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The map label for this gene is glpK [H]

Identifier: 119869638

GI number: 119869638

Start: 3792279

End: 3793727

Strand: Direct

Name: glpK [H]

Synonym: Mkms_3606

Alternate gene names: 119869638

Gene position: 3792279-3793727 (Clockwise)

Preceding gene: 119869637

Following gene: 119869639

Centisome position: 66.1

GC content: 71.91

Gene sequence:

>1449_bases
ATGACACATCTGCTCGCCATCGATCAGGGCACGTCGGGGACGAAGGCGATCGTCGTCGACTACGGCTCCGACGGGTCCGG
TCGGGTGGTCTCGGTCGCCGAGGTCGCGTTGCGGCCGCAGTACCTCGCCGGTGGCGCGGTCGAGCAGGACCCGGAGGCGA
TGTGGGATTCGGTGGTCGGTGCCGGCCGGGAAGCGTTGGCGCGGGCGGGTGTTCCCGTCGCGGCGGTCGCACTGGCCAAC
CAGGGTGAGACGGTCCTGGCGTGGGACCGTGACACCGGCCGTCCGCTGACACCCGCAATCGTCTGGCAGGACCGTCGGGC
CGAGTCGGTGTGCGCTCCGCTGGCCGGCTCGGCCGACCGGATCGCGCAGCGGACCGGGCTGGTGCTCGACCCGTACTTCT
CGGCGCCGAAGATGGCGTGGCTGCGGGCCGCACTCACCCGCTCCGGGGTCGTCACCACCACCGACACCTGGCTGGTGCAC
CGGATGTGCGGCGCGTTCGTCACCGACACCTCCACCGCGAGCCGGTCACTGCTGACCGCACTGGAATCCCCCACCTGGGA
CGACGAACTGCTCGACCTGTTCGGACTGGCCGGGGAGTCGCTGCCCGCGATCGTCGACAGCGACCAGATCGTCGGCGAGA
CAGACGTTTTCGGGCCGACGATCCCCGTCGCCGGTCTGATCGTCGACCAGCAGGCCGCCCTGCTGGCCGAGAGCTGCCTG
GAGCCGGGCGCCGCCAAATGCACGTACGGCACCGGCGCGTTCTTGCTGGCGCAACTCGGCGAGACCCCGGCCCGGTCGTC
GTCGGGGCTGACGACATCGGTGGCGTGGCGGCTGCGCGGTCAGACCTCGTACTGCGCCGACGGTCAGGTGTACACCGCCG
CATCGGCCGTGCGGTGGGCCATCGACCTCGGCCTGGTACCCGCCGCGGACCACCTCGACACCGTCGCGACCGATTCGAGC
GACGGGGTGCTGTGCGTCCCGGCGCTCGCGGGTCTGGCTGCGCCGTGGTGGGATTCGGCTGCGACGGCGTCGTTCACCGG
TATGACGCTGTCGAGCACCCGCGGACACCTGGTGCGGGCGCTGCTGGAGGGTATCGCCGCCCAGGTCACCGCGCTGGCCG
ACCTCGTCGGCACCGACCTCGGCCGTCCGCTGACCCGGTTGCGGGTCGACGGCGGGCTGACCCGCTCGACGGTGCTCATG
CAGGCCCAGGCCGATCTCGCGCAGATCCCGGTCGACGTGTACCCGTCCCTGCACGCGACCGCGCTGGGCGCCGCCGCATG
CGCGCGCCTGGCATTGGAGCCCTCGCTCACACCGGCCGAGGCCGTCGGCACGTGGACTCCCGTGCACACCTACGAACCCC
GCTGGTCCGCCGACCACGCCGCCGACTACCTCCAGCGGTGGCGCCGGGCCGCGGAATCGACACTGCAGAACCAAGGAGAG
ACCTCGTGA

Upstream 100 bases:

>100_bases
ACCTGGGGTACCTGCTGGCCACCCGCGGCCGCCACGGCTTGTCGATGCCCGATATGCACTCGATCGACGCCGAACTCGAC
CGTGAGGCCGCGAAGGACTG

Downstream 100 bases:

>100_bases
GTACGCCCGACGTCAGCGACGTCAGCGACATCATCGTCGTGGGTGCGGGCATCGTGGGCAGCGCGATCGCGCGCGCCCTG
GCCGGCACCGCGTTGTCGGT

Product: carbohydrate kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MTHLLAIDQGTSGTKAIVVDYGSDGSGRVVSVAEVALRPQYLAGGAVEQDPEAMWDSVVGAGREALARAGVPVAAVALAN
QGETVLAWDRDTGRPLTPAIVWQDRRAESVCAPLAGSADRIAQRTGLVLDPYFSAPKMAWLRAALTRSGVVTTTDTWLVH
RMCGAFVTDTSTASRSLLTALESPTWDDELLDLFGLAGESLPAIVDSDQIVGETDVFGPTIPVAGLIVDQQAALLAESCL
EPGAAKCTYGTGAFLLAQLGETPARSSSGLTTSVAWRLRGQTSYCADGQVYTAASAVRWAIDLGLVPAADHLDTVATDSS
DGVLCVPALAGLAAPWWDSAATASFTGMTLSSTRGHLVRALLEGIAAQVTALADLVGTDLGRPLTRLRVDGGLTRSTVLM
QAQADLAQIPVDVYPSLHATALGAAACARLALEPSLTPAEAVGTWTPVHTYEPRWSADHAADYLQRWRRAAESTLQNQGE
TS

Sequences:

>Translated_482_residues
MTHLLAIDQGTSGTKAIVVDYGSDGSGRVVSVAEVALRPQYLAGGAVEQDPEAMWDSVVGAGREALARAGVPVAAVALAN
QGETVLAWDRDTGRPLTPAIVWQDRRAESVCAPLAGSADRIAQRTGLVLDPYFSAPKMAWLRAALTRSGVVTTTDTWLVH
RMCGAFVTDTSTASRSLLTALESPTWDDELLDLFGLAGESLPAIVDSDQIVGETDVFGPTIPVAGLIVDQQAALLAESCL
EPGAAKCTYGTGAFLLAQLGETPARSSSGLTTSVAWRLRGQTSYCADGQVYTAASAVRWAIDLGLVPAADHLDTVATDSS
DGVLCVPALAGLAAPWWDSAATASFTGMTLSSTRGHLVRALLEGIAAQVTALADLVGTDLGRPLTRLRVDGGLTRSTVLM
QAQADLAQIPVDVYPSLHATALGAAACARLALEPSLTPAEAVGTWTPVHTYEPRWSADHAADYLQRWRRAAESTLQNQGE
TS
>Mature_481_residues
THLLAIDQGTSGTKAIVVDYGSDGSGRVVSVAEVALRPQYLAGGAVEQDPEAMWDSVVGAGREALARAGVPVAAVALANQ
GETVLAWDRDTGRPLTPAIVWQDRRAESVCAPLAGSADRIAQRTGLVLDPYFSAPKMAWLRAALTRSGVVTTTDTWLVHR
MCGAFVTDTSTASRSLLTALESPTWDDELLDLFGLAGESLPAIVDSDQIVGETDVFGPTIPVAGLIVDQQAALLAESCLE
PGAAKCTYGTGAFLLAQLGETPARSSSGLTTSVAWRLRGQTSYCADGQVYTAASAVRWAIDLGLVPAADHLDTVATDSSD
GVLCVPALAGLAAPWWDSAATASFTGMTLSSTRGHLVRALLEGIAAQVTALADLVGTDLGRPLTRLRVDGGLTRSTVLMQ
AQADLAQIPVDVYPSLHATALGAAACARLALEPSLTPAEAVGTWTPVHTYEPRWSADHAADYLQRWRRAAESTLQNQGET
S

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI4504007, Length=507, Percent_Identity=32.741617357002, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI42794763, Length=513, Percent_Identity=32.3586744639376, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI189409120, Length=507, Percent_Identity=32.741617357002, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI41393575, Length=435, Percent_Identity=34.2528735632184, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI88196792, Length=525, Percent_Identity=27.8095238095238, Blast_Score=195, Evalue=1e-49,
Organism=Escherichia coli, GI1790361, Length=451, Percent_Identity=36.3636363636364, Blast_Score=285, Evalue=6e-78,
Organism=Escherichia coli, GI1789987, Length=454, Percent_Identity=27.0925110132159, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1789168, Length=371, Percent_Identity=24.2587601078167, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17535599, Length=502, Percent_Identity=32.2709163346614, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71986140, Length=544, Percent_Identity=23.7132352941176, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71986147, Length=311, Percent_Identity=28.2958199356913, Blast_Score=114, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6321755, Length=442, Percent_Identity=32.1266968325792, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17864214, Length=503, Percent_Identity=33.2007952286282, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24654573, Length=449, Percent_Identity=33.630289532294, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24655555, Length=493, Percent_Identity=31.8458417849899, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24655560, Length=493, Percent_Identity=31.8458417849899, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24655570, Length=493, Percent_Identity=31.8458417849899, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24655574, Length=493, Percent_Identity=31.8458417849899, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24655565, Length=493, Percent_Identity=31.8458417849899, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24656367, Length=513, Percent_Identity=26.7056530214425, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI21357867, Length=532, Percent_Identity=26.3157894736842, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24656372, Length=363, Percent_Identity=27.2727272727273, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI19922058, Length=524, Percent_Identity=24.0458015267176, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24652871, Length=500, Percent_Identity=24, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI45552909, Length=301, Percent_Identity=28.2392026578073, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 50357; Mature: 50226

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHLLAIDQGTSGTKAIVVDYGSDGSGRVVSVAEVALRPQYLAGGAVEQDPEAMWDSVVG
CCEEEEEECCCCCCEEEEEEECCCCCCCEEEEHHHHHCCHHHCCCCCCCCHHHHHHHHHH
AGREALARAGVPVAAVALANQGETVLAWDRDTGRPLTPAIVWQDRRAESVCAPLAGSADR
CCHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCEEECCCCHHHHHHCCCCCHHH
IAQRTGLVLDPYFSAPKMAWLRAALTRSGVVTTTDTWLVHRMCGAFVTDTSTASRSLLTA
HHHHCCCEECCCCCCHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHCCCCHHHHHHHHH
LESPTWDDELLDLFGLAGESLPAIVDSDQIVGETDVFGPTIPVAGLIVDQQAALLAESCL
HCCCCCCHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCHHHEEECHHHHHHHHHHC
EPGAAKCTYGTGAFLLAQLGETPARSSSGLTTSVAWRLRGQTSYCADGQVYTAASAVRWA
CCCCCEEECCCHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEHHHHHHHH
IDLGLVPAADHLDTVATDSSDGVLCVPALAGLAAPWWDSAATASFTGMTLSSTRGHLVRA
HHCCCCCCCHHHHHHCCCCCCCEEEHHHHHHCCCCCCCCCCCCEECCEEECCHHHHHHHH
LLEGIAAQVTALADLVGTDLGRPLTRLRVDGGLTRSTVLMQAQADLAQIPVDVYPSLHAT
HHHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCHHHEEEEHHHHHHHCCHHHCCCHHHH
ALGAAACARLALEPSLTPAEAVGTWTPVHTYEPRWSADHAADYLQRWRRAAESTLQNQGE
HHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
TS
CC
>Mature Secondary Structure 
THLLAIDQGTSGTKAIVVDYGSDGSGRVVSVAEVALRPQYLAGGAVEQDPEAMWDSVVG
CEEEEEECCCCCCEEEEEEECCCCCCCEEEEHHHHHCCHHHCCCCCCCCHHHHHHHHHH
AGREALARAGVPVAAVALANQGETVLAWDRDTGRPLTPAIVWQDRRAESVCAPLAGSADR
CCHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCEEECCCCHHHHHHCCCCCHHH
IAQRTGLVLDPYFSAPKMAWLRAALTRSGVVTTTDTWLVHRMCGAFVTDTSTASRSLLTA
HHHHCCCEECCCCCCHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHCCCCHHHHHHHHH
LESPTWDDELLDLFGLAGESLPAIVDSDQIVGETDVFGPTIPVAGLIVDQQAALLAESCL
HCCCCCCHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCHHHEEECHHHHHHHHHHC
EPGAAKCTYGTGAFLLAQLGETPARSSSGLTTSVAWRLRGQTSYCADGQVYTAASAVRWA
CCCCCEEECCCHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEHHHHHHHH
IDLGLVPAADHLDTVATDSSDGVLCVPALAGLAAPWWDSAATASFTGMTLSSTRGHLVRA
HHCCCCCCCHHHHHHCCCCCCCEEEHHHHHHCCCCCCCCCCCCEECCEEECCHHHHHHHH
LLEGIAAQVTALADLVGTDLGRPLTRLRVDGGLTRSTVLMQAQADLAQIPVDVYPSLHAT
HHHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCHHHEEEEHHHHHHHCCHHHCCCHHHH
ALGAAACARLALEPSLTPAEAVGTWTPVHTYEPRWSADHAADYLQRWRRAAESTLQNQGE
HHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
TS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA