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The map label for this gene is acoA2 [H]

Identifier: 119900156

GI number: 119900156

Start: 4239989

End: 4240999

Strand: Direct

Name: acoA2 [H]

Synonym: azo3867

Alternate gene names: 119900156

Gene position: 4239989-4240999 (Clockwise)

Preceding gene: 119900152

Following gene: 119900157

Centisome position: 96.89

GC content: 70.52

Gene sequence:

>1011_bases
ATGGAAGCGACAGCCGAACAGCTGCTGTGGATGTACGAAAAGATGGTCGAGATCCGGGAGTACGAGGAGACCATGGCCAA
GGTCTACCTCGAGGCCAAGCTCCCGCCCAAGATCCAGAAGGGGCTCGCTTTCGACATCGGCGCCGGCCCGGTGCCGGGCG
AGATGCACCTGGCCGCCGGCCAGGAACCGGTGGCAGTGGGCGTGTGCGCCCACCTGCGCCGCGACGACACCGTGGTCGGC
GCCCACCGCCCGCACCACTTCGCGATCGCCAAGGATGTCGACCTGAACGCGATGACCGCCGAGATGTACGGCAAGGCCAC
CGGCCTGGGCCGCGGCAAGGGCGGCCACATGCACCTGTTCGACCCGGCGGTGAAGTTCTCCTGCAGCGGCATCGTCGGCG
CCGGCGCGCCGCAGGCCTGCGGCGCAGCGCTGGCGGCGAAGAAACTGGGCACCGACGCGGTGGCGATCGCCTTCTTCGGC
GAGGGCGCGGCCAACCAGGGCGCCTTCCACGAGGCGCTCAACCTCGCCGCGCTGTGGAAGCTGCCGGTGGTGTTTGTGGT
CGAGGACAACAAGTACGGCATCTCGGTGGAGAAGTCCGCGTCGACCGCGATCGCCTCCAACGCCGACCGCGCCGCCGCCT
ACGGCATGCCGGGCGTGCTGGTGGAGAAGAACGACGCGGTGGCGGTGTTCGAGGCCGCTGGGGTGGCGGTGGCGCGCGCG
CGCCGCGGCGAGGGCCCGACCCTGATCGAGGTCAAGACCGACCGCTACTACGGCCACTTCCAGGGCGACCCGGAGACCTA
CCGCCCCAAGGGCGAGGCCAAGGAGCTGCGCCAGCACGACCCCATCCCGACGCTGGGCGCGCTCTTGCGCAGCCGCGACC
TGCTCGACGACGAAGCCGACGCCGCGCTGCGCGCCCGTGTTTCCGCGCGCGTGCAGGCCGCCTACGACTTCGGCCGCAAC
AGCCCCTATCCGGAACCGCAGGACGCGCTGCTGCACGTCTTCGCCGAATGA

Upstream 100 bases:

>100_bases
CGCTCTTGCGATGTGGGTTGCGAGCACCGCCGCCGCGTAAGACCGGGCAACAGCCCTGGCAGGCGGCGGTGCCAGCCCAC
GAACGAGGAGGAATCCAGCG

Downstream 100 bases:

>100_bases
GAACCAGGAGACCCGCATGAGCACGACAACGACCACCCGCCGCCTGACCATGGCGCAGGCGATCTCGGAAGCGACCGCGC
AGGAAATGGCGCGCGACCCG

Product: acetoin dehydrogenase subunit alpha

Products: [dihydrolipoyllysine-residue acetyltransferase] ; $S-acetyldihydrolipoyllysine; CO2

Alternate protein names: Acetoin:DCPIP oxidoreductase-alpha; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit alpha [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MEATAEQLLWMYEKMVEIREYEETMAKVYLEAKLPPKIQKGLAFDIGAGPVPGEMHLAAGQEPVAVGVCAHLRRDDTVVG
AHRPHHFAIAKDVDLNAMTAEMYGKATGLGRGKGGHMHLFDPAVKFSCSGIVGAGAPQACGAALAAKKLGTDAVAIAFFG
EGAANQGAFHEALNLAALWKLPVVFVVEDNKYGISVEKSASTAIASNADRAAAYGMPGVLVEKNDAVAVFEAAGVAVARA
RRGEGPTLIEVKTDRYYGHFQGDPETYRPKGEAKELRQHDPIPTLGALLRSRDLLDDEADAALRARVSARVQAAYDFGRN
SPYPEPQDALLHVFAE

Sequences:

>Translated_336_residues
MEATAEQLLWMYEKMVEIREYEETMAKVYLEAKLPPKIQKGLAFDIGAGPVPGEMHLAAGQEPVAVGVCAHLRRDDTVVG
AHRPHHFAIAKDVDLNAMTAEMYGKATGLGRGKGGHMHLFDPAVKFSCSGIVGAGAPQACGAALAAKKLGTDAVAIAFFG
EGAANQGAFHEALNLAALWKLPVVFVVEDNKYGISVEKSASTAIASNADRAAAYGMPGVLVEKNDAVAVFEAAGVAVARA
RRGEGPTLIEVKTDRYYGHFQGDPETYRPKGEAKELRQHDPIPTLGALLRSRDLLDDEADAALRARVSARVQAAYDFGRN
SPYPEPQDALLHVFAE
>Mature_336_residues
MEATAEQLLWMYEKMVEIREYEETMAKVYLEAKLPPKIQKGLAFDIGAGPVPGEMHLAAGQEPVAVGVCAHLRRDDTVVG
AHRPHHFAIAKDVDLNAMTAEMYGKATGLGRGKGGHMHLFDPAVKFSCSGIVGAGAPQACGAALAAKKLGTDAVAIAFFG
EGAANQGAFHEALNLAALWKLPVVFVVEDNKYGISVEKSASTAIASNADRAAAYGMPGVLVEKNDAVAVFEAAGVAVARA
RRGEGPTLIEVKTDRYYGHFQGDPETYRPKGEAKELRQHDPIPTLGALLRSRDLLDDEADAALRARVSARVQAAYDFGRN
SPYPEPQDALLHVFAE

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde. The alpha subunit is probably the catalytic subunit of the enzyme [H]

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=287, Percent_Identity=35.5400696864112, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI291084742, Length=337, Percent_Identity=34.4213649851632, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI4505685, Length=337, Percent_Identity=34.4213649851632, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI291084744, Length=337, Percent_Identity=34.1246290801187, Blast_Score=158, Evalue=6e-39,
Organism=Homo sapiens, GI291084757, Length=337, Percent_Identity=30.2670623145401, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI11386135, Length=280, Percent_Identity=32.5, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI258645172, Length=280, Percent_Identity=32.1428571428571, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI32564172, Length=314, Percent_Identity=34.3949044585987, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17536047, Length=314, Percent_Identity=34.3949044585987, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI86563357, Length=258, Percent_Identity=31.0077519379845, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI86563355, Length=258, Percent_Identity=31.0077519379845, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321026, Length=286, Percent_Identity=35.6643356643357, Blast_Score=174, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24639748, Length=315, Percent_Identity=34.6031746031746, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24639740, Length=322, Percent_Identity=34.7826086956522, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24639744, Length=322, Percent_Identity=34.7826086956522, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI28571106, Length=322, Percent_Identity=34.7826086956522, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24639746, Length=272, Percent_Identity=36.7647058823529, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI21355903, Length=284, Percent_Identity=26.056338028169, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: 1.2.4.1

Molecular weight: Translated: 35891; Mature: 35891

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEATAEQLLWMYEKMVEIREYEETMAKVYLEAKLPPKIQKGLAFDIGAGPVPGEMHLAAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHCCCEEECCCCCCCCCEEECCC
QEPVAVGVCAHLRRDDTVVGAHRPHHFAIAKDVDLNAMTAEMYGKATGLGRGKGGHMHLF
CCCEEEHHHHHCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCEEEEE
DPAVKFSCSGIVGAGAPQACGAALAAKKLGTDAVAIAFFGEGAANQGAFHEALNLAALWK
CCCHHEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHEEEC
LPVVFVVEDNKYGISVEKSASTAIASNADRAAAYGMPGVLVEKNDAVAVFEAAGVAVARA
CCEEEEEECCCCCEEEECCCCHHHHCCCCCHHHCCCCCEEEECCCCEEEEECCCHHHHHH
RRGEGPTLIEVKTDRYYGHFQGDPETYRPKGEAKELRQHDPIPTLGALLRSRDLLDDEAD
HCCCCCEEEEEECCCEEEEECCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCHHH
AALRARVSARVQAAYDFGRNSPYPEPQDALLHVFAE
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEECC
>Mature Secondary Structure
MEATAEQLLWMYEKMVEIREYEETMAKVYLEAKLPPKIQKGLAFDIGAGPVPGEMHLAAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHCCCEEECCCCCCCCCEEECCC
QEPVAVGVCAHLRRDDTVVGAHRPHHFAIAKDVDLNAMTAEMYGKATGLGRGKGGHMHLF
CCCEEEHHHHHCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCEEEEE
DPAVKFSCSGIVGAGAPQACGAALAAKKLGTDAVAIAFFGEGAANQGAFHEALNLAALWK
CCCHHEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHEEEC
LPVVFVVEDNKYGISVEKSASTAIASNADRAAAYGMPGVLVEKNDAVAVFEAAGVAVARA
CCEEEEEECCCCCEEEECCCCHHHHCCCCCHHHCCCCCEEEECCCCEEEEECCCHHHHHH
RRGEGPTLIEVKTDRYYGHFQGDPETYRPKGEAKELRQHDPIPTLGALLRSRDLLDDEAD
HCCCCCEEEEEECCCEEEEECCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCHHH
AALRARVSARVQAAYDFGRNSPYPEPQDALLHVFAE
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pyruvate; [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

Specific reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S- $acetyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969503; 10368162; 9384377 [H]