGCGACCGCCGCGTGCTCTCGGCCGTCGCCGGGCAGGCCGCCGGTCTGGTCCG
CCAGCGCGAGCTCACCGAAGAGGCCGGCCGCGCCGAAGCCATCGCCCGCGCCGACGAGTTGCGCCGGTCGCTGCTCTCTG
CGGTCAGCCACGACCTGCGCACCCCGCTGGCGGCGGCCAAAGCCGCCGTGTCGAGCCTGCGCTCCGACGAGGTCGACTTC
TCCGCCGACGACCGGGCCGAACTCCTGGCCACCGTCGAGGAGTCGGTCGACCAGCTGACCGCCCTGGTCGCCAACCTGCT
CGATTCGTCGAGACTGGCCGCGGGGGTGGTGCGTCCACAGCTGAGTGCCGTCTACCTCGAGGAGGCGGTGCAGCGCGCCC
TTCTCGGAATCAGCAGGGGGGCCACGGGTTCCGGAGACATCGGGATCGACCGGGTCGAGGTGGACGTCGACGGGTGCGTG
GTGGCCGCGGACAGCGGTCTGCTCGAGCGGGTGCTGGCCAACCTCATCGACAACGCCCTGCGGTACGCGCCCGACGGCCC
GGTGCGTGTGACGGCCGGACGCGTGGGTGAGCGGGTGCTGATCGCCGTCACCGACACCGGGCCCGGCATACCCCCCGGCG
GCCAGGACAGGGTGTTCGGCGCCTTTCAGCGGCTCGGTGACCAGGACACGACCAGCGGCGTCGGGCTCGGGCTGTCGGTG
GCCCGCGGATTCGTCGAGGCGATGGGCGGTACGGTCACCGCGAACGACACCCCGGGCGGGGGCCTGACCGTCGAAATCGA
CCTCGCCGCACCGCAGGAGGCCCACGCGTGA

Upstream 100 bases:

>100_bases
GTCGCCGCCCACACCGAGGGGCGCACGTTGGGGTTCATGGGCGAGCCGCGGGTCAACGTCCTCGAACTCAACCTCGCCCT
GGACGGTGGATGATGAAGGC

Downstream 100 bases:

>100_bases
CCCGCGTGCTCGTCGTCGACGACGAACCGCAGATCCTGCGGGCGCTGAAGATCAACCTGTCGGTGCGCGGCTACGAGGTG
ACCACCGCCGCCACCGGCGC

Product: osmosensitive K+ channel signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 836; Mature: 835

Protein sequence:

>836_residues
MTVANGPKRGELRIYLGAAPGVGKTYAMLGEAHRRLARGTDVVAAVVETHGRAKTAELLDGIEVLPPRHVTYRGGRFPEL
DVDAVLARRPEVVLVDELAHTNTPGSRNAKRWQDVEALLAAGITVISTVNVQHLESLNDVVTQITGIEQRETVPDEVVRS
ADQVELVDITPEALRRRLSHGNVYAPERIDAALSNYFRRGNLTALRELALLWLADQVDAALAKYRADNRITDTWEARERV
VVAVTGGPESETLVRRASRIASKSSAELMVVHVVRGDGLTGVSAPEMGRVRELAASLGATLHTVTGDDVPTALLDFARER
NATQLVLGTSRRSRWARILDEGIGAAVVQRSGKIDVHMVTHDEAHRSPTASPRTRRAASWLAALAVPAAICALTVLLLDP
LLGVAGESAVFFVGVLLVALLGGVAPAALSAVLSGLLLNYFLINPRHTFTIAEPDSALTIVVMLAVAVAVAALVDGAASR
RREARHAAREAELLALFAGAVLRGADLTVLLERVRETYGQRAVSLLREKAGVVACVGADPCVDVNTADTAIEVGDDEFWL
LLAGRKLAARDRRVLSAVAGQAAGLVRQRELTEEAGRAEAIARADELRRSLLSAVSHDLRTPLAAAKAAVSSLRSDEVDF
SADDRAELLATVEESVDQLTALVANLLDSSRLAAGVVRPQLSAVYLEEAVQRALLGISRGATGSGDIGIDRVEVDVDGCV
VAADSGLLERVLANLIDNALRYAPDGPVRVTAGRVGERVLIAVTDTGPGIPPGGQDRVFGAFQRLGDQDTTSGVGLGLSV
ARGFVEAMGGTVTANDTPGGGLTVEIDLAAPQEAHA

Sequences:

>Translated_836_residues
MTVANGPKRGELRIYLGAAPGVGKTYAMLGEAHRRLARGTDVVAAVVETHGRAKTAELLDGIEVLPPRHVTYRGGRFPEL
DVDAVLARRPEVVLVDELAHTNTPGSRNAKRWQDVEALLAAGITVISTVNVQHLESLNDVVTQITGIEQRETVPDEVVRS
ADQVELVDITPEALRRRLSHGNVYAPERIDAALSNYFRRGNLTALRELALLWLADQVDAALAKYRADNRITDTWEARERV
VVAVTGGPESETLVRRASRIASKSSAELMVVHVVRGDGLTGVSAPEMGRVRELAASLGATLHTVTGDDVPTALLDFARER
NATQLVLGTSRRSRWARILDEGIGAAVVQRSGKIDVHMVTHDEAHRSPTASPRTRRAASWLAALAVPAAICALTVLLLDP
LLGVAGESAVFFVGVLLVALLGGVAPAALSAVLSGLLLNYFLINPRHTFTIAEPDSALTIVVMLAVAVAVAALVDGAASR
RREARHAAREAELLALFAGAVLRGADLTVLLERVRETYGQRAVSLLREKAGVVACVGADPCVDVNTADTAIEVGDDEFWL
LLAGRKLAARDRRVLSAVAGQAAGLVRQRELTEEAGRAEAIARADELRRSLLSAVSHDLRTPLAAAKAAVSSLRSDEVDF
SADDRAELLATVEESVDQLTALVANLLDSSRLAAGVVRPQLSAVYLEEAVQRALLGISRGATGSGDIGIDRVEVDVDGCV
VAADSGLLERVLANLIDNALRYAPDGPVRVTAGRVGERVLIAVTDTGPGIPPGGQDRVFGAFQRLGDQDTTSGVGLGLSV
ARGFVEAMGGTVTANDTPGGGLTVEIDLAAPQEAHA
>Mature_835_residues
TVANGPKRGELRIYLGAAPGVGKTYAMLGEAHRRLARGTDVVAAVVETHGRAKTAELLDGIEVLPPRHVTYRGGRFPELD
VDAVLARRPEVVLVDELAHTNTPGSRNAKRWQDVEALLAAGITVISTVNVQHLESLNDVVTQITGIEQRETVPDEVVRSA
DQVELVDITPEALRRRLSHGNVYAPERIDAALSNYFRRGNLTALRELALLWLADQVDAALAKYRADNRITDTWEARERVV
VAVTGGPESETLVRRASRIASKSSAELMVVHVVRGDGLTGVSAPEMGRVRELAASLGATLHTVTGDDVPTALLDFARERN
ATQLVLGTSRRSRWARILDEGIGAAVVQRSGKIDVHMVTHDEAHRSPTASPRTRRAASWLAALAVPAAICALTVLLLDPL
LGVAGESAVFFVGVLLVALLGGVAPAALSAVLSGLLLNYFLINPRHTFTIAEPDSALTIVVMLAVAVAVAALVDGAASRR
REARHAAREAELLALFAGAVLRGADLTVLLERVRETYGQRAVSLLREKAGVVACVGADPCVDVNTADTAIEVGDDEFWLL
LAGRKLAARDRRVLSAVAGQAAGLVRQRELTEEAGRAEAIARADELRRSLLSAVSHDLRTPLAAAKAAVSSLRSDEVDFS
ADDRAELLATVEESVDQLTALVANLLDSSRLAAGVVRPQLSAVYLEEAVQRALLGISRGATGSGDIGIDRVEVDVDGCVV
AADSGLLERVLANLIDNALRYAPDGPVRVTAGRVGERVLIAVTDTGPGIPPGGQDRVFGAFQRLGDQDTTSGVGLGLSVA
RGFVEAMGGTVTANDTPGGGLTVEIDLAAPQEAHA

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals [H]

COG id: COG2205

COG function: function code T; Osmosensitive K+ channel histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=882, Percent_Identity=33.9002267573696, Blast_Score=427, Evalue=1e-120,
Organism=Escherichia coli, GI1787894, Length=222, Percent_Identity=32.8828828828829, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI145693157, Length=351, Percent_Identity=25.3561253561254, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1789149, Length=250, Percent_Identity=27.2, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1788393, Length=236, Percent_Identity=27.9661016949153, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI87081816, Length=229, Percent_Identity=28.82096069869, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=242, Percent_Identity=28.5123966942149, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788713, Length=241, Percent_Identity=24.0663900414938, Blast_Score=77, Evalue=6e-15,
Organism=Escherichia coli, GI1789808, Length=228, Percent_Identity=26.7543859649123, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI1787374, Length=276, Percent_Identity=26.8115942028986, Blast_Score=74, Evalue=5e-14,
Organism=Escherichia coli, GI48994928, Length=295, Percent_Identity=26.1016949152542, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=26.3636363636364, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1788549, Length=249, Percent_Identity=26.5060240963855, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1790346, Length=243, Percent_Identity=26.7489711934156, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1790861, Length=221, Percent_Identity=29.8642533936652, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1786783, Length=215, Percent_Identity=28.3720930232558, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=28.8135593220339, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR014729
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR003852
- InterPro:   IPR006016 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF02702 KdpD; PF00582 Usp [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 88339; Mature: 88207

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVANGPKRGELRIYLGAAPGVGKTYAMLGEAHRRLARGTDVVAAVVETHGRAKTAELLD
CCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHC
GIEVLPPRHVTYRGGRFPELDVDAVLARRPEVVLVDELAHTNTPGSRNAKRWQDVEALLA
CHHCCCCCCEEECCCCCCCCCHHHHHHCCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHH
AGITVISTVNVQHLESLNDVVTQITGIEQRETVPDEVVRSADQVELVDITPEALRRRLSH
CCHHHHEECCHHHHHHHHHHHHHHHCCCHHCCCHHHHHCCCCCEEEEECCHHHHHHHHHC
GNVYAPERIDAALSNYFRRGNLTALRELALLWLADQVDAALAKYRADNRITDTWEARERV
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCE
VVAVTGGPESETLVRRASRIASKSSAELMVVHVVRGDGLTGVSAPEMGRVRELAASLGAT
EEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCE
LHTVTGDDVPTALLDFARERNATQLVLGTSRRSRWARILDEGIGAAVVQRSGKIDVHMVT
EEECCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCHHHHHCCCCEEEEEEE
HDEAHRSPTASPRTRRAASWLAALAVPAAICALTVLLLDPLLGVAGESAVFFVGVLLVAL
CCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LGGVAPAALSAVLSGLLLNYFLINPRHTFTIAEPDSALTIVVMLAVAVAVAALVDGAASR
HHCHHHHHHHHHHHHHHHHHHEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
RREARHAAREAELLALFAGAVLRGADLTVLLERVRETYGQRAVSLLREKAGVVACVGADP
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
CVDVNTADTAIEVGDDEFWLLLAGRKLAARDRRVLSAVAGQAAGLVRQRELTEEAGRAEA
CCCCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IARADELRRSLLSAVSHDLRTPLAAAKAAVSSLRSDEVDFSADDRAELLATVEESVDQLT
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
ALVANLLDSSRLAAGVVRPQLSAVYLEEAVQRALLGISRGATGSGDIGIDRVEVDVDGCV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCEE
VAADSGLLERVLANLIDNALRYAPDGPVRVTAGRVGERVLIAVTDTGPGIPPGGQDRVFG
EECCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHH
AFQRLGDQDTTSGVGLGLSVARGFVEAMGGTVTANDTPGGGLTVEIDLAAPQEAHA
HHHHCCCCCCCCCCCCHHHHHHHHHHHHCCEEECCCCCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure 
TVANGPKRGELRIYLGAAPGVGKTYAMLGEAHRRLARGTDVVAAVVETHGRAKTAELLD
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHC
GIEVLPPRHVTYRGGRFPELDVDAVLARRPEVVLVDELAHTNTPGSRNAKRWQDVEALLA
CHHCCCCCCEEECCCCCCCCCHHHHHHCCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHH
AGITVISTVNVQHLESLNDVVTQITGIEQRETVPDEVVRSADQVELVDITPEALRRRLSH
CCHHHHEECCHHHHHHHHHHHHHHHCCCHHCCCHHHHHCCCCCEEEEECCHHHHHHHHHC
GNVYAPERIDAALSNYFRRGNLTALRELALLWLADQVDAALAKYRADNRITDTWEARERV
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCE
VVAVTGGPESETLVRRASRIASKSSAELMVVHVVRGDGLTGVSAPEMGRVRELAASLGAT
EEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCE
LHTVTGDDVPTALLDFARERNATQLVLGTSRRSRWARILDEGIGAAVVQRSGKIDVHMVT
EEECCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCHHHHHCCCCEEEEEEE
HDEAHRSPTASPRTRRAASWLAALAVPAAICALTVLLLDPLLGVAGESAVFFVGVLLVAL
CCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LGGVAPAALSAVLSGLLLNYFLINPRHTFTIAEPDSALTIVVMLAVAVAVAALVDGAASR
HHCHHHHHHHHHHHHHHHHHHEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
RREARHAAREAELLALFAGAVLRGADLTVLLERVRETYGQRAVSLLREKAGVVACVGADP
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
CVDVNTADTAIEVGDDEFWLLLAGRKLAARDRRVLSAVAGQAAGLVRQRELTEEAGRAEA
CCCCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IARADELRRSLLSAVSHDLRTPLAAAKAAVSSLRSDEVDFSADDRAELLATVEESVDQLT
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
ALVANLLDSSRLAAGVVRPQLSAVYLEEAVQRALLGISRGATGSGDIGIDRVEVDVDGCV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCEE
VAADSGLLERVLANLIDNALRYAPDGPVRVTAGRVGERVLIAVTDTGPGIPPGGQDRVFG
EECCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHH
AFQRLGDQDTTSGVGLGLSVARGFVEAMGGTVTANDTPGGGLTVEIDLAAPQEAHA
HHHHCCCCCCCCCCCCHHHHHHHHHHHHCCEEECCCCCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]