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The map label for this gene is mhpC [C]

Identifier: 119870196

GI number: 119870196

Start: 4393499

End: 4394437

Strand: Direct

Name: mhpC [C]

Synonym: Mkms_4166

Alternate gene names: 119870196

Gene position: 4393499-4394437 (Clockwise)

Preceding gene: 119870191

Following gene: 119870197

Centisome position: 76.58

GC content: 68.58

Gene sequence:

>939_bases
GTGGACTACTGCGATAACGACCGCCTGCGGTGGGCGAACTCATCGCGATCGGCCCGATCGGCCGCGAGTAACGTGACGCC
CGTGTCCGTGAGTACCGCAGAGACCGTGTCGTTCCGGGGTGCAGAAGGGCTCACCCTGGTGGGCGACGAATGGAACCGCG
GCGCGGAGTCGGCCGCCGACCGGCCCACCGTGCTGATGCTCCACGGCGGCGGCCAGAACCGCTTCTCGTGGAAGAACACC
GGGCAGATCCTGGCCGACGCGGGGTTGCACGTCGTGGCGCTGGACAGCCGCGGCCACGGCGACAGCGACCGGTCCCCGGA
GGCCAACTACTCGGTGGAGATGCTGTGCGCGGACACGTGCGAGGTGCTCGACCAGATCGGGCGGCCCGTGGCGCTGATCG
GCGCCAGCATGGGCGGGCTGACCGGCATCCTGGTCGCCCGGGAGGCGGGGCCGCAGCGGGTCACCCAGTTGGTGCTCGTC
GACGTGGTGCCGCGCTTCGAGAAGGACGGCAGCGCCCGCATCCGTGACTTCATGTTCAACCACGTGCACGGTTTCGACAC
CCTGGAGCAGGCCGCCGATGCGGTGGCCGCCTATCTACCCCACCGAACCCGGCCGAAGAGCCACGAGGGCCTCAAGAAGA
ACCTGCGCCACCGCGACGGGCGGTGGTACTGGCACTGGGATCCGGCGTTCCTGACCAAACCCGGTGACGACCCGTTCGTC
CGGGCCGACAAACTCGAACAGGCCGCGGTCGAGTTGACCATTCCGATCCTGCTGATCCGTGGCAAGCTCTCCGACGTGGT
CAGTTCCGAAGGCGTGCAGGAGTTCCTGCGCAAGGTCCCCGGTGCCGAGTTCGTCGAGCTGTCCGATGCCGGCCACACCG
CGGCCGGTGACGACAACGACGCGTTCACCGAAGCCGTCGTCGGTTTCGTCAGCCGGTGA

Upstream 100 bases:

>100_bases
GAGTTGGGGAAGATCGACGTGTAGAAGGCGACGGCCTCCTCCAGGTCGTCGTCGAACCAGAGCGACGGGGTGATCTGGGG
CATCGGAGTTCTCCTTGCTC

Downstream 100 bases:

>100_bases
CCGCAGGACGTCGCACCGCCGGGTTCGACTTCCTCGAACAGCCGGCGCTTCCCGCCCCACGGGTCAGCGAAGCCGAAGCG
CAGCGCATCCTCGCCACCCA

Product: alpha/beta hydrolase fold protein

Products: 2-oxopent-4-enoate; succinate [C]

Alternate protein names: Hydrolase; Alpha/Beta Hydrolase Fold Protein; Alpha/Beta Hydrolase; Hydrolase Alpha/Beta Fold Family; Alpha/Beta Fold Family Hydrolase; Hydrolase Alpha/Beta Fold Family Protein; Cation Diffusion Facilitator Family Transporter; Hydrolase Alpha/Beta Hydrolase Fold Family Protein; Hydrolase Or Acyltransferase; Peroxidase BpoA; Peroxidase BpoB; Peroxiredoxin; Alpha/Beta Hydrolase Superfamily Protein; Hydrolase/Acyltransferase; 2-Hydroxy-6-Oxo-6-Phenylhexa-2 4-Dienoate Hydrolase; Non-Haem Bromoperoxidase; Hydrolase Of Alpha/Beta Fold Superfamily; Alpha/Beta Hydrolase Fold Family Protein; Alpha/Beta Family Hydrolase; Esterase YbfF; Hydrolases Or Acyltransferases; Non-Heme Peroxidase; Alpha/Beta Hydrolase Fold Family

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MDYCDNDRLRWANSSRSARSAASNVTPVSVSTAETVSFRGAEGLTLVGDEWNRGAESAADRPTVLMLHGGGQNRFSWKNT
GQILADAGLHVVALDSRGHGDSDRSPEANYSVEMLCADTCEVLDQIGRPVALIGASMGGLTGILVAREAGPQRVTQLVLV
DVVPRFEKDGSARIRDFMFNHVHGFDTLEQAADAVAAYLPHRTRPKSHEGLKKNLRHRDGRWYWHWDPAFLTKPGDDPFV
RADKLEQAAVELTIPILLIRGKLSDVVSSEGVQEFLRKVPGAEFVELSDAGHTAAGDDNDAFTEAVVGFVSR

Sequences:

>Translated_312_residues
MDYCDNDRLRWANSSRSARSAASNVTPVSVSTAETVSFRGAEGLTLVGDEWNRGAESAADRPTVLMLHGGGQNRFSWKNT
GQILADAGLHVVALDSRGHGDSDRSPEANYSVEMLCADTCEVLDQIGRPVALIGASMGGLTGILVAREAGPQRVTQLVLV
DVVPRFEKDGSARIRDFMFNHVHGFDTLEQAADAVAAYLPHRTRPKSHEGLKKNLRHRDGRWYWHWDPAFLTKPGDDPFV
RADKLEQAAVELTIPILLIRGKLSDVVSSEGVQEFLRKVPGAEFVELSDAGHTAAGDDNDAFTEAVVGFVSR
>Mature_312_residues
MDYCDNDRLRWANSSRSARSAASNVTPVSVSTAETVSFRGAEGLTLVGDEWNRGAESAADRPTVLMLHGGGQNRFSWKNT
GQILADAGLHVVALDSRGHGDSDRSPEANYSVEMLCADTCEVLDQIGRPVALIGASMGGLTGILVAREAGPQRVTQLVLV
DVVPRFEKDGSARIRDFMFNHVHGFDTLEQAADAVAAYLPHRTRPKSHEGLKKNLRHRDGRWYWHWDPAFLTKPGDDPFV
RADKLEQAAVELTIPILLIRGKLSDVVSSEGVQEFLRKVPGAEFVELSDAGHTAAGDDNDAFTEAVVGFVSR

Specific function: 3-hydroxyphenylpropionate degradation. [C]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI23200012, Length=267, Percent_Identity=28.4644194756554, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI23200008, Length=267, Percent_Identity=28.4644194756554, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI7706645, Length=152, Percent_Identity=28.9473684210526, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.- [C]

Molecular weight: Translated: 33976; Mature: 33976

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYCDNDRLRWANSSRSARSAASNVTPVSVSTAETVSFRGAEGLTLVGDEWNRGAESAAD
CCCCCCCCEEECCCCCHHHHHHCCCCCEEECCCCEEEECCCCCEEEECCCCCCCCHHCCC
RPTVLMLHGGGQNRFSWKNTGQILADAGLHVVALDSRGHGDSDRSPEANYSVEMLCADTC
CCEEEEEECCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCCCCEEEEEEHHHH
EVLDQIGRPVALIGASMGGLTGILVAREAGPQRVTQLVLVDVVPRFEKDGSARIRDFMFN
HHHHHHCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
HVHGFDTLEQAADAVAAYLPHRTRPKSHEGLKKNLRHRDGRWYWHWDPAFLTKPGDDPFV
HHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEECCEEEECCCCCCCE
RADKLEQAAVELTIPILLIRGKLSDVVSSEGVQEFLRKVPGAEFVELSDAGHTAAGDDND
EHHHHHHHHHHEEEEEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCH
AFTEAVVGFVSR
HHHHHHHHHHCC
>Mature Secondary Structure
MDYCDNDRLRWANSSRSARSAASNVTPVSVSTAETVSFRGAEGLTLVGDEWNRGAESAAD
CCCCCCCCEEECCCCCHHHHHHCCCCCEEECCCCEEEECCCCCEEEECCCCCCCCHHCCC
RPTVLMLHGGGQNRFSWKNTGQILADAGLHVVALDSRGHGDSDRSPEANYSVEMLCADTC
CCEEEEEECCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCCCCEEEEEEHHHH
EVLDQIGRPVALIGASMGGLTGILVAREAGPQRVTQLVLVDVVPRFEKDGSARIRDFMFN
HHHHHHCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
HVHGFDTLEQAADAVAAYLPHRTRPKSHEGLKKNLRHRDGRWYWHWDPAFLTKPGDDPFV
HHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEECCEEEECCCCCCCE
RADKLEQAAVELTIPILLIRGKLSDVVSSEGVQEFLRKVPGAEFVELSDAGHTAAGDDND
EHHHHHHHHHHEEEEEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCH
AFTEAVVGFVSR
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-hydroxy-6-ketononadienedicarboxylate; H2O [C]

Specific reaction: 2-hydroxy-6-ketononadienedicarboxylate + H2O = 2-oxopent-4-enoate + succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA