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The map label for this gene is aceE [H]

Identifier: 119869456

GI number: 119869456

Start: 3589188

End: 3591977

Strand: Direct

Name: aceE [H]

Synonym: Mkms_3424

Alternate gene names: 119869456

Gene position: 3589188-3591977 (Clockwise)

Preceding gene: 119869452

Following gene: 119869457

Centisome position: 62.56

GC content: 67.31

Gene sequence:

>2790_bases
TTGACCACCGAGTTCGTGCGCCAGGATCTGGCCCAAAACTCCTCCACCGCAGCCGAACACGATCGTGTCCGGGTGATCCG
TGAGGGTGTTGCATCGTATCTGCCCGACATCGATCCCGATGAGACGAGCGAATGGCTGGAGTCGTTCGACCAGCTGCTCG
AACGCTCCGGACCGGCGAGAGCCCGCTACCTGCTGTTGCGGCTGCTCGAACGCTCCGGGGAGCAGCGGGTGGCCATCCCC
GCGCTCACCTCGACCGACTACGTGAACACGATCCCGACCGAACTCGAGCCGTGGTTCCCCGGCGACGAGGACGTCGAACG
CCGCTACCGGGCCTGGATCCGGTGGAACGCCGCGATCATGGTGCACCGCGCGCAGCGTCCGGGAGTCGGTGTGGGCGGCC
ACATCTCGACGTACGCGTCGTCGGCCGCGCTCTACGAGGTGGGCTTCAACCACTTCTTCCGCGGTAAGAGCCACTCCGGC
GGCGGCGACCAGGTGTTCATCCAGGGCCACGCCTCCCCCGGGATCTACGCGCGCGCCTATCTCGAGGGCAGGCTGACCGC
CGACCAACTCGACGGGTTCCGCCAGGAGCACAGCCACCCCGGCGGCGGTATCCCGTCGTACCCGCATCCGCGGCTGATGC
CCGACTTCTGGGAGTTCCCCACGGTCTCGATGGGCCTGGGCCCGATGAACGCGATCTACCAGGCCCGGTTCAACCACTAC
CTGCACGACCGCGGCATCAAGGACACCACCGACCAGCATGTGTGGGCGTTCCTCGGCGACGGCGAGATGGACGAACCGGA
GAGCCGGGGGCTCATCCACGTGGCCGCCCTCGAGGCGCTGGACAACCTGACGTTCGTCGTCAACTGCAACCTGCAGCGCC
TCGACGGCCCGGTGCGCGGCAACGGCAAGATCATCCAGGAACTGGAGTCGTTCTTCCGCGGCGCCGGCTGGAACGTCATC
AAGGTGGTGTGGGGCCGCGAATGGGATGCGCTGCTGCACGCCGACCGCGACGGCGCACTGGTCAACCTGATGAACACCAC
CCCCGACGGCGACTACCAGACCTACAAGGCCAACGACGGCGGCTACGTACGCGACCACTTCTTCGGCCGTGACCCGCGCA
CCAAGGCGCTGGTGGAACCGATGACCGACGCCGAGATCTGGAACCTCAAGCGCGGCGGGCACGACTACCGCAAGGTCTAC
GCCGCGTACCGCGCGGCGATGGAGCACAAGGGCCAGCCGACGGTCATCCTCGCCAAGACCATCAAGGGCTACACCCTGGG
TAAGCACTTCGAGGGCCGCAACGCCACCCATCAGATGAAAAAGCTTGCGCTGCAAGACCTCAAGGACTTCCGCGACGCCC
AGCGCATCCCGATCGGCGATGCCCAGCTCGAGGAGAACCCCTACCTGCCGCCGTACTACCACCCCGGCCCCGAGGCGCCC
GAGATCCGCTACATGCTCGACCGCAGGCGCGCGCTCGGCGGTTTCGTGCCGGAGCGTCGCACGAAGTCCAAGGCACTCGC
GCTGCCGAGCAGCGATGCCTACAAGGCGCTGAAGAAGGGCTCCGGCAAGCAGGAGGTCGCCACCACGATGGCGACAGTCC
GCACCTTCAAGGAGATCCTGCGCGACAAGCAGATCGGCCATCGCATCGTGCCGATCATCCCCGACGAGGCGCGCACGTTC
GGGATGGACTCCTGGTTCCCGAACCTCAAGATCTACAACCGCAACGGGCAGCTCTACACCTCCGTCGACGCCGAGCTGAT
GCTGGCGTACCGGGAGAGCGAGGTCGGGCAGATCCTGCACGAGGGGATCAACGAGGCCGGTTCGGTGGGCACGTTCATCG
CTGCGGGCACGTCGTACGCCACGCACAACGAGCCGATGATCCCGATCTACATCTTCTATTCGATGTTCGGGTTCCAGCGC
ACCGGTGACAGCTTCTGGGCGGCCGCCGACCAGATGGCCCGTGGATTCGTGCTGGGCGCGACGGCCGGGCGCACCACGCT
GGTCGGTGAGGGGTTGCAGCACGCCGACGGCCACTCACTGCTGCTGGCGTCGACCAACCCCGCGGTGGTGGCCTACGACC
CGGCGTTCGCCTACGAGATCGCCTACATCATCGAATCCGGGCTGCACCGGATGTACGGGGAGAACCCGGAGAACGTCTAC
TTCTATCTGACGATCTACAACGAGCCCTACGTCCAGCCGGCGGAACCGGAGAACCTCGACGTCGAGGGTCTGTTGCGCGG
GATCTACCGGTACCGGGCCGCGGCGGAGAAGAAATCCAACACCGCCCAGATCCTGGTGTCCGGCGTGGCGATGCCCTCGG
CGCTCAAGGCCGCCGAGATGCTGGCCGAGGAGTGGGACGTGGCCGCCGACGTGTGGTCGGTGACCAGCTGGAACGAGCTC
AACCGCGACGGCGTCCAGGTCGAGAAGGACCTGCTGCGCCATCCGGACCGGCCGGCGGGCACCCCGTACATCACCACGGC
GCTCGCCGACGCGGCCGGACCGGTCGTGGCGGTCTCGGACTGGATGCGCGCGGTGCCCGAGCAGATCCGGCCGTGGGTAC
CCGGTACGTACATCACGCTCGGCACGGACGGTTTCGGATTCTCCGACACCCGGCCCGCCGCGCGGCGGTTCTACAACACC
GACGCCGAGTCGATCACCGTGGCGGTGCTCGAAGGGCTGGCCCGCGACGGCAACATCGACATCTCGGTGGCCGTCGAGGC
GGCCCGCCGCTACGAGATCGACGACGTGCTGGCGGCGCCGGAGCAGACCTCCGATCCCGGGGTGGCCTGA

Upstream 100 bases:

>100_bases
TGGGGCACGATGGGGGAAGGATGGAGGTTGTCGCGCACGTGGAGAGCCACAAACCCCCCGCGGTCGCGGCGTACCGATAC
CGCCTGACAAGGAGCGGAAG

Downstream 100 bases:

>100_bases
GTACCTCCCGCGAGCAGACACAGAATCGCGTCCCCGAAGGCGGCCTAACGCGATTCTGTGTCTGCTCGGCACACCCGGCT
TGGAGGTATCCGCCAGAACC

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 929; Mature: 928

Protein sequence:

>929_residues
MTTEFVRQDLAQNSSTAAEHDRVRVIREGVASYLPDIDPDETSEWLESFDQLLERSGPARARYLLLRLLERSGEQRVAIP
ALTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFNHFFRGKSHSG
GGDQVFIQGHASPGIYARAYLEGRLTADQLDGFRQEHSHPGGGIPSYPHPRLMPDFWEFPTVSMGLGPMNAIYQARFNHY
LHDRGIKDTTDQHVWAFLGDGEMDEPESRGLIHVAALEALDNLTFVVNCNLQRLDGPVRGNGKIIQELESFFRGAGWNVI
KVVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDGGYVRDHFFGRDPRTKALVEPMTDAEIWNLKRGGHDYRKVY
AAYRAAMEHKGQPTVILAKTIKGYTLGKHFEGRNATHQMKKLALQDLKDFRDAQRIPIGDAQLEENPYLPPYYHPGPEAP
EIRYMLDRRRALGGFVPERRTKSKALALPSSDAYKALKKGSGKQEVATTMATVRTFKEILRDKQIGHRIVPIIPDEARTF
GMDSWFPNLKIYNRNGQLYTSVDAELMLAYRESEVGQILHEGINEAGSVGTFIAAGTSYATHNEPMIPIYIFYSMFGFQR
TGDSFWAAADQMARGFVLGATAGRTTLVGEGLQHADGHSLLLASTNPAVVAYDPAFAYEIAYIIESGLHRMYGENPENVY
FYLTIYNEPYVQPAEPENLDVEGLLRGIYRYRAAAEKKSNTAQILVSGVAMPSALKAAEMLAEEWDVAADVWSVTSWNEL
NRDGVQVEKDLLRHPDRPAGTPYITTALADAAGPVVAVSDWMRAVPEQIRPWVPGTYITLGTDGFGFSDTRPAARRFYNT
DAESITVAVLEGLARDGNIDISVAVEAARRYEIDDVLAAPEQTSDPGVA

Sequences:

>Translated_929_residues
MTTEFVRQDLAQNSSTAAEHDRVRVIREGVASYLPDIDPDETSEWLESFDQLLERSGPARARYLLLRLLERSGEQRVAIP
ALTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFNHFFRGKSHSG
GGDQVFIQGHASPGIYARAYLEGRLTADQLDGFRQEHSHPGGGIPSYPHPRLMPDFWEFPTVSMGLGPMNAIYQARFNHY
LHDRGIKDTTDQHVWAFLGDGEMDEPESRGLIHVAALEALDNLTFVVNCNLQRLDGPVRGNGKIIQELESFFRGAGWNVI
KVVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDGGYVRDHFFGRDPRTKALVEPMTDAEIWNLKRGGHDYRKVY
AAYRAAMEHKGQPTVILAKTIKGYTLGKHFEGRNATHQMKKLALQDLKDFRDAQRIPIGDAQLEENPYLPPYYHPGPEAP
EIRYMLDRRRALGGFVPERRTKSKALALPSSDAYKALKKGSGKQEVATTMATVRTFKEILRDKQIGHRIVPIIPDEARTF
GMDSWFPNLKIYNRNGQLYTSVDAELMLAYRESEVGQILHEGINEAGSVGTFIAAGTSYATHNEPMIPIYIFYSMFGFQR
TGDSFWAAADQMARGFVLGATAGRTTLVGEGLQHADGHSLLLASTNPAVVAYDPAFAYEIAYIIESGLHRMYGENPENVY
FYLTIYNEPYVQPAEPENLDVEGLLRGIYRYRAAAEKKSNTAQILVSGVAMPSALKAAEMLAEEWDVAADVWSVTSWNEL
NRDGVQVEKDLLRHPDRPAGTPYITTALADAAGPVVAVSDWMRAVPEQIRPWVPGTYITLGTDGFGFSDTRPAARRFYNT
DAESITVAVLEGLARDGNIDISVAVEAARRYEIDDVLAAPEQTSDPGVA
>Mature_928_residues
TTEFVRQDLAQNSSTAAEHDRVRVIREGVASYLPDIDPDETSEWLESFDQLLERSGPARARYLLLRLLERSGEQRVAIPA
LTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFNHFFRGKSHSGG
GDQVFIQGHASPGIYARAYLEGRLTADQLDGFRQEHSHPGGGIPSYPHPRLMPDFWEFPTVSMGLGPMNAIYQARFNHYL
HDRGIKDTTDQHVWAFLGDGEMDEPESRGLIHVAALEALDNLTFVVNCNLQRLDGPVRGNGKIIQELESFFRGAGWNVIK
VVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDGGYVRDHFFGRDPRTKALVEPMTDAEIWNLKRGGHDYRKVYA
AYRAAMEHKGQPTVILAKTIKGYTLGKHFEGRNATHQMKKLALQDLKDFRDAQRIPIGDAQLEENPYLPPYYHPGPEAPE
IRYMLDRRRALGGFVPERRTKSKALALPSSDAYKALKKGSGKQEVATTMATVRTFKEILRDKQIGHRIVPIIPDEARTFG
MDSWFPNLKIYNRNGQLYTSVDAELMLAYRESEVGQILHEGINEAGSVGTFIAAGTSYATHNEPMIPIYIFYSMFGFQRT
GDSFWAAADQMARGFVLGATAGRTTLVGEGLQHADGHSLLLASTNPAVVAYDPAFAYEIAYIIESGLHRMYGENPENVYF
YLTIYNEPYVQPAEPENLDVEGLLRGIYRYRAAAEKKSNTAQILVSGVAMPSALKAAEMLAEEWDVAADVWSVTSWNELN
RDGVQVEKDLLRHPDRPAGTPYITTALADAAGPVVAVSDWMRAVPEQIRPWVPGTYITLGTDGFGFSDTRPAARRFYNTD
AESITVAVLEGLARDGNIDISVAVEAARRYEIDDVLAAPEQTSDPGVA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=882, Percent_Identity=52.0408163265306, Blast_Score=912, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 103617; Mature: 103485

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEFVRQDLAQNSSTAAEHDRVRVIREGVASYLPDIDPDETSEWLESFDQLLERSGPAR
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHH
ARYLLLRLLERSGEQRVAIPALTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIM
HHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECEEEE
VHRAQRPGVGVGGHISTYASSAALYEVGFNHFFRGKSHSGGGDQVFIQGHASPGIYARAY
EEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCEEEEE
LEGRLTADQLDGFRQEHSHPGGGIPSYPHPRLMPDFWEFPTVSMGLGPMNAIYQARFNHY
EECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCEECCCHHHHHHHHHHHHH
LHDRGIKDTTDQHVWAFLGDGEMDEPESRGLIHVAALEALDNLTFVVNCNLQRLDGPVRG
HHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEHHHHHHCCEEEEEECCHHHCCCCCCC
NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDG
CCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCC
GYVRDHFFGRDPRTKALVEPMTDAEIWNLKRGGHDYRKVYAAYRAAMEHKGQPTVILAKT
CEEEHHCCCCCCCCHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEC
IKGYTLGKHFEGRNATHQMKKLALQDLKDFRDAQRIPIGDAQLEENPYLPPYYHPGPEAP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
EIRYMLDRRRALGGFVPERRTKSKALALPSSDAYKALKKGSGKQEVATTMATVRTFKEIL
HHHHHHHHHHHHCCCCCCHHCCCCEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RDKQIGHRIVPIIPDEARTFGMDSWFPNLKIYNRNGQLYTSVDAELMLAYRESEVGQILH
HHHHCCCEEEEEECCCHHHCCCCCCCCCCEEECCCCCEEEECCCEEEEEHHHHHHHHHHH
EGINEAGSVGTFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGDSFWAAADQMARGFVLGA
HHHHHCCCCCEEEECCCCCCCCCCCEEHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEC
TAGRTTLVGEGLQHADGHSLLLASTNPAVVAYDPAFAYEIAYIIESGLHRMYGENPENVY
CCCCCEECCCCCCCCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEE
FYLTIYNEPYVQPAEPENLDVEGLLRGIYRYRAAAEKKSNTAQILVSGVAMPSALKAAEM
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHHCCHHHHHHHHH
LAEEWDVAADVWSVTSWNELNRDGVQVEKDLLRHPDRPAGTPYITTALADAAGPVVAVSD
HHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEHHH
WMRAVPEQIRPWVPGTYITLGTDGFGFSDTRPAARRFYNTDAESITVAVLEGLARDGNID
HHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCEE
ISVAVEAARRYEIDDVLAAPEQTSDPGVA
EEEEEHHHHHCCHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TTEFVRQDLAQNSSTAAEHDRVRVIREGVASYLPDIDPDETSEWLESFDQLLERSGPAR
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHH
ARYLLLRLLERSGEQRVAIPALTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIM
HHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECEEEE
VHRAQRPGVGVGGHISTYASSAALYEVGFNHFFRGKSHSGGGDQVFIQGHASPGIYARAY
EEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCEEEEE
LEGRLTADQLDGFRQEHSHPGGGIPSYPHPRLMPDFWEFPTVSMGLGPMNAIYQARFNHY
EECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCEECCCHHHHHHHHHHHHH
LHDRGIKDTTDQHVWAFLGDGEMDEPESRGLIHVAALEALDNLTFVVNCNLQRLDGPVRG
HHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEHHHHHHCCEEEEEECCHHHCCCCCCC
NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDG
CCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCC
GYVRDHFFGRDPRTKALVEPMTDAEIWNLKRGGHDYRKVYAAYRAAMEHKGQPTVILAKT
CEEEHHCCCCCCCCHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEC
IKGYTLGKHFEGRNATHQMKKLALQDLKDFRDAQRIPIGDAQLEENPYLPPYYHPGPEAP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
EIRYMLDRRRALGGFVPERRTKSKALALPSSDAYKALKKGSGKQEVATTMATVRTFKEIL
HHHHHHHHHHHHCCCCCCHHCCCCEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RDKQIGHRIVPIIPDEARTFGMDSWFPNLKIYNRNGQLYTSVDAELMLAYRESEVGQILH
HHHHCCCEEEEEECCCHHHCCCCCCCCCCEEECCCCCEEEECCCEEEEEHHHHHHHHHHH
EGINEAGSVGTFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGDSFWAAADQMARGFVLGA
HHHHHCCCCCEEEECCCCCCCCCCCEEHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEC
TAGRTTLVGEGLQHADGHSLLLASTNPAVVAYDPAFAYEIAYIIESGLHRMYGENPENVY
CCCCCEECCCCCCCCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEE
FYLTIYNEPYVQPAEPENLDVEGLLRGIYRYRAAAEKKSNTAQILVSGVAMPSALKAAEM
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHHCCHHHHHHHHH
LAEEWDVAADVWSVTSWNELNRDGVQVEKDLLRHPDRPAGTPYITTALADAAGPVVAVSD
HHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEHHH
WMRAVPEQIRPWVPGTYITLGTDGFGFSDTRPAARRFYNTDAESITVAVLEGLARDGNID
HHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCEE
ISVAVEAARRYEIDDVLAAPEQTSDPGVA
EEEEEHHHHHCCHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA