Click here to switch to the map view.

The map label for this gene is drrC [H]

Identifier: 119868905

GI number: 119868905

Start: 2997478

End: 2998341

Strand: Reverse

Name: drrC [H]

Synonym: Mkms_2873

Alternate gene names: 119868905

Gene position: 2998341-2997478 (Counterclockwise)

Preceding gene: 119868906

Following gene: 119868904

Centisome position: 52.26

GC content: 65.74

Gene sequence:

>864_bases
ATGACGATGACGCACAACGGGACTCGGCCGGCCGACTCCACGATCCTGCAGGAGGACAGCTTCCCGAAGATCAACCGACC
CCGTCGGGAGAACTCGCCGCGGACGCTGTTCCCACACGCCTGGGTGCAGACCAAGCGGCTGCTGATGCGGTTCCTCCGGG
ATCCGATGACGTTCTTCTTCGGCGTGGTCTTCCCGATCTTCATGCTCCTGGTGCTGGACATCGTTCTCGGTGATGCGATC
TCGGCAGTCACCGGCAACTCGGCGGTGTACGGCAGTGTCCCGCTGATGACGGTGATCGGCGCCATGAACGGTGCATCCGT
CGGTGCGGTCGGCATCATCGCCGAACAGAACGACGGCATGCTGGCACGGTTGTGGGTGACGCCGATCCACCGCGCATCGG
GGCTGCTGGCCCGGATCACCGCCGAGGCGCTGCGCGTGGTGATCAACTCCGTGCTGCTGCTGGCCGTCGGTTTCGCGCTC
GGGCTCCGCTTCGAGCAGGGGATTCCCGCGGCGGTCGCCTGGGTCTGCGTTCCGGTGCTCTTCGGCGTCGCCTTCGCCAT
CCTGGTGCTCACCGTGGCGTTGTACTGGCCGAGCCCGACGATGGTGAACGCGATCGTCCTCGTGAACTCGTTGTGCCTGT
TCTTCTCCAGCGGATTCGTCCCGCTGAACCAGTACCCGTCGTGGGTCCAGCCGGCCGTCGAGCACCAACCGGTGTCGTAT
GCGATCGAGACCATGCGCGGGCTGTCGCTGGGCGGCCCCGTCCTGGAACCCGGTATCGGAATCCTGGCCTGGTCGGGCGG
CATCATCCTGGCCTGCCTCATCCCGATGGTCATCGGCTACCGGAAAGCCAGCATGCGCGGATGA

Upstream 100 bases:

>100_bases
AGGTCAGCTGGCCGGTCATCGGCCCGTCGGTGGCATGGCTGGTCGGGGTGATGGTGATCATGGTGCCGGTGTCGGTGATG
CTACTTCGGAGGCGATCCTG

Downstream 100 bases:

>100_bases
GCGGGCAGCTTCGCGGACGGCCTCCGCATTGCGGCACCGGTCACCGGGCAGCCCACCGGGAAGGACTCTGATGGCGTACT
CCACGTCGGTGATCCGACGG

Product: daunorubicin resistance ABC transporter inner membrane subunit C

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MTMTHNGTRPADSTILQEDSFPKINRPRRENSPRTLFPHAWVQTKRLLMRFLRDPMTFFFGVVFPIFMLLVLDIVLGDAI
SAVTGNSAVYGSVPLMTVIGAMNGASVGAVGIIAEQNDGMLARLWVTPIHRASGLLARITAEALRVVINSVLLLAVGFAL
GLRFEQGIPAAVAWVCVPVLFGVAFAILVLTVALYWPSPTMVNAIVLVNSLCLFFSSGFVPLNQYPSWVQPAVEHQPVSY
AIETMRGLSLGGPVLEPGIGILAWSGGIILACLIPMVIGYRKASMRG

Sequences:

>Translated_287_residues
MTMTHNGTRPADSTILQEDSFPKINRPRRENSPRTLFPHAWVQTKRLLMRFLRDPMTFFFGVVFPIFMLLVLDIVLGDAI
SAVTGNSAVYGSVPLMTVIGAMNGASVGAVGIIAEQNDGMLARLWVTPIHRASGLLARITAEALRVVINSVLLLAVGFAL
GLRFEQGIPAAVAWVCVPVLFGVAFAILVLTVALYWPSPTMVNAIVLVNSLCLFFSSGFVPLNQYPSWVQPAVEHQPVSY
AIETMRGLSLGGPVLEPGIGILAWSGGIILACLIPMVIGYRKASMRG
>Mature_286_residues
TMTHNGTRPADSTILQEDSFPKINRPRRENSPRTLFPHAWVQTKRLLMRFLRDPMTFFFGVVFPIFMLLVLDIVLGDAIS
AVTGNSAVYGSVPLMTVIGAMNGASVGAVGIIAEQNDGMLARLWVTPIHRASGLLARITAEALRVVINSVLLLAVGFALG
LRFEQGIPAAVAWVCVPVLFGVAFAILVLTVALYWPSPTMVNAIVLVNSLCLFFSSGFVPLNQYPSWVQPAVEHQPVSYA
IETMRGLSLGGPVLEPGIGILAWSGGIILACLIPMVIGYRKASMRG

Specific function: Probably part of the ABC transporter complex drrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525
- InterPro:   IPR004377
- InterPro:   IPR005943 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 30974; Mature: 30843

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS51012 ABC_TM2 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMTHNGTRPADSTILQEDSFPKINRPRRENSPRTLFPHAWVQTKRLLMRFLRDPMTFFF
CCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHH
GVVFPIFMLLVLDIVLGDAISAVTGNSAVYGSVPLMTVIGAMNGASVGAVGIIAEQNDGM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHCCCCCCCCEEEEEEECCCCE
LARLWVTPIHRASGLLARITAEALRVVINSVLLLAVGFALGLRFEQGIPAAVAWVCVPVL
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
FGVAFAILVLTVALYWPSPTMVNAIVLVNSLCLFFSSGFVPLNQYPSWVQPAVEHQPVSY
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHH
AIETMRGLSLGGPVLEPGIGILAWSGGIILACLIPMVIGYRKASMRG
HHHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TMTHNGTRPADSTILQEDSFPKINRPRRENSPRTLFPHAWVQTKRLLMRFLRDPMTFFF
CCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHH
GVVFPIFMLLVLDIVLGDAISAVTGNSAVYGSVPLMTVIGAMNGASVGAVGIIAEQNDGM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHCCCCCCCCEEEEEEECCCCE
LARLWVTPIHRASGLLARITAEALRVVINSVLLLAVGFALGLRFEQGIPAAVAWVCVPVL
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
FGVAFAILVLTVALYWPSPTMVNAIVLVNSLCLFFSSGFVPLNQYPSWVQPAVEHQPVSY
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHH
AIETMRGLSLGGPVLEPGIGILAWSGGIILACLIPMVIGYRKASMRG
HHHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]