Click here to switch to the map view.

The map label for this gene is zraS [H]

Identifier: 119899781

GI number: 119899781

Start: 3832128

End: 3834263

Strand: Reverse

Name: zraS [H]

Synonym: azo3492

Alternate gene names: 119899781

Gene position: 3834263-3832128 (Counterclockwise)

Preceding gene: 119899782

Following gene: 119899780

Centisome position: 87.62

GC content: 69.48

Gene sequence:

>2136_bases
ATGCGTCTGCCCCGCTTGCTGCGCCCGCTGCTCGACTACTTCGCCGGCTCGGTCCGCGCCAAGCTGCTGTTCCTGGTGCT
TGCCCCGTTGATGCTCGGTTTCCCGATCATCATGGGGCTGACCTGGTACTGGAGCCACACCTACTACCACAAGCTGCTGG
TCTTCAAGGTCGGCAGCGACCTGGTCAGCGCGCACGAGTACTTCGACCGCGTGGTTGCCGACGTCGGCAACCGGGTCGAG
GGCTTCGCCGATTCGCGCCGGCTCGCGGCGGCGCTTGCGCACGAAGCGCCGTCTGCCGACCGCTCCGCCCCCGGCGCGGC
GCACCAGGGCGTGCCGGGCGAACTGCAGGTGCTGCTGGAGCAGGTGCGCGGCGAGCGCGGGCTCGACTATCTCAACGTGC
TGGATGTGAATGGCCGCGTGCTGCGTTCGTCCGGCACCCTACCAGCCGGTGCCGAGCGCGCCCACTGGCCGCTGGTGATG
CGCGCGATCCGCGAGGGCGCCGCGAGCGGCGTGGAGGTGTTCGAAGCCGCCGAGCTGGGCGCGATCGCTCCCGCCCTGCG
CGAACGCGCCCGGCTGGCCTTGCGCGACACGCCGCGTGCGCGCGCCGACGACCGTGACGAGGAAACGCGCGGCATGGTGA
TCCAGGCCGCGGCGCCGGTGGTGGATGCGCGCGGCAACCTGGTCGCGGTGGTCGAGGGCGGGCTGTTGCTCAACGGCAAT
CTCGCGATCGTCGATACGATCAACGCCATCGTCTATCGAGACGGTTCGCTGCCGCTCGGCAGCAAGGGCACCGCCACGCT
GTTTCTCGGCGACGCCCGTATCGCCACCAACGTGCGCCTGTTCGCCGGCGAACGCGCGCTCGGCACGCGCGCCTCGGCCG
AGGTGCGCGAGCACGTGCTGGAGCAGGGCCACACCTGGCTGGAGACCGCCTTCGTGGTAAACGACTGGTACGTGTCCGGT
TACGAGCCGGTGCTCGACAGCGCCGGCGAGCGCGTCGGCATGCTCTACGTCGGCTTCCTCGAGGCGCCATTCCGGGTGGC
CAAGACCGTGGCGCTGCTGGTGATCTTCTGCCTGTTCCTGCTGATCAGCCTCGCCGGCGCAGTGTGGTCGCTGCAGTGGG
CGCGCAGCATCTTCCGCCCGATCGAGCGCATGCACGGCACCATCGGCCGCATCGAGGCGGGCGAGGGCGCGGCGCGGGTG
GGCGAGGTGGGCAGCCGCGACGAGCTCGGCCTGCTCGCGCGCGAGTTCGACCGCCTGCTCGATACCCTGGCGGGCAAGCG
CGAGCAATTGCAGCAACTGGCCGAGTCGCTGGACCGCAAGGTGGTCGAACGCACGCGCGACCTCGAGGCCGCCAACGCGG
AACTGCGCACCGCGCAGCGCCAACTGGTGATGACCGAGAAGCTTGCCGCGATCGGCGAACTGACCGCGGGCGTCGCGCAC
GAGATCAGCAACCCCACCGCGGTCATCCAGGGCAACCTCGAATTGCTGCGCGAGGAACTCGGCGAACACGCGACGCCGGT
GCTGAACGAGATCCGCCTGATCGACGAACAGGTCAACCGCATCCGCAAGATCGTCACCAAGCTGCTGCAGTTCGCCCGCC
CCGGCGAGTTCGCCGGCTATGCCGCCGCGGTGGACGTGAATACGGTGCTGGCGGATTGCCTGGTGCTGACGCGCCAGCAT
CTGTCGCGCCAAGGCGTGACCGTGCGGCACGAGCCGGGCACGCTGCGGCTGGTCGAGATCAACGAGCAGGAGTTGCAGCA
GGTCTTGATCAACCTGATCGTCAACGCGGTGCAGGCGATGCCGGCCGGCGGCACGCTGACGTTGACCACCGCGGACTGGG
ACGAGCGCGGGCCGGGCGGAATCGTGGCGCGCGGGGTATGCGTCACGGTGCGCGACACCGGGCAGGGTATCCGCGACGAG
GATCTCGCGCGTATATTCGACCCCTTTTTCACCACCAAGAAGACGCAGGGCACCGGACTCGGACTGTCGATCAGCTACTC
GCTCGTCGAGCGCTATGGCGGCCGCATCACGGTGGAAAGCGTGCCCGGCGCAGGCGCGGCCTTCACCGTCTGGCTGCTGA
CCGAGCCCGAATATCACGTCGAGCCGGTAGAGCCGGCGCGCAACGGCGGCGCCTGA

Upstream 100 bases:

>100_bases
AGGCCGCGCGCCGGCTGGCGGTATCGCGCAAGACCCTGGACCGCAAGTTCGCCGAATGGGGTGAGGCCGCAACCCCCGGC
GGCGGCGACTGACCCGCCCG

Downstream 100 bases:

>100_bases
CGCAGCCCACCCCGCACCCACTGCAACGGAACATGAACGTCATCGGATTCGCCGGCTGGTCCGGCAGCGGCAAGACCACT
CTCGTCGAACAGGTGGTGGC

Product: putative sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 711; Mature: 711

Protein sequence:

>711_residues
MRLPRLLRPLLDYFAGSVRAKLLFLVLAPLMLGFPIIMGLTWYWSHTYYHKLLVFKVGSDLVSAHEYFDRVVADVGNRVE
GFADSRRLAAALAHEAPSADRSAPGAAHQGVPGELQVLLEQVRGERGLDYLNVLDVNGRVLRSSGTLPAGAERAHWPLVM
RAIREGAASGVEVFEAAELGAIAPALRERARLALRDTPRARADDRDEETRGMVIQAAAPVVDARGNLVAVVEGGLLLNGN
LAIVDTINAIVYRDGSLPLGSKGTATLFLGDARIATNVRLFAGERALGTRASAEVREHVLEQGHTWLETAFVVNDWYVSG
YEPVLDSAGERVGMLYVGFLEAPFRVAKTVALLVIFCLFLLISLAGAVWSLQWARSIFRPIERMHGTIGRIEAGEGAARV
GEVGSRDELGLLAREFDRLLDTLAGKREQLQQLAESLDRKVVERTRDLEAANAELRTAQRQLVMTEKLAAIGELTAGVAH
EISNPTAVIQGNLELLREELGEHATPVLNEIRLIDEQVNRIRKIVTKLLQFARPGEFAGYAAAVDVNTVLADCLVLTRQH
LSRQGVTVRHEPGTLRLVEINEQELQQVLINLIVNAVQAMPAGGTLTLTTADWDERGPGGIVARGVCVTVRDTGQGIRDE
DLARIFDPFFTTKKTQGTGLGLSISYSLVERYGGRITVESVPGAGAAFTVWLLTEPEYHVEPVEPARNGGA

Sequences:

>Translated_711_residues
MRLPRLLRPLLDYFAGSVRAKLLFLVLAPLMLGFPIIMGLTWYWSHTYYHKLLVFKVGSDLVSAHEYFDRVVADVGNRVE
GFADSRRLAAALAHEAPSADRSAPGAAHQGVPGELQVLLEQVRGERGLDYLNVLDVNGRVLRSSGTLPAGAERAHWPLVM
RAIREGAASGVEVFEAAELGAIAPALRERARLALRDTPRARADDRDEETRGMVIQAAAPVVDARGNLVAVVEGGLLLNGN
LAIVDTINAIVYRDGSLPLGSKGTATLFLGDARIATNVRLFAGERALGTRASAEVREHVLEQGHTWLETAFVVNDWYVSG
YEPVLDSAGERVGMLYVGFLEAPFRVAKTVALLVIFCLFLLISLAGAVWSLQWARSIFRPIERMHGTIGRIEAGEGAARV
GEVGSRDELGLLAREFDRLLDTLAGKREQLQQLAESLDRKVVERTRDLEAANAELRTAQRQLVMTEKLAAIGELTAGVAH
EISNPTAVIQGNLELLREELGEHATPVLNEIRLIDEQVNRIRKIVTKLLQFARPGEFAGYAAAVDVNTVLADCLVLTRQH
LSRQGVTVRHEPGTLRLVEINEQELQQVLINLIVNAVQAMPAGGTLTLTTADWDERGPGGIVARGVCVTVRDTGQGIRDE
DLARIFDPFFTTKKTQGTGLGLSISYSLVERYGGRITVESVPGAGAAFTVWLLTEPEYHVEPVEPARNGGA
>Mature_711_residues
MRLPRLLRPLLDYFAGSVRAKLLFLVLAPLMLGFPIIMGLTWYWSHTYYHKLLVFKVGSDLVSAHEYFDRVVADVGNRVE
GFADSRRLAAALAHEAPSADRSAPGAAHQGVPGELQVLLEQVRGERGLDYLNVLDVNGRVLRSSGTLPAGAERAHWPLVM
RAIREGAASGVEVFEAAELGAIAPALRERARLALRDTPRARADDRDEETRGMVIQAAAPVVDARGNLVAVVEGGLLLNGN
LAIVDTINAIVYRDGSLPLGSKGTATLFLGDARIATNVRLFAGERALGTRASAEVREHVLEQGHTWLETAFVVNDWYVSG
YEPVLDSAGERVGMLYVGFLEAPFRVAKTVALLVIFCLFLLISLAGAVWSLQWARSIFRPIERMHGTIGRIEAGEGAARV
GEVGSRDELGLLAREFDRLLDTLAGKREQLQQLAESLDRKVVERTRDLEAANAELRTAQRQLVMTEKLAAIGELTAGVAH
EISNPTAVIQGNLELLREELGEHATPVLNEIRLIDEQVNRIRKIVTKLLQFARPGEFAGYAAAVDVNTVLADCLVLTRQH
LSRQGVTVRHEPGTLRLVEINEQELQQVLINLIVNAVQAMPAGGTLTLTTADWDERGPGGIVARGVCVTVRDTGQGIRDE
DLARIFDPFFTTKKTQGTGLGLSISYSLVERYGGRITVESVPGAGAAFTVWLLTEPEYHVEPVEPARNGGA

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=239, Percent_Identity=36.8200836820084, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI1788549, Length=248, Percent_Identity=33.4677419354839, Blast_Score=134, Evalue=3e-32,
Organism=Escherichia coli, GI145693157, Length=398, Percent_Identity=25.1256281407035, Blast_Score=91, Evalue=4e-19,
Organism=Escherichia coli, GI1789149, Length=433, Percent_Identity=22.1709006928406, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790300, Length=248, Percent_Identity=29.4354838709677, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1788393, Length=334, Percent_Identity=24.251497005988, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1786600, Length=227, Percent_Identity=31.2775330396476, Blast_Score=80, Evalue=7e-16,
Organism=Escherichia coli, GI1790346, Length=227, Percent_Identity=25.1101321585903, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=28.1385281385281, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1790861, Length=219, Percent_Identity=29.2237442922374, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 77401; Mature: 77401

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLPRLLRPLLDYFAGSVRAKLLFLVLAPLMLGFPIIMGLTWYWSHTYYHKLLVFKVGSD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHCHH
LVSAHEYFDRVVADVGNRVEGFADSRRLAAALAHEAPSADRSAPGAAHQGVPGELQVLLE
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
QVRGERGLDYLNVLDVNGRVLRSSGTLPAGAERAHWPLVMRAIREGAASGVEVFEAAELG
HHCCCCCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
AIAPALRERARLALRDTPRARADDRDEETRGMVIQAAAPVVDARGNLVAVVEGGLLLNGN
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCEEEEECCCEECCCCCEEEEEECCEEEECC
LAIVDTINAIVYRDGSLPLGSKGTATLFLGDARIATNVRLFAGERALGTRASAEVREHVL
EEEEEEEEEEEEECCCCCCCCCCCEEEEEECCEEECCEEEEECCCCCCCCHHHHHHHHHH
EQGHTWLETAFVVNDWYVSGYEPVLDSAGERVGMLYVGFLEAPFRVAKTVALLVIFCLFL
HCCCHHHHHEEEEECCEECCCCHHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHH
LISLAGAVWSLQWARSIFRPIERMHGTIGRIEAGEGAARVGEVGSRDELGLLAREFDRLL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHCCCCCCCHHHHHHHHHHHHH
DTLAGKREQLQQLAESLDRKVVERTRDLEAANAELRTAQRQLVMTEKLAAIGELTAGVAH
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EISNPTAVIQGNLELLREELGEHATPVLNEIRLIDEQVNRIRKIVTKLLQFARPGEFAGY
HCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
AAAVDVNTVLADCLVLTRQHLSRQGVTVRHEPGTLRLVEINEQELQQVLINLIVNAVQAM
EEEEHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHC
PAGGTLTLTTADWDERGPGGIVARGVCVTVRDTGQGIRDEDLARIFDPFFTTKKTQGTGL
CCCCEEEEEECCCCCCCCCCEEECCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCC
GLSISYSLVERYGGRITVESVPGAGAAFTVWLLTEPEYHVEPVEPARNGGA
CEEEHHHHHHHHCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRLPRLLRPLLDYFAGSVRAKLLFLVLAPLMLGFPIIMGLTWYWSHTYYHKLLVFKVGSD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHCHH
LVSAHEYFDRVVADVGNRVEGFADSRRLAAALAHEAPSADRSAPGAAHQGVPGELQVLLE
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
QVRGERGLDYLNVLDVNGRVLRSSGTLPAGAERAHWPLVMRAIREGAASGVEVFEAAELG
HHCCCCCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
AIAPALRERARLALRDTPRARADDRDEETRGMVIQAAAPVVDARGNLVAVVEGGLLLNGN
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCEEEEECCCEECCCCCEEEEEECCEEEECC
LAIVDTINAIVYRDGSLPLGSKGTATLFLGDARIATNVRLFAGERALGTRASAEVREHVL
EEEEEEEEEEEEECCCCCCCCCCCEEEEEECCEEECCEEEEECCCCCCCCHHHHHHHHHH
EQGHTWLETAFVVNDWYVSGYEPVLDSAGERVGMLYVGFLEAPFRVAKTVALLVIFCLFL
HCCCHHHHHEEEEECCEECCCCHHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHH
LISLAGAVWSLQWARSIFRPIERMHGTIGRIEAGEGAARVGEVGSRDELGLLAREFDRLL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHCCCCCCCHHHHHHHHHHHHH
DTLAGKREQLQQLAESLDRKVVERTRDLEAANAELRTAQRQLVMTEKLAAIGELTAGVAH
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EISNPTAVIQGNLELLREELGEHATPVLNEIRLIDEQVNRIRKIVTKLLQFARPGEFAGY
HCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
AAAVDVNTVLADCLVLTRQHLSRQGVTVRHEPGTLRLVEINEQELQQVLINLIVNAVQAM
EEEEHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHC
PAGGTLTLTTADWDERGPGGIVARGVCVTVRDTGQGIRDEDLARIFDPFFTTKKTQGTGL
CCCCEEEEEECCCCCCCCCCEEECCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCC
GLSISYSLVERYGGRITVESVPGAGAAFTVWLLTEPEYHVEPVEPARNGGA
CEEEHHHHHHHHCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]