| Definition | Mycobacterium sp. KMS chromosome, complete genome. |
|---|---|
| Accession | NC_008705 |
| Length | 5,737,227 |
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The map label for this gene is kduD [C]
Identifier: 119867841
GI number: 119867841
Start: 1911996
End: 1912814
Strand: Reverse
Name: kduD [C]
Synonym: Mkms_1802
Alternate gene names: 119867841
Gene position: 1912814-1911996 (Counterclockwise)
Preceding gene: 119867842
Following gene: 119867836
Centisome position: 33.34
GC content: 69.35
Gene sequence:
>819_bases ATGACCGGCCGCCTCGCAGGCAAGGTCGCCTTCATCACCGGCGCGGCCCGCGGCCAGGGGCGTGCGCACGCCGAGCGCCT GGCGACCGAGGGTGCCGACATCATCGCCGTAGACATCGCGGGCAAGCTGCCGGACTGCGTCCCGTACGACCATTCGACAC CGGAGGACCTCGCCGAGACCGTGTCGCTGGTCGAGGCGACCGGCCGCAGGATCCTGGCTTCGGTGGTCGACACCCGCGAC CACGATGCCCTGCGGGAGACGGTCGATGCCGGGGTCGCCGAACTGGGCCGCCTCGACGTCATCGTCGCCAACGCGGGTAT CACCGCACCGCAGGCGTGGAACACCATCACACCGGCGGACTTCCGCGACGTCACCGACGTCAACATCACCGGCACCTGGA ACACCGTGATGGCCGGCGCACAGCACATCGTCGACGGCGACCGAGGCGGTTCCATCATCCTGATCAGTTCGGCCGCGGGC CTGAAGATGCAGCCGTTCATGGTGCACTACACCGCCAGCAAGCACGCCGTCACCGGGATGGCGCGGGCGTTCGCCGCCGA ACTCGGCAAGCATCGGATCCGGGTCAACAGCGTGCATCCCGGCGCGGTCGCCACCCCGATGGGCACCGGGGACATGGTCG AGGGGCTGATGCGCGCCGACGCCGCCAACCCCGGCTTGATGAACATGGTCACCCCGTTCATCCAGGACATCGCGCAACCG GAGGACATCGCCGACGCGGTGGCGTGGCTGGCCAGCGACGAATCGCGGTTCGTCACGGCCGCGGCGATCGCCGTCGACTG CGGGTCTACCCAGTTCTGA
Upstream 100 bases:
>100_bases ACGTCAGGCTGCTGCGACTCTACGAGGGCACCAGCGAGATCCAGCGCCTGATCATCGGCGGCGCACTGGTGAAGGCCGCG CAGCGGACGGCGGCGAACTC
Downstream 100 bases:
>100_bases CGGTCCGGGCCGGCGACCGCTGCGCGAACACCCGGGTGAGGAATGCCGCCTGGTCCGTCGCAGCCCTGTCGTGCCAGTCG TGGCCGGGCCAGACGTCGAA
Product: short-chain dehydrogenase/reductase SDR
Products: @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate!; NADH. [C]
Alternate protein names: NA
Number of amino acids: Translated: 272; Mature: 271
Protein sequence:
>272_residues MTGRLAGKVAFITGAARGQGRAHAERLATEGADIIAVDIAGKLPDCVPYDHSTPEDLAETVSLVEATGRRILASVVDTRD HDALRETVDAGVAELGRLDVIVANAGITAPQAWNTITPADFRDVTDVNITGTWNTVMAGAQHIVDGDRGGSIILISSAAG LKMQPFMVHYTASKHAVTGMARAFAAELGKHRIRVNSVHPGAVATPMGTGDMVEGLMRADAANPGLMNMVTPFIQDIAQP EDIADAVAWLASDESRFVTAAAIAVDCGSTQF
Sequences:
>Translated_272_residues MTGRLAGKVAFITGAARGQGRAHAERLATEGADIIAVDIAGKLPDCVPYDHSTPEDLAETVSLVEATGRRILASVVDTRD HDALRETVDAGVAELGRLDVIVANAGITAPQAWNTITPADFRDVTDVNITGTWNTVMAGAQHIVDGDRGGSIILISSAAG LKMQPFMVHYTASKHAVTGMARAFAAELGKHRIRVNSVHPGAVATPMGTGDMVEGLMRADAANPGLMNMVTPFIQDIAQP EDIADAVAWLASDESRFVTAAAIAVDCGSTQF >Mature_271_residues TGRLAGKVAFITGAARGQGRAHAERLATEGADIIAVDIAGKLPDCVPYDHSTPEDLAETVSLVEATGRRILASVVDTRDH DALRETVDAGVAELGRLDVIVANAGITAPQAWNTITPADFRDVTDVNITGTWNTVMAGAQHIVDGDRGGSIILISSAAGL KMQPFMVHYTASKHAVTGMARAFAAELGKHRIRVNSVHPGAVATPMGTGDMVEGLMRADAANPGLMNMVTPFIQDIAQPE DIADAVAWLASDESRFVTAAAIAVDCGSTQF
Specific function: Unknown
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=280, Percent_Identity=33.2142857142857, Blast_Score=111, Evalue=8e-25, Organism=Homo sapiens, GI10190704, Length=272, Percent_Identity=33.0882352941176, Blast_Score=105, Evalue=5e-23, Organism=Homo sapiens, GI31542939, Length=204, Percent_Identity=34.8039215686275, Blast_Score=88, Evalue=9e-18, Organism=Homo sapiens, GI4504505, Length=250, Percent_Identity=27.6, Blast_Score=80, Evalue=3e-15, Organism=Homo sapiens, GI4758504, Length=271, Percent_Identity=30.2583025830258, Blast_Score=78, Evalue=1e-14, Organism=Homo sapiens, GI32483357, Length=272, Percent_Identity=25, Blast_Score=75, Evalue=4e-14, Organism=Homo sapiens, GI40254986, Length=208, Percent_Identity=33.1730769230769, Blast_Score=75, Evalue=5e-14, Organism=Homo sapiens, GI224922801, Length=182, Percent_Identity=34.0659340659341, Blast_Score=75, Evalue=6e-14, Organism=Homo sapiens, GI4503301, Length=272, Percent_Identity=25.3676470588235, Blast_Score=75, Evalue=9e-14, Organism=Homo sapiens, GI59889578, Length=196, Percent_Identity=29.0816326530612, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI7705925, Length=264, Percent_Identity=26.8939393939394, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI40254992, Length=263, Percent_Identity=28.1368821292776, Blast_Score=73, Evalue=4e-13, Organism=Homo sapiens, GI19923817, Length=279, Percent_Identity=23.6559139784946, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI5031737, Length=281, Percent_Identity=24.1992882562278, Blast_Score=66, Evalue=3e-11, Organism=Escherichia coli, GI1789208, Length=271, Percent_Identity=32.8413284132841, Blast_Score=115, Evalue=2e-27, Organism=Escherichia coli, GI87082100, Length=275, Percent_Identity=30.9090909090909, Blast_Score=113, Evalue=1e-26, Organism=Escherichia coli, GI1787335, Length=263, Percent_Identity=30.0380228136882, Blast_Score=100, Evalue=1e-22, Organism=Escherichia coli, GI1788459, Length=261, Percent_Identity=29.5019157088123, Blast_Score=93, Evalue=2e-20, Organism=Escherichia coli, GI2367365, Length=267, Percent_Identity=30.7116104868914, Blast_Score=91, Evalue=7e-20, Organism=Escherichia coli, GI1787905, Length=268, Percent_Identity=29.4776119402985, Blast_Score=90, Evalue=1e-19, Organism=Escherichia coli, GI87082160, Length=266, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=8e-19, Organism=Escherichia coli, GI1789378, Length=270, Percent_Identity=29.6296296296296, Blast_Score=84, Evalue=1e-17, Organism=Escherichia coli, GI1790717, Length=264, Percent_Identity=29.5454545454545, Blast_Score=81, Evalue=6e-17, Organism=Escherichia coli, GI2367175, Length=261, Percent_Identity=29.1187739463602, Blast_Score=79, Evalue=3e-16, Organism=Escherichia coli, GI1786812, Length=272, Percent_Identity=27.9411764705882, Blast_Score=75, Evalue=7e-15, Organism=Escherichia coli, GI1787526, Length=267, Percent_Identity=27.7153558052434, Blast_Score=69, Evalue=4e-13, Organism=Escherichia coli, GI1788891, Length=268, Percent_Identity=28.7313432835821, Blast_Score=67, Evalue=1e-12, Organism=Caenorhabditis elegans, GI193204405, Length=285, Percent_Identity=29.8245614035088, Blast_Score=96, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17559104, Length=275, Percent_Identity=31.6363636363636, Blast_Score=93, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17562906, Length=286, Percent_Identity=29.7202797202797, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17562908, Length=284, Percent_Identity=28.5211267605634, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17531453, Length=285, Percent_Identity=28.0701754385965, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17561402, Length=268, Percent_Identity=27.2388059701493, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI25147288, Length=272, Percent_Identity=29.0441176470588, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17562904, Length=282, Percent_Identity=27.6595744680851, Blast_Score=87, Evalue=9e-18, Organism=Caenorhabditis elegans, GI17560220, Length=285, Percent_Identity=30.1754385964912, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17536025, Length=272, Percent_Identity=28.6764705882353, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17555706, Length=279, Percent_Identity=27.2401433691756, Blast_Score=84, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17560150, Length=272, Percent_Identity=28.3088235294118, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17562910, Length=278, Percent_Identity=26.6187050359712, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17560676, Length=269, Percent_Identity=23.7918215613383, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17536651, Length=272, Percent_Identity=25.7352941176471, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17562990, Length=282, Percent_Identity=27.6595744680851, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI17544670, Length=292, Percent_Identity=26.7123287671233, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI115534694, Length=263, Percent_Identity=30.0380228136882, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17568967, Length=235, Percent_Identity=26.8085106382979, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI72000259, Length=273, Percent_Identity=28.2051282051282, Blast_Score=74, Evalue=5e-14, Organism=Caenorhabditis elegans, GI17563726, Length=277, Percent_Identity=25.9927797833935, Blast_Score=74, Evalue=6e-14, Organism=Caenorhabditis elegans, GI17561272, Length=270, Percent_Identity=27.037037037037, Blast_Score=73, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17560332, Length=280, Percent_Identity=28.2142857142857, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17567345, Length=215, Percent_Identity=27.4418604651163, Blast_Score=71, Evalue=7e-13, Organism=Caenorhabditis elegans, GI71994604, Length=271, Percent_Identity=26.1992619926199, Blast_Score=70, Evalue=8e-13, Organism=Caenorhabditis elegans, GI17538480, Length=286, Percent_Identity=27.6223776223776, Blast_Score=70, Evalue=8e-13, Organism=Caenorhabditis elegans, GI17538182, Length=212, Percent_Identity=32.5471698113208, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17538486, Length=275, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=5e-12, Organism=Caenorhabditis elegans, GI71994600, Length=270, Percent_Identity=27.037037037037, Blast_Score=67, Evalue=9e-12, Organism=Caenorhabditis elegans, GI71982365, Length=201, Percent_Identity=24.8756218905473, Blast_Score=67, Evalue=1e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=265, Percent_Identity=27.1698113207547, Blast_Score=95, Evalue=2e-20, Organism=Saccharomyces cerevisiae, GI6322861, Length=262, Percent_Identity=28.2442748091603, Blast_Score=82, Evalue=7e-17, Organism=Saccharomyces cerevisiae, GI6323882, Length=262, Percent_Identity=27.0992366412214, Blast_Score=63, Evalue=5e-11, Organism=Drosophila melanogaster, GI24643142, Length=266, Percent_Identity=30.8270676691729, Blast_Score=99, Evalue=3e-21, Organism=Drosophila melanogaster, GI24639444, Length=268, Percent_Identity=31.7164179104478, Blast_Score=97, Evalue=1e-20, Organism=Drosophila melanogaster, GI24644339, Length=272, Percent_Identity=29.0441176470588, Blast_Score=87, Evalue=9e-18, Organism=Drosophila melanogaster, GI28571526, Length=265, Percent_Identity=28.6792452830189, Blast_Score=84, Evalue=8e-17, Organism=Drosophila melanogaster, GI23397609, Length=271, Percent_Identity=30.6273062730627, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI21357041, Length=263, Percent_Identity=29.277566539924, Blast_Score=80, Evalue=1e-15, Organism=Drosophila melanogaster, GI21355319, Length=271, Percent_Identity=26.5682656826568, Blast_Score=78, Evalue=6e-15, Organism=Drosophila melanogaster, GI17737361, Length=211, Percent_Identity=31.7535545023697, Blast_Score=78, Evalue=8e-15, Organism=Drosophila melanogaster, GI24644337, Length=174, Percent_Identity=30.4597701149425, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI21357673, Length=201, Percent_Identity=28.3582089552239, Blast_Score=75, Evalue=4e-14, Organism=Drosophila melanogaster, GI18859837, Length=266, Percent_Identity=25.5639097744361, Blast_Score=71, Evalue=8e-13, Organism=Drosophila melanogaster, GI24649181, Length=275, Percent_Identity=27.6363636363636, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI281364892, Length=209, Percent_Identity=29.6650717703349, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI24663911, Length=256, Percent_Identity=27.34375, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI24641232, Length=212, Percent_Identity=28.7735849056604, Blast_Score=67, Evalue=9e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.125 [C]
Molecular weight: Translated: 28424; Mature: 28293
Theoretical pI: Translated: 4.82; Mature: 4.82
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 3.7 %Met (Translated Protein) 4.4 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 3.3 %Met (Mature Protein) 4.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTGRLAGKVAFITGAARGQGRAHAERLATEGADIIAVDIAGKLPDCVPYDHSTPEDLAET CCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHH VSLVEATGRRILASVVDTRDHDALRETVDAGVAELGRLDVIVANAGITAPQAWNTITPAD HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCC FRDVTDVNITGTWNTVMAGAQHIVDGDRGGSIILISSAAGLKMQPFMVHYTASKHAVTGM CCCCCEEEEECCHHHHHHHHHHHCCCCCCCEEEEEECCCCCEECCEEEEEECCHHHHHHH ARAFAAELGKHRIRVNSVHPGAVATPMGTGDMVEGLMRADAANPGLMNMVTPFIQDIAQP HHHHHHHHHHCEEEEECCCCCCEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC EDIADAVAWLASDESRFVTAAAIAVDCGSTQF HHHHHHHHHHHCCCCCEEEEEEEEEECCCCCC >Mature Secondary Structure TGRLAGKVAFITGAARGQGRAHAERLATEGADIIAVDIAGKLPDCVPYDHSTPEDLAET CCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHH VSLVEATGRRILASVVDTRDHDALRETVDAGVAELGRLDVIVANAGITAPQAWNTITPAD HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCC FRDVTDVNITGTWNTVMAGAQHIVDGDRGGSIILISSAAGLKMQPFMVHYTASKHAVTGM CCCCCEEEEECCHHHHHHHHHHHCCCCCCCEEEEEECCCCCEECCEEEEEECCHHHHHHH ARAFAAELGKHRIRVNSVHPGAVATPMGTGDMVEGLMRADAANPGLMNMVTPFIQDIAQP HHHHHHHHHHCEEEEECCCCCCEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC EDIADAVAWLASDESRFVTAAAIAVDCGSTQF HHHHHHHHHHHCCCCCEEEEEEEEEECCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NAD+ [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 15.4 {2-deoxygluconate}} [C]
Substrates: @DEOX03.txt*2-Deoxy-D-Gluconate!; NAD(+) [C]
Specific reaction: @DEOX03.txt*2-Deoxy-D-Gluconate! + NAD(+) = @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate! + NADH. [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA