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The map label for this gene is tcmA [H]

Identifier: 119868649

GI number: 119868649

Start: 2748462

End: 2749925

Strand: Reverse

Name: tcmA [H]

Synonym: Mkms_2614

Alternate gene names: 119868649

Gene position: 2749925-2748462 (Counterclockwise)

Preceding gene: 119868652

Following gene: 119868647

Centisome position: 47.93

GC content: 70.77

Gene sequence:

>1464_bases
GTGGTGGGCACGGGGGTTGCGCGCTCGACCACCGGCACGGTGCGCCCGGCGTTGCTGGTGGGCGGTCTGAGCGTCGTCGT
CCTCACCGTCGCCGTCCTGCAGACCGCGGTGGTGCCGGTGCTCGGGGTGATCGGCGATCAACTCGGCGCCTCCACGGTCG
CGGTGAGTTGGGCGGTGACCGCCAACCTGCTGGCCGCGATCGCGGCGACACCGCTGCTCGGTCGCCTGGCCGATCTGTAC
AGCAAGAAACGTGTGCTTCTCGGTGTCCTCGTCGTGGTGCTGATCGGATCGGTTCTCGCGGCGGTGACCTCGTCGTTGCC
GCTGCTGATCGTCGCGCGGGTGCTGCAGGGCGCCTCCTATGCGCTCTACCCGATCAGCGTGGCGGTGCTGCGCGAGGAAC
TGCCGCACGGACGGTTGGCCGGGGCGATGGCGGTCATGTCGGGCACCCTCGGCTTCGGCGGCGGGGTCGGACTGGTGGTC
GTCGGGCTGCTGATGAGCGGCGACGCGGACTACCACCGGGTGTTCTGGCTGACCACCGGGTTCACCGTCGTCGTCCTCGC
GATCGTCGTGTTCCTGGTGCCCGCGCGGCGCCGCCGTGCCGAGGGGTCGATCGACTGGCTGGGCGCCGTCGGCCTGGCTG
CGGGCCTGTCGGCGCTGCTGCTGGCCATCACGCAGGGCAACGCGTGGGGCTGGGGGTCGGGCCGGACCGTGGCCTGTGCA
CTCGGCGGTGCGGCCGCACTGGTCGCGTGGTGGATGTGGGAGAAGCGGCGCATCCACCCCTTGGTGTCGACGCGCATGCT
CGCCAAGCCGGCGATGCTGCTGACCAACCTCGCCACGATCTTCGTGGGGATGGGGTTGTACTTCGCGTTCCTCGGACTGA
CGCAGTTCGTGCAGATCCCGCGCGAGGCGGCCGGATACGGGTTCGGCGCGAGCGTGCTGCAGTCGAGTGTGGTGTACCTG
CTACCCGGTGCCGTGACGGGGTTCGCCGTCGCGCTGGTCAGTGGCCGCTTCATCGACCGGTACGGCGCCCGCCGGGTGCT
CGTCGTCGCGGCGATGGCCGGTGTCGTCGGGTTCGTCCTGCTGGCCGTGGCACACGATCAGCCGTGGCAGGTGATCGTGG
CGGGGATCCTGGCCAACGCCTACATCAGCCTGGGTTACGGCGCGCTGCCTGCACTGGTCGTCGCCGAGGTCGAGGCGGGC
GAGACCGGCGTGGCGACCGGGATGAACGCGATCGCGCGGACGGTCGGCAGTTCTCTGGCCGCGGCCGTGGTCGCGGTGCT
GCTGGGCCGCACGGCGCCGGGCACTCAGGTGCCGTTGGAGAGCAGTTTCGTGGTCGTCTTCGTCGCGGGTGCCGTCACCG
CGGCGCTCGCACTGACACTGATCGCACTCACCCGCACCCGCCGACAGGTAGTGGACCCCGACGCCCTCGCCCAGTCACGG
GCGATGAACCACGAATGGGGTTAG

Upstream 100 bases:

>100_bases
GACGAGTCCAGCCCTCGTACCCCGCACCGCCGCCGGGCAATCTTGGGCGCCGCTGAGCTAGCGTCTAAGACGTCGAGATG
GTCTAACGATCGGAGTTCTG

Downstream 100 bases:

>100_bases
CGCAGCGACGCGAGGTTGCTCACCGATTTGCGCACGTCGGATTCGATGACTCTTGCGACCAGGGAACCGACCCGCGTGTT
GAGCAGGCCACCGGACAGGT

Product: major facilitator superfamily transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MVGTGVARSTTGTVRPALLVGGLSVVVLTVAVLQTAVVPVLGVIGDQLGASTVAVSWAVTANLLAAIAATPLLGRLADLY
SKKRVLLGVLVVVLIGSVLAAVTSSLPLLIVARVLQGASYALYPISVAVLREELPHGRLAGAMAVMSGTLGFGGGVGLVV
VGLLMSGDADYHRVFWLTTGFTVVVLAIVVFLVPARRRRAEGSIDWLGAVGLAAGLSALLLAITQGNAWGWGSGRTVACA
LGGAAALVAWWMWEKRRIHPLVSTRMLAKPAMLLTNLATIFVGMGLYFAFLGLTQFVQIPREAAGYGFGASVLQSSVVYL
LPGAVTGFAVALVSGRFIDRYGARRVLVVAAMAGVVGFVLLAVAHDQPWQVIVAGILANAYISLGYGALPALVVAEVEAG
ETGVATGMNAIARTVGSSLAAAVVAVLLGRTAPGTQVPLESSFVVVFVAGAVTAALALTLIALTRTRRQVVDPDALAQSR
AMNHEWG

Sequences:

>Translated_487_residues
MVGTGVARSTTGTVRPALLVGGLSVVVLTVAVLQTAVVPVLGVIGDQLGASTVAVSWAVTANLLAAIAATPLLGRLADLY
SKKRVLLGVLVVVLIGSVLAAVTSSLPLLIVARVLQGASYALYPISVAVLREELPHGRLAGAMAVMSGTLGFGGGVGLVV
VGLLMSGDADYHRVFWLTTGFTVVVLAIVVFLVPARRRRAEGSIDWLGAVGLAAGLSALLLAITQGNAWGWGSGRTVACA
LGGAAALVAWWMWEKRRIHPLVSTRMLAKPAMLLTNLATIFVGMGLYFAFLGLTQFVQIPREAAGYGFGASVLQSSVVYL
LPGAVTGFAVALVSGRFIDRYGARRVLVVAAMAGVVGFVLLAVAHDQPWQVIVAGILANAYISLGYGALPALVVAEVEAG
ETGVATGMNAIARTVGSSLAAAVVAVLLGRTAPGTQVPLESSFVVVFVAGAVTAALALTLIALTRTRRQVVDPDALAQSR
AMNHEWG
>Mature_487_residues
MVGTGVARSTTGTVRPALLVGGLSVVVLTVAVLQTAVVPVLGVIGDQLGASTVAVSWAVTANLLAAIAATPLLGRLADLY
SKKRVLLGVLVVVLIGSVLAAVTSSLPLLIVARVLQGASYALYPISVAVLREELPHGRLAGAMAVMSGTLGFGGGVGLVV
VGLLMSGDADYHRVFWLTTGFTVVVLAIVVFLVPARRRRAEGSIDWLGAVGLAAGLSALLLAITQGNAWGWGSGRTVACA
LGGAAALVAWWMWEKRRIHPLVSTRMLAKPAMLLTNLATIFVGMGLYFAFLGLTQFVQIPREAAGYGFGASVLQSSVVYL
LPGAVTGFAVALVSGRFIDRYGARRVLVVAAMAGVVGFVLLAVAHDQPWQVIVAGILANAYISLGYGALPALVVAEVEAG
ETGVATGMNAIARTVGSSLAAAVVAVLLGRTAPGTQVPLESSFVVVFVAGAVTAALALTLIALTRTRRQVVDPDALAQSR
AMNHEWG

Specific function: Resistance to tetracenomycin C by an active tetracenomycin C efflux system which is probably energized by transmembrane electrochemical gradients [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49940; Mature: 49940

Theoretical pI: Translated: 10.68; Mature: 10.68

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGTGVARSTTGTVRPALLVGGLSVVVLTVAVLQTAVVPVLGVIGDQLGASTVAVSWAVT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ANLLAAIAATPLLGRLADLYSKKRVLLGVLVVVLIGSVLAAVTSSLPLLIVARVLQGASY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCE
ALYPISVAVLREELPHGRLAGAMAVMSGTLGFGGGVGLVVVGLLMSGDADYHRVFWLTTG
EHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEHHH
FTVVVLAIVVFLVPARRRRAEGSIDWLGAVGLAAGLSALLLAITQGNAWGWGSGRTVACA
HHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
LGGAAALVAWWMWEKRRIHPLVSTRMLAKPAMLLTNLATIFVGMGLYFAFLGLTQFVQIP
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
REAAGYGFGASVLQSSVVYLLPGAVTGFAVALVSGRFIDRYGARRVLVVAAMAGVVGFVL
HHHCCCCCCHHHHHCCHHHHCCCHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHH
LAVAHDQPWQVIVAGILANAYISLGYGALPALVVAEVEAGETGVATGMNAIARTVGSSLA
HHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHH
AAVVAVLLGRTAPGTQVPLESSFVVVFVAGAVTAALALTLIALTRTRRQVVDPDALAQSR
HHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AMNHEWG
CCCCCCC
>Mature Secondary Structure
MVGTGVARSTTGTVRPALLVGGLSVVVLTVAVLQTAVVPVLGVIGDQLGASTVAVSWAVT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ANLLAAIAATPLLGRLADLYSKKRVLLGVLVVVLIGSVLAAVTSSLPLLIVARVLQGASY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCE
ALYPISVAVLREELPHGRLAGAMAVMSGTLGFGGGVGLVVVGLLMSGDADYHRVFWLTTG
EHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEHHH
FTVVVLAIVVFLVPARRRRAEGSIDWLGAVGLAAGLSALLLAITQGNAWGWGSGRTVACA
HHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
LGGAAALVAWWMWEKRRIHPLVSTRMLAKPAMLLTNLATIFVGMGLYFAFLGLTQFVQIP
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
REAAGYGFGASVLQSSVVYLLPGAVTGFAVALVSGRFIDRYGARRVLVVAAMAGVVGFVL
HHHCCCCCCHHHHHCCHHHHCCCHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHH
LAVAHDQPWQVIVAGILANAYISLGYGALPALVVAEVEAGETGVATGMNAIARTVGSSLA
HHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHH
AAVVAVLLGRTAPGTQVPLESSFVVVFVAGAVTAALALTLIALTRTRRQVVDPDALAQSR
HHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AMNHEWG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1592819 [H]