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The map label for this gene is gdhII [H]

Identifier: 119869931

GI number: 119869931

Start: 4107611

End: 4108468

Strand: Direct

Name: gdhII [H]

Synonym: Mkms_3901

Alternate gene names: 119869931

Gene position: 4107611-4108468 (Clockwise)

Preceding gene: 119869926

Following gene: 119869932

Centisome position: 71.6

GC content: 67.6

Gene sequence:

>858_bases
ATGCCCAGCGAACAACGGGTGCCCAGCCAACGGACGTTGACTGATCGCACCCTGGTGGTGTCCGGCGGAAGCCGCGGCAT
CGGTCTGGCGATCGCGATCGGCGCGGCCCGCCAGGGCGCCAACGTCGTCTTGCTCGCCAAGACCGCCGAACCGCACCCCA
AACTGCCCGGCACCGTGCACACCGCCGTCGCCGACGTCGAAGCCGCCGGCGGTAAGGCCGTCGCCGTAGTCGGGGACGTC
CGCAAGGAAGAAGACGTCGCGCGCGCCGTCGACACCGCGGTCGAGCACTTCGGCGGCATCGACATCTGCGTCAACAACGC
CAGCGCCATCGCCACCGAACCGACCGAACAGCTGTCGGCCAAGAAGTTCGATCTGATGATGGACATCAACGTCCGCGGCA
CCTTTCTGCTGACGAAGGCCTGCCTGCCGCATCTGCGCGAATCGCCCAACCCGCACGTGCTCACGCTGGCACCGCCGCTG
AACATGAACCCGCACTGGCTGGGCGCCCACCCGGCGTACACCCTGTCGAAGTACGGGATGACGCTGCTGTCGCTCGGCTG
GGCTGCCGAATACGCCGAGGCTGGGATCGCGTTCAACTGCCTGTGGCCGGAGACCTACATCGCCACCTCGGCGGTGGCCA
ACATCGGCGCCGACGCACTGAAGACGTCGCGTGATCCGCAGATCATGGCCGACGCCGCGGTCGAGGTGCTGTCCCGCCCC
GCGCGCGAGACCACCGGTCAGTGCTTCATCGACTCGGCCGTGCTCGCTTCGGCCGGGGTGAGCGACCTGTCGCGTTACGG
TGGCGGGGACAACCCGACCCTCGACATCTTCGTCGACAAGGCACTGGACAAGTCATGA

Upstream 100 bases:

>100_bases
CCCAGCGCCCACCTGCACCGGCGCATGCGACACAATCGCTGGATACGTCACTTGCAGAAAATGAGAATGGCAATACCATC
GAGGTGAGTCGAGGAGGCCC

Downstream 100 bases:

>100_bases
GTATCTCGCTGCTGCTCGAGATGTCGGTCTCGGCCGACCCGGAGCGGACCGCCGTCGTCTCCGACGGCCTGCGGTTGTCC
GTCGAAGAGCTGTCCGCACT

Product: short chain dehydrogenase

Products: NA

Alternate protein names: GLCDH-II [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MPSEQRVPSQRTLTDRTLVVSGGSRGIGLAIAIGAARQGANVVLLAKTAEPHPKLPGTVHTAVADVEAAGGKAVAVVGDV
RKEEDVARAVDTAVEHFGGIDICVNNASAIATEPTEQLSAKKFDLMMDINVRGTFLLTKACLPHLRESPNPHVLTLAPPL
NMNPHWLGAHPAYTLSKYGMTLLSLGWAAEYAEAGIAFNCLWPETYIATSAVANIGADALKTSRDPQIMADAAVEVLSRP
ARETTGQCFIDSAVLASAGVSDLSRYGGGDNPTLDIFVDKALDKS

Sequences:

>Translated_285_residues
MPSEQRVPSQRTLTDRTLVVSGGSRGIGLAIAIGAARQGANVVLLAKTAEPHPKLPGTVHTAVADVEAAGGKAVAVVGDV
RKEEDVARAVDTAVEHFGGIDICVNNASAIATEPTEQLSAKKFDLMMDINVRGTFLLTKACLPHLRESPNPHVLTLAPPL
NMNPHWLGAHPAYTLSKYGMTLLSLGWAAEYAEAGIAFNCLWPETYIATSAVANIGADALKTSRDPQIMADAAVEVLSRP
ARETTGQCFIDSAVLASAGVSDLSRYGGGDNPTLDIFVDKALDKS
>Mature_284_residues
PSEQRVPSQRTLTDRTLVVSGGSRGIGLAIAIGAARQGANVVLLAKTAEPHPKLPGTVHTAVADVEAAGGKAVAVVGDVR
KEEDVARAVDTAVEHFGGIDICVNNASAIATEPTEQLSAKKFDLMMDINVRGTFLLTKACLPHLRESPNPHVLTLAPPLN
MNPHWLGAHPAYTLSKYGMTLLSLGWAAEYAEAGIAFNCLWPETYIATSAVANIGADALKTSRDPQIMADAAVEVLSRPA
RETTGQCFIDSAVLASAGVSDLSRYGGGDNPTLDIFVDKALDKS

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254986, Length=277, Percent_Identity=44.7653429602888, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI19923817, Length=206, Percent_Identity=27.1844660194175, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI32483357, Length=195, Percent_Identity=32.8205128205128, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI33667109, Length=192, Percent_Identity=31.25, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI5031737, Length=193, Percent_Identity=31.0880829015544, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI126723191, Length=203, Percent_Identity=31.0344827586207, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4504505, Length=190, Percent_Identity=27.8947368421053, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI10190704, Length=216, Percent_Identity=25.462962962963, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI109715829, Length=256, Percent_Identity=26.953125, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87082100, Length=206, Percent_Identity=31.5533980582524, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789208, Length=219, Percent_Identity=28.7671232876712, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1789378, Length=192, Percent_Identity=30.2083333333333, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790717, Length=259, Percent_Identity=24.7104247104247, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=28.6290322580645, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=254, Percent_Identity=50.3937007874016, Blast_Score=258, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17558628, Length=253, Percent_Identity=49.0118577075099, Blast_Score=239, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI17544670, Length=213, Percent_Identity=26.7605633802817, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=211, Percent_Identity=26.0663507109005, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=200, Percent_Identity=29, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=190, Percent_Identity=26.8421052631579, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=197, Percent_Identity=26.3959390862944, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=205, Percent_Identity=26.8292682926829, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357673, Length=273, Percent_Identity=52.3809523809524, Blast_Score=297, Evalue=6e-81,
Organism=Drosophila melanogaster, GI23397609, Length=210, Percent_Identity=32.3809523809524, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24644339, Length=189, Percent_Identity=29.6296296296296, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI18859837, Length=240, Percent_Identity=27.0833333333333, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571526, Length=193, Percent_Identity=30.0518134715026, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355319, Length=199, Percent_Identity=28.1407035175879, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21357041, Length=197, Percent_Identity=28.4263959390863, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356301, Length=199, Percent_Identity=26.6331658291457, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.47 [H]

Molecular weight: Translated: 29906; Mature: 29775

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSEQRVPSQRTLTDRTLVVSGGSRGIGLAIAIGAARQGANVVLLAKTAEPHPKLPGTVH
CCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCCCHH
TAVADVEAAGGKAVAVVGDVRKEEDVARAVDTAVEHFGGIDICVNNASAIATEPTEQLSA
HHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCEEEEEECCCEEECCCHHHHHH
KKFDLMMDINVRGTFLLTKACLPHLRESPNPHVLTLAPPLNMNPHWLGAHPAYTLSKYGM
HHEEEEEEECCCCEEEEHHHHHHHHHCCCCCCEEEECCCCCCCCCEECCCCCHHHHHHCH
TLLSLGWAAEYAEAGIAFNCLWPETYIATSAVANIGADALKTSRDPQIMADAAVEVLSRP
HHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHCC
ARETTGQCFIDSAVLASAGVSDLSRYGGGDNPTLDIFVDKALDKS
CHHCCCCEEEHHHHHHHCCHHHHHHCCCCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
PSEQRVPSQRTLTDRTLVVSGGSRGIGLAIAIGAARQGANVVLLAKTAEPHPKLPGTVH
CCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCCCHH
TAVADVEAAGGKAVAVVGDVRKEEDVARAVDTAVEHFGGIDICVNNASAIATEPTEQLSA
HHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCEEEEEECCCEEECCCHHHHHH
KKFDLMMDINVRGTFLLTKACLPHLRESPNPHVLTLAPPLNMNPHWLGAHPAYTLSKYGM
HHEEEEEEECCCCEEEEHHHHHHHHHCCCCCCEEEECCCCCCCCCEECCCCCHHHHHHCH
TLLSLGWAAEYAEAGIAFNCLWPETYIATSAVANIGADALKTSRDPQIMADAAVEVLSRP
HHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHCC
ARETTGQCFIDSAVLASAGVSDLSRYGGGDNPTLDIFVDKALDKS
CHHCCCCEEEHHHHHHHCCHHHHHHCCCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA