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The map label for this gene is nuoL [H]

Identifier: 119867636

GI number: 119867636

Start: 1706563

End: 1708491

Strand: Reverse

Name: nuoL [H]

Synonym: Mkms_1590

Alternate gene names: 119867636

Gene position: 1708491-1706563 (Counterclockwise)

Preceding gene: 119867637

Following gene: 119867635

Centisome position: 29.78

GC content: 69.26

Gene sequence:

>1929_bases
ATGAGCACAGCGGTGTGGCTGCTGATCGCGCTGCCGCTGGCCGGTGCCGTGGTCCTGCTGCTGGCCGGGCGACGGTCGGA
CCGGTGGGGACACCTGCTGGGCACCGCCGCGGCGGTGGCCTCGTTCGTGGTCGGCGTGGTGCTGTTCGCCGGCATGCTCG
GCCGTCCCGCCGAGGACCGGGCCGTCCACGAGACCCTGTTCTCCTGGGTGCCGGTCGGCGACCTGCAGGTCGACTTCGGC
CTGCAACTCGACCAGTTGTCGATGTGCTTCGTGCTGTTGATCACCGGGGTCGGCTCGCTGATCCACGTGTACTCGATCGG
TTACATGGCACCGGGAGCGCAGCTTGCGGAGCGACCCACAGACACAGGCCCGAGTCGTCGACTTTTCTTCGCCTACCTCA
ACCTGTTCCTGGCCGCGATGCTGCTGCTCGTCCTCGCCGACAACTACCTCGGGCTCTACGTGGGCTGGGAGGGTGTCGGC
CTGGCGTCGTACCTGCTGATCGGCTTCTGGTCGTACAAACCGTCGGCGGCCACCGCGGCGAAGAAGGCCTTCGTCGTCAA
CCGCGTCGGCGACATGGGTCTGGCGATCGCGCTGATGATCATGTTCGCCACCGTCGGATCGGTGTCGTTCGCCGGGGTGT
TCGGCGCCGCACCGCAACTCGGCGAGGGCACGCTCACCGCGATCGGGCTGCTGCTGCTGCTCGGCGCGTGCGGTAAATCC
GCGCAGGTACCGCTGCAGTCCTGGCTGGGTGACGCGATGGAGGGCCCGACACCGGTGTCGGCGCTCATCCACGCGGCCAC
GATGGTCACCGCGGGCGTGTACCTGATCGTGCGCTCCGGCCCGGTCTTCGACCTGGCGCCGACCGCGCAGCTGGCCGTCG
TCATCGTCGGCACCGTCACGCTGCTGTTCGGCGCGATCATCGGCTGCGCCAAGGACGACATCAAGAAGGCGCTGGCGGCA
TCGACCATGAGCCAGATCGGTTACATGGTGCTGGCCGCCGGGCTCGGCCCGGCCGGGTACGCGTTCGCGATCATGCATCT
GCTGACCCACGGGTTCTTCAAGGCCGGCTTGTTCCTCGGGGCCGGATCGGTCATGCACGCCATGGACGACGAGGTGAACA
TGCGCCGCTACGGCGGCCTGCGCAAGGCGCTGCCGATCACCTTCGCCACCTTCGGGCTCGGCTACCTCGCGATCATCGGG
GTGCCGCCGCTGGCCGGGTTCTTCTCCAAGGACGGCATCATCGAGGCCGCGCTCGGCGCCGGTGGCGTCAAGGGCTGGAT
CCTCGGCGGTGCGGCGATCCTCGGCGCCGGGATCACCGCGTTCTACATGACGAGGGTGATGTTGATGACGTTCTTCGGTG
AGAAGCGTTGGGCTGCAGTGGGAGATGGGCCCGAGGTACATCCACACGAGGCGCCTGCCGTCATGACCGTGCCGATGATC
GTGCTGGCCGTCGGATCGGTGGCCTCGGGCGGGCTGCTGGCGATCGGCGGCGCGCTGTCGCACTGGCTCGAACCCGTGGT
CGGCACCCACGAGGAGACGCACGCGGTGCCCGTCGTCGTGGCCACCATCGTCATCCTGTCGGTCGTCGCCGTCGGTATCG
CGGTCGCCTACCGCATGTACGCGACCCGCGAGGTGCCCGCCGAGGTTCCGGTGGGGTCGGCGCTGACCGTCGCCGCGCGC
CGCGACCTCTACGGCGATGCGCTCAACGAGGCCGTGTTCATGCGGCCCGGCCAGGCAGTGACGGCGGGCATGGTCAGCGT
CGACGACCGGGCGATCGACGGCGCCGCGACCGGCCTCGCCACGCTGGTGGCCCGCGCATCGAACGGATTGCGCGGTCTGC
AAACCGGATTCGCCCGGTCCTACGCGCTGGGCATGCTCGGCGGCGCGGCGCTCGTGGTGGCGGCGATCCTGGCGGTGAAC
CTGTGGTGA

Upstream 100 bases:

>100_bases
ACCTGCAGACCCTGCTCGAGCTCGGCGCCGATCAGAACTCCACGGTGGTGTTCCCGCTACCGGTGGACATCATCACCCCC
TTCCTGCGGGGGCTCAAGTC

Downstream 100 bases:

>100_bases
TTCCCTGGCTGAGCGTGCTGTGGGCGGCGCCGATCGTCGGCGCCGGTGTGGTGATGTTGGTGCCCCGTCGCACTCTGGCG
AAGTGGGTGGCGCTGGCGGT

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MSTAVWLLIALPLAGAVVLLLAGRRSDRWGHLLGTAAAVASFVVGVVLFAGMLGRPAEDRAVHETLFSWVPVGDLQVDFG
LQLDQLSMCFVLLITGVGSLIHVYSIGYMAPGAQLAERPTDTGPSRRLFFAYLNLFLAAMLLLVLADNYLGLYVGWEGVG
LASYLLIGFWSYKPSAATAAKKAFVVNRVGDMGLAIALMIMFATVGSVSFAGVFGAAPQLGEGTLTAIGLLLLLGACGKS
AQVPLQSWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGPVFDLAPTAQLAVVIVGTVTLLFGAIIGCAKDDIKKALAA
STMSQIGYMVLAAGLGPAGYAFAIMHLLTHGFFKAGLFLGAGSVMHAMDDEVNMRRYGGLRKALPITFATFGLGYLAIIG
VPPLAGFFSKDGIIEAALGAGGVKGWILGGAAILGAGITAFYMTRVMLMTFFGEKRWAAVGDGPEVHPHEAPAVMTVPMI
VLAVGSVASGGLLAIGGALSHWLEPVVGTHEETHAVPVVVATIVILSVVAVGIAVAYRMYATREVPAEVPVGSALTVAAR
RDLYGDALNEAVFMRPGQAVTAGMVSVDDRAIDGAATGLATLVARASNGLRGLQTGFARSYALGMLGGAALVVAAILAVN
LW

Sequences:

>Translated_642_residues
MSTAVWLLIALPLAGAVVLLLAGRRSDRWGHLLGTAAAVASFVVGVVLFAGMLGRPAEDRAVHETLFSWVPVGDLQVDFG
LQLDQLSMCFVLLITGVGSLIHVYSIGYMAPGAQLAERPTDTGPSRRLFFAYLNLFLAAMLLLVLADNYLGLYVGWEGVG
LASYLLIGFWSYKPSAATAAKKAFVVNRVGDMGLAIALMIMFATVGSVSFAGVFGAAPQLGEGTLTAIGLLLLLGACGKS
AQVPLQSWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGPVFDLAPTAQLAVVIVGTVTLLFGAIIGCAKDDIKKALAA
STMSQIGYMVLAAGLGPAGYAFAIMHLLTHGFFKAGLFLGAGSVMHAMDDEVNMRRYGGLRKALPITFATFGLGYLAIIG
VPPLAGFFSKDGIIEAALGAGGVKGWILGGAAILGAGITAFYMTRVMLMTFFGEKRWAAVGDGPEVHPHEAPAVMTVPMI
VLAVGSVASGGLLAIGGALSHWLEPVVGTHEETHAVPVVVATIVILSVVAVGIAVAYRMYATREVPAEVPVGSALTVAAR
RDLYGDALNEAVFMRPGQAVTAGMVSVDDRAIDGAATGLATLVARASNGLRGLQTGFARSYALGMLGGAALVVAAILAVN
LW
>Mature_641_residues
STAVWLLIALPLAGAVVLLLAGRRSDRWGHLLGTAAAVASFVVGVVLFAGMLGRPAEDRAVHETLFSWVPVGDLQVDFGL
QLDQLSMCFVLLITGVGSLIHVYSIGYMAPGAQLAERPTDTGPSRRLFFAYLNLFLAAMLLLVLADNYLGLYVGWEGVGL
ASYLLIGFWSYKPSAATAAKKAFVVNRVGDMGLAIALMIMFATVGSVSFAGVFGAAPQLGEGTLTAIGLLLLLGACGKSA
QVPLQSWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGPVFDLAPTAQLAVVIVGTVTLLFGAIIGCAKDDIKKALAAS
TMSQIGYMVLAAGLGPAGYAFAIMHLLTHGFFKAGLFLGAGSVMHAMDDEVNMRRYGGLRKALPITFATFGLGYLAIIGV
PPLAGFFSKDGIIEAALGAGGVKGWILGGAAILGAGITAFYMTRVMLMTFFGEKRWAAVGDGPEVHPHEAPAVMTVPMIV
LAVGSVASGGLLAIGGALSHWLEPVVGTHEETHAVPVVVATIVILSVVAVGIAVAYRMYATREVPAEVPVGSALTVAARR
DLYGDALNEAVFMRPGQAVTAGMVSVDDRAIDGAATGLATLVARASNGLRGLQTGFARSYALGMLGGAALVVAAILAVNL
W

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=477, Percent_Identity=34.8008385744235, Blast_Score=274, Evalue=2e-73,
Organism=Escherichia coli, GI1788614, Length=497, Percent_Identity=44.8692152917505, Blast_Score=343, Evalue=2e-95,
Organism=Escherichia coli, GI1788829, Length=435, Percent_Identity=32.8735632183908, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1788827, Length=474, Percent_Identity=29.3248945147679, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788831, Length=353, Percent_Identity=29.1784702549575, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI2367154, Length=401, Percent_Identity=26.9326683291771, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI1788613, Length=276, Percent_Identity=27.8985507246377, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI145693160, Length=361, Percent_Identity=25.7617728531856, Blast_Score=73, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 66257; Mature: 66126

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAVWLLIALPLAGAVVLLLAGRRSDRWGHLLGTAAAVASFVVGVVLFAGMLGRPAEDR
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AVHETLFSWVPVGDLQVDFGLQLDQLSMCFVLLITGVGSLIHVYSIGYMAPGAQLAERPT
HHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCC
DTGPSRRLFFAYLNLFLAAMLLLVLADNYLGLYVGWEGVGLASYLLIGFWSYKPSAATAA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHH
KKAFVVNRVGDMGLAIALMIMFATVGSVSFAGVFGAAPQLGEGTLTAIGLLLLLGACGKS
HHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
AQVPLQSWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGPVFDLAPTAQLAVVIVGTVT
CCCCHHHHHCHHCCCCCHHHHHHHHHHHHHHCEEEEEECCCCEECCCHHHHHHHHHHHHH
LLFGAIIGCAKDDIKKALAASTMSQIGYMVLAAGLGPAGYAFAIMHLLTHGFFKAGLFLG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHC
AGSVMHAMDDEVNMRRYGGLRKALPITFATFGLGYLAIIGVPPLAGFFSKDGIIEAALGA
CCHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHCC
GGVKGWILGGAAILGAGITAFYMTRVMLMTFFGEKRWAAVGDGPEVHPHEAPAVMTVPMI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHH
VLAVGSVASGGLLAIGGALSHWLEPVVGTHEETHAVPVVVATIVILSVVAVGIAVAYRMY
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATREVPAEVPVGSALTVAARRDLYGDALNEAVFMRPGQAVTAGMVSVDDRAIDGAATGLA
HCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHEECCCCHHHHCEEECCCCCCCHHHHHHH
TLVARASNGLRGLQTGFARSYALGMLGGAALVVAAILAVNLW
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STAVWLLIALPLAGAVVLLLAGRRSDRWGHLLGTAAAVASFVVGVVLFAGMLGRPAEDR
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AVHETLFSWVPVGDLQVDFGLQLDQLSMCFVLLITGVGSLIHVYSIGYMAPGAQLAERPT
HHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCC
DTGPSRRLFFAYLNLFLAAMLLLVLADNYLGLYVGWEGVGLASYLLIGFWSYKPSAATAA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHH
KKAFVVNRVGDMGLAIALMIMFATVGSVSFAGVFGAAPQLGEGTLTAIGLLLLLGACGKS
HHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
AQVPLQSWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGPVFDLAPTAQLAVVIVGTVT
CCCCHHHHHCHHCCCCCHHHHHHHHHHHHHHCEEEEEECCCCEECCCHHHHHHHHHHHHH
LLFGAIIGCAKDDIKKALAASTMSQIGYMVLAAGLGPAGYAFAIMHLLTHGFFKAGLFLG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHC
AGSVMHAMDDEVNMRRYGGLRKALPITFATFGLGYLAIIGVPPLAGFFSKDGIIEAALGA
CCHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHCC
GGVKGWILGGAAILGAGITAFYMTRVMLMTFFGEKRWAAVGDGPEVHPHEAPAVMTVPMI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHH
VLAVGSVASGGLLAIGGALSHWLEPVVGTHEETHAVPVVVATIVILSVVAVGIAVAYRMY
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATREVPAEVPVGSALTVAARRDLYGDALNEAVFMRPGQAVTAGMVSVDDRAIDGAATGLA
HCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHEECCCCHHHHCEEECCCCCCCHHHHHHH
TLVARASNGLRGLQTGFARSYALGMLGGAALVVAAILAVNLW
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]