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The map label for this gene is accD5 [H]

Identifier: 119867361

GI number: 119867361

Start: 1402110

End: 1403780

Strand: Reverse

Name: accD5 [H]

Synonym: Mkms_1311

Alternate gene names: 119867361

Gene position: 1403780-1402110 (Counterclockwise)

Preceding gene: 119867364

Following gene: 119867360

Centisome position: 24.47

GC content: 66.91

Gene sequence:

>1671_bases
GTGCCGGAACCAGGTCGCATAGCATCAACCCCCATGACGAGCGTGACTGATCCTTCCGCGCCCTCCGGCGCCCATGAGAT
CGACATTCACACCACCGCCGGGAAGCTGGCCGATCTGCGCAAGCGCACCGAAGAGGCACAGCATCCGGTCGGTGAGGCCG
CCGTCGAGAAGGTGCACGCCAAGGGCAAGCTGACCGCCCGCGAGCGCATCCTCGCGCTGCTCGACGAGGACTCGTTCGTC
GAACTCGACGCGCTGGCCAAGCACCGCAGCACCAACTTCGGTCTGCAGGCCAACCGGCCGCCGGGCGACGGTGTGGTGAC
CGGGTACGGCACCATCGACGGCCGCGAGGTCTGCATCTTCAGCCAGGACGCCACGGTCTTCGGCGGCAGCCTCGGCGAGG
TGTACGGCGAGAAGATCGTCAAGGTGCAGGAGCTGGCCATCAAGACCGGCCGCCCGCTCATCGGCATCAACGACGGCGCC
GGCGCACGCATCCAGGAGGGCGTGGTCTCGCTCGGCCTCTACAGCCGGATCTTCCACAACAACATCAAGGCCTCGGGCGT
CATCCCGCAGATCTCGCTGATCATGGGTGCGGCCGCGGGCGGTCACGTCTACTCCCCCGCGCTCACCGACTTCGTGATCA
TGGTCGACAAGACCAGCCAGATGTTCATCACCGGGCCCGATGTCATCAAGACGGTCACCGGCGAAGAGGTGACCATGGAG
GAGCTCGGCGGCGGCCACACCCACATGGCGAAGTCCGGCCTGGCCCACTACGTCGCCTCCGGTGAGCAGGACGCGTTCGA
CTACGTCCGCGATCTGCTGTCCTACCTGCCGCCCAATAACTACGCCGATCCGCCGCGCTACCCGTCGCCGCAGCCCGCCG
GCCCGATCGAGGAGACCCTCACCGACGAGGACCTCGAGCTGGACACGCTGATCCCGGACTCGCCGAACCAGCCGTACGAC
ATGCACGAGGTGATCACGCGCATCCTCGACGACGACGAGTTCCTGGAGATCCAGGAGGGCTACGCGAGCAACATCATCGT
CGGCTTCGGGCGCATCGACGGCCGCCCGGTGGGCATCGTCGCCAACCAGCCGACCCAGTTCGCCGGCTGCCTCGACATCA
ACGCCTCGGAGAAGGCCGCGCGCTTCGTGCGGACGTGCGACTGCTTCAACATCCCGATCGTCATGCTCGTCGACGTCCCG
GGGTTCCTGCCCGGCACCGAGCAGGAGTACAACGGCATCATCCGCCGCGGCGCCAAGCTGCTGTACGCCTACGGTGAGGC
CACGGTCGCCAAGATCACCGTCATCACCCGCAAGGCCTACGGCGGCGCGTACTGCGTCATGGGCTCCAAGGACATGGGCT
GCGACGTCAACGTCGCCTGGCCGACGGCACAGATCGCGGTCATGGGCGCCTCGGGTGCGGTCGGCTTCGTCTACCGCCAG
CAGCTCAAAGAGGCGGCCAAGGACGGCCAGGACGTCGACGCGTTGCGCCTCGAACTGCAGCAGGAGTACGAGGACACCCT
GGTCAACCCATACATCGCGGCCGAGCGCGGTTACGTCGACGCGGTCATCCCGCCGTCGCACACCCGCGGTTACATCGGCA
CCGCACTGCGACTGCTGGAGCGAAAGATCGCCCAGACGCCGCCCAAGAAGCACGGCAACATCCCGCTCTGA

Upstream 100 bases:

>100_bases
GCCCCCTGCGGATCAGTTTGCTGGCCTCCAGCGGCGCCTCGACCGGGCGGGCGGACGGGCCGACACGCGGCGAGTTCCCA
TTTCTAAGGGGATCGTGAAA

Downstream 100 bases:

>100_bases
GTCGCCGGCAGAGGAGTAACGCACATGTCGCAGGACACCGACATCACCGAGGTCAGCGATCACCGTCAGCTGACCATCGA
CCTACCTCCCGCCCCTGACC

Product: carboxyl transferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MPEPGRIASTPMTSVTDPSAPSGAHEIDIHTTAGKLADLRKRTEEAQHPVGEAAVEKVHAKGKLTARERILALLDEDSFV
ELDALAKHRSTNFGLQANRPPGDGVVTGYGTIDGREVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGA
GARIQEGVVSLGLYSRIFHNNIKASGVIPQISLIMGAAAGGHVYSPALTDFVIMVDKTSQMFITGPDVIKTVTGEEVTME
ELGGGHTHMAKSGLAHYVASGEQDAFDYVRDLLSYLPPNNYADPPRYPSPQPAGPIEETLTDEDLELDTLIPDSPNQPYD
MHEVITRILDDDEFLEIQEGYASNIIVGFGRIDGRPVGIVANQPTQFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVP
GFLPGTEQEYNGIIRRGAKLLYAYGEATVAKITVITRKAYGGAYCVMGSKDMGCDVNVAWPTAQIAVMGASGAVGFVYRQ
QLKEAAKDGQDVDALRLELQQEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIGTALRLLERKIAQTPPKKHGNIPL

Sequences:

>Translated_556_residues
MPEPGRIASTPMTSVTDPSAPSGAHEIDIHTTAGKLADLRKRTEEAQHPVGEAAVEKVHAKGKLTARERILALLDEDSFV
ELDALAKHRSTNFGLQANRPPGDGVVTGYGTIDGREVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGA
GARIQEGVVSLGLYSRIFHNNIKASGVIPQISLIMGAAAGGHVYSPALTDFVIMVDKTSQMFITGPDVIKTVTGEEVTME
ELGGGHTHMAKSGLAHYVASGEQDAFDYVRDLLSYLPPNNYADPPRYPSPQPAGPIEETLTDEDLELDTLIPDSPNQPYD
MHEVITRILDDDEFLEIQEGYASNIIVGFGRIDGRPVGIVANQPTQFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVP
GFLPGTEQEYNGIIRRGAKLLYAYGEATVAKITVITRKAYGGAYCVMGSKDMGCDVNVAWPTAQIAVMGASGAVGFVYRQ
QLKEAAKDGQDVDALRLELQQEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIGTALRLLERKIAQTPPKKHGNIPL
>Mature_555_residues
PEPGRIASTPMTSVTDPSAPSGAHEIDIHTTAGKLADLRKRTEEAQHPVGEAAVEKVHAKGKLTARERILALLDEDSFVE
LDALAKHRSTNFGLQANRPPGDGVVTGYGTIDGREVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAG
ARIQEGVVSLGLYSRIFHNNIKASGVIPQISLIMGAAAGGHVYSPALTDFVIMVDKTSQMFITGPDVIKTVTGEEVTMEE
LGGGHTHMAKSGLAHYVASGEQDAFDYVRDLLSYLPPNNYADPPRYPSPQPAGPIEETLTDEDLELDTLIPDSPNQPYDM
HEVITRILDDDEFLEIQEGYASNIIVGFGRIDGRPVGIVANQPTQFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVPG
FLPGTEQEYNGIIRRGAKLLYAYGEATVAKITVITRKAYGGAYCVMGSKDMGCDVNVAWPTAQIAVMGASGAVGFVYRQQ
LKEAAKDGQDVDALRLELQQEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIGTALRLLERKIAQTPPKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=511, Percent_Identity=54.7945205479452, Blast_Score=528, Evalue=1e-150,
Organism=Homo sapiens, GI295821216, Length=531, Percent_Identity=52.7306967984934, Blast_Score=517, Evalue=1e-146,
Organism=Homo sapiens, GI11545863, Length=531, Percent_Identity=32.015065913371, Blast_Score=226, Evalue=4e-59,
Organism=Escherichia coli, GI1788655, Length=188, Percent_Identity=28.7234042553192, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25147362, Length=539, Percent_Identity=51.9480519480519, Blast_Score=532, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI25147359, Length=539, Percent_Identity=51.9480519480519, Blast_Score=532, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17552936, Length=526, Percent_Identity=32.6996197718631, Blast_Score=254, Evalue=7e-68,
Organism=Caenorhabditis elegans, GI71997163, Length=302, Percent_Identity=24.1721854304636, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6323863, Length=232, Percent_Identity=25, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24586065, Length=535, Percent_Identity=33.4579439252336, Blast_Score=254, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 59919; Mature: 59787

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEPGRIASTPMTSVTDPSAPSGAHEIDIHTTAGKLADLRKRTEEAQHPVGEAAVEKVHA
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
KGKLTARERILALLDEDSFVELDALAKHRSTNFGLQANRPPGDGVVTGYGTIDGREVCIF
CCCHHHHHHHHHHCCCCCCEEHHHHHHHCCCCCCEECCCCCCCCEEEEEECCCCCEEEEE
SQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGVVSLGLYSRIFHN
ECCCCEECCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHC
NIKASGVIPQISLIMGAAAGGHVYSPALTDFVIMVDKTSQMFITGPDVIKTVTGEEVTME
CCCCCCCCCCHHHHHCCCCCCCEECCCCCEEEEEEECCCEEEEECCHHHEECCCCEEEHH
ELGGGHTHMAKSGLAHYVASGEQDAFDYVRDLLSYLPPNNYADPPRYPSPQPAGPIEETL
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHC
TDEDLELDTLIPDSPNQPYDMHEVITRILDDDEFLEIQEGYASNIIVGFGRIDGRPVGIV
CCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCHHEEECCCCCCCEEEEEECCCCEEEEEE
ANQPTQFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVPGFLPGTEQEYNGIIRRGAKL
ECCCCCEEEEEECCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCEE
LYAYGEATVAKITVITRKAYGGAYCVMGSKDMGCDVNVAWPTAQIAVMGASGAVGFVYRQ
EEEECCCEEEEEEEEEEECCCCEEEEECCCCCCCEEEEECCCEEEEEEECCCCHHHHHHH
QLKEAAKDGQDVDALRLELQQEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIGTALRLLE
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCCCHHHHHHHHHH
RKIAQTPPKKHGNIPL
HHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PEPGRIASTPMTSVTDPSAPSGAHEIDIHTTAGKLADLRKRTEEAQHPVGEAAVEKVHA
CCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
KGKLTARERILALLDEDSFVELDALAKHRSTNFGLQANRPPGDGVVTGYGTIDGREVCIF
CCCHHHHHHHHHHCCCCCCEEHHHHHHHCCCCCCEECCCCCCCCEEEEEECCCCCEEEEE
SQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGVVSLGLYSRIFHN
ECCCCEECCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHC
NIKASGVIPQISLIMGAAAGGHVYSPALTDFVIMVDKTSQMFITGPDVIKTVTGEEVTME
CCCCCCCCCCHHHHHCCCCCCCEECCCCCEEEEEEECCCEEEEECCHHHEECCCCEEEHH
ELGGGHTHMAKSGLAHYVASGEQDAFDYVRDLLSYLPPNNYADPPRYPSPQPAGPIEETL
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHC
TDEDLELDTLIPDSPNQPYDMHEVITRILDDDEFLEIQEGYASNIIVGFGRIDGRPVGIV
CCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCHHEEECCCCCCCEEEEEECCCCEEEEEE
ANQPTQFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVPGFLPGTEQEYNGIIRRGAKL
ECCCCCEEEEEECCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCEE
LYAYGEATVAKITVITRKAYGGAYCVMGSKDMGCDVNVAWPTAQIAVMGASGAVGFVYRQ
EEEECCCEEEEEEEEEEECCCCEEEEECCCCCCCEEEEECCCEEEEEEECCCCHHHHHHH
QLKEAAKDGQDVDALRLELQQEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIGTALRLLE
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCCCHHHHHHHHHH
RKIAQTPPKKHGNIPL
HHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]