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The map label for this gene is echA8 [H]

Identifier: 119868170

GI number: 119868170

Start: 2258209

End: 2258976

Strand: Reverse

Name: echA8 [H]

Synonym: Mkms_2134

Alternate gene names: 119868170

Gene position: 2258976-2258209 (Counterclockwise)

Preceding gene: 119868173

Following gene: 119868168

Centisome position: 39.37

GC content: 70.7

Gene sequence:

>768_bases
ATGAGTAACGCTGACACCCCTGACGTCCTGGCGATCGAGACCACCGATCGGGTCCGCACCCTGACACTGAACCGGCCGCA
GGCCCGCAATGCGTTGTCCAAGGCACTGCGGGAGGCGTTCTTCACCGCATTGCGGAATGCGGAGTACGACGACGACGTCG
ACGTGGTGATCGTGACCGGCGCGGACCCGGTGTTCTGCGCGGGCCTGGACCTCAAGGAACTCGGCGACCAGACCCAGTTG
CCGGACATCTCCCCGAAGTGGCCGTCGATGACCAAACCGGTCATCGGCGCGATCAACGGTGCGGCGGTGACCGGCGGGCT
GGAACTCGCGCTGTACTGCGACATCCTGATCGCCTCGGAGCAGGCCCGCTTCGCCGACACCCACGCCCGGGTGGGCCTGC
TGCCGACCTGGGGCCTCTCGGTGCGCCTGCCGCAGAAGGTGGGCGTCGGCATGGCCCGGCGGATGAGCCTGACCGGGGAC
TACCTGTCGGCGACCGACGCGTTGCGGGCCGGCCTGGTCACCGAGGTCGTCCCCCACGCCGAACTGCTGCCCACCGCGCG
GGCGATCGCCGCGTCCATCGTCGGCAACAACCAGCGTGCGGTGCGCTCGCTGCTGGAGTCCTACCACCGCATCGACGAGT
CCCAGACCGCGGGCGCGTTGTGGCTGGAGGCCGACGCCGCGCGCCGGTGGATGGCGTCGGCCACCGGCGACGACATCGCC
GCCAACCGCGCCGCGGTGTTGGAGCGGGGCCGCGCCCAGGTGCGCTGA

Upstream 100 bases:

>100_bases
TCGATCTCCTCAGCCGTCGCCGCCGGCTCCAGGCCGCGCAGCTCGGTGATGTTTCGGCACATGACAGCCACGATAGGCGC
GGCGGCTACCGTCTAGCACC

Downstream 100 bases:

>100_bases
CCCGGCGGGCCCCCTAGGTGTGTTCGGCCGCGAGCTCCTCGACGCTCATCCCGTCGACGAGACGGTCCAGCGCGCCGATC
ATCGTCGGACATTCCCGGGC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MSNADTPDVLAIETTDRVRTLTLNRPQARNALSKALREAFFTALRNAEYDDDVDVVIVTGADPVFCAGLDLKELGDQTQL
PDISPKWPSMTKPVIGAINGAAVTGGLELALYCDILIASEQARFADTHARVGLLPTWGLSVRLPQKVGVGMARRMSLTGD
YLSATDALRAGLVTEVVPHAELLPTARAIAASIVGNNQRAVRSLLESYHRIDESQTAGALWLEADAARRWMASATGDDIA
ANRAAVLERGRAQVR

Sequences:

>Translated_255_residues
MSNADTPDVLAIETTDRVRTLTLNRPQARNALSKALREAFFTALRNAEYDDDVDVVIVTGADPVFCAGLDLKELGDQTQL
PDISPKWPSMTKPVIGAINGAAVTGGLELALYCDILIASEQARFADTHARVGLLPTWGLSVRLPQKVGVGMARRMSLTGD
YLSATDALRAGLVTEVVPHAELLPTARAIAASIVGNNQRAVRSLLESYHRIDESQTAGALWLEADAARRWMASATGDDIA
ANRAAVLERGRAQVR
>Mature_254_residues
SNADTPDVLAIETTDRVRTLTLNRPQARNALSKALREAFFTALRNAEYDDDVDVVIVTGADPVFCAGLDLKELGDQTQLP
DISPKWPSMTKPVIGAINGAAVTGGLELALYCDILIASEQARFADTHARVGLLPTWGLSVRLPQKVGVGMARRMSLTGDY
LSATDALRAGLVTEVVPHAELLPTARAIAASIVGNNQRAVRSLLESYHRIDESQTAGALWLEADAARRWMASATGDDIAA
NRAAVLERGRAQVR

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=248, Percent_Identity=35.0806451612903, Blast_Score=130, Evalue=8e-31,
Organism=Homo sapiens, GI31542718, Length=191, Percent_Identity=33.5078534031414, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI70995211, Length=232, Percent_Identity=30.6034482758621, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI37594469, Length=257, Percent_Identity=25.6809338521401, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI37594471, Length=257, Percent_Identity=25.6809338521401, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI20127408, Length=174, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI116235487, Length=226, Percent_Identity=28.3185840707965, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI45643119, Length=250, Percent_Identity=24.8, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI260275230, Length=250, Percent_Identity=24.8, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI260274832, Length=250, Percent_Identity=24.8, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4502327, Length=192, Percent_Identity=30.7291666666667, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI25453481, Length=166, Percent_Identity=27.710843373494, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI51538573, Length=166, Percent_Identity=27.710843373494, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI4757966, Length=166, Percent_Identity=27.710843373494, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI51538581, Length=166, Percent_Identity=27.710843373494, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI68989263, Length=152, Percent_Identity=31.5789473684211, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787659, Length=211, Percent_Identity=35.5450236966825, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI221142681, Length=205, Percent_Identity=34.1463414634146, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1788597, Length=210, Percent_Identity=32.8571428571429, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787660, Length=186, Percent_Identity=34.4086021505376, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788682, Length=189, Percent_Identity=30.6878306878307, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790281, Length=186, Percent_Identity=25.8064516129032, Blast_Score=64, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI25145438, Length=216, Percent_Identity=34.2592592592593, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17554946, Length=221, Percent_Identity=30.316742081448, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17540714, Length=185, Percent_Identity=36.7567567567568, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17560910, Length=169, Percent_Identity=34.3195266272189, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17535521, Length=254, Percent_Identity=27.5590551181102, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17549921, Length=195, Percent_Identity=31.2820512820513, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17534483, Length=204, Percent_Identity=28.4313725490196, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17540306, Length=192, Percent_Identity=29.6875, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17536985, Length=261, Percent_Identity=24.904214559387, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320241, Length=198, Percent_Identity=27.7777777777778, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20129971, Length=213, Percent_Identity=33.8028169014084, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24653477, Length=213, Percent_Identity=33.8028169014084, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21357171, Length=206, Percent_Identity=30.0970873786408, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24653139, Length=174, Percent_Identity=32.183908045977, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24650670, Length=192, Percent_Identity=32.2916666666667, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19922422, Length=218, Percent_Identity=27.9816513761468, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19920382, Length=213, Percent_Identity=28.169014084507, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24654903, Length=184, Percent_Identity=23.3695652173913, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27371; Mature: 27240

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNADTPDVLAIETTDRVRTLTLNRPQARNALSKALREAFFTALRNAEYDDDVDVVIVTG
CCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEC
ADPVFCAGLDLKELGDQTQLPDISPKWPSMTKPVIGAINGAAVTGGLELALYCDILIASE
CCCEEEECCCHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCEEECCEEEEEEEEEHEECC
QARFADTHARVGLLPTWGLSVRLPQKVGVGMARRMSLTGDYLSATDALRAGLVTEVVPHA
CHHHHHHHCCEECCCCCCCEEECCHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCH
ELLPTARAIAASIVGNNQRAVRSLLESYHRIDESQTAGALWLEADAARRWMASATGDDIA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHCCCCCHH
ANRAAVLERGRAQVR
HHHHHHHHCCHHCCC
>Mature Secondary Structure 
SNADTPDVLAIETTDRVRTLTLNRPQARNALSKALREAFFTALRNAEYDDDVDVVIVTG
CCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEC
ADPVFCAGLDLKELGDQTQLPDISPKWPSMTKPVIGAINGAAVTGGLELALYCDILIASE
CCCEEEECCCHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCEEECCEEEEEEEEEHEECC
QARFADTHARVGLLPTWGLSVRLPQKVGVGMARRMSLTGDYLSATDALRAGLVTEVVPHA
CHHHHHHHCCEECCCCCCCEEECCHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCH
ELLPTARAIAASIVGNNQRAVRSLLESYHRIDESQTAGALWLEADAARRWMASATGDDIA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHCCCCCHH
ANRAAVLERGRAQVR
HHHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]