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The map label for this gene is kasA [H]

Identifier: 119869460

GI number: 119869460

Start: 3594833

End: 3596083

Strand: Direct

Name: kasA [H]

Synonym: Mkms_3428

Alternate gene names: 119869460

Gene position: 3594833-3596083 (Clockwise)

Preceding gene: 119869459

Following gene: 119869461

Centisome position: 62.66

GC content: 68.59

Gene sequence:

>1251_bases
GTGACCAGGCCTTCCACTGCTAACGGCGGTTTCCCGAGCGTCGTGGTGACTGCCGTCGAGGCCACCACGTCGCTCGCCGC
GGACATCGAGAGCACGTGGAAGGGCCTGCTGGCTGGCGAGAGCGGCATCCGCGTTCTCGAAGACGACTTCGTCACCAAGT
GGGACCTGCCCGTGCGGATCGGCGGTCATCTCGTCGACAACGTCGACGACCACATGACCCGCATCGACATGCGTCGCATG
TCGTACGTGCAGCGCATGTCCAAGCTGGTCTCGGGTCGCCTGTGGGAGACCGCGGGCAGGCCCGAGGTCGATCCGGACCG
GTTCGCCGTGATCATCGGCACCGGTCTGGGCGGCGGCGAGAAGATCGTCGAGACCTACGACGCGATGAACGAGGGCGGCC
CCCGCAAGGTGTCGCCGCTCGCGGTCCAGATGATCATGCCGAACGGTGCGGCGGCCGTCGCCGGTCTGGAACTGGGCGCC
CGCGCCGGGGTCATCACCCCGGTGTCGGCCTGCTCGTCCGGCTCGGAGGCGATCGCGCACGGCTGGCGTCAGATCGTCAT
GGGTGACGCGGACTTCGCCGTCGTCGGCGGCGTGGAGGGCGGCATCGAGGCGCTGCCCATCGCGGCGTTCTCGATGATGC
GCGCCATGTCGACCCGCAACGACGACCCCGCCGGGGCGTCGCGGCCGTTCGACAAGAACCGCGACGGGTTCGTGTTCGGC
GAAGCCGGGGCGATGATGATCATCGAGACCGAGGAGCATGCCCTGGCCCGCGGCGCCAAGCCGTTGGCCCGCCTCATGGG
CGCGGGCATCACCAGCGACGCGTTCCACATGGTGGCCCCGGCCGCGGACGGTCTTCGGGCCGGCCACGCGATGAAGCGTG
CGATGGAGACTGCGGGGATCGATCCCAAGGACGTCAACCACGTCAACGCACACGCCACCGCGACGCCGATCGGTGACACG
GCCGAGGCCAACGCCATCCGGGTCGCCGGTGTGGAGCACGCCGCGGTGTACGCGCCGAAGTCGGCGCTCGGCCACTCCAT
CGGGGCGGTCGGTGCGCTCGAGTCGATCCTCACGGTGCTCGCACTGCGTGACGGCGTCATCCCGCCGACACTGAACTACG
AGACACCGGACCCCGAGATCGATCTCGATGTCGTTGCGGGCGAGCCACGGTATGGCGACTACCAGTACGCCATCAACAAC
TCGTTCGGATTCGGCGGCCACAATGTGGCCTTGGCGTTCGGTCGTTACTGA

Upstream 100 bases:

>100_bases
TCGCCGGTCTGCGCACCGTCGGTGACGTGGTCGCCTACATCCAGAAGCTCGAGGAAGAGAACCCCGAAGCTGCCGCCGCT
CTCCGCGATAAGTTCTCGCA

Downstream 100 bases:

>100_bases
GTAGCGCACGACCAACGGAAAGACACATACGGAGCAGTAATGGCACGGTTAACCAGGCTTTCGACGGGGAACGGTTTCCC
CAACGTGGTCGTCACGGGAG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: Beta-ketoacyl-ACP synthase 1; KAS 1 [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTRPSTANGGFPSVVVTAVEATTSLAADIESTWKGLLAGESGIRVLEDDFVTKWDLPVRIGGHLVDNVDDHMTRIDMRRM
SYVQRMSKLVSGRLWETAGRPEVDPDRFAVIIGTGLGGGEKIVETYDAMNEGGPRKVSPLAVQMIMPNGAAAVAGLELGA
RAGVITPVSACSSGSEAIAHGWRQIVMGDADFAVVGGVEGGIEALPIAAFSMMRAMSTRNDDPAGASRPFDKNRDGFVFG
EAGAMMIIETEEHALARGAKPLARLMGAGITSDAFHMVAPAADGLRAGHAMKRAMETAGIDPKDVNHVNAHATATPIGDT
AEANAIRVAGVEHAAVYAPKSALGHSIGAVGALESILTVLALRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYQYAINN
SFGFGGHNVALAFGRY

Sequences:

>Translated_416_residues
MTRPSTANGGFPSVVVTAVEATTSLAADIESTWKGLLAGESGIRVLEDDFVTKWDLPVRIGGHLVDNVDDHMTRIDMRRM
SYVQRMSKLVSGRLWETAGRPEVDPDRFAVIIGTGLGGGEKIVETYDAMNEGGPRKVSPLAVQMIMPNGAAAVAGLELGA
RAGVITPVSACSSGSEAIAHGWRQIVMGDADFAVVGGVEGGIEALPIAAFSMMRAMSTRNDDPAGASRPFDKNRDGFVFG
EAGAMMIIETEEHALARGAKPLARLMGAGITSDAFHMVAPAADGLRAGHAMKRAMETAGIDPKDVNHVNAHATATPIGDT
AEANAIRVAGVEHAAVYAPKSALGHSIGAVGALESILTVLALRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYQYAINN
SFGFGGHNVALAFGRY
>Mature_415_residues
TRPSTANGGFPSVVVTAVEATTSLAADIESTWKGLLAGESGIRVLEDDFVTKWDLPVRIGGHLVDNVDDHMTRIDMRRMS
YVQRMSKLVSGRLWETAGRPEVDPDRFAVIIGTGLGGGEKIVETYDAMNEGGPRKVSPLAVQMIMPNGAAAVAGLELGAR
AGVITPVSACSSGSEAIAHGWRQIVMGDADFAVVGGVEGGIEALPIAAFSMMRAMSTRNDDPAGASRPFDKNRDGFVFGE
AGAMMIIETEEHALARGAKPLARLMGAGITSDAFHMVAPAADGLRAGHAMKRAMETAGIDPKDVNHVNAHATATPIGDTA
EANAIRVAGVEHAAVYAPKSALGHSIGAVGALESILTVLALRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYQYAINNS
FGFGGHNVALAFGRY

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=415, Percent_Identity=35.6626506024096, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=42.4657534246575, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI41872631, Length=254, Percent_Identity=27.9527559055118, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1787337, Length=409, Percent_Identity=41.320293398533, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788663, Length=404, Percent_Identity=33.1683168316832, Blast_Score=165, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI71983541, Length=411, Percent_Identity=34.5498783454988, Blast_Score=217, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI71983535, Length=262, Percent_Identity=38.9312977099237, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI212642053, Length=254, Percent_Identity=31.1023622047244, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17550940, Length=272, Percent_Identity=25.3676470588235, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=441, Percent_Identity=31.5192743764172, Blast_Score=204, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24644341, Length=434, Percent_Identity=38.4792626728111, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24581345, Length=252, Percent_Identity=27.7777777777778, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI221330659, Length=256, Percent_Identity=26.953125, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI19920632, Length=256, Percent_Identity=26.953125, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43560; Mature: 43429

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPSTANGGFPSVVVTAVEATTSLAADIESTWKGLLAGESGIRVLEDDFVTKWDLPVRI
CCCCCCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCEEE
GGHLVDNVDDHMTRIDMRRMSYVQRMSKLVSGRLWETAGRPEVDPDRFAVIIGTGLGGGE
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCH
KIVETYDAMNEGGPRKVSPLAVQMIMPNGAAAVAGLELGARAGVITPVSACSSGSEAIAH
HHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCHHHCCCCCHHHHH
GWRQIVMGDADFAVVGGVEGGIEALPIAAFSMMRAMSTRNDDPAGASRPFDKNRDGFVFG
HHHHEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEE
EAGAMMIIETEEHALARGAKPLARLMGAGITSDAFHMVAPAADGLRAGHAMKRAMETAGI
CCCEEEEEECCHHHHHHCCHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCC
DPKDVNHVNAHATATPIGDTAEANAIRVAGVEHAAVYAPKSALGHSIGAVGALESILTVL
CCCCCCCCCCCCEECCCCCCCCCCEEEEECCCHHEEECCHHHHHHHHHHHHHHHHHHHHH
ALRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYQYAINNSFGFGGHNVALAFGRY
HHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
TRPSTANGGFPSVVVTAVEATTSLAADIESTWKGLLAGESGIRVLEDDFVTKWDLPVRI
CCCCCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCEEE
GGHLVDNVDDHMTRIDMRRMSYVQRMSKLVSGRLWETAGRPEVDPDRFAVIIGTGLGGGE
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCH
KIVETYDAMNEGGPRKVSPLAVQMIMPNGAAAVAGLELGARAGVITPVSACSSGSEAIAH
HHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCHHHCCCCCHHHHH
GWRQIVMGDADFAVVGGVEGGIEALPIAAFSMMRAMSTRNDDPAGASRPFDKNRDGFVFG
HHHHEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEE
EAGAMMIIETEEHALARGAKPLARLMGAGITSDAFHMVAPAADGLRAGHAMKRAMETAGI
CCCEEEEEECCHHHHHHCCHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCC
DPKDVNHVNAHATATPIGDTAEANAIRVAGVEHAAVYAPKSALGHSIGAVGALESILTVL
CCCCCCCCCCCCEECCCCCCCCCCEEEEECCCHHEEECCHHHHHHHHHHHHHHHHHHHHH
ALRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYQYAINNSFGFGGHNVALAFGRY
HHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]