Click here to switch to the map view.

The map label for this gene is gmd [H]

Identifier: 119899876

GI number: 119899876

Start: 3937403

End: 3938488

Strand: Reverse

Name: gmd [H]

Synonym: azo3587

Alternate gene names: 119899876

Gene position: 3938488-3937403 (Counterclockwise)

Preceding gene: 119899877

Following gene: 119899875

Centisome position: 90.0

GC content: 59.94

Gene sequence:

>1086_bases
ATGAAAAAAGTCGCGTTGATCACGGGTGTAACCGGCCAGGACGGCTCCTATCTCGCCGAGTTGCTGTTGGCCAAGGGCTA
TGAGGTCCACGGCATCAAGCGCCGCACGTCGCTCTTCAACACCGACCGGATCGACCATCTGTATCAGGACCCGCACGAAG
AAGGGCGCCGCTTCATTCTTCACTACGGCGACATGACGGACTCATCCAGCCTGATCCGCATCATCCAGCAGGTGCAGCCG
GACGAAATCTACAACCTCGCGGCGCAGTCCCATGTCGCGGTCTCGTTCGAAGAACCTGAGTACACCGCCAACTCGGACGC
GCTTGGCGCCTTGCGCATCCTTGAGGCGATCCGCATCCTCGGCCTGGAGAAGAAGTCCCGCTTCTATCAGGCGTCGACCT
CCGAGTTGTACGGCTTGGTCCAGGAGATCCCGCAGAAGGAGACGACGCCGTTCTACCCGCGGTCGCCCTATGCCGTCGCC
AAGATGTATGCGTACTGGATCACGGTGAATTACCGCGAGGCCTATGGGATCTATGCCTGCAACGGCATCTTGTTCAACCA
CGAGAGCCCGGTGCGGGGTGAAACCTTTGTTACCCGCAAAATCACCCGCGCGCTCGCGCGCATCAAACTCGGGCTGCAAG
ACTGCCTTTTCCTCGGCAACCTGAACGCGAAGCGCGATTGGGGCCATGCCAAGGACTACGTGGAGATGCAGTGGATGATG
CTGCAGCAGGACAAGCCGGAGGATTTCGTCATCGCCACGGGTGTGCAATACAGCGTGAGGGAGTTCGTCGACGCGGCTGC
GCGCGAGATCGGCATCCGCATCACCTGGAAGGGCGAAGGGGTGGACGAGAAGGGGTATGACGAAAGCGGCCGCTGCATCG
TCGCAGTCGATGAGCGCTACTTCAGGCCTACCGAGGTCGAGACGCTGCTGGGCGATGCCTCCAAGGCCCGGCGCCTGCTT
GGTTGGACACCACGGATTTCGTTTAGCGAACTTGTGTCGGAGATGATGCGCGAAGACATGAAGGCGGCGGAGCGTGATGA
ACTCGTCAAGACGCATGGCTATTCGGCCTATGACTACCACGAATAA

Upstream 100 bases:

>100_bases
GTTTTCCGCATAAGGTTGCGGTATTGAACTGATAGCTGCCCGGCAAGGGCGCGCGGTCGGCGAATGAAGCACAAGATTTC
TATCAAGTAAGCAGAGAAAC

Downstream 100 bases:

>100_bases
TCTGCCCTTGGACAAGGATGCCCGGATCTATGTTGCGGGGCACCGCGGCATGGTCGGCTCCGCCATCGAGCGGCGTCTGG
TGGCTGCCGGTTATTCCAAT

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MKKVALITGVTGQDGSYLAELLLAKGYEVHGIKRRTSLFNTDRIDHLYQDPHEEGRRFILHYGDMTDSSSLIRIIQQVQP
DEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRILGLEKKSRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVA
KMYAYWITVNYREAYGIYACNGILFNHESPVRGETFVTRKITRALARIKLGLQDCLFLGNLNAKRDWGHAKDYVEMQWMM
LQQDKPEDFVIATGVQYSVREFVDAAAREIGIRITWKGEGVDEKGYDESGRCIVAVDERYFRPTEVETLLGDASKARRLL
GWTPRISFSELVSEMMREDMKAAERDELVKTHGYSAYDYHE

Sequences:

>Translated_361_residues
MKKVALITGVTGQDGSYLAELLLAKGYEVHGIKRRTSLFNTDRIDHLYQDPHEEGRRFILHYGDMTDSSSLIRIIQQVQP
DEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRILGLEKKSRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVA
KMYAYWITVNYREAYGIYACNGILFNHESPVRGETFVTRKITRALARIKLGLQDCLFLGNLNAKRDWGHAKDYVEMQWMM
LQQDKPEDFVIATGVQYSVREFVDAAAREIGIRITWKGEGVDEKGYDESGRCIVAVDERYFRPTEVETLLGDASKARRLL
GWTPRISFSELVSEMMREDMKAAERDELVKTHGYSAYDYHE
>Mature_361_residues
MKKVALITGVTGQDGSYLAELLLAKGYEVHGIKRRTSLFNTDRIDHLYQDPHEEGRRFILHYGDMTDSSSLIRIIQQVQP
DEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRILGLEKKSRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVA
KMYAYWITVNYREAYGIYACNGILFNHESPVRGETFVTRKITRALARIKLGLQDCLFLGNLNAKRDWGHAKDYVEMQWMM
LQQDKPEDFVIATGVQYSVREFVDAAAREIGIRITWKGEGVDEKGYDESGRCIVAVDERYFRPTEVETLLGDASKARRLL
GWTPRISFSELVSEMMREDMKAAERDELVKTHGYSAYDYHE

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=343, Percent_Identity=62.9737609329446, Blast_Score=454, Evalue=1e-128,
Organism=Escherichia coli, GI1788366, Length=365, Percent_Identity=71.2328767123288, Blast_Score=557, Evalue=1e-160,
Organism=Escherichia coli, GI48994969, Length=339, Percent_Identity=27.7286135693215, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788353, Length=323, Percent_Identity=24.7678018575851, Blast_Score=78, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17507723, Length=349, Percent_Identity=66.189111747851, Blast_Score=482, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17539424, Length=341, Percent_Identity=65.3958944281525, Blast_Score=473, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI133901790, Length=341, Percent_Identity=65.3958944281525, Blast_Score=472, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17539422, Length=341, Percent_Identity=65.3958944281525, Blast_Score=472, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI133901788, Length=341, Percent_Identity=65.3958944281525, Blast_Score=472, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI133901786, Length=341, Percent_Identity=65.3958944281525, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24158427, Length=348, Percent_Identity=65.5172413793103, Blast_Score=473, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 41390; Mature: 41390

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVALITGVTGQDGSYLAELLLAKGYEVHGIKRRTSLFNTDRIDHLYQDPHEEGRRFIL
CCCEEEEEECCCCCHHHHHHHHHHCCCCEECHHHHHHHHCCHHHHHHHCCCCHHCCEEEE
HYGDMTDSSSLIRIIQQVQPDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRIL
EECCCCCHHHHHHHHHHCCHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
GLEKKSRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVAKMYAYWITVNYREAYGIYAC
CCCHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHEEEEEEEEEEEHHHCCEEEE
NGILFNHESPVRGETFVTRKITRALARIKLGLQDCLFLGNLNAKRDWGHAKDYVEMQWMM
CEEEECCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
LQQDKPEDFVIATGVQYSVREFVDAAAREIGIRITWKGEGVDEKGYDESGRCIVAVDERY
HCCCCCCCEEEECCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCEEEEECCCC
FRPTEVETLLGDASKARRLLGWTPRISFSELVSEMMREDMKAAERDELVKTHGYSAYDYH
CCCCHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
E
C
>Mature Secondary Structure
MKKVALITGVTGQDGSYLAELLLAKGYEVHGIKRRTSLFNTDRIDHLYQDPHEEGRRFIL
CCCEEEEEECCCCCHHHHHHHHHHCCCCEECHHHHHHHHCCHHHHHHHCCCCHHCCEEEE
HYGDMTDSSSLIRIIQQVQPDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRIL
EECCCCCHHHHHHHHHHCCHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
GLEKKSRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVAKMYAYWITVNYREAYGIYAC
CCCHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHEEEEEEEEEEEHHHCCEEEE
NGILFNHESPVRGETFVTRKITRALARIKLGLQDCLFLGNLNAKRDWGHAKDYVEMQWMM
CEEEECCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
LQQDKPEDFVIATGVQYSVREFVDAAAREIGIRITWKGEGVDEKGYDESGRCIVAVDERY
HCCCCCCCEEEECCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCEEEEECCCC
FRPTEVETLLGDASKARRLLGWTPRISFSELVSEMMREDMKAAERDELVKTHGYSAYDYH
CCCCHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9098074; 10521656 [H]