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The map label for this gene is ald [H]

Identifier: 119868186

GI number: 119868186

Start: 2272766

End: 2273881

Strand: Reverse

Name: ald [H]

Synonym: Mkms_2150

Alternate gene names: 119868186

Gene position: 2273881-2272766 (Counterclockwise)

Preceding gene: 119868188

Following gene: 119868179

Centisome position: 39.63

GC content: 67.29

Gene sequence:

>1116_bases
ATGCGCGTCGGGATCCCGACCGAGATCAAGAACAACGAGTACCGCGTCGCCATCACCCCTGCCGGGGTGGCGGAACTGAC
CAGCCGTGGACACGATGTGCTGATCCAATCCGGCGCAGGCGAAGGGTCGGCCATCTCTGATGCCGACTTCAAAGCGGCAG
GCGCCCAACTCATCGCGGGTGCGGACGAAGTGTGGGCCGAGGCGGACCTCCTGCTGAAGGTCAAGGAGCCGATCGAACCC
GAGTATTCCCGGATGCGGGAGGGCCAGACGCTGTTCACCTACCTGCACCTGGCCGCGTCCCAACCCTGCACGGACGCATT
GCTCGCATCCCGGACGACGTCGATCGCCTACGAGACCGTGCAGACCGCTGACGGTGCGCTGCCGCTGCTCGCGCCGATGA
GCGAGGTGGCCGGCCGGCTCTCCGCTCAGGTCGGTGCCTACCACCTGATGCGCACGCAGGGTGGCCGCGGCGTGCTGATG
GGCGGCGTCCCCGGCGTCGCCCCGGCCAAGGTCGTGGTCATCGGCGGCGGTATGGCCGGCGACAACGCCGCCGCTGTGGC
CTGGGGAATGGGCGCACACGTCACGGTGTTCGACGTCAACATCAACATCCTGCGCAAGATCGATGCCGAGTACGGCGGCG
CCATCGAGACCCGTTACTCCTCTCGCCTCGAACTGGAGGAGGCCGTCACGCAGGCCGACCTGGTGATCGGCGCCGTGCTG
ATCCCTGGAGCGAAAGCACCGAAGCTCGTCACCAATTCGACTGTGGCGCAGATGAAGTCGGGTGCAGTTCTGGTCGACAT
CGCGATCGACCAGGGCGGCTGCTTCGAGGACTCACGGCCCACCACACACGACGACCCGACGTTCAAGGTGCACGACGCGG
TCTTCTACTGCGTGGCCAACATGCCGGGTGCCGTGCCGCGCACCTCGACGTTTGCCCTCACCAACGCGACCATGCCCTAC
GTGCTCAAACTGGCCGACAAGGGCTGGCGCGCCGCATGCCAGGCCGACCCCGCACTGGCCAAGGGTCTGTCCACCCACGC
CGGTGCACTACTCAGCGAGCAGGTGGCCGCCGACCTCGACCTGCCCTTCACCGATCCGGCGACCGTCCTCGCCTGA

Upstream 100 bases:

>100_bases
TTCTTCGACCATCGGGTCAATATACCGAAGAGCCGTCATTACGATTGCGCTCAAGCCGACGTTTCTTCACAATTTTGGCA
CCACCTACTTGAGGAGAATC

Downstream 100 bases:

>100_bases
CCGTCATCCGAGGTCACCGTCGAGGTAGAACCAGCGCCGGGCGCGAACGGCGAACCGGGACCGCTCGTGGAGGGTCCCCG
TTCGCCGGCCCTGGCGGTAG

Product: L-alanine dehydrogenase

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MRVGIPTEIKNNEYRVAITPAGVAELTSRGHDVLIQSGAGEGSAISDADFKAAGAQLIAGADEVWAEADLLLKVKEPIEP
EYSRMREGQTLFTYLHLAASQPCTDALLASRTTSIAYETVQTADGALPLLAPMSEVAGRLSAQVGAYHLMRTQGGRGVLM
GGVPGVAPAKVVVIGGGMAGDNAAAVAWGMGAHVTVFDVNINILRKIDAEYGGAIETRYSSRLELEEAVTQADLVIGAVL
IPGAKAPKLVTNSTVAQMKSGAVLVDIAIDQGGCFEDSRPTTHDDPTFKVHDAVFYCVANMPGAVPRTSTFALTNATMPY
VLKLADKGWRAACQADPALAKGLSTHAGALLSEQVAADLDLPFTDPATVLA

Sequences:

>Translated_371_residues
MRVGIPTEIKNNEYRVAITPAGVAELTSRGHDVLIQSGAGEGSAISDADFKAAGAQLIAGADEVWAEADLLLKVKEPIEP
EYSRMREGQTLFTYLHLAASQPCTDALLASRTTSIAYETVQTADGALPLLAPMSEVAGRLSAQVGAYHLMRTQGGRGVLM
GGVPGVAPAKVVVIGGGMAGDNAAAVAWGMGAHVTVFDVNINILRKIDAEYGGAIETRYSSRLELEEAVTQADLVIGAVL
IPGAKAPKLVTNSTVAQMKSGAVLVDIAIDQGGCFEDSRPTTHDDPTFKVHDAVFYCVANMPGAVPRTSTFALTNATMPY
VLKLADKGWRAACQADPALAKGLSTHAGALLSEQVAADLDLPFTDPATVLA
>Mature_371_residues
MRVGIPTEIKNNEYRVAITPAGVAELTSRGHDVLIQSGAGEGSAISDADFKAAGAQLIAGADEVWAEADLLLKVKEPIEP
EYSRMREGQTLFTYLHLAASQPCTDALLASRTTSIAYETVQTADGALPLLAPMSEVAGRLSAQVGAYHLMRTQGGRGVLM
GGVPGVAPAKVVVIGGGMAGDNAAAVAWGMGAHVTVFDVNINILRKIDAEYGGAIETRYSSRLELEEAVTQADLVIGAVL
IPGAKAPKLVTNSTVAQMKSGAVLVDIAIDQGGCFEDSRPTTHDDPTFKVHDAVFYCVANMPGAVPRTSTFALTNATMPY
VLKLADKGWRAACQADPALAKGLSTHAGALLSEQVAADLDLPFTDPATVLA

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=308, Percent_Identity=34.0909090909091, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI122939153, Length=308, Percent_Identity=34.0909090909091, Blast_Score=149, Evalue=4e-36,
Organism=Escherichia coli, GI1787887, Length=350, Percent_Identity=31.1428571428571, Blast_Score=135, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17550456, Length=354, Percent_Identity=31.638418079096, Blast_Score=146, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 38626; Mature: 38626

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00836 ALADH_PNT_1 ; PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGIPTEIKNNEYRVAITPAGVAELTSRGHDVLIQSGAGEGSAISDADFKAAGAQLIAG
CCCCCCCCCCCCEEEEEECCCCHHHHHCCCCEEEEECCCCCCCCCCCCCHHHCCHHEECC
ADEVWAEADLLLKVKEPIEPEYSRMREGQTLFTYLHLAASQPCTDALLASRTTSIAYETV
CHHHHHCCEEEEEECCCCCHHHHHHHCCCCEEEHHHHHCCCCHHHHHHHHCHHHHHHHHH
QTADGALPLLAPMSEVAGRLSAQVGAYHLMRTQGGRGVLMGGVPGVAPAKVVVIGGGMAG
HHCCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEECCCCCCCCEEEEEEECCCCC
DNAAAVAWGMGAHVTVFDVNINILRKIDAEYGGAIETRYSSRLELEEAVTQADLVIGAVL
CCCEEEEECCCCEEEEEEECEEEEEEECHHHCCEEEECCCCCHHHHHHHHHHHHHEEEEE
IPGAKAPKLVTNSTVAQMKSGAVLVDIAIDQGGCFEDSRPTTHDDPTFKVHDAVFYCVAN
ECCCCCCCEECCCHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEHHEEEEEECC
MPGAVPRTSTFALTNATMPYVLKLADKGWRAACQADPALAKGLSTHAGALLSEQVAADLD
CCCCCCCCCEEEEECCCCCEEEEECCCCCHHHHCCCHHHHHCCCHHHHHHHHHHHHHCCC
LPFTDPATVLA
CCCCCCHHHCC
>Mature Secondary Structure
MRVGIPTEIKNNEYRVAITPAGVAELTSRGHDVLIQSGAGEGSAISDADFKAAGAQLIAG
CCCCCCCCCCCCEEEEEECCCCHHHHHCCCCEEEEECCCCCCCCCCCCCHHHCCHHEECC
ADEVWAEADLLLKVKEPIEPEYSRMREGQTLFTYLHLAASQPCTDALLASRTTSIAYETV
CHHHHHCCEEEEEECCCCCHHHHHHHCCCCEEEHHHHHCCCCHHHHHHHHCHHHHHHHHH
QTADGALPLLAPMSEVAGRLSAQVGAYHLMRTQGGRGVLMGGVPGVAPAKVVVIGGGMAG
HHCCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEECCCCCCCCEEEEEEECCCCC
DNAAAVAWGMGAHVTVFDVNINILRKIDAEYGGAIETRYSSRLELEEAVTQADLVIGAVL
CCCEEEEECCCCEEEEEEECEEEEEEECHHHCCEEEECCCCCHHHHHHHHHHHHHEEEEE
IPGAKAPKLVTNSTVAQMKSGAVLVDIAIDQGGCFEDSRPTTHDDPTFKVHDAVFYCVAN
ECCCCCCCEECCCHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEHHEEEEEECC
MPGAVPRTSTFALTNATMPYVLKLADKGWRAACQADPALAKGLSTHAGALLSEQVAADLD
CCCCCCCCCEEEEECCCCCEEEEECCCCCHHHHCCCHHHHHCCCHHHHHHHHHHHHHCCC
LPFTDPATVLA
CCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]