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The map label for this gene is pyrD

Identifier: 119869256

GI number: 119869256

Start: 3381010

End: 3382080

Strand: Direct

Name: pyrD

Synonym: Mkms_3224

Alternate gene names: 119869256

Gene position: 3381010-3382080 (Clockwise)

Preceding gene: 119869255

Following gene: 119869263

Centisome position: 58.93

GC content: 71.9

Gene sequence:

>1071_bases
GTGACCGGCTACCACGCGCTGCGGCGGGTGCTGTTCCTGATCTCCCCCGAGCGCATCCACACCTGGGTTTTCGCGCTGCT
TCGCGCCGTCACCACACCGGACCTCCTGCGTCGCGCACTGCAGGGCCGGCTCGCCCCCCGCGATCCCGTGCTGGCCAGCA
CCGTGTTCGGCGTGCGCTTCCCGGGGCCGCTCGGGCTGGCGGCCGGTTTCGACAAGGACGGTCGCGGCCTGCACACCTGG
CCCGCACTCGGATTCGGGTACGCCGAGGTGGGCACCGTCACCGCCCACCCGCAGCCCGGTAACCCCGAACCGCGGTTGTT
CCGTCTGCCCGAGGACCGGGCGCTGCTCAACCGCATGGGATTCAACAACGACGGCGCCGCCCGGCTCGCGCAGCGCCTCA
CCCGCCACACCTCCGACGCCCCCGTCGGCGTGAACATCGGCAAGACCAAGGCGACCCCCGCCGACCGAGCCGTCGAGGAC
TACGCCCAGAGCGCCCGCCAACTCGGCCCGCTCGCCACCTTTCTCGTGGTCAACGTCAGCTCGCCGAACACGCCGGGCCT
GCGTGACCTGCAGGCGGTGGAATCGTTGCGGCCCATTCTGACCGCGGTGCGCGCCCAGACCTCGACACCGGTGCTGGTGA
AGATCGCCCCCGACCTGTCCGACGCCGACGTCGACGAGATCGCCGACCTGGCAGTCGAACTGGGGTTGGCCGGCATCGTG
GCCACCAACACCACGATCTCGCGCGCGGGGCTGAAGACCCCCGGCGTCGAAGAGCTCGGCCCCGGCGGGGTGTCCGGTGC
CCCGGTCGCCGCCCGCTCCCTCGAGGTGCTGCGCCGGCTGTACCGCCGGGCGGGTGACCGGCTGGTGCTGATCAGCGTCG
GGGGTATCGAGACCGCCGACGACGCCTGGGAGCGCATCACCTCGGGCGCCTCACTGCTGCAGGGGTACACCGGTTTCGTC
TACGGGGGCGGCCTGTGGGCCAAGCACATTCACGACGGGCTGGCGACCCGGCTGCGCGCGGAGGGCTTCACCTCACTGTC
CGATGCAGTGGGCTCCGCGATGCGGCAGTGA

Upstream 100 bases:

>100_bases
GCGGCTGGGAGCTGACCCGGGTGCGCGCCTACACCGACGGCAGTCGGCGGGTGCTGCTGCGGCGCCGCAAGACCGCGAGC
ACGGTGGAGCAGCCGGGGCA

Downstream 100 bases:

>100_bases
GTTCCGGGCGCGAGCAGACACAGAATCGCGTTCCTGCGCACCGGATCACGCGATTCTGCGTCTGCTCGCGGCTGAGCCGG
ACCTACTTCTGCTCGTAGGT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MTGYHALRRVLFLISPERIHTWVFALLRAVTTPDLLRRALQGRLAPRDPVLASTVFGVRFPGPLGLAAGFDKDGRGLHTW
PALGFGYAEVGTVTAHPQPGNPEPRLFRLPEDRALLNRMGFNNDGAARLAQRLTRHTSDAPVGVNIGKTKATPADRAVED
YAQSARQLGPLATFLVVNVSSPNTPGLRDLQAVESLRPILTAVRAQTSTPVLVKIAPDLSDADVDEIADLAVELGLAGIV
ATNTTISRAGLKTPGVEELGPGGVSGAPVAARSLEVLRRLYRRAGDRLVLISVGGIETADDAWERITSGASLLQGYTGFV
YGGGLWAKHIHDGLATRLRAEGFTSLSDAVGSAMRQ

Sequences:

>Translated_356_residues
MTGYHALRRVLFLISPERIHTWVFALLRAVTTPDLLRRALQGRLAPRDPVLASTVFGVRFPGPLGLAAGFDKDGRGLHTW
PALGFGYAEVGTVTAHPQPGNPEPRLFRLPEDRALLNRMGFNNDGAARLAQRLTRHTSDAPVGVNIGKTKATPADRAVED
YAQSARQLGPLATFLVVNVSSPNTPGLRDLQAVESLRPILTAVRAQTSTPVLVKIAPDLSDADVDEIADLAVELGLAGIV
ATNTTISRAGLKTPGVEELGPGGVSGAPVAARSLEVLRRLYRRAGDRLVLISVGGIETADDAWERITSGASLLQGYTGFV
YGGGLWAKHIHDGLATRLRAEGFTSLSDAVGSAMRQ
>Mature_355_residues
TGYHALRRVLFLISPERIHTWVFALLRAVTTPDLLRRALQGRLAPRDPVLASTVFGVRFPGPLGLAAGFDKDGRGLHTWP
ALGFGYAEVGTVTAHPQPGNPEPRLFRLPEDRALLNRMGFNNDGAARLAQRLTRHTSDAPVGVNIGKTKATPADRAVEDY
AQSARQLGPLATFLVVNVSSPNTPGLRDLQAVESLRPILTAVRAQTSTPVLVKIAPDLSDADVDEIADLAVELGLAGIVA
TNTTISRAGLKTPGVEELGPGGVSGAPVAARSLEVLRRLYRRAGDRLVLISVGGIETADDAWERITSGASLLQGYTGFVY
GGGLWAKHIHDGLATRLRAEGFTSLSDAVGSAMRQ

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=360, Percent_Identity=43.0555555555556, Blast_Score=243, Evalue=1e-64,
Organism=Homo sapiens, GI119943098, Length=285, Percent_Identity=27.3684210526316, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787177, Length=338, Percent_Identity=42.0118343195266, Blast_Score=255, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17509475, Length=326, Percent_Identity=40.4907975460123, Blast_Score=223, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6322633, Length=272, Percent_Identity=26.8382352941176, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281361352, Length=348, Percent_Identity=39.0804597701149, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI17137316, Length=348, Percent_Identity=39.0804597701149, Blast_Score=235, Evalue=4e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_MYCSJ (A3Q1C6)

Other databases:

- EMBL:   CP000580
- RefSeq:   YP_001071444.1
- ProteinModelPortal:   A3Q1C6
- SMR:   A3Q1C6
- STRING:   A3Q1C6
- EnsemblBacteria:   EBMYCT00000050366
- GeneID:   4878887
- GenomeReviews:   CP000580_GR
- KEGG:   mjl:Mjls_3174
- eggNOG:   COG0167
- GeneTree:   EBGT00050000017343
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- PhylomeDB:   A3Q1C6
- ProtClustDB:   PRK05286
- BioCyc:   MSP164757:MJLS_3174-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 37864; Mature: 37733

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 181-181

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGYHALRRVLFLISPERIHTWVFALLRAVTTPDLLRRALQGRLAPRDPVLASTVFGVRF
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHCEEC
PGPLGLAAGFDKDGRGLHTWPALGFGYAEVGTVTAHPQPGNPEPRLFRLPEDRALLNRMG
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCEEEECCCCCCCCCCEEECCHHHHHHHHCC
FNNDGAARLAQRLTRHTSDAPVGVNIGKTKATPADRAVEDYAQSARQLGPLATFLVVNVS
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECC
SPNTPGLRDLQAVESLRPILTAVRAQTSTPVLVKIAPDLSDADVDEIADLAVELGLAGIV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHEE
ATNTTISRAGLKTPGVEELGPGGVSGAPVAARSLEVLRRLYRRAGDRLVLISVGGIETAD
ECCCCHHHCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHH
DAWERITSGASLLQGYTGFVYGGGLWAKHIHDGLATRLRAEGFTSLSDAVGSAMRQ
HHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TGYHALRRVLFLISPERIHTWVFALLRAVTTPDLLRRALQGRLAPRDPVLASTVFGVRF
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHCEEC
PGPLGLAAGFDKDGRGLHTWPALGFGYAEVGTVTAHPQPGNPEPRLFRLPEDRALLNRMG
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCEEEECCCCCCCCCCEEECCHHHHHHHHCC
FNNDGAARLAQRLTRHTSDAPVGVNIGKTKATPADRAVEDYAQSARQLGPLATFLVVNVS
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECC
SPNTPGLRDLQAVESLRPILTAVRAQTSTPVLVKIAPDLSDADVDEIADLAVELGLAGIV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHEE
ATNTTISRAGLKTPGVEELGPGGVSGAPVAARSLEVLRRLYRRAGDRLVLISVGGIETAD
ECCCCHHHCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHH
DAWERITSGASLLQGYTGFVYGGGLWAKHIHDGLATRLRAEGFTSLSDAVGSAMRQ
HHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA