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The map label for this gene is purE [H]

Identifier: 119867366

GI number: 119867366

Start: 1408292

End: 1408804

Strand: Direct

Name: purE [H]

Synonym: Mkms_1316

Alternate gene names: 119867366

Gene position: 1408292-1408804 (Clockwise)

Preceding gene: 119867365

Following gene: 119867367

Centisome position: 24.55

GC content: 73.1

Gene sequence:

>513_bases
GTGAACGCACCCGCCCCGCGCGTCGGGGTCATCATGGGCAGCGACAGCGACTGGTCGGTGATGGCCGACGCCGCCGAAGC
GCTCGCCGAGTTCGAGGTGGCCTTCGAGGTGGGCGTGGTATCCGCGCACCGCACCCCCGGCCGCATGCTCGATTACGCGC
GCACCGCCGCCGACCGGGGGATCGAGGTCATCATCGCCGGTGCCGGCGGGGCGGCCCACCTGCCGGGCATGGTGGCTTCG
GCGACACCGTTGCCGGTCATCGGCGTGCCGGTGCCGCTGGCCCGGCTGGACGGGATGGATTCGCTGCTGTCGATCGTGCA
GATGCCCGCCGGGGTGCCGGTGGCCACGGTGTCGATCGGCGGCGCGCGCAACGCCGGACTGCTGGCCGTGCGGATCCTCG
CCTCGGCCGACCGCGCGCTGCGGGCGCGCATGGTCCGGTTCCAGGCGGGCCTCGAGCAGATGGTGCTCGAGAAGGATGAA
GCGCTGCGGAACCGGCTACTCGGTGCGGACTGA

Upstream 100 bases:

>100_bases
TGTTGCGTGAGCGGGCCGAGCGGGCCGCGCACTGGTTGTCCCACGCCGAGTGGACCGACGGATGGGATCCGCACGCCGAA
GTCAGGGAAGGAATCTCGAG

Downstream 100 bases:

>100_bases
ACGCAGGTAAAGTTACCGGTGAGTAGCAAGGAGGCCACGATGGCTGGTTGGACCGGAAACCCGTCCTTCGACGTGTTCGG
TTTGCCCGAGGAACACCAGG

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MNAPAPRVGVIMGSDSDWSVMADAAEALAEFEVAFEVGVVSAHRTPGRMLDYARTAADRGIEVIIAGAGGAAHLPGMVAS
ATPLPVIGVPVPLARLDGMDSLLSIVQMPAGVPVATVSIGGARNAGLLAVRILASADRALRARMVRFQAGLEQMVLEKDE
ALRNRLLGAD

Sequences:

>Translated_170_residues
MNAPAPRVGVIMGSDSDWSVMADAAEALAEFEVAFEVGVVSAHRTPGRMLDYARTAADRGIEVIIAGAGGAAHLPGMVAS
ATPLPVIGVPVPLARLDGMDSLLSIVQMPAGVPVATVSIGGARNAGLLAVRILASADRALRARMVRFQAGLEQMVLEKDE
ALRNRLLGAD
>Mature_170_residues
MNAPAPRVGVIMGSDSDWSVMADAAEALAEFEVAFEVGVVSAHRTPGRMLDYARTAADRGIEVIIAGAGGAAHLPGMVAS
ATPLPVIGVPVPLARLDGMDSLLSIVQMPAGVPVATVSIGGARNAGLLAVRILASADRALRARMVRFQAGLEQMVLEKDE
ALRNRLLGAD

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=116, Percent_Identity=57.7586206896552, Blast_Score=131, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324702, Length=157, Percent_Identity=61.1464968152866, Blast_Score=177, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17535; Mature: 17535

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPAPRVGVIMGSDSDWSVMADAAEALAEFEVAFEVGVVSAHRTPGRMLDYARTAADRG
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCC
IEVIIAGAGGAAHLPGMVASATPLPVIGVPVPLARLDGMDSLLSIVQMPAGVPVATVSIG
EEEEEECCCCCCCCCCCCCCCCCCCEECCCCCHHHHCCHHHHHHHHHCCCCCCEEEEEEC
GARNAGLLAVRILASADRALRARMVRFQAGLEQMVLEKDEALRNRLLGAD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNAPAPRVGVIMGSDSDWSVMADAAEALAEFEVAFEVGVVSAHRTPGRMLDYARTAADRG
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCC
IEVIIAGAGGAAHLPGMVASATPLPVIGVPVPLARLDGMDSLLSIVQMPAGVPVATVSIG
EEEEEECCCCCCCCCCCCCCCCCCCEECCCCCHHHHCCHHHHHHHHHCCCCCCEEEEEEC
GARNAGLLAVRILASADRALRARMVRFQAGLEQMVLEKDEALRNRLLGAD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7489918; 11234002 [H]