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The map label for this gene is menE [H]

Identifier: 119869932

GI number: 119869932

Start: 4108465

End: 4109979

Strand: Direct

Name: menE [H]

Synonym: Mkms_3902

Alternate gene names: 119869932

Gene position: 4108465-4109979 (Clockwise)

Preceding gene: 119869931

Following gene: 119869933

Centisome position: 71.61

GC content: 70.1

Gene sequence:

>1515_bases
ATGAGTATCTCGCTGCTGCTCGAGATGTCGGTCTCGGCCGACCCGGAGCGGACCGCCGTCGTCTCCGACGGCCTGCGGTT
GTCCGTCGAAGAGCTGTCCGCACTGGCCGACGGGGGCGCCGGCGTCATCGCGAAGTCCGGCGCGGCGCACGTCGCCTACG
TCGGCACCGGCGGAGTCCTGCTGCCGCTGCTGTTGTTCGCCTCGGCCAGGGCCGCGATCCCGTTCACCCCACTCAACTAC
CGGCTCAGCCGCGAGGGCCTGCACGAACTCATCGCTCGGCTCCCCGATGCCCTGGTGATCGCCGACCCGGACTACCGGGA
GGTCGTCGCGGGTGCGGGCAAGCAGCTGATGGACTCCGAGGAGTTCCTCGCCGCCGCGCGGACGGCCGAACCCACCGCGG
AGTTCGCCGACCCCGACTCGGTGGCCGTCGTGCTGTTCACCTCGGGTACCACCTCACGCCCCAAAGCCGTTGAGCTGACC
CACAACAACCTGACCAGCTATGTGACCGGCACCGTCGAGTTCGCCTCTGCCGACCCGGAGGACGCCGCGCTGATCTGTGT
ACCGCCGTACCACATCGCCGGCGTCGGCGCCGCGATGTCGAATCTGTACGCGGGCCGGAAGATGGTGTATCTGCGGCATT
TCGACGCGCGCGAGTGGATCCGGCTGGTCAGCACCGAGGGCGTCACCACCGCCACGGTCGTGCCCACCATGCTCGACCGC
ATCGTGTCCGCGCTGTCCGAGGAGCCGGTGGCGCTGCCCACGCTGCGCAACCTGGCCTACGGGGGTTCCAAGGTGGCCCT
GCCGCTGGTGCGCCGAGCCCTCGAACTGCTGCCCGGCGTCGGATTCGTCAACGCCTACGGGCTCACCGAGACCAGCTCCA
CGATCGCAGTGCTCGGCCCCGACGACCACCGCGCCGCACTCGCCTCCGACGACGCGGCGGTGGCGCGCCGACTCGGCTCG
GTGGGTCAGATCGTGCCCGGTATCGAGGTACAGATCCGCGCCGACGACGGCACCGTGCTCGGCCCCGGGGAGACCGGCGA
GCTGTTCGTGCGGGGCGATCAGGTCTCGGGTCGCTACACCGACATCGGCTCGGTGCTCGACGCGGACGGCTGGTTCCCCA
CCAAAGACGTTGCCTCCCTTGATGAGGACGGCTACCTGTTCATCGGCGGCCGCTCCGACGACACCATCATCCGCGGCGGG
GAGAACATCGCACCCGCCGAGATCGAGGACGTGCTCGTCGAGCACCCCGACGTGCGTGACGTCGCCGTCGTCGGCCCCGA
GGATCCGCAGTGGGGGCAGATCATCGTCGCGGTGGTGGTGCCGGCTCCCGGCGCGGACCCCGACGCCGACGATCTGCGCG
CGCACGTGCGCAAGCACCTACGCGGCTCCCGCACCCCCGACCGGGTGGTGTTCCGCGCCGAACTACCCACCAACGCCACC
GGCAAGGTGCTGCGCCGCGAACTGATCGAGGAATACGCTGCCGCAGCAAGAGACCCCGAGAAGGAGCCCGCATGA

Upstream 100 bases:

>100_bases
CGGCCGTGCTCGCTTCGGCCGGGGTGAGCGACCTGTCGCGTTACGGTGGCGGGGACAACCCGACCCTCGACATCTTCGTC
GACAAGGCACTGGACAAGTC

Downstream 100 bases:

>100_bases
TCAAGAACGGCACCCGCCTGAAGAGCCAGGTGTGCGACACCCAGGTGATCGTGGTGCGAAGCGCCGAGAGTCTCGACGAT
CTGCGCGCCGGCGGTGCGCC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MSISLLLEMSVSADPERTAVVSDGLRLSVEELSALADGGAGVIAKSGAAHVAYVGTGGVLLPLLLFASARAAIPFTPLNY
RLSREGLHELIARLPDALVIADPDYREVVAGAGKQLMDSEEFLAAARTAEPTAEFADPDSVAVVLFTSGTTSRPKAVELT
HNNLTSYVTGTVEFASADPEDAALICVPPYHIAGVGAAMSNLYAGRKMVYLRHFDAREWIRLVSTEGVTTATVVPTMLDR
IVSALSEEPVALPTLRNLAYGGSKVALPLVRRALELLPGVGFVNAYGLTETSSTIAVLGPDDHRAALASDDAAVARRLGS
VGQIVPGIEVQIRADDGTVLGPGETGELFVRGDQVSGRYTDIGSVLDADGWFPTKDVASLDEDGYLFIGGRSDDTIIRGG
ENIAPAEIEDVLVEHPDVRDVAVVGPEDPQWGQIIVAVVVPAPGADPDADDLRAHVRKHLRGSRTPDRVVFRAELPTNAT
GKVLRRELIEEYAAAARDPEKEPA

Sequences:

>Translated_504_residues
MSISLLLEMSVSADPERTAVVSDGLRLSVEELSALADGGAGVIAKSGAAHVAYVGTGGVLLPLLLFASARAAIPFTPLNY
RLSREGLHELIARLPDALVIADPDYREVVAGAGKQLMDSEEFLAAARTAEPTAEFADPDSVAVVLFTSGTTSRPKAVELT
HNNLTSYVTGTVEFASADPEDAALICVPPYHIAGVGAAMSNLYAGRKMVYLRHFDAREWIRLVSTEGVTTATVVPTMLDR
IVSALSEEPVALPTLRNLAYGGSKVALPLVRRALELLPGVGFVNAYGLTETSSTIAVLGPDDHRAALASDDAAVARRLGS
VGQIVPGIEVQIRADDGTVLGPGETGELFVRGDQVSGRYTDIGSVLDADGWFPTKDVASLDEDGYLFIGGRSDDTIIRGG
ENIAPAEIEDVLVEHPDVRDVAVVGPEDPQWGQIIVAVVVPAPGADPDADDLRAHVRKHLRGSRTPDRVVFRAELPTNAT
GKVLRRELIEEYAAAARDPEKEPA
>Mature_503_residues
SISLLLEMSVSADPERTAVVSDGLRLSVEELSALADGGAGVIAKSGAAHVAYVGTGGVLLPLLLFASARAAIPFTPLNYR
LSREGLHELIARLPDALVIADPDYREVVAGAGKQLMDSEEFLAAARTAEPTAEFADPDSVAVVLFTSGTTSRPKAVELTH
NNLTSYVTGTVEFASADPEDAALICVPPYHIAGVGAAMSNLYAGRKMVYLRHFDAREWIRLVSTEGVTTATVVPTMLDRI
VSALSEEPVALPTLRNLAYGGSKVALPLVRRALELLPGVGFVNAYGLTETSSTIAVLGPDDHRAALASDDAAVARRLGSV
GQIVPGIEVQIRADDGTVLGPGETGELFVRGDQVSGRYTDIGSVLDADGWFPTKDVASLDEDGYLFIGGRSDDTIIRGGE
NIAPAEIEDVLVEHPDVRDVAVVGPEDPQWGQIIVAVVVPAPGADPDADDLRAHVRKHLRGSRTPDRVVFRAELPTNATG
KVLRRELIEEYAAAARDPEKEPA

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=559, Percent_Identity=27.0125223613596, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI187761345, Length=401, Percent_Identity=29.925187032419, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI187761343, Length=401, Percent_Identity=29.925187032419, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI38505220, Length=390, Percent_Identity=27.6923076923077, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI115511026, Length=389, Percent_Identity=26.2210796915167, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI42544132, Length=512, Percent_Identity=23.828125, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI58082049, Length=505, Percent_Identity=25.3465346534653, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI122937307, Length=509, Percent_Identity=24.5579567779961, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI157311624, Length=504, Percent_Identity=24.6031746031746, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI157311622, Length=504, Percent_Identity=24.6031746031746, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI13375727, Length=448, Percent_Identity=24.3303571428571, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI8923896, Length=122, Percent_Identity=34.4262295081967, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI253970489, Length=122, Percent_Identity=34.4262295081967, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI145693145, Length=378, Percent_Identity=29.6296296296296, Blast_Score=149, Evalue=6e-37,
Organism=Escherichia coli, GI1788107, Length=364, Percent_Identity=30.2197802197802, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI221142682, Length=459, Percent_Identity=26.5795206971678, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1786810, Length=521, Percent_Identity=28.0230326295585, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1788595, Length=354, Percent_Identity=28.2485875706215, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790505, Length=151, Percent_Identity=35.7615894039735, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786801, Length=382, Percent_Identity=26.4397905759162, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786529, Length=396, Percent_Identity=26.010101010101, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17558820, Length=377, Percent_Identity=30.2387267904509, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17531443, Length=377, Percent_Identity=28.1167108753316, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71994690, Length=372, Percent_Identity=28.494623655914, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71994694, Length=372, Percent_Identity=28.494623655914, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71994703, Length=372, Percent_Identity=28.494623655914, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32563687, Length=442, Percent_Identity=26.9230769230769, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17557194, Length=382, Percent_Identity=26.4397905759162, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17559526, Length=395, Percent_Identity=27.8481012658228, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71996755, Length=373, Percent_Identity=27.8820375335121, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17560308, Length=366, Percent_Identity=28.9617486338798, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17538037, Length=390, Percent_Identity=25.8974358974359, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17560140, Length=419, Percent_Identity=24.582338902148, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71985884, Length=395, Percent_Identity=24.8101265822785, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI115534440, Length=376, Percent_Identity=27.1276595744681, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71983001, Length=422, Percent_Identity=26.303317535545, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71982997, Length=422, Percent_Identity=26.303317535545, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319699, Length=373, Percent_Identity=28.1501340482574, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6319264, Length=129, Percent_Identity=34.8837209302326, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=442, Percent_Identity=26.0180995475113, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24581924, Length=411, Percent_Identity=30.1703163017032, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI21356947, Length=448, Percent_Identity=27.4553571428571, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI21355181, Length=396, Percent_Identity=31.0606060606061, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24653035, Length=365, Percent_Identity=28.4931506849315, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI18859661, Length=374, Percent_Identity=30.4812834224599, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI20130357, Length=461, Percent_Identity=29.0672451193059, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI161076582, Length=380, Percent_Identity=27.6315789473684, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24648255, Length=517, Percent_Identity=25.531914893617, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24648253, Length=517, Percent_Identity=25.3384912959381, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24648260, Length=361, Percent_Identity=28.5318559556787, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI21356441, Length=446, Percent_Identity=24.4394618834081, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24656500, Length=380, Percent_Identity=27.6315789473684, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21358303, Length=469, Percent_Identity=24.0938166311301, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI19922652, Length=398, Percent_Identity=27.1356783919598, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24648257, Length=373, Percent_Identity=26.2734584450402, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281365686, Length=372, Percent_Identity=23.3870967741935, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI221329755, Length=404, Percent_Identity=22.7722772277228, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24667959, Length=382, Percent_Identity=25.9162303664921, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI62472339, Length=382, Percent_Identity=25.9162303664921, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355225, Length=382, Percent_Identity=23.8219895287958, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24667955, Length=382, Percent_Identity=25.9162303664921, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 53272; Mature: 53141

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISLLLEMSVSADPERTAVVSDGLRLSVEELSALADGGAGVIAKSGAAHVAYVGTGGVL
CCEEEEEEEECCCCCCCEEEECCCCEEEHHHHHHHCCCCCCEEEECCCCEEEEEECCHHH
LPLLLFASARAAIPFTPLNYRLSREGLHELIARLPDALVIADPDYREVVAGAGKQLMDSE
HHHHHHHCCCCCCCCCCCCCEECHHHHHHHHHHCCCEEEEECCCHHHHHHCCCHHHCCHH
EFLAAARTAEPTAEFADPDSVAVVLFTSGTTSRPKAVELTHNNLTSYVTGTVEFASADPE
HHHHHHHCCCCCHHCCCCCCEEEEEEECCCCCCCCEEEEECCCCCEEEEEEEEEECCCCC
DAALICVPPYHIAGVGAAMSNLYAGRKMVYLRHFDAREWIRLVSTEGVTTATVVPTMLDR
CCEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHH
IVSALSEEPVALPTLRNLAYGGSKVALPLVRRALELLPGVGFVNAYGLTETSSTIAVLGP
HHHHHCCCCCCCHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEECC
DDHRAALASDDAAVARRLGSVGQIVPGIEVQIRADDGTVLGPGETGELFVRGDQVSGRYT
CCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCEEECCCCCCCEEEECCCCCCCEE
DIGSVLDADGWFPTKDVASLDEDGYLFIGGRSDDTIIRGGENIAPAEIEDVLVEHPDVRD
CCCHHHCCCCCCCCCHHHCCCCCCEEEEECCCCCCEEECCCCCCCHHHHHHHHCCCCCCE
VAVVGPEDPQWGQIIVAVVVPAPGADPDADDLRAHVRKHLRGSRTPDRVVFRAELPTNAT
EEEECCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCH
GKVLRRELIEEYAAAARDPEKEPA
HHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SISLLLEMSVSADPERTAVVSDGLRLSVEELSALADGGAGVIAKSGAAHVAYVGTGGVL
CEEEEEEEECCCCCCCEEEECCCCEEEHHHHHHHCCCCCCEEEECCCCEEEEEECCHHH
LPLLLFASARAAIPFTPLNYRLSREGLHELIARLPDALVIADPDYREVVAGAGKQLMDSE
HHHHHHHCCCCCCCCCCCCCEECHHHHHHHHHHCCCEEEEECCCHHHHHHCCCHHHCCHH
EFLAAARTAEPTAEFADPDSVAVVLFTSGTTSRPKAVELTHNNLTSYVTGTVEFASADPE
HHHHHHHCCCCCHHCCCCCCEEEEEEECCCCCCCCEEEEECCCCCEEEEEEEEEECCCCC
DAALICVPPYHIAGVGAAMSNLYAGRKMVYLRHFDAREWIRLVSTEGVTTATVVPTMLDR
CCEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHH
IVSALSEEPVALPTLRNLAYGGSKVALPLVRRALELLPGVGFVNAYGLTETSSTIAVLGP
HHHHHCCCCCCCHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEECC
DDHRAALASDDAAVARRLGSVGQIVPGIEVQIRADDGTVLGPGETGELFVRGDQVSGRYT
CCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCEEECCCCCCCEEEECCCCCCCEE
DIGSVLDADGWFPTKDVASLDEDGYLFIGGRSDDTIIRGGENIAPAEIEDVLVEHPDVRD
CCCHHHCCCCCCCCCHHHCCCCCCEEEEECCCCCCEEECCCCCCCHHHHHHHHCCCCCCE
VAVVGPEDPQWGQIIVAVVVPAPGADPDADDLRAHVRKHLRGSRTPDRVVFRAELPTNAT
EEEECCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCH
GKVLRRELIEEYAAAARDPEKEPA
HHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA