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The map label for this gene is aslA [H]

Identifier: 119870218

GI number: 119870218

Start: 4414555

End: 4416099

Strand: Direct

Name: aslA [H]

Synonym: Mkms_4188

Alternate gene names: 119870218

Gene position: 4414555-4416099 (Clockwise)

Preceding gene: 119870215

Following gene: 119870219

Centisome position: 76.95

GC content: 63.11

Gene sequence:

>1545_bases
ATGCCGAACTCCACACCCAACATCCTCGTGATCTGGGGTGACGACATCGGGATCAGCAACCTCAGTTGCTATAGCCGCGG
CATGATGGGGTACCGCACACCCAACATCGACCGGATCGCCGACGAGGGCATGCTCTTCACCGACTCTTACGGCGAGCAGA
GCTGCACCGCGGGCCGGTCGTCGTTCATCACCGGCCAGAGCGTCTACCGCACCGGCATGAGCAAGGTCGGGATGCCCGGC
GTCGACATCGGACTGCAGAAGGAGGACCCGACCATCGCCGAGCTGCTCAAACCGTTGGGTTACGCCACCGGGCAGTTCGG
CAAGAACCACCTCGGTGACCTCAACAAGTACCTTCCGACCGCCCATGGGTTCGACGAGTTCTTCGGCAATCTGTACCACC
TCAACGCCGAGGAGGAACCCGAGAACGCCGACTACCCGACCGAGGAGGAGGCACCGGTGATGCGTCGGGCATTGTTGCCG
CGCGGCGTCATCCACTCCTGGGCCACCGAGGAGGATTCGGGCGAGGTCGATGACCGGTACGGCCCGGCGGGAAAGCAGCG
CATCGAGGACACCGGACCGCTGACCAAGAAGCGGATGGAGACCATCGACGACGAAACCACGGACGCCTGTGTTGATTTCA
TCACCCGTGCGCACGGGACCGGCACCCCGTTCTTCGTGTGGATGAACATGACGCACATGCACTTCCGGACGCACACCAAG
CCGGAGAGCCTGGGACAAGCCGGGCGCTGGCAGTCGCCGTACCACGACACGATGATCGACCACGACCGCAACGTCGGTCA
GCTACTCGACCTGCTCGACGAGCTGGGTATCGCCGACGACACCATCGTCATCTACTCCACCGACAACGGCCCGCATGCCA
ACAGCTGGCCCGACGGTGCCACCACACCGTTCCGCAGCGAGAAGGCCACCAACTGGGAGGGCGCTTTCCGGATCCCGGAA
CTCATTCGCTGGCCCGGCAAGATCGAACCGCGCAGTGTGTCCAATGAGATTGTGCAGCATCACGATTGGCTTCCGACCTT
CCTGGCCGCCGCCGGTGACCCCGACATCGTCGACAAGCTCAAAGCCGGGCACACGATCGGGGACATCACGTACAAGGTGC
ACATCGACGGGTACAACCTGGTGCCCTATCTGACCGGCGAGGTGGCCAAGAGCCCGCGCCGCGGAATGATCTACTTCTCC
GACGACTGCGACGTACTCGGTATCCGCGCGGAGAACTGGAAGGTGGTCTTCCAGGAGCAGCGTTGCCAGGGAACCCTGCA
GATCTGGTTCGAGCCGTTCACCCCGCTGCGGGCGCCGAAACTGTTCAACCTGCGCACCGATCCGTACGAGCGCGCCGACA
TCACGTCGAACACCTACTGGGACTGGGTCATCGACCGCATCTACCTGGTGCTCTACGGATCTGCAATCGCGACTCAGTTC
CTCGAGACGTTCAAGGAGTTCCCGCCGCGCCAGGAACCGGCGTCCTTCACCATCGACCACGCGGTCGATGAGCTCAACAA
GTTCCTGTCCACCCGAGGCGGCTGA

Upstream 100 bases:

>100_bases
ACCATCGACCAAGCGGTCCTCGACTCGAGGTGTTTCTCGGCAACGGTTGACACTCCCGCCTCCCGAACTCGGCCGCACAG
TTCAAGAAAGGGCCTTGCAC

Downstream 100 bases:

>100_bases
TGCTCGACACGTGGACCGACGGGCCCACGCAGTCCGCCATCGTCGATTTCGTCAACCGGGCGGCCGCCGACATCCCACCC
GAGGAGCGCGTCGCGGTGTT

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MPNSTPNILVIWGDDIGISNLSCYSRGMMGYRTPNIDRIADEGMLFTDSYGEQSCTAGRSSFITGQSVYRTGMSKVGMPG
VDIGLQKEDPTIAELLKPLGYATGQFGKNHLGDLNKYLPTAHGFDEFFGNLYHLNAEEEPENADYPTEEEAPVMRRALLP
RGVIHSWATEEDSGEVDDRYGPAGKQRIEDTGPLTKKRMETIDDETTDACVDFITRAHGTGTPFFVWMNMTHMHFRTHTK
PESLGQAGRWQSPYHDTMIDHDRNVGQLLDLLDELGIADDTIVIYSTDNGPHANSWPDGATTPFRSEKATNWEGAFRIPE
LIRWPGKIEPRSVSNEIVQHHDWLPTFLAAAGDPDIVDKLKAGHTIGDITYKVHIDGYNLVPYLTGEVAKSPRRGMIYFS
DDCDVLGIRAENWKVVFQEQRCQGTLQIWFEPFTPLRAPKLFNLRTDPYERADITSNTYWDWVIDRIYLVLYGSAIATQF
LETFKEFPPRQEPASFTIDHAVDELNKFLSTRGG

Sequences:

>Translated_514_residues
MPNSTPNILVIWGDDIGISNLSCYSRGMMGYRTPNIDRIADEGMLFTDSYGEQSCTAGRSSFITGQSVYRTGMSKVGMPG
VDIGLQKEDPTIAELLKPLGYATGQFGKNHLGDLNKYLPTAHGFDEFFGNLYHLNAEEEPENADYPTEEEAPVMRRALLP
RGVIHSWATEEDSGEVDDRYGPAGKQRIEDTGPLTKKRMETIDDETTDACVDFITRAHGTGTPFFVWMNMTHMHFRTHTK
PESLGQAGRWQSPYHDTMIDHDRNVGQLLDLLDELGIADDTIVIYSTDNGPHANSWPDGATTPFRSEKATNWEGAFRIPE
LIRWPGKIEPRSVSNEIVQHHDWLPTFLAAAGDPDIVDKLKAGHTIGDITYKVHIDGYNLVPYLTGEVAKSPRRGMIYFS
DDCDVLGIRAENWKVVFQEQRCQGTLQIWFEPFTPLRAPKLFNLRTDPYERADITSNTYWDWVIDRIYLVLYGSAIATQF
LETFKEFPPRQEPASFTIDHAVDELNKFLSTRGG
>Mature_513_residues
PNSTPNILVIWGDDIGISNLSCYSRGMMGYRTPNIDRIADEGMLFTDSYGEQSCTAGRSSFITGQSVYRTGMSKVGMPGV
DIGLQKEDPTIAELLKPLGYATGQFGKNHLGDLNKYLPTAHGFDEFFGNLYHLNAEEEPENADYPTEEEAPVMRRALLPR
GVIHSWATEEDSGEVDDRYGPAGKQRIEDTGPLTKKRMETIDDETTDACVDFITRAHGTGTPFFVWMNMTHMHFRTHTKP
ESLGQAGRWQSPYHDTMIDHDRNVGQLLDLLDELGIADDTIVIYSTDNGPHANSWPDGATTPFRSEKATNWEGAFRIPEL
IRWPGKIEPRSVSNEIVQHHDWLPTFLAAAGDPDIVDKLKAGHTIGDITYKVHIDGYNLVPYLTGEVAKSPRRGMIYFSD
DCDVLGIRAENWKVVFQEQRCQGTLQIWFEPFTPLRAPKLFNLRTDPYERADITSNTYWDWVIDRIYLVLYGSAIATQFL
ETFKEFPPRQEPASFTIDHAVDELNKFLSTRGG

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=472, Percent_Identity=29.2372881355932, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI146229329, Length=472, Percent_Identity=29.2372881355932, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI6005990, Length=472, Percent_Identity=29.2372881355932, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI146229324, Length=472, Percent_Identity=29.2372881355932, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI53831991, Length=523, Percent_Identity=26.7686424474187, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4503899, Length=410, Percent_Identity=29.0243902439024, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI45430057, Length=359, Percent_Identity=28.6908077994429, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI31742482, Length=532, Percent_Identity=26.6917293233083, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI58743319, Length=452, Percent_Identity=27.6548672566372, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI157266309, Length=516, Percent_Identity=27.1317829457364, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI71852584, Length=531, Percent_Identity=26.1770244821092, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI146229327, Length=400, Percent_Identity=27, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI109389362, Length=506, Percent_Identity=26.0869565217391, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI38569405, Length=492, Percent_Identity=24.7967479674797, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI38569407, Length=403, Percent_Identity=26.302729528536, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI59797060, Length=493, Percent_Identity=23.7322515212982, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI71852586, Length=148, Percent_Identity=36.4864864864865, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1790233, Length=507, Percent_Identity=28.2051282051282, Blast_Score=165, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI115533416, Length=461, Percent_Identity=25.3796095444685, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17559078, Length=142, Percent_Identity=36.6197183098592, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24666175, Length=417, Percent_Identity=26.378896882494, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI281363223, Length=463, Percent_Identity=25.2699784017279, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281366397, Length=444, Percent_Identity=26.1261261261261, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281366395, Length=444, Percent_Identity=26.1261261261261, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24666163, Length=444, Percent_Identity=26.1261261261261, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24666109, Length=126, Percent_Identity=34.9206349206349, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 57988; Mature: 57857

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNSTPNILVIWGDDIGISNLSCYSRGMMGYRTPNIDRIADEGMLFTDSYGEQSCTAGRS
CCCCCCCEEEEECCCCCCCCCHHHHCCCCCCCCCCHHHHHCCCEEEECCCCCCHHHCCCH
SFITGQSVYRTGMSKVGMPGVDIGLQKEDPTIAELLKPLGYATGQFGKNHLGDLNKYLPT
HCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
AHGFDEFFGNLYHLNAEEEPENADYPTEEEAPVMRRALLPRGVIHSWATEEDSGEVDDRY
CCCHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHCCCCCCCCCCCCCC
GPAGKQRIEDTGPLTKKRMETIDDETTDACVDFITRAHGTGTPFFVWMNMTHMHFRTHTK
CCCHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEECEEEEEECCCC
PESLGQAGRWQSPYHDTMIDHDRNVGQLLDLLDELGIADDTIVIYSTDNGPHANSWPDGA
HHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCC
TTPFRSEKATNWEGAFRIPELIRWPGKIEPRSVSNEIVQHHDWLPTFLAAAGDPDIVDKL
CCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCHHHHHHH
KAGHTIGDITYKVHIDGYNLVPYLTGEVAKSPRRGMIYFSDDCDVLGIRAENWKVVFQEQ
HCCCEEEEEEEEEEECCEEECCEECCHHHCCCCCCEEEECCCCCEEEEECCCCEEEEEEC
RCQGTLQIWFEPFTPLRAPKLFNLRTDPYERADITSNTYWDWVIDRIYLVLYGSAIATQF
CCCCEEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LETFKEFPPRQEPASFTIDHAVDELNKFLSTRGG
HHHHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PNSTPNILVIWGDDIGISNLSCYSRGMMGYRTPNIDRIADEGMLFTDSYGEQSCTAGRS
CCCCCCEEEEECCCCCCCCCHHHHCCCCCCCCCCHHHHHCCCEEEECCCCCCHHHCCCH
SFITGQSVYRTGMSKVGMPGVDIGLQKEDPTIAELLKPLGYATGQFGKNHLGDLNKYLPT
HCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
AHGFDEFFGNLYHLNAEEEPENADYPTEEEAPVMRRALLPRGVIHSWATEEDSGEVDDRY
CCCHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHCCCCCCCCCCCCCC
GPAGKQRIEDTGPLTKKRMETIDDETTDACVDFITRAHGTGTPFFVWMNMTHMHFRTHTK
CCCHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEECEEEEEECCCC
PESLGQAGRWQSPYHDTMIDHDRNVGQLLDLLDELGIADDTIVIYSTDNGPHANSWPDGA
HHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCC
TTPFRSEKATNWEGAFRIPELIRWPGKIEPRSVSNEIVQHHDWLPTFLAAAGDPDIVDKL
CCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCHHHHHHH
KAGHTIGDITYKVHIDGYNLVPYLTGEVAKSPRRGMIYFSDDCDVLGIRAENWKVVFQEQ
HCCCEEEEEEEEEEECCEEECCEECCHHHCCCCCCEEEECCCCCEEEEECCCCEEEEEEC
RCQGTLQIWFEPFTPLRAPKLFNLRTDPYERADITSNTYWDWVIDRIYLVLYGSAIATQF
CCCCEEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LETFKEFPPRQEPASFTIDHAVDELNKFLSTRGG
HHHHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]