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The map label for this gene is ddc [H]

Identifier: 119868778

GI number: 119868778

Start: 2871449

End: 2872840

Strand: Direct

Name: ddc [H]

Synonym: Mkms_2746

Alternate gene names: 119868778

Gene position: 2871449-2872840 (Clockwise)

Preceding gene: 119868776

Following gene: 119868780

Centisome position: 50.05

GC content: 74.78

Gene sequence:

>1392_bases
ATGCCTGATCGCACCGCCGGCCTGCACGCCGCCGTCCGGCACGCCGAGACGTACCTCGCCGGACTCGACGAACGACCGGT
CGGCGCGGCCGCCACGGCCGCGGAGGTCCGCGACCGCCTGGGCGGTCCGCTGCCCGAACACCCGACCGATCCGGCGGAGG
TGATCGAGGCGCTGGCCACCGGCGCCGAACCGGGCCTGGTCGCCAGTGCGGGACCCCGCCACTTCGGATTCGTCGTCGGG
GGCGCCCTGCCCGCCGCGCTCGCGGCCGACTGGCTGGTGTCGGCGTGGGACCAGTGCGCCGCGTTCCACGCCCTGTCCCC
CGCCGGATCGGCGATCGAGGACGTCGCCGCCGGATGGGTCCTCGACCTGCTCGGCCTGCCTGCCACCGCCAGCGTCGGCT
TCGTCACCGGCGGTCAGGGTGCCAACACGACGTGTCTGGCGGCGGCGCGGCAGGCGGTATTCGCCGCCGCGGGCTGGGAT
GTCGAACGAGACGGCCTCATCGGGGCCCCACCGCTCCGGGTGTTCTGCGGGGAGCAGGCCCACGCCACGATCCACACCGC
GCTGCGGTTGCTCGGTCTGGGCGCGGACACCGCCGTCCGCATCCCCGCCGACGGGCAGGGCCGGATGGACCCGGAGGCGC
TGCGGCACGCCCTGGACGACGGCGCCGGACCGGCGATCGTGTGCGCTCAGGCCGGCAACGTGGCCACCGGTGCGTTCGAC
GCGTTCGAGCCGATCGCCGAGGCGTGCGCGGCGCACGGCGCGTGGTTGCACGTCGACGGCGCCTTCGGGTTGTGGGCCGC
GGCCGCGCCGCGGACCCGCCATCTCACCCACGCCGTCGAACGCGCCGACTCGTGGGCGGTCGACGCGCACAAGTGGCTCA
ACGTCCCCTATGACTGTGCGGCGGCGATCGTCGCGCACCCCGACGCTCACCGGGCCGCGATGCGCCTCACCGGCCCCTAC
CTCGTCGCGGATCCCGGGCAGCGCGACAACACCACCTACGTGCCCGAGAGTTCACGGCGGGCCCGGTCGGTGCCGGTGTA
CGCGGCCATCCGCTCACTGGGGCGAACCGGCGTCGCGGACATGGTCGAACGCAACTGCGCCCAGGCCCGCCGGATGGCCG
AGCACCTCCGCGCCATCCCCGGCGCCACCGTGCTCAACGAGGTGGTGCTCAACCAGGTGCTGGTCGCGCTGCCGGGCGGT
GACGAGGCCAACCGCGCCGCGGTGGCCGCCATCCAGCGCGACGGCACCTGCTGGCTGGGCGGCACCACGTGGCAGGGTGC
CCATGTTCTGCGGGTGAGCGTGTCGAACTGGGCGACCACCGACGACGACATCGACCGCTCGGCGGCGGCCATCGCCGCGG
TGGCCGCGACCGGTCAGATGCCGACGATGTAA

Upstream 100 bases:

>100_bases
GCAGGTGCAGATCCGAAGCGCTCACAGGTGGCGACGGTGCCACACCCGCACCGGCAAGCGCACCTGATTTTTCGCCGCGG
CGGGTCATAGGCTCGGTCGC

Downstream 100 bases:

>100_bases
TCGGTGGTGTAGAACTCCGCGGGCAACTGCGAATGCGGTTGCGGGCGATCGATGGCCAGCCACGAGCCGGTCGCACCGGA
CATGATCGGGCTCGACAGCG

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MPDRTAGLHAAVRHAETYLAGLDERPVGAAATAAEVRDRLGGPLPEHPTDPAEVIEALATGAEPGLVASAGPRHFGFVVG
GALPAALAADWLVSAWDQCAAFHALSPAGSAIEDVAAGWVLDLLGLPATASVGFVTGGQGANTTCLAAARQAVFAAAGWD
VERDGLIGAPPLRVFCGEQAHATIHTALRLLGLGADTAVRIPADGQGRMDPEALRHALDDGAGPAIVCAQAGNVATGAFD
AFEPIAEACAAHGAWLHVDGAFGLWAAAAPRTRHLTHAVERADSWAVDAHKWLNVPYDCAAAIVAHPDAHRAAMRLTGPY
LVADPGQRDNTTYVPESSRRARSVPVYAAIRSLGRTGVADMVERNCAQARRMAEHLRAIPGATVLNEVVLNQVLVALPGG
DEANRAAVAAIQRDGTCWLGGTTWQGAHVLRVSVSNWATTDDDIDRSAAAIAAVAATGQMPTM

Sequences:

>Translated_463_residues
MPDRTAGLHAAVRHAETYLAGLDERPVGAAATAAEVRDRLGGPLPEHPTDPAEVIEALATGAEPGLVASAGPRHFGFVVG
GALPAALAADWLVSAWDQCAAFHALSPAGSAIEDVAAGWVLDLLGLPATASVGFVTGGQGANTTCLAAARQAVFAAAGWD
VERDGLIGAPPLRVFCGEQAHATIHTALRLLGLGADTAVRIPADGQGRMDPEALRHALDDGAGPAIVCAQAGNVATGAFD
AFEPIAEACAAHGAWLHVDGAFGLWAAAAPRTRHLTHAVERADSWAVDAHKWLNVPYDCAAAIVAHPDAHRAAMRLTGPY
LVADPGQRDNTTYVPESSRRARSVPVYAAIRSLGRTGVADMVERNCAQARRMAEHLRAIPGATVLNEVVLNQVLVALPGG
DEANRAAVAAIQRDGTCWLGGTTWQGAHVLRVSVSNWATTDDDIDRSAAAIAAVAATGQMPTM
>Mature_462_residues
PDRTAGLHAAVRHAETYLAGLDERPVGAAATAAEVRDRLGGPLPEHPTDPAEVIEALATGAEPGLVASAGPRHFGFVVGG
ALPAALAADWLVSAWDQCAAFHALSPAGSAIEDVAAGWVLDLLGLPATASVGFVTGGQGANTTCLAAARQAVFAAAGWDV
ERDGLIGAPPLRVFCGEQAHATIHTALRLLGLGADTAVRIPADGQGRMDPEALRHALDDGAGPAIVCAQAGNVATGAFDA
FEPIAEACAAHGAWLHVDGAFGLWAAAAPRTRHLTHAVERADSWAVDAHKWLNVPYDCAAAIVAHPDAHRAAMRLTGPYL
VADPGQRDNTTYVPESSRRARSVPVYAAIRSLGRTGVADMVERNCAQARRMAEHLRAIPGATVLNEVVLNQVLVALPGGD
EANRAAVAAIQRDGTCWLGGTTWQGAHVLRVSVSNWATTDDDIDRSAAAIAAVAATGQMPTM

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197383062, Length=334, Percent_Identity=27.8443113772455, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4503281, Length=466, Percent_Identity=26.8240343347639, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI132814448, Length=466, Percent_Identity=26.8240343347639, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI92110055, Length=447, Percent_Identity=25.9507829977629, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI194294551, Length=332, Percent_Identity=27.710843373494, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI58331246, Length=448, Percent_Identity=25, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI197276620, Length=354, Percent_Identity=26.271186440678, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI4503875, Length=354, Percent_Identity=26.271186440678, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI190341074, Length=230, Percent_Identity=25.6521739130435, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17534817, Length=464, Percent_Identity=26.5086206896552, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17534819, Length=464, Percent_Identity=26.5086206896552, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17555682, Length=439, Percent_Identity=23.2346241457859, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI71993062, Length=416, Percent_Identity=23.5576923076923, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71993058, Length=355, Percent_Identity=24.5070422535211, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI133931025, Length=424, Percent_Identity=21.4622641509434, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28573972, Length=449, Percent_Identity=27.3942093541203, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24652373, Length=482, Percent_Identity=26.5560165975104, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24586044, Length=474, Percent_Identity=27.0042194092827, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17136594, Length=364, Percent_Identity=25, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI221476190, Length=462, Percent_Identity=24.4588744588745, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24585143, Length=462, Percent_Identity=24.4588744588745, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24585139, Length=462, Percent_Identity=24.4588744588745, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24585135, Length=466, Percent_Identity=22.9613733905579, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24657193, Length=301, Percent_Identity=24.9169435215947, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24657185, Length=301, Percent_Identity=24.9169435215947, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24657188, Length=301, Percent_Identity=24.9169435215947, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17136190, Length=465, Percent_Identity=21.9354838709677, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21356415, Length=253, Percent_Identity=27.6679841897233, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 47746; Mature: 47615

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDRTAGLHAAVRHAETYLAGLDERPVGAAATAAEVRDRLGGPLPEHPTDPAEVIEALAT
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHC
GAEPGLVASAGPRHFGFVVGGALPAALAADWLVSAWDQCAAFHALSPAGSAIEDVAAGWV
CCCCCEEECCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LDLLGLPATASVGFVTGGQGANTTCLAAARQAVFAAAGWDVERDGLIGAPPLRVFCGEQA
HHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEECCCH
HATIHTALRLLGLGADTAVRIPADGQGRMDPEALRHALDDGAGPAIVCAQAGNVATGAFD
HHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCHH
AFEPIAEACAAHGAWLHVDGAFGLWAAAAPRTRHLTHAVERADSWAVDAHKWLNVPYDCA
HHHHHHHHHHCCCCEEEECCCCHHHHHCCCCHHHHHHHHHHHCCCEECHHHHCCCCHHHH
AAIVAHPDAHRAAMRLTGPYLVADPGQRDNTTYVPESSRRARSVPVYAAIRSLGRTGVAD
HHHHCCCCHHHHHHEECCCEEEECCCCCCCCEECCCCCCCHHCCHHHHHHHHHCCCCHHH
MVERNCAQARRMAEHLRAIPGATVLNEVVLNQVLVALPGGDEANRAAVAAIQRDGTCWLG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCCCCCHHEEEEEECCCEEEEC
GTTWQGAHVLRVSVSNWATTDDDIDRSAAAIAAVAATGQMPTM
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PDRTAGLHAAVRHAETYLAGLDERPVGAAATAAEVRDRLGGPLPEHPTDPAEVIEALAT
CCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHC
GAEPGLVASAGPRHFGFVVGGALPAALAADWLVSAWDQCAAFHALSPAGSAIEDVAAGWV
CCCCCEEECCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LDLLGLPATASVGFVTGGQGANTTCLAAARQAVFAAAGWDVERDGLIGAPPLRVFCGEQA
HHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEECCCH
HATIHTALRLLGLGADTAVRIPADGQGRMDPEALRHALDDGAGPAIVCAQAGNVATGAFD
HHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCHH
AFEPIAEACAAHGAWLHVDGAFGLWAAAAPRTRHLTHAVERADSWAVDAHKWLNVPYDCA
HHHHHHHHHHCCCCEEEECCCCHHHHHCCCCHHHHHHHHHHHCCCEECHHHHCCCCHHHH
AAIVAHPDAHRAAMRLTGPYLVADPGQRDNTTYVPESSRRARSVPVYAAIRSLGRTGVAD
HHHHCCCCHHHHHHEECCCEEEECCCCCCCCEECCCCCCCHHCCHHHHHHHHHCCCCHHH
MVERNCAQARRMAEHLRAIPGATVLNEVVLNQVLVALPGGDEANRAAVAAIQRDGTCWLG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCCCCCHHEEEEEECCCEEEEC
GTTWQGAHVLRVSVSNWATTDDDIDRSAAAIAAVAATGQMPTM
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]