Click here to switch to the map view.

The map label for this gene is accD6 [H]

Identifier: 119869462

GI number: 119869462

Start: 3597442

End: 3598863

Strand: Direct

Name: accD6 [H]

Synonym: Mkms_3430

Alternate gene names: 119869462

Gene position: 3597442-3598863 (Clockwise)

Preceding gene: 119869461

Following gene: 119869463

Centisome position: 62.7

GC content: 71.24

Gene sequence:

>1422_bases
ATGACGGTCATGGCCCCCGAGACGGTCGGCGAAACGCTCGACCCGCGCGATCCGCTGCTGCGCCTGCGCACGTTCTTCGA
TGACGGCACCGTCGAGTTGCTGCACGAGCGGGACCGCTCGGGTGTGCTCGCCGCGGCCGGCACCGTCAACGGCGTCCGCA
GCATCGCGTTCTGCACCGACGGGACCGTGATGGGCGGCGCCATGGGCGTCGAGGGCTGCCGCCACATCGTCAACGCCTAC
GACACCGCGATCGAGGAACAGAGCCCGATCGTCGGCATCTGGCACTCCGGCGGCGCCCGCCTGGCCGAGGGGGTCAAGGC
CCTGCACGCGGTCGGTCTGGTGTTCGAGGCCATGATCCGGGCGTCCGGCTACATCCCGCAGATTTCCGTGGTCGTCGGTT
TCGCCGCGGGCGGCGCCGCCTACGGACCGGCCCTGACCGACGTGATCGTGATGGCGCCCGACAGCAAGGTCTTCGTGACC
GGCCCCGACGTGGTGCGCAGCGTCACCGGCGAGGACGTCGACATGGTCTCGCTCGGCGGACCCGAGGCCCACCACAAGAA
GTCCGGTGTCTGCCACATCGTCGCCAGCGATGAACTCGACGCCTACGAGCGCGGTCGCCGCCTGGTCGGACTGTTCAGCC
AGCAGGGCCATTTCGACCGCACCAAGGCCGAAGCCCAGGACAGCGACTTGGCCGCGCTGCTGCCGGAGTCGGCGCGGCGC
GCCTACGACGTGCACCCGCTGATCACCGCACTGCTCGACGACGGCGTGCCGTTCGAGGAGTTCCAGGGCAAGTGGGCGCC
GTCGATGGTCGTCGGCCTCGGCCGGCTGGCCGGGCGCACCGTCGGCGTGCTGGCCAACAACCCGCTGCGGCTGGGCGGCT
GCCTGAACTCCGAAAGCGCCGAGAAGGCCGCGCGTTTCGTGCGGCTGTGCGATGCGTTCGGCATCCCGCTGGTCGTCGTC
GTCGACGTGCCGGGCTACCTGCCCGGCGTGGATCAGGAGTGGGGCGGCGTGGTCCGCCGCGGCGCCAAGCTGCTGCACGC
GTTCGGTGAGGCCACCGTCCCGCGCGTCACGCTGGTCACCCGCAAGATCTACGGCGGCGCCTACATCGCGATGAACTCGC
GGTCGCTGGGTGCGACGAAGGTCTTCGCCTGGCCCGACGCCGAGGTCGCCGTCATGGGCGCCAAGGCCGCGGTCGGCATC
CTGCACAAGAAGAAGCTGGCCGCCGCCGCCCCCGAGGACCGCGAGGCGCTGCACGAGGAGCTCGCCGCCGAACACGAACG
CATCGCCGGCGGCGTGGACTCCGCCATCGAGATCGGCGTGGTGGACGAGAAGATCGACCCCGCCCACACCCGCAGCAAGC
TGACCCAGGCGCTGGCCGAGGCGCCCGCCCGCCGCGGCCGGCACAAGAACATCCCGCTGTAG

Upstream 100 bases:

>100_bases
GATTCGGTGGGCACAACGTCGCGCTCGCTTTCGGGAAGTACTGAGCACCACAGCTTCTCGACAGTCAGCTGACATCGGAA
CGGGCACTAGGAGGATTTGA

Downstream 100 bases:

>100_bases
GCGCTCTACGCAGAACACCCGGAAGATCCCCGGCCGCCGCATGGCGTCGCCGGGGATTTCTGCGTCTGCCTGGCAGCAGC
GCCGGCGGCGCGTAGCGTGG

Product: propionyl-CoA carboxylase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTVMAPETVGETLDPRDPLLRLRTFFDDGTVELLHERDRSGVLAAAGTVNGVRSIAFCTDGTVMGGAMGVEGCRHIVNAY
DTAIEEQSPIVGIWHSGGARLAEGVKALHAVGLVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVIVMAPDSKVFVT
GPDVVRSVTGEDVDMVSLGGPEAHHKKSGVCHIVASDELDAYERGRRLVGLFSQQGHFDRTKAEAQDSDLAALLPESARR
AYDVHPLITALLDDGVPFEEFQGKWAPSMVVGLGRLAGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVV
VDVPGYLPGVDQEWGGVVRRGAKLLHAFGEATVPRVTLVTRKIYGGAYIAMNSRSLGATKVFAWPDAEVAVMGAKAAVGI
LHKKKLAAAAPEDREALHEELAAEHERIAGGVDSAIEIGVVDEKIDPAHTRSKLTQALAEAPARRGRHKNIPL

Sequences:

>Translated_473_residues
MTVMAPETVGETLDPRDPLLRLRTFFDDGTVELLHERDRSGVLAAAGTVNGVRSIAFCTDGTVMGGAMGVEGCRHIVNAY
DTAIEEQSPIVGIWHSGGARLAEGVKALHAVGLVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVIVMAPDSKVFVT
GPDVVRSVTGEDVDMVSLGGPEAHHKKSGVCHIVASDELDAYERGRRLVGLFSQQGHFDRTKAEAQDSDLAALLPESARR
AYDVHPLITALLDDGVPFEEFQGKWAPSMVVGLGRLAGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVV
VDVPGYLPGVDQEWGGVVRRGAKLLHAFGEATVPRVTLVTRKIYGGAYIAMNSRSLGATKVFAWPDAEVAVMGAKAAVGI
LHKKKLAAAAPEDREALHEELAAEHERIAGGVDSAIEIGVVDEKIDPAHTRSKLTQALAEAPARRGRHKNIPL
>Mature_472_residues
TVMAPETVGETLDPRDPLLRLRTFFDDGTVELLHERDRSGVLAAAGTVNGVRSIAFCTDGTVMGGAMGVEGCRHIVNAYD
TAIEEQSPIVGIWHSGGARLAEGVKALHAVGLVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVIVMAPDSKVFVTG
PDVVRSVTGEDVDMVSLGGPEAHHKKSGVCHIVASDELDAYERGRRLVGLFSQQGHFDRTKAEAQDSDLAALLPESARRA
YDVHPLITALLDDGVPFEEFQGKWAPSMVVGLGRLAGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVVV
DVPGYLPGVDQEWGGVVRRGAKLLHAFGEATVPRVTLVTRKIYGGAYIAMNSRSLGATKVFAWPDAEVAVMGAKAAVGIL
HKKKLAAAAPEDREALHEELAAEHERIAGGVDSAIEIGVVDEKIDPAHTRSKLTQALAEAPARRGRHKNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=444, Percent_Identity=41.6666666666667, Blast_Score=318, Evalue=5e-87,
Organism=Homo sapiens, GI295821216, Length=426, Percent_Identity=42.2535211267606, Blast_Score=311, Evalue=8e-85,
Organism=Homo sapiens, GI11545863, Length=480, Percent_Identity=29.5833333333333, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI25147362, Length=444, Percent_Identity=40.5405405405405, Blast_Score=317, Evalue=7e-87,
Organism=Caenorhabditis elegans, GI25147359, Length=444, Percent_Identity=40.5405405405405, Blast_Score=317, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI17552936, Length=434, Percent_Identity=30.184331797235, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71997163, Length=429, Percent_Identity=22.3776223776224, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24586065, Length=509, Percent_Identity=29.0766208251473, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 50027; Mature: 49896

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVMAPETVGETLDPRDPLLRLRTFFDDGTVELLHERDRSGVLAAAGTVNGVRSIAFCTD
CCEECCHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCEEEECCCCCCHHEEEEECC
GTVMGGAMGVEGCRHIVNAYDTAIEEQSPIVGIWHSGGARLAEGVKALHAVGLVFEAMIR
CCEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ASGYIPQISVVVGFAAGGAAYGPALTDVIVMAPDSKVFVTGPDVVRSVTGEDVDMVSLGG
HCCCCCEEEEEEEEECCCCCCCCHHHEEEEECCCCEEEEECHHHHHHCCCCCEEEEECCC
PEAHHKKSGVCHIVASDELDAYERGRRLVGLFSQQGHFDRTKAEAQDSDLAALLPESARR
CHHHCCCCCEEEEEECCCCCHHHCCCCEEEHHHCCCCCCHHHHHCCCCCHHHHCCHHHHH
AYDVHPLITALLDDGVPFEEFQGKWAPSMVVGLGRLAGRTVGVLANNPLRLGGCLNSESA
HCCHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHH
EKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAKLLHAFGEATVPRVTLVT
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEE
RKIYGGAYIAMNSRSLGATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAAPEDREALHEE
HHHCCCEEEEECCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHH
LAAEHERIAGGVDSAIEIGVVDEKIDPAHTRSKLTQALAEAPARRGRHKNIPL
HHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TVMAPETVGETLDPRDPLLRLRTFFDDGTVELLHERDRSGVLAAAGTVNGVRSIAFCTD
CEECCHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCEEEECCCCCCHHEEEEECC
GTVMGGAMGVEGCRHIVNAYDTAIEEQSPIVGIWHSGGARLAEGVKALHAVGLVFEAMIR
CCEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ASGYIPQISVVVGFAAGGAAYGPALTDVIVMAPDSKVFVTGPDVVRSVTGEDVDMVSLGG
HCCCCCEEEEEEEEECCCCCCCCHHHEEEEECCCCEEEEECHHHHHHCCCCCEEEEECCC
PEAHHKKSGVCHIVASDELDAYERGRRLVGLFSQQGHFDRTKAEAQDSDLAALLPESARR
CHHHCCCCCEEEEEECCCCCHHHCCCCEEEHHHCCCCCCHHHHHCCCCCHHHHCCHHHHH
AYDVHPLITALLDDGVPFEEFQGKWAPSMVVGLGRLAGRTVGVLANNPLRLGGCLNSESA
HCCHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHH
EKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAKLLHAFGEATVPRVTLVT
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEE
RKIYGGAYIAMNSRSLGATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAAPEDREALHEE
HHHCCCEEEEECCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHH
LAAEHERIAGGVDSAIEIGVVDEKIDPAHTRSKLTQALAEAPARRGRHKNIPL
HHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]