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The map label for this gene is cmr [C]

Identifier: 119870161

GI number: 119870161

Start: 4362904

End: 4364136

Strand: Direct

Name: cmr [C]

Synonym: Mkms_4131

Alternate gene names: 119870161

Gene position: 4362904-4364136 (Clockwise)

Preceding gene: 119870160

Following gene: 119870164

Centisome position: 76.05

GC content: 72.1

Gene sequence:

>1233_bases
ATGTCCCACACTCGGCGCGAAGCCGTTGTCGACCGTCCCCTACCGTCGGATGCCGTGTTGCGTCCCCTGAGCCGATACGC
CTTCGCGTTGCTGGCCTACGCGTTCGCGGTCACCATGGTCGGCACCACGGTGCCCACTCCGCTCTACGCCCTCTACGCCG
ACCGGATGGACTTCGCGGTGTTGACCACCACGGTCATCTATGCGGCGTACGCCGGCGGCGTGCTGGTCGCACTGCTGGCC
TTCGGGCGGTGGTCGGACGCCGTCGGCCGACGCCCGATGCTGTTGGCCGGTGTGGGGTTCGCGATCGCCAGCGCGCTGGT
GTTCCTGGTCGCCGATTCGGTGGCGGTGTTGCTGGTCGGGCGGGTGCTGTCCGGTCTGTCGGCGGGCGTCTTCACCGGGA
CGGGAACGGCGGCCGTCATCGAGGCCGCCCCGCAGCGCTGGCGCTCCCGGGCGGCCGCGGTGGCCACGGTCGCCAACATC
GGCGGACTGGGCGCGGGCCCGTTGCTCGCCGGCCTGCTCGTCCAGTACGCACCGCAGCCCCTGGATCTGGTGTTCGCCGT
CCACATCGCGATGGCGGTGCTGGCCGGTGTCGCGGTGTTCGTCGTCCCCGAGACCTCACCGCGCAGCGGCCGCATCGGGC
TGCAGCGGCTCTCGGTTCCGCCCGAGGCGCGGTCGGTGTTCGTGATCGCCGCCCTGGCGGCCTTCGCCGGCTTCGCGGTC
ACCGGGTTGTTCACCGCCGTGGCGCCGTCGTTCCTCGCCGACGTCGTCGGCATCGAGAACCATGCGGTGGCAGGCGCGAT
CGCCTGCTCGATCTTCGCCGCCTCGGCCGTCACCCAGGTGGCCGCCAACCGGGTCGCCCCGTCGCGGGCGGTGGCCGCCG
GTTGCGCCATCCTCGTGGCCGGGATGGCGGTTCTGGCTGTGGCGCTGCACTTCTCGTCGCTGCCGGGTCTCATCGCCGCG
GCGGTGATCGCCGGTGTCGGTCAGGGGATGAGTTTCAGTCGCGGGCTGGCCGCGGTCGCCGAACGCACCCCACCCGAGCG
GCGCGCCGAGGTCAACTCCACCTACTTCGTCGTCGCCTACGTGGCGATCTCGCTGCCGGTGATCGGTGAGGGTCTGGCCG
CGCAGGCGGTGGGGTTGCAGACCGCGGGCGTGGGCTTCGCGCTCGCCGTCGCGGCGCTCGCCACGGTGTGCCTGATCGCC
ATCCTGTTGCGGGAGAGGACCCGCGTGGGTTAG

Upstream 100 bases:

>100_bases
GCGGAAAAGGCCGTCTCGCACTGAGGCCGGCCCGCTGAGCCCAGGACGTCTCGCGCCGGGTGTGTGAATAACGAGGCCGC
CGAACGGCGTTGCACCTCGC

Downstream 100 bases:

>100_bases
CCGCTCTTACGGCGGAATTCGCGGCGGTTCTCCACCGGGCCGTGGCCGTGCGCCTTGGCCTGCTGCGGTCCGCCCTTGCG
CTGACCCGCGGAGTCCGTCG

Product: major facilitator superfamily transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Facilitator Superfamily Protein; Facilitator Superfamily Multidrug Resistance Protein; Multi-Drug Efflux Transporter; Facilitator Superfamily Transporter Permease; Facilitator Superfamily Transporter; Facilitator Superfamily; Facilitator Superfamily Multidrug Efflux Transporter; Permease Of Facilitator Superfamily; Drug Efflux Protein; Facilitator Family Transporter; Multidrug ABC Transporter; Drug Resistance Efflux Protein; Multidrug Efflux Protein

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSHTRREAVVDRPLPSDAVLRPLSRYAFALLAYAFAVTMVGTTVPTPLYALYADRMDFAVLTTTVIYAAYAGGVLVALLA
FGRWSDAVGRRPMLLAGVGFAIASALVFLVADSVAVLLVGRVLSGLSAGVFTGTGTAAVIEAAPQRWRSRAAAVATVANI
GGLGAGPLLAGLLVQYAPQPLDLVFAVHIAMAVLAGVAVFVVPETSPRSGRIGLQRLSVPPEARSVFVIAALAAFAGFAV
TGLFTAVAPSFLADVVGIENHAVAGAIACSIFAASAVTQVAANRVAPSRAVAAGCAILVAGMAVLAVALHFSSLPGLIAA
AVIAGVGQGMSFSRGLAAVAERTPPERRAEVNSTYFVVAYVAISLPVIGEGLAAQAVGLQTAGVGFALAVAALATVCLIA
ILLRERTRVG

Sequences:

>Translated_410_residues
MSHTRREAVVDRPLPSDAVLRPLSRYAFALLAYAFAVTMVGTTVPTPLYALYADRMDFAVLTTTVIYAAYAGGVLVALLA
FGRWSDAVGRRPMLLAGVGFAIASALVFLVADSVAVLLVGRVLSGLSAGVFTGTGTAAVIEAAPQRWRSRAAAVATVANI
GGLGAGPLLAGLLVQYAPQPLDLVFAVHIAMAVLAGVAVFVVPETSPRSGRIGLQRLSVPPEARSVFVIAALAAFAGFAV
TGLFTAVAPSFLADVVGIENHAVAGAIACSIFAASAVTQVAANRVAPSRAVAAGCAILVAGMAVLAVALHFSSLPGLIAA
AVIAGVGQGMSFSRGLAAVAERTPPERRAEVNSTYFVVAYVAISLPVIGEGLAAQAVGLQTAGVGFALAVAALATVCLIA
ILLRERTRVG
>Mature_409_residues
SHTRREAVVDRPLPSDAVLRPLSRYAFALLAYAFAVTMVGTTVPTPLYALYADRMDFAVLTTTVIYAAYAGGVLVALLAF
GRWSDAVGRRPMLLAGVGFAIASALVFLVADSVAVLLVGRVLSGLSAGVFTGTGTAAVIEAAPQRWRSRAAAVATVANIG
GLGAGPLLAGLLVQYAPQPLDLVFAVHIAMAVLAGVAVFVVPETSPRSGRIGLQRLSVPPEARSVFVIAALAAFAGFAVT
GLFTAVAPSFLADVVGIENHAVAGAIACSIFAASAVTQVAANRVAPSRAVAAGCAILVAGMAVLAVALHFSSLPGLIAAA
VIAGVGQGMSFSRGLAAVAERTPPERRAEVNSTYFVVAYVAISLPVIGEGLAAQAVGLQTAGVGFALAVAALATVCLIAI
LLRERTRVG

Specific function: Efflux Pump Driven By The Proton Motive Force. Confers Resistance To Basic, Aromatic And Lipophilic Drugs As Well As Neutral, Non-Aromatic, Zwitterionic Or Nonaromatic Hydrophilic Antibiotics. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 41499; Mature: 41368

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCCHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SHTRREAVVDRPLPSDAVLRPLSRYAFALLAYAFAVTMVGTTVPTPLYALYADRMDFAV
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LTTTVIYAAYAGGVLVALLAFGRWSDAVGRRPMLLAGVGFAIASALVFLVADSVAVLLVG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVLSGLSAGVFTGTGTAAVIEAAPQRWRSRAAAVATVANIGGLGAGPLLAGLLVQYAPQP
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCH
LDLVFAVHIAMAVLAGVAVFVVPETSPRSGRIGLQRLSVPPEARSVFVIAALAAFAGFAV
HHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHH
TGLFTAVAPSFLADVVGIENHAVAGAIACSIFAASAVTQVAANRVAPSRAVAAGCAILVA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GMAVLAVALHFSSLPGLIAAAVIAGVGQGMSFSRGLAAVAERTPPERRAEVNSTYFVVAY
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHCCCHHHHHHH
VAISLPVIGEGLAAQAVGLQTAGVGFALAVAALATVCLIAILLRERTRVG
HHHHHHHHCCCHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA