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The map label for this gene is cobA2 [H]

Identifier: 119899840

GI number: 119899840

Start: 3895824

End: 3896717

Strand: Reverse

Name: cobA2 [H]

Synonym: azo3551

Alternate gene names: 119899840

Gene position: 3896717-3895824 (Counterclockwise)

Preceding gene: 119899841

Following gene: 119899839

Centisome position: 89.05

GC content: 72.26

Gene sequence:

>894_bases
ATGACGCATTCCCGCCTGCGCAATCCGCGCCCCGGCCCGTTGCCGGGTCATGTCTACCTGGTCGGCGCCGGCCCCGGCGA
TCCGGAACTGCTGACGCTGCGCGGTGCGCGCCTGGTCGAGGGCGCCGACGTCGTGGTTTATGACAACCTCGTCAGCCCGG
CGATCATCGACCTCGCGCCGGCCCGCGCGGAACGCATCTACGTGGGCAAGAAGGCGGCCGACCACACCCTGCCGCAGGAC
GAGATCAACCAGCTGCTGGTGAAGCTTGCCGGCGAGGGCAAGCGGGTGGTGCGGCTGAAGGGCGGCGACCCCTTCATCTT
CGGCCGTGGCGGCGAGGAGATGGAGGTGCTGGTGGCCGCTGGCGTGACCGTGGAGGTGGTGCCGGGCGTCACCGCGGCGG
CCGGCATCGCCGCCTACGCCGGCATACCGCTGACGCACCGCGAACATGCGCAGTCCGTCGTGTTCACCACCGGCTTCCTG
AAGGACGGTGCGCTCGATCTCGACTGGCCGATGCTGGCGCGGCGCGGGCAGACGCTGGTGATCTACATGGGCATTTCGCG
GCTGGCCGAGATCTGCGCGCAACTCGTCGCCCATGGCCTGCCGGCCACCACGCCGGCCGGCGTCATCGAGCGCGGCACCA
CCGCGGCGCAGCGCGTGGTGACCGCGGACCTGATGACCCTGCCCGCGCGCGTGACCGAGGCCGGCATCCGTCCGCCCGCG
CTGACGATCGTCGGTGACGTTGTCGGGTTGTACCCGCGCCTCGCGTGGTTTTCCGCCGCGCCGCCGGAAGGCGAACCGCA
TCTGCCGCATGCCGGCTGCAGCGCGGTGCATGCCGGGCAGGTCGCGGAGGGCCTCGACGGCGACGCCGCGGCCGGGCGCG
GGGACGCGTGTTGA

Upstream 100 bases:

>100_bases
GAACTGGTGGCCGCGGCCGACACCGTGACCGACATGACGCCGGTCAAGCATGCCTTTGCCGCCGGGGTGAAGGCGATGCC
CGGCATGGAGTGGTGACGCG

Downstream 100 bases:

>100_bases
GCGCCGCACGCCGCTGCCCCGCGCTGTTGGTCGCCGCGCCGGCCTCGGGCCAGGGCAAGACCACGGTCACCGCGGCGCTT
GCCCGGCTGCACACCCGGCT

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MTHSRLRNPRPGPLPGHVYLVGAGPGDPELLTLRGARLVEGADVVVYDNLVSPAIIDLAPARAERIYVGKKAADHTLPQD
EINQLLVKLAGEGKRVVRLKGGDPFIFGRGGEEMEVLVAAGVTVEVVPGVTAAAGIAAYAGIPLTHREHAQSVVFTTGFL
KDGALDLDWPMLARRGQTLVIYMGISRLAEICAQLVAHGLPATTPAGVIERGTTAAQRVVTADLMTLPARVTEAGIRPPA
LTIVGDVVGLYPRLAWFSAAPPEGEPHLPHAGCSAVHAGQVAEGLDGDAAAGRGDAC

Sequences:

>Translated_297_residues
MTHSRLRNPRPGPLPGHVYLVGAGPGDPELLTLRGARLVEGADVVVYDNLVSPAIIDLAPARAERIYVGKKAADHTLPQD
EINQLLVKLAGEGKRVVRLKGGDPFIFGRGGEEMEVLVAAGVTVEVVPGVTAAAGIAAYAGIPLTHREHAQSVVFTTGFL
KDGALDLDWPMLARRGQTLVIYMGISRLAEICAQLVAHGLPATTPAGVIERGTTAAQRVVTADLMTLPARVTEAGIRPPA
LTIVGDVVGLYPRLAWFSAAPPEGEPHLPHAGCSAVHAGQVAEGLDGDAAAGRGDAC
>Mature_296_residues
THSRLRNPRPGPLPGHVYLVGAGPGDPELLTLRGARLVEGADVVVYDNLVSPAIIDLAPARAERIYVGKKAADHTLPQDE
INQLLVKLAGEGKRVVRLKGGDPFIFGRGGEEMEVLVAAGVTVEVVPGVTAAAGIAAYAGIPLTHREHAQSVVFTTGFLK
DGALDLDWPMLARRGQTLVIYMGISRLAEICAQLVAHGLPATTPAGVIERGTTAAQRVVTADLMTLPARVTEAGIRPPAL
TIVGDVVGLYPRLAWFSAAPPEGEPHLPHAGCSAVHAGQVAEGLDGDAAAGRGDAC

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=243, Percent_Identity=54.320987654321, Blast_Score=261, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6322922, Length=234, Percent_Identity=35.4700854700855, Blast_Score=136, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 30867; Mature: 30736

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHSRLRNPRPGPLPGHVYLVGAGPGDPELLTLRGARLVEGADVVVYDNLVSPAIIDLAP
CCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEECCCEEECCCCEEEECCCCCCHHHHCCC
ARAERIYVGKKAADHTLPQDEINQLLVKLAGEGKRVVRLKGGDPFIFGRGGEEMEVLVAA
CCCCEEEECCCHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCCEEEEEEC
GVTVEVVPGVTAAAGIAAYAGIPLTHREHAQSVVFTTGFLKDGALDLDWPMLARRGQTLV
CCEEEECCCCHHHHHHHHHHCCCCCCHHHHCEEEEEECCCCCCCCCCCCHHHHCCCCEEE
IYMGISRLAEICAQLVAHGLPATTPAGVIERGTTAAQRVVTADLMTLPARVTEAGIRPPA
EEECHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCH
LTIVGDVVGLYPRLAWFSAAPPEGEPHLPHAGCSAVHAGQVAEGLDGDAAAGRGDAC
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
THSRLRNPRPGPLPGHVYLVGAGPGDPELLTLRGARLVEGADVVVYDNLVSPAIIDLAP
CCCCCCCCCCCCCCCEEEEEECCCCCCCEEEECCCEEECCCCEEEECCCCCCHHHHCCC
ARAERIYVGKKAADHTLPQDEINQLLVKLAGEGKRVVRLKGGDPFIFGRGGEEMEVLVAA
CCCCEEEECCCHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCCEEEEEEC
GVTVEVVPGVTAAAGIAAYAGIPLTHREHAQSVVFTTGFLKDGALDLDWPMLARRGQTLV
CCEEEECCCCHHHHHHHHHHCCCCCCHHHHCEEEEEECCCCCCCCCCCCHHHHCCCCEEE
IYMGISRLAEICAQLVAHGLPATTPAGVIERGTTAAQRVVTADLMTLPARVTEAGIRPPA
EEECHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCH
LTIVGDVVGLYPRLAWFSAAPPEGEPHLPHAGCSAVHAGQVAEGLDGDAAAGRGDAC
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA