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The map label for this gene is 119869191

Identifier: 119869191

GI number: 119869191

Start: 3306040

End: 3307272

Strand: Direct

Name: 119869191

Synonym: Mkms_3159

Alternate gene names: NA

Gene position: 3306040-3307272 (Clockwise)

Preceding gene: 119869188

Following gene: 119869194

Centisome position: 57.62

GC content: 71.21

Gene sequence:

>1233_bases
ATGCAGGACATCTGGATCCTCGGCGCGTACCAGAGCGATTTCGCCCGCAACCTGAGCCGGGAGGGCAGCGATTTCGGCGA
TCTGACCGCCGAGGTGGTCGGGCACACGCTGGCCTCGGCGCGGATGGACGCGGACGCCGTCGAGGTCGTCCACGTCGGCA
ACGCGTTCGGCGAGTTGTTCGCGGGCCAAGGGCATCTCGGCGCCATGCCCGCGACCGTCGACGACGCGCTGTGGGGAGTA
CCCGCCTCCCGGCACGAGGCCGCGTGCGCGTCGGGCAGCGTCGCCACCCTCGCCGCGATCGCCGACCTGCGCTCGCGCGC
CTACGACGTGGCACTGGTCGCCGGCCTCGAACTGGAGAAGACGGTGCCCGGACCTGTCGGCGCGGCCCACCTGGCCGCGG
CCGCCTGGGTCGGGCACGAGGGAGAGGATACGAAAAACATCTGGGCACAGGTGTTTTCGCGCGTCGCCGATGAATACGAC
CGCCGCTACGGACTCGACGAGATCCATCTGCGCGCGATCGCCGACCTCAACTACGACAACGCGCGCCGCAACGGCAACGC
CCAGACCCGCGGCTGGGCAGTGCCCCACCTCGCGACCGACGGCGCCGACGACGACGACCGCAACCCCGTCGTGGAGGGCC
GTCTGCGGCGCTATGACTGCAGCCAGCTCACCGACGGCGGTGCGGGCATCGTGCTGGTGACCGACGACTATCTGCGGGAC
CACCCCGACGCCCGGCCACTGGCCCGCATCGAGGGCTGGGGCCACCGCACGGTCGGCCTCGGATTGACCCAGAAGCTCCG
GCGCGACGCGGACTCGCCGTACGTGCTCCCCCACGTGCGCGGTGCGGTGCACGACGCGTTCGGCCGCGCCGGGATCGGTT
CCGACGCCCTGGACGCGGTGGACGGCTTCGAGGTGCACGACTGTTTCACCCCGAGCGAGTACCTGGCCATCGACCACATC
GGGCTGACCGGACCGGGAGAGTCCTGGCAGGCCGTCGAGAACGGTGACATCGCGATCGGCGGCCGGCTTCCGATCAATCC
CGGCGGCGGCCTGATCGGCGGTGGGCATCCGGTGGGCGCCACCGGCGTCCGGATGCTCGTCGACGCGGCCAAACAGGTCA
GCGGCACCGCCGGTGACTATCAGGTCGACGGCGCCGTCCGATTCGGCACCCTCAACATCGGCGGGAGCACCGCCACCACG
GTGAGCTTCCTCGTCGGGTTGCCGCCGCGCTGA

Upstream 100 bases:

>100_bases
ATCGGCGGGCAGCGTCGAGGCGAAGGTCTGCAGGCGTTCCACTCGCATGGCCGAAAACTACAGTTGACAGAGTGACTCTG
TCAATTGAACTATAGGCGTC

Downstream 100 bases:

>100_bases
TCCTCACGCCTTGGCGATCGCCACCCGCACCCCGTCGCCGATCTCGGACCCGTCGGCCGGCTCACCGAATTCGAAAGCGG
TGGCGAGGATCTCCCCGGCG

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MQDIWILGAYQSDFARNLSREGSDFGDLTAEVVGHTLASARMDADAVEVVHVGNAFGELFAGQGHLGAMPATVDDALWGV
PASRHEAACASGSVATLAAIADLRSRAYDVALVAGLELEKTVPGPVGAAHLAAAAWVGHEGEDTKNIWAQVFSRVADEYD
RRYGLDEIHLRAIADLNYDNARRNGNAQTRGWAVPHLATDGADDDDRNPVVEGRLRRYDCSQLTDGGAGIVLVTDDYLRD
HPDARPLARIEGWGHRTVGLGLTQKLRRDADSPYVLPHVRGAVHDAFGRAGIGSDALDAVDGFEVHDCFTPSEYLAIDHI
GLTGPGESWQAVENGDIAIGGRLPINPGGGLIGGGHPVGATGVRMLVDAAKQVSGTAGDYQVDGAVRFGTLNIGGSTATT
VSFLVGLPPR

Sequences:

>Translated_410_residues
MQDIWILGAYQSDFARNLSREGSDFGDLTAEVVGHTLASARMDADAVEVVHVGNAFGELFAGQGHLGAMPATVDDALWGV
PASRHEAACASGSVATLAAIADLRSRAYDVALVAGLELEKTVPGPVGAAHLAAAAWVGHEGEDTKNIWAQVFSRVADEYD
RRYGLDEIHLRAIADLNYDNARRNGNAQTRGWAVPHLATDGADDDDRNPVVEGRLRRYDCSQLTDGGAGIVLVTDDYLRD
HPDARPLARIEGWGHRTVGLGLTQKLRRDADSPYVLPHVRGAVHDAFGRAGIGSDALDAVDGFEVHDCFTPSEYLAIDHI
GLTGPGESWQAVENGDIAIGGRLPINPGGGLIGGGHPVGATGVRMLVDAAKQVSGTAGDYQVDGAVRFGTLNIGGSTATT
VSFLVGLPPR
>Mature_410_residues
MQDIWILGAYQSDFARNLSREGSDFGDLTAEVVGHTLASARMDADAVEVVHVGNAFGELFAGQGHLGAMPATVDDALWGV
PASRHEAACASGSVATLAAIADLRSRAYDVALVAGLELEKTVPGPVGAAHLAAAAWVGHEGEDTKNIWAQVFSRVADEYD
RRYGLDEIHLRAIADLNYDNARRNGNAQTRGWAVPHLATDGADDDDRNPVVEGRLRRYDCSQLTDGGAGIVLVTDDYLRD
HPDARPLARIEGWGHRTVGLGLTQKLRRDADSPYVLPHVRGAVHDAFGRAGIGSDALDAVDGFEVHDCFTPSEYLAIDHI
GLTGPGESWQAVENGDIAIGGRLPINPGGGLIGGGHPVGATGVRMLVDAAKQVSGTAGDYQVDGAVRFGTLNIGGSTATT
VSFLVGLPPR

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=432, Percent_Identity=24.0740740740741, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI302344767, Length=356, Percent_Identity=24.438202247191, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI302344760, Length=356, Percent_Identity=24.438202247191, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI302344762, Length=275, Percent_Identity=26.1818181818182, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI55956775, Length=227, Percent_Identity=25.1101321585903, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17537653, Length=406, Percent_Identity=28.0788177339901, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI19921506, Length=418, Percent_Identity=24.1626794258373, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24585051, Length=418, Percent_Identity=24.4019138755981, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 43133; Mature: 43133

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDIWILGAYQSDFARNLSREGSDFGDLTAEVVGHTLASARMDADAVEVVHVGNAFGELF
CCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
AGQGHLGAMPATVDDALWGVPASRHEAACASGSVATLAAIADLRSRAYDVALVAGLELEK
CCCCCCCCCCCCHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHEEEEEECCEECC
TVPGPVGAAHLAAAAWVGHEGEDTKNIWAQVFSRVADEYDRRYGLDEIHLRAIADLNYDN
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCC
ARRNGNAQTRGWAVPHLATDGADDDDRNPVVEGRLRRYDCSQLTDGGAGIVLVTDDYLRD
CCCCCCCCCCCEECCEEECCCCCCCCCCCHHHCHHHHCCHHHCCCCCCEEEEEECHHHHC
HPDARPLARIEGWGHRTVGLGLTQKLRRDADSPYVLPHVRGAVHDAFGRAGIGSDALDAV
CCCCCCHHHHCCCCCEEECCCHHHHHHHCCCCCEECHHHHHHHHHHHCCCCCCCHHHHHH
DGFEVHDCFTPSEYLAIDHIGLTGPGESWQAVENGDIAIGGRLPINPGGGLIGGGHPVGA
CCCEEEECCCCCCEEEEEECCCCCCCCCCCEECCCCEEECCEECCCCCCCCCCCCCCCCH
TGVRMLVDAAKQVSGTAGDYQVDGAVRFGTLNIGGSTATTVSFLVGLPPR
HHHHHHHHHHHHHCCCCCCEEECCEEEEEEEECCCCHHHHHHHEECCCCC
>Mature Secondary Structure
MQDIWILGAYQSDFARNLSREGSDFGDLTAEVVGHTLASARMDADAVEVVHVGNAFGELF
CCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
AGQGHLGAMPATVDDALWGVPASRHEAACASGSVATLAAIADLRSRAYDVALVAGLELEK
CCCCCCCCCCCCHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHEEEEEECCEECC
TVPGPVGAAHLAAAAWVGHEGEDTKNIWAQVFSRVADEYDRRYGLDEIHLRAIADLNYDN
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCC
ARRNGNAQTRGWAVPHLATDGADDDDRNPVVEGRLRRYDCSQLTDGGAGIVLVTDDYLRD
CCCCCCCCCCCEECCEEECCCCCCCCCCCHHHCHHHHCCHHHCCCCCCEEEEEECHHHHC
HPDARPLARIEGWGHRTVGLGLTQKLRRDADSPYVLPHVRGAVHDAFGRAGIGSDALDAV
CCCCCCHHHHCCCCCEEECCCHHHHHHHCCCCCEECHHHHHHHHHHHCCCCCCCHHHHHH
DGFEVHDCFTPSEYLAIDHIGLTGPGESWQAVENGDIAIGGRLPINPGGGLIGGGHPVGA
CCCEEEECCCCCCEEEEEECCCCCCCCCCCEECCCCEEECCEECCCCCCCCCCCCCCCCH
TGVRMLVDAAKQVSGTAGDYQVDGAVRFGTLNIGGSTATTVSFLVGLPPR
HHHHHHHHHHHHHCCCCCCEEECCEEEEEEEECCCCHHHHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]