Click here to switch to the map view.

The map label for this gene is vanX [H]

Identifier: 119870282

GI number: 119870282

Start: 4478898

End: 4479704

Strand: Direct

Name: vanX [H]

Synonym: Mkms_4252

Alternate gene names: 119870282

Gene position: 4478898-4479704 (Clockwise)

Preceding gene: 119870274

Following gene: 119870286

Centisome position: 78.07

GC content: 67.53

Gene sequence:

>807_bases
ATGCCGAAAACACTGAGGGGTGTGCTGGGGATCGTGTCCGCCGCGGTGCTGGCGGCGGTGGCGGCGCCGGTCGCTTCGGC
CCAGCCCGAACCGACGGCCCCGGCGGACTTCGTCTCGCTCACCGACGTCGACCCGTCGATCCTGCTGGACGTCCGCTACA
TCACGCCGCACAACTTCACCGGTGATCCGGTCGACGGGTACCGGGCGCCGCTGTGCCTGCTCACCCGGCCGGCGGCCGAG
GCGCTGCGGCGCGCGCAGCAGGAGTTCGTCGAACAGGGCTACTCGCTGAAGGTCTACGACTGCTACCGGCCGCAGCGCGC
CGTGAACGATTTCGTGGCGTGGGCGAAGAACCTTCCCGACCAGCGGATGAAGGCCGAGTTCTACCCCCGAGTGGACAAGA
CGCAGCTGTTCGCCGACGGGTACATCGCCGAGAACTCGGGGCACAGCCGCGGCAGCACCGTCGACCTCACGCTGGTCGCG
TTGCCCGCCGAGGAGCAGCCGGCCTTCGTGCCGGGCCAGCCACTGGTCGACTGCGCCGCACCGGTCGCGGAACGCTTCGG
CGACGACACCATCGACATGGGCACCGGTTACGACTGCTTCGACACCCTGGCGCACACGCTCGACCCGCGGATCCAGGGTG
AGCAGCTCAAGAACCGGCTGCTGCTGAAGGACGGACTCGAGAAGCAGGGGTTGGAGAACTACGAGAACGAGTGGTGGCAC
TTCACGTTCAAACCCGAGACGTATCCGGACACCTACTTCGACTTCCCCGTCGACCCATCCTCGCTGACGGGTTTAGGCCA
CCGGTAG

Upstream 100 bases:

>100_bases
TGAGCGATGTGGTGACAATCCCCGATAGTTTTACATCGCACGTTCACTTTCCGCTCACCGTGACGCAGCGCGATGCCCGC
CGTGGTGTTGCAATGGGCAC

Downstream 100 bases:

>100_bases
GAGCACCGCGCGGGTCGACTGCCACAGCGAGACCGGGATGAGCGTCGGCCGCGAGGTCGCGACCGCGCTGCCGAGGACCC
TGGCGGTGGCGCGGCCCTTG

Product: M15D family D-Ala-D-Ala dipeptidase VanX

Products: NA

Alternate protein names: D-Ala-D-Ala dipeptidase [H]

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MPKTLRGVLGIVSAAVLAAVAAPVASAQPEPTAPADFVSLTDVDPSILLDVRYITPHNFTGDPVDGYRAPLCLLTRPAAE
ALRRAQQEFVEQGYSLKVYDCYRPQRAVNDFVAWAKNLPDQRMKAEFYPRVDKTQLFADGYIAENSGHSRGSTVDLTLVA
LPAEEQPAFVPGQPLVDCAAPVAERFGDDTIDMGTGYDCFDTLAHTLDPRIQGEQLKNRLLLKDGLEKQGLENYENEWWH
FTFKPETYPDTYFDFPVDPSSLTGLGHR

Sequences:

>Translated_268_residues
MPKTLRGVLGIVSAAVLAAVAAPVASAQPEPTAPADFVSLTDVDPSILLDVRYITPHNFTGDPVDGYRAPLCLLTRPAAE
ALRRAQQEFVEQGYSLKVYDCYRPQRAVNDFVAWAKNLPDQRMKAEFYPRVDKTQLFADGYIAENSGHSRGSTVDLTLVA
LPAEEQPAFVPGQPLVDCAAPVAERFGDDTIDMGTGYDCFDTLAHTLDPRIQGEQLKNRLLLKDGLEKQGLENYENEWWH
FTFKPETYPDTYFDFPVDPSSLTGLGHR
>Mature_267_residues
PKTLRGVLGIVSAAVLAAVAAPVASAQPEPTAPADFVSLTDVDPSILLDVRYITPHNFTGDPVDGYRAPLCLLTRPAAEA
LRRAQQEFVEQGYSLKVYDCYRPQRAVNDFVAWAKNLPDQRMKAEFYPRVDKTQLFADGYIAENSGHSRGSTVDLTLVAL
PAEEQPAFVPGQPLVDCAAPVAERFGDDTIDMGTGYDCFDTLAHTLDPRIQGEQLKNRLLLKDGLEKQGLENYENEWWHF
TFKPETYPDTYFDFPVDPSSLTGLGHR

Specific function: Hydrolyzes the cellular pool of D-Ala-D-Ala dipeptides. May play a role in immunity or defense against glycopeptide antibiotics (perhaps at a moderate level) in the soil environment. Might confer vancomycin resistance to S.coelicolor [H]

COG id: COG2173

COG function: function code M; D-alanyl-D-alanine dipeptidase

Gene ontology:

Cell location: Secreted (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M15D family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009045
- InterPro:   IPR000755 [H]

Pfam domain/function: PF01427 Peptidase_M15 [H]

EC number: =3.4.13.22 [H]

Molecular weight: Translated: 29694; Mature: 29562

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKTLRGVLGIVSAAVLAAVAAPVASAQPEPTAPADFVSLTDVDPSILLDVRYITPHNFT
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHEEEEEEECCCCCC
GDPVDGYRAPLCLLTRPAAEALRRAQQEFVEQGYSLKVYDCYRPQRAVNDFVAWAKNLPD
CCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCH
QRMKAEFYPRVDKTQLFADGYIAENSGHSRGSTVDLTLVALPAEEQPAFVPGQPLVDCAA
HHHHHHHCCCCCCCEEEECCEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHH
PVAERFGDDTIDMGTGYDCFDTLAHTLDPRIQGEQLKNRLLLKDGLEKQGLENYENEWWH
HHHHHCCCCCEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCEE
FTFKPETYPDTYFDFPVDPSSLTGLGHR
EEECCCCCCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure 
PKTLRGVLGIVSAAVLAAVAAPVASAQPEPTAPADFVSLTDVDPSILLDVRYITPHNFT
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHEEEEEEECCCCCC
GDPVDGYRAPLCLLTRPAAEALRRAQQEFVEQGYSLKVYDCYRPQRAVNDFVAWAKNLPD
CCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCH
QRMKAEFYPRVDKTQLFADGYIAENSGHSRGSTVDLTLVALPAEEQPAFVPGQPLVDCAA
HHHHHHHCCCCCCCEEEECCEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHH
PVAERFGDDTIDMGTGYDCFDTLAHTLDPRIQGEQLKNRLLLKDGLEKQGLENYENEWWH
HHHHHCCCCCEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCEE
FTFKPETYPDTYFDFPVDPSSLTGLGHR
EEECCCCCCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11881895; 12000953 [H]