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The map label for this gene is malR [H]

Identifier: 119870274

GI number: 119870274

Start: 4470982

End: 4471683

Strand: Direct

Name: malR [H]

Synonym: Mkms_4244

Alternate gene names: 119870274

Gene position: 4470982-4471683 (Clockwise)

Preceding gene: 119870273

Following gene: 119870282

Centisome position: 77.93

GC content: 72.36

Gene sequence:

>702_bases
GTGAGCACTCGGCCGATCTCGGTGCTCATCGTCGAGGACGATCCGCTGATCGCCGAGGCCCACCAGACCTACCTGTCGCG
CCTGACCGGTTTCGCCACCGCGGCGGTCGCGCACACCGCGCGCGACGCGATGCGGGCGGCGTCGGAGGCGGCGACCGGTG
AGCACCCGATCGATCTGGTGTTGCTCGACCTCGGCCTGCCGGACGCCACCGGGATCTCGCTGGCCTCGGCGCTGTCGGGG
CTGCGCCCGGCACCGGACATCATCGCGATCACCTCGGAGCGCGACCTGGAGATGGTGCGGGCGGCGGTATCGCACGGCGC
GCTGGCGTACCTGCTCAAACCGTTCACCTTCGCGGCGTTCCGGGACCGGTTGGAGCGCTACCGGCGCTACCGCGACGCGC
TGCCCGCGGGTATCGACGCGGCCAGCCAGACCGAGGTCGACCGGGCCCTCGCCGAACTCCGGGGTTCCGCCGACCGGGCC
ACGGCACCCAAGGGCACCGCACCGGGCACCAATGACGAGATCGCCAGGGCGGTGCGCGATTCCGCCGACGGGCTCACCGC
GGACCAGGTCGCCTCACAGGTGGGCGTGTCCCGGGTGACGGCATGGCGCTACCTCGAGCGGCTTGCCGACGACGGCACCG
TCACCCGCCTCACCGACTACGGCAGGGCGGGGCGGCCCAAGACGCGTTATCAGTGGCGTTAG

Upstream 100 bases:

>100_bases
TGGCGCTCGTCGCGCAGGTGGCGGCCAGGCACGGCGGTACGGTCACCGCCGACGTCACCTACGGTTCGGTGGTGACCGTG
ACGGTGCCGCTGGGAGTCTC

Downstream 100 bases:

>100_bases
ACGGCGGGCGACAGTTCCCGCATGTCGGGCCGGACGATCGGATCGGTCGCCGCGAAATGCTTCCGGGGCGTGGCGAGTGA
CGTCATGGCGCCGGCGTGGT

Product: Fis family transcriptional regulator

Products: NA

Alternate protein names: Malate response regulator [H]

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MSTRPISVLIVEDDPLIAEAHQTYLSRLTGFATAAVAHTARDAMRAASEAATGEHPIDLVLLDLGLPDATGISLASALSG
LRPAPDIIAITSERDLEMVRAAVSHGALAYLLKPFTFAAFRDRLERYRRYRDALPAGIDAASQTEVDRALAELRGSADRA
TAPKGTAPGTNDEIARAVRDSADGLTADQVASQVGVSRVTAWRYLERLADDGTVTRLTDYGRAGRPKTRYQWR

Sequences:

>Translated_233_residues
MSTRPISVLIVEDDPLIAEAHQTYLSRLTGFATAAVAHTARDAMRAASEAATGEHPIDLVLLDLGLPDATGISLASALSG
LRPAPDIIAITSERDLEMVRAAVSHGALAYLLKPFTFAAFRDRLERYRRYRDALPAGIDAASQTEVDRALAELRGSADRA
TAPKGTAPGTNDEIARAVRDSADGLTADQVASQVGVSRVTAWRYLERLADDGTVTRLTDYGRAGRPKTRYQWR
>Mature_232_residues
STRPISVLIVEDDPLIAEAHQTYLSRLTGFATAAVAHTARDAMRAASEAATGEHPIDLVLLDLGLPDATGISLASALSGL
RPAPDIIAITSERDLEMVRAAVSHGALAYLLKPFTFAAFRDRLERYRRYRDALPAGIDAASQTEVDRALAELRGSADRAT
APKGTAPGTNDEIARAVRDSADGLTADQVASQVGVSRVTAWRYLERLADDGTVTRLTDYGRAGRPKTRYQWR

Specific function: Member of a two-component regulatory system malK/malR. Activates transcription of maeA, maeN and yflS in presence of malate by binding to their promoter region [H]

COG id: COG4565

COG function: function code KT; Response regulator of citrate/malate metabolism

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790566, Length=230, Percent_Identity=30.4347826086957, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1786838, Length=229, Percent_Identity=31.0043668122271, Blast_Score=108, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 25100; Mature: 24969

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRPISVLIVEDDPLIAEAHQTYLSRLTGFATAAVAHTARDAMRAASEAATGEHPIDLV
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
LLDLGLPDATGISLASALSGLRPAPDIIAITSERDLEMVRAAVSHGALAYLLKPFTFAAF
EEECCCCCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDRLERYRRYRDALPAGIDAASQTEVDRALAELRGSADRATAPKGTAPGTNDEIARAVRD
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
SADGLTADQVASQVGVSRVTAWRYLERLADDGTVTRLTDYGRAGRPKTRYQWR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
STRPISVLIVEDDPLIAEAHQTYLSRLTGFATAAVAHTARDAMRAASEAATGEHPIDLV
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
LLDLGLPDATGISLASALSGLRPAPDIIAITSERDLEMVRAAVSHGALAYLLKPFTFAAF
EEECCCCCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDRLERYRRYRDALPAGIDAASQTEVDRALAELRGSADRATAPKGTAPGTNDEIARAVRD
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
SADGLTADQVASQVGVSRVTAWRYLERLADDGTVTRLTDYGRAGRPKTRYQWR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377; 12949159; 12949160 [H]