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The map label for this gene is limC [H]

Identifier: 119869782

GI number: 119869782

Start: 3970900

End: 3971760

Strand: Direct

Name: limC [H]

Synonym: Mkms_3751

Alternate gene names: 119869782

Gene position: 3970900-3971760 (Clockwise)

Preceding gene: 119869781

Following gene: 119869783

Centisome position: 69.21

GC content: 67.36

Gene sequence:

>861_bases
GTGGGGCGCGTAGAAGGCAAGGTCGCATTCATCACGGGCGCAGCGCGCGGGCAGGGTCGCAGCCACGCCATCCGACTGGC
CGAAGAAGGCGCCGACATCATCGCCATCGACATCTGCGCCGACATCGAGACCGTGGGTTACCCGCTGGCCACCCGGGAAG
ATCTCGAGGAGACCGCCCAGTACGTGGAGAAGGCGGGCCGCAAGGCCGTGATCGCCCAGGCCGACGTCCGTGACGCCGCC
CAACTGAAGCAGGCGGTGGACAACGGCGTGGCCGAACTCGGACACCTCGACATCGTCGTCGCGCAGGCCGGCATCGCGGC
GATGAAGGGCGCCCCGCCGATGCAGGCGTGGACCGACGGCATCAACACGAATTTCGTCGGGACCATCAATGCCATCCAGG
TGGCGCTGCCCCACCTCAAGGAGGGCGCCTCGATCATCGCCACCGCCTCGGCGGCCGCGCTGATGGACGCCTCGAAGAAG
GACCGCCCGGGCGCCGACCCCGGGGGGATGGGCTACATGACCTCCAAGCGTCTCATCTCCCAGTACATGCACGACCTGGC
GACCGAGTTGGCGGTGCGCAACATCCGCGCCAACGTCATCCACCCCACCAACTGCAACACCGACATGCTGCAGAGCGAGC
CGATGTACCGCTCGTTCCGGCCCGACCTCGAGAAGCCCACGCGCGCCGACGCGGAGCTCGCGTTCGGTGTCCAGCAGGCC
ATGCCTGTGCCGTTCATCGAGCCCGAGGACATCAGCAACGCGGTGCTGTGGCTGGCCTCCGACGAGTCACGCTTTGTCAC
CGGCATGCAGTTGCGCGTGGACGCTGGCGGCTACCTCAAGTGGTACGACTACCACGTCTGA

Upstream 100 bases:

>100_bases
GGCTACATCACCGGCCAGATCCTCGGCGTCAACGGCGGCCGTAACACCTGACGGTCATGCATCACCAACGGAATCAACCG
GTTACACGAGAGGACAAGCT

Downstream 100 bases:

>100_bases
TCCGAACACCGTTGTACCGCAGCGACTTCGAGGAGAGCAGTGAAGGTAAGGGTTGACCCGGACCGTTGTCAGGGGCACAC
GCTGTGCTCGATGATCGCAC

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: (4R,6S)-carveol dehydrogenase; CDH; Carveol dehydrogenase [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MGRVEGKVAFITGAARGQGRSHAIRLAEEGADIIAIDICADIETVGYPLATREDLEETAQYVEKAGRKAVIAQADVRDAA
QLKQAVDNGVAELGHLDIVVAQAGIAAMKGAPPMQAWTDGINTNFVGTINAIQVALPHLKEGASIIATASAAALMDASKK
DRPGADPGGMGYMTSKRLISQYMHDLATELAVRNIRANVIHPTNCNTDMLQSEPMYRSFRPDLEKPTRADAELAFGVQQA
MPVPFIEPEDISNAVLWLASDESRFVTGMQLRVDAGGYLKWYDYHV

Sequences:

>Translated_286_residues
MGRVEGKVAFITGAARGQGRSHAIRLAEEGADIIAIDICADIETVGYPLATREDLEETAQYVEKAGRKAVIAQADVRDAA
QLKQAVDNGVAELGHLDIVVAQAGIAAMKGAPPMQAWTDGINTNFVGTINAIQVALPHLKEGASIIATASAAALMDASKK
DRPGADPGGMGYMTSKRLISQYMHDLATELAVRNIRANVIHPTNCNTDMLQSEPMYRSFRPDLEKPTRADAELAFGVQQA
MPVPFIEPEDISNAVLWLASDESRFVTGMQLRVDAGGYLKWYDYHV
>Mature_285_residues
GRVEGKVAFITGAARGQGRSHAIRLAEEGADIIAIDICADIETVGYPLATREDLEETAQYVEKAGRKAVIAQADVRDAAQ
LKQAVDNGVAELGHLDIVVAQAGIAAMKGAPPMQAWTDGINTNFVGTINAIQVALPHLKEGASIIATASAAALMDASKKD
RPGADPGGMGYMTSKRLISQYMHDLATELAVRNIRANVIHPTNCNTDMLQSEPMYRSFRPDLEKPTRADAELAFGVQQAM
PVPFIEPEDISNAVLWLASDESRFVTGMQLRVDAGGYLKWYDYHV

Specific function: Catalyzes the oxidation of carveol to carvone, with a strong stereoselectivity since it efficiently converts only the (6S)-stereoisomers, of which (-)-(4R,6S)-trans-carveol is the better substrate. Displays a broad substrate specificity with a preference

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI31542939, Length=289, Percent_Identity=26.9896193771626, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4504505, Length=289, Percent_Identity=26.643598615917, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI87082100, Length=282, Percent_Identity=30.8510638297872, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1789208, Length=282, Percent_Identity=28.7234042553192, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786812, Length=281, Percent_Identity=28.1138790035587, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787335, Length=282, Percent_Identity=29.0780141843972, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789378, Length=285, Percent_Identity=27.3684210526316, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787905, Length=282, Percent_Identity=28.7234042553192, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790717, Length=277, Percent_Identity=27.4368231046931, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI2367175, Length=270, Percent_Identity=24.8148148148148, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=292, Percent_Identity=27.3972602739726, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=294, Percent_Identity=27.2108843537415, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=280, Percent_Identity=27.1428571428571, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=281, Percent_Identity=27.7580071174377, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=291, Percent_Identity=27.1477663230241, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=291, Percent_Identity=26.1168384879725, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=292, Percent_Identity=26.027397260274, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=292, Percent_Identity=28.0821917808219, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71982365, Length=143, Percent_Identity=32.1678321678322, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=283, Percent_Identity=26.5017667844523, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=293, Percent_Identity=25.2559726962457, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI28571526, Length=280, Percent_Identity=27.5, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21357673, Length=205, Percent_Identity=29.2682926829268, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI23397609, Length=283, Percent_Identity=27.5618374558304, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI18859837, Length=233, Percent_Identity=26.1802575107296, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357041, Length=274, Percent_Identity=26.2773722627737, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24644339, Length=276, Percent_Identity=25.3623188405797, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 30807; Mature: 30676

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRVEGKVAFITGAARGQGRSHAIRLAEEGADIIAIDICADIETVGYPLATREDLEETAQ
CCCCCCEEEEEEECCCCCCCHHEEEEECCCCCEEEEEEECCHHHHCCCCCCHHHHHHHHH
YVEKAGRKAVIAQADVRDAAQLKQAVDNGVAELGHLDIVVAQAGIAAMKGAPPMQAWTDG
HHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHCCCCCHHHHHCC
INTNFVGTINAIQVALPHLKEGASIIATASAAALMDASKKDRPGADPGGMGYMTSKRLIS
CCCCEEEEHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
QYMHDLATELAVRNIRANVIHPTNCNTDMLQSEPMYRSFRPDLEKPTRADAELAFGVQQA
HHHHHHHHHHHHHHHHCCEECCCCCCHHHHCCCCCHHHCCCCCCCCCCCCHHHHHHHHHC
MPVPFIEPEDISNAVLWLASDESRFVTGMQLRVDAGGYLKWYDYHV
CCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEECCCCEEEEEEECC
>Mature Secondary Structure 
GRVEGKVAFITGAARGQGRSHAIRLAEEGADIIAIDICADIETVGYPLATREDLEETAQ
CCCCCEEEEEEECCCCCCCHHEEEEECCCCCEEEEEEECCHHHHCCCCCCHHHHHHHHH
YVEKAGRKAVIAQADVRDAAQLKQAVDNGVAELGHLDIVVAQAGIAAMKGAPPMQAWTDG
HHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHCCCCCHHHHHCC
INTNFVGTINAIQVALPHLKEGASIIATASAAALMDASKKDRPGADPGGMGYMTSKRLIS
CCCCEEEEHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
QYMHDLATELAVRNIRANVIHPTNCNTDMLQSEPMYRSFRPDLEKPTRADAELAFGVQQA
HHHHHHHHHHHHHHHHCCEECCCCCCHHHHCCCCCHHHCCCCCCCCCCCCHHHHHHHHHC
MPVPFIEPEDISNAVLWLASDESRFVTGMQLRVDAGGYLKWYDYHV
CCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10473585 [H]