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The map label for this gene is ywcA [H]

Identifier: 119870160

GI number: 119870160

Start: 4361202

End: 4362827

Strand: Direct

Name: ywcA [H]

Synonym: Mkms_4130

Alternate gene names: 119870160

Gene position: 4361202-4362827 (Clockwise)

Preceding gene: 119870159

Following gene: 119870161

Centisome position: 76.02

GC content: 66.73

Gene sequence:

>1626_bases
GTGACCGTGCTCGCCGCCGAGACCATCGGCAACCCCGTCGCCAACATGTCGATCTTCGCCCTGTTCGTCCTGGTGACGCT
CTTCATCGTCATCAAGGCGAGTAAGAAGAACGCCACCGCCACCGAGTTCTTCACCGCGGGCCGCGCCTTCACCGGTCCGC
AGAACGGCATCGCGATCAGCGGTGACTACCTGTCGGCCGCGAGCTTCCTCGGCATCGCCGGCGCCATCGCCGTCTACGGC
TACGACGGGTTCCTGTACTCGATCGGATTCCTGGTCGCCTGGCTGGTGGCGCTGCTGCTGGTCGCCGAACTGCTGCGCAA
CACGGGAAAATTCACCATGGCCGACGTGCTGAGCTTCCGGCTCAAACAACGTCCGGTGCGGTTGGCCGCGGCCACCAACA
CCCTGGCGGTGTCGTTGTTCTACCTGCTCGCCCAGATGGCCGGCGCCGGCGTGCTGGTCGCACTGCTGCTCAACATCGAA
AGCGACCTCGGACAGTCGATCGTGATCGCCGTCGTGGGCGTGCTGATGATCGTCTACGTCCTGGTCGGCGGGATGAAGGG
CACCACCTGGGTGCAGATCATCAAGGCGGTCCTGCTGATCGGCGGCGCGGGGATCATGACGATCATGGTGCTGGCGAAGT
TCAACTTCAACTTCTCCGAGATCCTCGGCAGCGCACAGGCGATGGTGAGCAGCAGCGAGGACGCCAAGGTCGCCTCGCGC
GACGTGCTTGCCCCCGGCGCGCAGTACGGCGCGTCGCTGACCACGCAGATCAACTTCATCTCGCTGGCGCTGGCCCTGGT
GCTCGGCACCGCCGGCCTGCCGCACGTGCTGATGCGCTTCTACACGGTGCCCACCGCCAAGGAGGCCCGCCGGTCGGTGG
TCTGGGCGATCGCGCTCATCGGCGCGTTCTACCTGTTCACCCTGGCCCTGGGTTACGGCGCCGCGGCCCTGGTCGGACCC
GACCGCATCCTGGCCGCCCCCGGTGGCGTGAATTCCGCTGCGCCGCAACTGGCGTTCGAACTCGGCGGCGTAGTGCTGCT
GGGCGTCATCTCCGCGGTGGCGTTCGCGACGATCCTCGCGGTCGTCGCCGGTCTGACCATCACCGCGTCGGCGTCCTTCG
CGCACGACATCTACGCCAGCGTGATGAAGAGCCATCAGGTCACCGAGAGCGAGCAGGTCAAGATCTCGCGGATCACCGCG
GTGGTGCTGGGCACGCTGGCGATCGGGTTGGGCATCCTGGCCCGCGAGCAGAACGTCGCGTTCCTGGTGGCGCTCGCGTT
CGCGGTGGCCGCCGCGGCGAATCTGCCGACCATCCTCTACTCGCTGTACTGGCGGCGTTTCAACACCCGCGGTGCGCTGT
GGAGCATGTACGGCGGGTTGATCTCGACGATCGTGCTGATCGTATTCTCGCCCGCGGTCTCGGGCACGGCGACCTCGATG
ATCAAGGGCGCCGACTTCGCCTGGTTCCCGCTGGCCAACCCGGGCATCGTGTCGATCCCGCTGGCGTTCATCCTCGGCAT
CGTCGGCACCCTGACCTCACCAGACGACGAGGATCCGACGATCGCCGCCGAGATGGAGGTGCGCTCGCTGACCGGGGTGG
GTGCGGAAAAGGCCGTCTCGCACTGA

Upstream 100 bases:

>100_bases
TCACCACATTCCTCATCACGGGGATCTACGTCCGCTTCGCCAACAAGGTGATCGACCCGCGCGCGGCGGCCATCCGCGCC
GAACTGGAAGGCCACGCACC

Downstream 100 bases:

>100_bases
GGCCGGCCCGCTGAGCCCAGGACGTCTCGCGCCGGGTGTGTGAATAACGAGGCCGCCGAACGGCGTTGCACCTCGCATGT
CCCACACTCGGCGCGAAGCC

Product: SSS family solute/sodium (Na+) symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MTVLAAETIGNPVANMSIFALFVLVTLFIVIKASKKNATATEFFTAGRAFTGPQNGIAISGDYLSAASFLGIAGAIAVYG
YDGFLYSIGFLVAWLVALLLVAELLRNTGKFTMADVLSFRLKQRPVRLAAATNTLAVSLFYLLAQMAGAGVLVALLLNIE
SDLGQSIVIAVVGVLMIVYVLVGGMKGTTWVQIIKAVLLIGGAGIMTIMVLAKFNFNFSEILGSAQAMVSSSEDAKVASR
DVLAPGAQYGASLTTQINFISLALALVLGTAGLPHVLMRFYTVPTAKEARRSVVWAIALIGAFYLFTLALGYGAAALVGP
DRILAAPGGVNSAAPQLAFELGGVVLLGVISAVAFATILAVVAGLTITASASFAHDIYASVMKSHQVTESEQVKISRITA
VVLGTLAIGLGILAREQNVAFLVALAFAVAAAANLPTILYSLYWRRFNTRGALWSMYGGLISTIVLIVFSPAVSGTATSM
IKGADFAWFPLANPGIVSIPLAFILGIVGTLTSPDDEDPTIAAEMEVRSLTGVGAEKAVSH

Sequences:

>Translated_541_residues
MTVLAAETIGNPVANMSIFALFVLVTLFIVIKASKKNATATEFFTAGRAFTGPQNGIAISGDYLSAASFLGIAGAIAVYG
YDGFLYSIGFLVAWLVALLLVAELLRNTGKFTMADVLSFRLKQRPVRLAAATNTLAVSLFYLLAQMAGAGVLVALLLNIE
SDLGQSIVIAVVGVLMIVYVLVGGMKGTTWVQIIKAVLLIGGAGIMTIMVLAKFNFNFSEILGSAQAMVSSSEDAKVASR
DVLAPGAQYGASLTTQINFISLALALVLGTAGLPHVLMRFYTVPTAKEARRSVVWAIALIGAFYLFTLALGYGAAALVGP
DRILAAPGGVNSAAPQLAFELGGVVLLGVISAVAFATILAVVAGLTITASASFAHDIYASVMKSHQVTESEQVKISRITA
VVLGTLAIGLGILAREQNVAFLVALAFAVAAAANLPTILYSLYWRRFNTRGALWSMYGGLISTIVLIVFSPAVSGTATSM
IKGADFAWFPLANPGIVSIPLAFILGIVGTLTSPDDEDPTIAAEMEVRSLTGVGAEKAVSH
>Mature_540_residues
TVLAAETIGNPVANMSIFALFVLVTLFIVIKASKKNATATEFFTAGRAFTGPQNGIAISGDYLSAASFLGIAGAIAVYGY
DGFLYSIGFLVAWLVALLLVAELLRNTGKFTMADVLSFRLKQRPVRLAAATNTLAVSLFYLLAQMAGAGVLVALLLNIES
DLGQSIVIAVVGVLMIVYVLVGGMKGTTWVQIIKAVLLIGGAGIMTIMVLAKFNFNFSEILGSAQAMVSSSEDAKVASRD
VLAPGAQYGASLTTQINFISLALALVLGTAGLPHVLMRFYTVPTAKEARRSVVWAIALIGAFYLFTLALGYGAAALVGPD
RILAAPGGVNSAAPQLAFELGGVVLLGVISAVAFATILAVVAGLTITASASFAHDIYASVMKSHQVTESEQVKISRITAV
VLGTLAIGLGILAREQNVAFLVALAFAVAAAANLPTILYSLYWRRFNTRGALWSMYGGLISTIVLIVFSPAVSGTATSMI
KGADFAWFPLANPGIVSIPLAFILGIVGTLTSPDDEDPTIAAEMEVRSLTGVGAEKAVSH

Specific function: Unknown

COG id: COG4147

COG function: function code R; Predicted symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Escherichia coli, GI1790503, Length=535, Percent_Identity=46.7289719626168, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1787251, Length=469, Percent_Identity=24.3070362473348, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082237, Length=446, Percent_Identity=23.7668161434978, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 56269; Mature: 56138

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLAAETIGNPVANMSIFALFVLVTLFIVIKASKKNATATEFFTAGRAFTGPQNGIAIS
CCEEECHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCEEEE
GDYLSAASFLGIAGAIAVYGYDGFLYSIGFLVAWLVALLLVAELLRNTGKFTMADVLSFR
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LKQRPVRLAAATNTLAVSLFYLLAQMAGAGVLVALLLNIESDLGQSIVIAVVGVLMIVYV
HHCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
LVGGMKGTTWVQIIKAVLLIGGAGIMTIMVLAKFNFNFSEILGSAQAMVSSSEDAKVASR
HHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHH
DVLAPGAQYGASLTTQINFISLALALVLGTAGLPHVLMRFYTVPTAKEARRSVVWAIALI
HHCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GAFYLFTLALGYGAAALVGPDRILAAPGGVNSAAPQLAFELGGVVLLGVISAVAFATILA
HHHHHHHHHHHCCCCEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVAGLTITASASFAHDIYASVMKSHQVTESEQVKISRITAVVLGTLAIGLGILAREQNVA
HHHCCCEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
FLVALAFAVAAAANLPTILYSLYWRRFNTRGALWSMYGGLISTIVLIVFSPAVSGTATSM
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
IKGADFAWFPLANPGIVSIPLAFILGIVGTLTSPDDEDPTIAAEMEVRSLTGVGAEKAVS
HCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHCCCHHHHCC
H
C
>Mature Secondary Structure 
TVLAAETIGNPVANMSIFALFVLVTLFIVIKASKKNATATEFFTAGRAFTGPQNGIAIS
CEEECHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCEEEE
GDYLSAASFLGIAGAIAVYGYDGFLYSIGFLVAWLVALLLVAELLRNTGKFTMADVLSFR
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LKQRPVRLAAATNTLAVSLFYLLAQMAGAGVLVALLLNIESDLGQSIVIAVVGVLMIVYV
HHCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
LVGGMKGTTWVQIIKAVLLIGGAGIMTIMVLAKFNFNFSEILGSAQAMVSSSEDAKVASR
HHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHH
DVLAPGAQYGASLTTQINFISLALALVLGTAGLPHVLMRFYTVPTAKEARRSVVWAIALI
HHCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GAFYLFTLALGYGAAALVGPDRILAAPGGVNSAAPQLAFELGGVVLLGVISAVAFATILA
HHHHHHHHHHHCCCCEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVAGLTITASASFAHDIYASVMKSHQVTESEQVKISRITAVVLGTLAIGLGILAREQNVA
HHHCCCEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
FLVALAFAVAAAANLPTILYSLYWRRFNTRGALWSMYGGLISTIVLIVFSPAVSGTATSM
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
IKGADFAWFPLANPGIVSIPLAFILGIVGTLTSPDDEDPTIAAEMEVRSLTGVGAEKAVS
HCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHCCCHHHHCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]