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The map label for this gene is purK [H]

Identifier: 119867365

GI number: 119867365

Start: 1407114

End: 1408295

Strand: Direct

Name: purK [H]

Synonym: Mkms_1315

Alternate gene names: 119867365

Gene position: 1407114-1408295 (Clockwise)

Preceding gene: 119867363

Following gene: 119867366

Centisome position: 24.53

GC content: 71.57

Gene sequence:

>1182_bases
ATGATCGGCGGGGGTCAACTCGCCCGGATGACCCACCAGGCGGCGATCGCGCTGGGCCAGACTCTGCGGGTGCTCGCCAC
CGGCCCGCAGGAGCCGGCCGCCCAGGTGACCCCCGACGTGGTGATCGGATCGCATACCGACCTCGACGCGCTCCGGCGCG
CGGCCGCCGGTGCGACCGTACTGACCTTCGACCACGAACACGTCCCCACCGAAGCACTCGAGACGCTGGTGGCCGAGGGG
GTCAACGTGGCGCCGCCGCCGGCCGCGCTGGTGCACGCGCAGGACAAGCTGGTGATGCGCAGGCGACTCGAAGCGATGGG
TGCGCCGATCCCGCGCTACACCGCCGTCGACACCGTCGACGACGTCGTGGCCTTCTCGTCCGAGGTCGATGGCCCGGTCG
TGCTCAAGACGGTCCGCGGGGGATACGACGGCCGCGGCGTGGTGCTGACCGCCGACGCCGAGGAGGCGCGCGACGTGGCC
GCCCGCTACCTCGCCGACGGTGTGCCGATCCTGGCCGAGGAGCGTGTCGACATGCGCCGCGAGCTCGCGGCCCTGGTGGC
CCGGTCACCGTTCGGGCAGGGTGCGGCGTGGCCGGTGGTCGAGACCGTGCAGCGCGACGGCATCTGCGTCGTGGTGCTGG
CCCCGGCGCCGGAGTTGTCCGACGACCTGGGCTCGAGCGCCCAGCAGCTGGGGTTGAAGCTGGCCGCCGAACTCGGCGTG
GTCGGGGTGCTCGCCGTCGAACTCTTCGAAACGGTCGACGGCCGGCTGCTGGTCAACGAATTGGCGATGCGGCCGCACAA
CTCCGGGCACTGGAGCATGGACGGCGCGGTCACCGGCCAGTTCGAACAGCACGTCCGCGCGGTGCTGGACTATCCGCTCG
GCGACACCTCGCTGCTCGCCCCGGCCACCGTGATGGCCAATGTCCTCGGGGCGCCGCAGACTCCGGCGATGACGATGGAC
GAACGGGTGCACCACCTGTTCGCCCGCATGCCGGACGCCAAGGTGCACCTGTACGGCAAGGGGGAGCGGCCCGGCCGCAA
GATCGGCCACGTCAACCTCACCGGTGACGATCCGGCGGTGTTGCGTGAGCGGGCCGAGCGGGCCGCGCACTGGTTGTCCC
ACGCCGAGTGGACCGACGGATGGGATCCGCACGCCGAAGTCAGGGAAGGAATCTCGAGGTGA

Upstream 100 bases:

>100_bases
GTTCCTGGTCAATGCGCCCCACCCGGGCCATGACACGATAGGCGGCGTGCCGAGCCATACTCCTTCCACCTCTTCGGCCT
CTTCGCCACCGGTGGTGGCC

Downstream 100 bases:

>100_bases
ACGCACCCGCCCCGCGCGTCGGGGTCATCATGGGCAGCGACAGCGACTGGTCGGTGATGGCCGACGCCGCCGAAGCGCTC
GCCGAGTTCGAGGTGGCCTT

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MIGGGQLARMTHQAAIALGQTLRVLATGPQEPAAQVTPDVVIGSHTDLDALRRAAAGATVLTFDHEHVPTEALETLVAEG
VNVAPPPAALVHAQDKLVMRRRLEAMGAPIPRYTAVDTVDDVVAFSSEVDGPVVLKTVRGGYDGRGVVLTADAEEARDVA
ARYLADGVPILAEERVDMRRELAALVARSPFGQGAAWPVVETVQRDGICVVVLAPAPELSDDLGSSAQQLGLKLAAELGV
VGVLAVELFETVDGRLLVNELAMRPHNSGHWSMDGAVTGQFEQHVRAVLDYPLGDTSLLAPATVMANVLGAPQTPAMTMD
ERVHHLFARMPDAKVHLYGKGERPGRKIGHVNLTGDDPAVLRERAERAAHWLSHAEWTDGWDPHAEVREGISR

Sequences:

>Translated_393_residues
MIGGGQLARMTHQAAIALGQTLRVLATGPQEPAAQVTPDVVIGSHTDLDALRRAAAGATVLTFDHEHVPTEALETLVAEG
VNVAPPPAALVHAQDKLVMRRRLEAMGAPIPRYTAVDTVDDVVAFSSEVDGPVVLKTVRGGYDGRGVVLTADAEEARDVA
ARYLADGVPILAEERVDMRRELAALVARSPFGQGAAWPVVETVQRDGICVVVLAPAPELSDDLGSSAQQLGLKLAAELGV
VGVLAVELFETVDGRLLVNELAMRPHNSGHWSMDGAVTGQFEQHVRAVLDYPLGDTSLLAPATVMANVLGAPQTPAMTMD
ERVHHLFARMPDAKVHLYGKGERPGRKIGHVNLTGDDPAVLRERAERAAHWLSHAEWTDGWDPHAEVREGISR
>Mature_393_residues
MIGGGQLARMTHQAAIALGQTLRVLATGPQEPAAQVTPDVVIGSHTDLDALRRAAAGATVLTFDHEHVPTEALETLVAEG
VNVAPPPAALVHAQDKLVMRRRLEAMGAPIPRYTAVDTVDDVVAFSSEVDGPVVLKTVRGGYDGRGVVLTADAEEARDVA
ARYLADGVPILAEERVDMRRELAALVARSPFGQGAAWPVVETVQRDGICVVVLAPAPELSDDLGSSAQQLGLKLAAELGV
VGVLAVELFETVDGRLLVNELAMRPHNSGHWSMDGAVTGQFEQHVRAVLDYPLGDTSLLAPATVMANVLGAPQTPAMTMD
ERVHHLFARMPDAKVHLYGKGERPGRKIGHVNLTGDDPAVLRERAERAAHWLSHAEWTDGWDPHAEVREGISR

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=370, Percent_Identity=29.4594594594595, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1788155, Length=384, Percent_Identity=25.5208333333333, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324702, Length=379, Percent_Identity=32.9815303430079, Blast_Score=183, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 41919; Mature: 41919

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGGGQLARMTHQAAIALGQTLRVLATGPQEPAAQVTPDVVIGSHTDLDALRRAAAGATV
CCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCEEECCCCCHHHHHHHHCCCEE
LTFDHEHVPTEALETLVAEGVNVAPPPAALVHAQDKLVMRRRLEAMGAPIPRYTAVDTVD
EEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
DVVAFSSEVDGPVVLKTVRGGYDGRGVVLTADAEEARDVAARYLADGVPILAEERVDMRR
HHHHHHCCCCCCEEEEEECCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHH
ELAALVARSPFGQGAAWPVVETVQRDGICVVVLAPAPELSDDLGSSAQQLGLKLAAELGV
HHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCHHHCCHHHHHHHHHHHHHHH
VGVLAVELFETVDGRLLVNELAMRPHNSGHWSMDGAVTGQFEQHVRAVLDYPLGDTSLLA
HHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCCCHHHH
PATVMANVLGAPQTPAMTMDERVHHLFARMPDAKVHLYGKGERPGRKIGHVNLTGDDPAV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEECEEEECCCCHHH
LRERAERAAHWLSHAEWTDGWDPHAEVREGISR
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MIGGGQLARMTHQAAIALGQTLRVLATGPQEPAAQVTPDVVIGSHTDLDALRRAAAGATV
CCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCEEECCCCCHHHHHHHHCCCEE
LTFDHEHVPTEALETLVAEGVNVAPPPAALVHAQDKLVMRRRLEAMGAPIPRYTAVDTVD
EEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
DVVAFSSEVDGPVVLKTVRGGYDGRGVVLTADAEEARDVAARYLADGVPILAEERVDMRR
HHHHHHCCCCCCEEEEEECCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHH
ELAALVARSPFGQGAAWPVVETVQRDGICVVVLAPAPELSDDLGSSAQQLGLKLAAELGV
HHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCHHHCCHHHHHHHHHHHHHHH
VGVLAVELFETVDGRLLVNELAMRPHNSGHWSMDGAVTGQFEQHVRAVLDYPLGDTSLLA
HHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCCCHHHH
PATVMANVLGAPQTPAMTMDERVHHLFARMPDAKVHLYGKGERPGRKIGHVNLTGDDPAV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEECEEEECCCCHHH
LRERAERAAHWLSHAEWTDGWDPHAEVREGISR
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]