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The map label for this gene is acoB2 [H]

Identifier: 119900157

GI number: 119900157

Start: 4241016

End: 4242053

Strand: Direct

Name: acoB2 [H]

Synonym: azo3868

Alternate gene names: 119900157

Gene position: 4241016-4242053 (Clockwise)

Preceding gene: 119900156

Following gene: 119900158

Centisome position: 96.91

GC content: 66.57

Gene sequence:

>1038_bases
ATGAGCACGACAACGACCACCCGCCGCCTGACCATGGCGCAGGCGATCTCGGAAGCGACCGCGCAGGAAATGGCGCGCGA
CCCGCGCGTCTTCGTCATGGGCGAGGACGTCGGCAAGTACGGCGGCATCTTCAGCGCCACCACCGGGCTGCTCGACCAGT
TCGGCCCGGAGCGCGTGATGGACACGCCGATCTCGGAAACCGGCTTCATGGGCGCCGCGCTCGGCGCCGCCGCCGAAGGC
CTGCGGCCGATCTCGGAGCTGATGTTCGTCGATTTCTTCGGCGTCTGCTTCGACCAGATCTACAACCACATCGCCAAGAA
CCACTACATGTCGGGCGGCGCCTGCAAGTATCCGCTGGTCATCACCACCGGCATCGGCGGCGGCTACAACGACGCCGCCC
AGCACTCGCAGTGCCTGTACTCGATCTTCGCCCACGTCCCCGGCCTCAAGGTGGTGGTGCCGTCCAACGCCTACGACGCC
AAGGGCCTGATGACGAGCGCGATCCGCGACGACAACCCGGTGGTCTTCCTGTACCACAAGGGCATCATGGGTTTGAGCTG
GATGTCCTACTTCGAGGGCAGCACCAACGAGGTCCCGGAAGAGCAATACACCATCCCCTTCGGCCAGGCCCGCGTTGTGC
GCGAAGGCAGCGACGTCACCATCGTGACCCTGTCGCAGATGGTGCAGAAGTCGGTGCTGGCGGCGGAAAAGCTGGCCGAG
GAAGGCATCTCCGCCGAGGTGCTCGACCTGCGCACCCTGGTCCCGCTCGACCGCGCCGCGGTGCTGAAGTCGGTGAAGCG
CACCGGCCGCCTGCTGGTCGCCGACGAGGACTACCTGAGCTACGGCCTCTCCGGCGAGATCGCCGCGCTGGTAGCCGAGA
ACATCGACACCGTCCGCCTCAAGGCCCCGGTCCGCCGCCTCGCGGTACCCGACGTGCCGATCCCCTTCAGCCGCCCGCTG
GAGAACTTCGCGATCCCGCAGGTGGAGAACATCGTCGCCAGCGTGCGCGGGCTGATGACTTTCAAGCTCGACCAGTAG

Upstream 100 bases:

>100_bases
CGCGTGCAGGCCGCCTACGACTTCGGCCGCAACAGCCCCTATCCGGAACCGCAGGACGCGCTGCTGCACGTCTTCGCCGA
ATGAGAACCAGGAGACCCGC

Downstream 100 bases:

>100_bases
CGCCGGCGGTTCGGCCGCCTGCTCCCTCCCCTTCAAGGGGAGATGGTTTTGTCCCTCCCCCTTCAAGGGGGAGGTTAGGA
GGGGGATGGGGGTAGGTTCA

Product: acetoin dehydrogenase subunit beta

Products: [dihydrolipoyllysine-residue acetyltransferase] ; $S-acetyldihydrolipoyllysine; CO2

Alternate protein names: Acetoin:DCPIP oxidoreductase-beta; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit beta [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSTTTTTRRLTMAQAISEATAQEMARDPRVFVMGEDVGKYGGIFSATTGLLDQFGPERVMDTPISETGFMGAALGAAAEG
LRPISELMFVDFFGVCFDQIYNHIAKNHYMSGGACKYPLVITTGIGGGYNDAAQHSQCLYSIFAHVPGLKVVVPSNAYDA
KGLMTSAIRDDNPVVFLYHKGIMGLSWMSYFEGSTNEVPEEQYTIPFGQARVVREGSDVTIVTLSQMVQKSVLAAEKLAE
EGISAEVLDLRTLVPLDRAAVLKSVKRTGRLLVADEDYLSYGLSGEIAALVAENIDTVRLKAPVRRLAVPDVPIPFSRPL
ENFAIPQVENIVASVRGLMTFKLDQ

Sequences:

>Translated_345_residues
MSTTTTTRRLTMAQAISEATAQEMARDPRVFVMGEDVGKYGGIFSATTGLLDQFGPERVMDTPISETGFMGAALGAAAEG
LRPISELMFVDFFGVCFDQIYNHIAKNHYMSGGACKYPLVITTGIGGGYNDAAQHSQCLYSIFAHVPGLKVVVPSNAYDA
KGLMTSAIRDDNPVVFLYHKGIMGLSWMSYFEGSTNEVPEEQYTIPFGQARVVREGSDVTIVTLSQMVQKSVLAAEKLAE
EGISAEVLDLRTLVPLDRAAVLKSVKRTGRLLVADEDYLSYGLSGEIAALVAENIDTVRLKAPVRRLAVPDVPIPFSRPL
ENFAIPQVENIVASVRGLMTFKLDQ
>Mature_344_residues
STTTTTRRLTMAQAISEATAQEMARDPRVFVMGEDVGKYGGIFSATTGLLDQFGPERVMDTPISETGFMGAALGAAAEGL
RPISELMFVDFFGVCFDQIYNHIAKNHYMSGGACKYPLVITTGIGGGYNDAAQHSQCLYSIFAHVPGLKVVVPSNAYDAK
GLMTSAIRDDNPVVFLYHKGIMGLSWMSYFEGSTNEVPEEQYTIPFGQARVVREGSDVTIVTLSQMVQKSVLAAEKLAEE
GISAEVLDLRTLVPLDRAAVLKSVKRTGRLLVADEDYLSYGLSGEIAALVAENIDTVRLKAPVRRLAVPDVPIPFSRPLE
NFAIPQVENIVASVRGLMTFKLDQ

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde, in vitro. The beta subunit is probably not the catalytic subunit of the enzyme [H]

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=334, Percent_Identity=39.5209580838323, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI291084858, Length=334, Percent_Identity=38.3233532934132, Blast_Score=241, Evalue=5e-64,
Organism=Homo sapiens, GI4557353, Length=340, Percent_Identity=37.6470588235294, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI34101272, Length=340, Percent_Identity=37.6470588235294, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI133778974, Length=316, Percent_Identity=27.2151898734177, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI225637459, Length=279, Percent_Identity=24.3727598566308, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI225637463, Length=279, Percent_Identity=25.089605734767, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI225637461, Length=279, Percent_Identity=25.089605734767, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538422, Length=335, Percent_Identity=42.089552238806, Blast_Score=258, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17506935, Length=336, Percent_Identity=36.3095238095238, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319698, Length=343, Percent_Identity=41.6909620991254, Blast_Score=271, Evalue=1e-73,
Organism=Drosophila melanogaster, GI21358145, Length=325, Percent_Identity=42.7692307692308, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24650940, Length=325, Percent_Identity=42.7692307692308, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI160714828, Length=339, Percent_Identity=34.8082595870207, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI160714832, Length=339, Percent_Identity=34.8082595870207, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24650943, Length=85, Percent_Identity=45.8823529411765, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24650945, Length=85, Percent_Identity=45.8823529411765, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: 1.2.4.1

Molecular weight: Translated: 37446; Mature: 37315

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTTTTRRLTMAQAISEATAQEMARDPRVFVMGEDVGKYGGIFSATTGLLDQFGPERVM
CCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHCCHHHHHHHHHHHCCCHHHH
DTPISETGFMGAALGAAAEGLRPISELMFVDFFGVCFDQIYNHIAKNHYMSGGACKYPLV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCEE
ITTGIGGGYNDAAQHSQCLYSIFAHVPGLKVVVPSNAYDAKGLMTSAIRDDNPVVFLYHK
EEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEEEC
GIMGLSWMSYFEGSTNEVPEEQYTIPFGQARVVREGSDVTIVTLSQMVQKSVLAAEKLAE
CCHHHHHHHHHCCCCCCCCCCCEECCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHH
EGISAEVLDLRTLVPLDRAAVLKSVKRTGRLLVADEDYLSYGLSGEIAALVAENIDTVRL
CCCCEEHHHHHHHCCCHHHHHHHHHHHCCCEEEECCHHHHCCCCCHHHHHHHCCCCEEEE
KAPVRRLAVPDVPIPFSRPLENFAIPQVENIVASVRGLMTFKLDQ
HHHHHHHCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure 
STTTTTRRLTMAQAISEATAQEMARDPRVFVMGEDVGKYGGIFSATTGLLDQFGPERVM
CCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHCCHHHHHHHHHHHCCCHHHH
DTPISETGFMGAALGAAAEGLRPISELMFVDFFGVCFDQIYNHIAKNHYMSGGACKYPLV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCEE
ITTGIGGGYNDAAQHSQCLYSIFAHVPGLKVVVPSNAYDAKGLMTSAIRDDNPVVFLYHK
EEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEEEC
GIMGLSWMSYFEGSTNEVPEEQYTIPFGQARVVREGSDVTIVTLSQMVQKSVLAAEKLAE
CCHHHHHHHHHCCCCCCCCCCCEECCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHH
EGISAEVLDLRTLVPLDRAAVLKSVKRTGRLLVADEDYLSYGLSGEIAALVAENIDTVRL
CCCCEEHHHHHHHCCCHHHHHHHHHHHCCCEEEECCHHHHCCCCCHHHHHHHCCCCEEEE
KAPVRRLAVPDVPIPFSRPLENFAIPQVENIVASVRGLMTFKLDQ
HHHHHHHCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pyruvate; [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

Specific reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S- $acetyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2061286 [H]