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The map label for this gene is hisN [H]

Identifier: 119867674

GI number: 119867674

Start: 1744689

End: 1745486

Strand: Reverse

Name: hisN [H]

Synonym: Mkms_1629

Alternate gene names: 119867674

Gene position: 1745486-1744689 (Counterclockwise)

Preceding gene: 119867676

Following gene: 119867673

Centisome position: 30.42

GC content: 69.17

Gene sequence:

>798_bases
ATGAGCACCGGTTCCTCCAGCGTGGCCGACGATCTGGCGTTGGCGTTGCGGCTCGCCGACCATGCCGACGCCGTCACCGT
CGACCGGTTCCGCGCACTGGACCTCCACGTCGAGACCAAACCCGATCTCACGCCCGTGACCGACGCCGACCGTTCCGTGG
AGAACGATCTGCGGCGCGCACTCGCCGGGGAGCGCGGCGACGACTCGGTCCTCGGTGAAGAGTTCGGTGGCACAGCTGTT
TTCAGCGGCCGGCAGTGGGTGATCGACCCGATCGACGGGACGAAGAACTTCGTGCGGGGTGTCCCGATCTGGGCGACGCT
GATCTCGCTGCTGAACGACGGGGTGCCGGTGGTCGGCGTGGTCAGTGCGCCAGCCCTGCACCGTCGCTGGTGGGCGGCCG
ATGGGCTGGGCGCCTTCGTCACGGTCTCCGGCGAGTCGCCGCGGCGGCTGTCGGTGTCGAAGGTGGCCGAACTGGATTCG
GCCAGCCTGTCGTTCTCCAGCCTGTCCGGGTGGGCCAAGCGCGGTCTGCGAGACCGATTCATCGACCTCACGGACGCCGT
CTGGCGCGTCCGAGGGTTCGGCGACTTCTTCTCCTACTGCCTGTTGGCCGAGGGGGCGGTGGACATCGCGGCCGAACCCG
AGGTGTCGCTGTGGGATCTGGCCGCGATCGACATTCTCGTGCGCGAGGCCGGTGGGACGTTCACGAATCTCGACGGCGCG
GCGGGTCCGCACGGAGGCAGCGTGGTCGCCTCCAACGGCCTGCTCCACGACGCGGCGCTGGGCCACCTCTCGCGTTAA

Upstream 100 bases:

>100_bases
GGCTCCGCATGATCCACGGCGCGGCCAGCACGGCGATCGCCCCGATCAACAACAGGAGCACAGCGAATTCCCACACACGG
CCATGGTAGGACTTGCAGAC

Downstream 100 bases:

>100_bases
GGGGACTTTCTCTCGCGTTAAGGGGACTTTCCGGGGCCCTCGGCCACTGCATCCACAGCACTCTGCCCTTCGGTGAACAG
GTGTGAACTAACTAACACGC

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MSTGSSSVADDLALALRLADHADAVTVDRFRALDLHVETKPDLTPVTDADRSVENDLRRALAGERGDDSVLGEEFGGTAV
FSGRQWVIDPIDGTKNFVRGVPIWATLISLLNDGVPVVGVVSAPALHRRWWAADGLGAFVTVSGESPRRLSVSKVAELDS
ASLSFSSLSGWAKRGLRDRFIDLTDAVWRVRGFGDFFSYCLLAEGAVDIAAEPEVSLWDLAAIDILVREAGGTFTNLDGA
AGPHGGSVVASNGLLHDAALGHLSR

Sequences:

>Translated_265_residues
MSTGSSSVADDLALALRLADHADAVTVDRFRALDLHVETKPDLTPVTDADRSVENDLRRALAGERGDDSVLGEEFGGTAV
FSGRQWVIDPIDGTKNFVRGVPIWATLISLLNDGVPVVGVVSAPALHRRWWAADGLGAFVTVSGESPRRLSVSKVAELDS
ASLSFSSLSGWAKRGLRDRFIDLTDAVWRVRGFGDFFSYCLLAEGAVDIAAEPEVSLWDLAAIDILVREAGGTFTNLDGA
AGPHGGSVVASNGLLHDAALGHLSR
>Mature_264_residues
STGSSSVADDLALALRLADHADAVTVDRFRALDLHVETKPDLTPVTDADRSVENDLRRALAGERGDDSVLGEEFGGTAVF
SGRQWVIDPIDGTKNFVRGVPIWATLISLLNDGVPVVGVVSAPALHRRWWAADGLGAFVTVSGESPRRLSVSKVAELDSA
SLSFSSLSGWAKRGLRDRFIDLTDAVWRVRGFGDFFSYCLLAEGAVDIAAEPEVSLWDLAAIDILVREAGGTFTNLDGAA
GPHGGSVVASNGLLHDAALGHLSR

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1788882, Length=271, Percent_Identity=27.3062730627306, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI193202570, Length=241, Percent_Identity=30.2904564315353, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193202572, Length=238, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320493, Length=204, Percent_Identity=30.8823529411765, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24664922, Length=249, Percent_Identity=26.9076305220884, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21357329, Length=210, Percent_Identity=30.952380952381, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24664918, Length=212, Percent_Identity=28.7735849056604, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664926, Length=205, Percent_Identity=27.8048780487805, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357957, Length=238, Percent_Identity=26.890756302521, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28062; Mature: 27930

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGSSSVADDLALALRLADHADAVTVDRFRALDLHVETKPDLTPVTDADRSVENDLRRA
CCCCCCHHHHHHHHHHHHHCCCCCEEHHHEEEEEEEEECCCCCCCCCCCHHHHHHHHHHH
LAGERGDDSVLGEEFGGTAVFSGRQWVIDPIDGTKNFVRGVPIWATLISLLNDGVPVVGV
HCCCCCCCCHHHHHCCCEEEECCCEEEEECCCCCHHHHCCCCHHHHHHHHHHCCCCEEEE
VSAPALHRRWWAADGLGAFVTVSGESPRRLSVSKVAELDSASLSFSSLSGWAKRGLRDRF
ECCCHHHHHHHCCCCCCEEEEECCCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHCHHHHH
IDLTDAVWRVRGFGDFFSYCLLAEGAVDIAAEPEVSLWDLAAIDILVREAGGTFTNLDGA
HHHHHHHHHHHCHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEECCCCC
AGPHGGSVVASNGLLHDAALGHLSR
CCCCCCCEEECCCCCHHHHHHHCCC
>Mature Secondary Structure 
STGSSSVADDLALALRLADHADAVTVDRFRALDLHVETKPDLTPVTDADRSVENDLRRA
CCCCCHHHHHHHHHHHHHCCCCCEEHHHEEEEEEEEECCCCCCCCCCCHHHHHHHHHHH
LAGERGDDSVLGEEFGGTAVFSGRQWVIDPIDGTKNFVRGVPIWATLISLLNDGVPVVGV
HCCCCCCCCHHHHHCCCEEEECCCEEEEECCCCCHHHHCCCCHHHHHHHHHHCCCCEEEE
VSAPALHRRWWAADGLGAFVTVSGESPRRLSVSKVAELDSASLSFSSLSGWAKRGLRDRF
ECCCHHHHHHHCCCCCCEEEEECCCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHCHHHHH
IDLTDAVWRVRGFGDFFSYCLLAEGAVDIAAEPEVSLWDLAAIDILVREAGGTFTNLDGA
HHHHHHHHHHHCHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEECCCCC
AGPHGGSVVASNGLLHDAALGHLSR
CCCCCCCEEECCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]