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The map label for this gene is proC [H]

Identifier: 119899755

GI number: 119899755

Start: 3802601

End: 3803425

Strand: Reverse

Name: proC [H]

Synonym: azo3466

Alternate gene names: 119899755

Gene position: 3803425-3802601 (Counterclockwise)

Preceding gene: 119899756

Following gene: 119899754

Centisome position: 86.91

GC content: 71.03

Gene sequence:

>825_bases
ATGAAAATTACCTTCCTCGGCGGCGGCAACATGGCTGCAGCCCTGATCGGTGGTCTGGTGGAACGCGGCTTTGCGGCCGC
AGATCTGTGCGCGATCGACCTCGATGGCGCAACCCGCGAGCGCCTCGCCGCACGTTTCGGCGTTCGCACCGCAGATGCGG
CGGACGACGCCGCGCTCGCATGCGACGTGCTGGTGCTGGCGGTGAAGCCGCAGCAGATGAAGGCGGCGCTGGCACCGATC
GCGGGGCGCCTGTCCGCACAACTGGTGGTCAGTATCGCTGCCGGTCTGCGCGTTGCCGACCTCGGGCGCTGGCTTGGTGA
GGCGGGCAAGCCCTATGCGCGGATCGTGCGCTGCATGCCCAACACCCCGGCGCTGATCGGCGCTGGCGTTACCGGTCTGT
ACGCGGGTGCGGTGGTGGATGCGGCGGGACGCGAGGCGGCCGAACGGGTGCTCGCCGCGGTCGGCAGCACCGTATGGGTG
CAGGACGAAGCACAGATCGACGCGGTTACCGCGGTTTCCGGCAGCGGCCCGGCCTACGTCTTCCATTTCATCGAGGCGCT
GGAGGCGGCCGGGCGTGCGCTCGGCTTCGACGAGGCGGTTGCGCGCAAGCTCGCGCTCGACACGACCCTGGGCGCCGCGC
GCCTCGCGGCCGGTTCGGACGAGGCGCCGGCGGTGCTGCGCGAACGCGTGACCTCCAAAGGCGGTACCACCGCCGCCGCG
CTTGCCAGTCTTGCGACCGCCGGCTGGCATGACGCGCTGGGTGTTGCGGTGGCTGCCGCCGCTGCGCGCGGACGCGAACT
GGGCGACGAGTTGGGCCGGGATTGA

Upstream 100 bases:

>100_bases
GAGTCGGCAGCGGTGGCGGGCGGTTGAGTCCGGCGGTCCGGCGTGGCCCGGCGCGCGTCCTGTCAATAATCAGTTCATCT
CATCTGGCGGTGGAACCGAC

Downstream 100 bases:

>100_bases
GCCGCCAGGACCGAACCGATGCTGACCAACATCTTCCTGCTGATCCTCGACACCGCCGTCGGCTTTCTCACGCTGATGCT
GCTCGCGCGCTTCTTCATGC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MKITFLGGGNMAAALIGGLVERGFAAADLCAIDLDGATRERLAARFGVRTADAADDAALACDVLVLAVKPQQMKAALAPI
AGRLSAQLVVSIAAGLRVADLGRWLGEAGKPYARIVRCMPNTPALIGAGVTGLYAGAVVDAAGREAAERVLAAVGSTVWV
QDEAQIDAVTAVSGSGPAYVFHFIEALEAAGRALGFDEAVARKLALDTTLGAARLAAGSDEAPAVLRERVTSKGGTTAAA
LASLATAGWHDALGVAVAAAAARGRELGDELGRD

Sequences:

>Translated_274_residues
MKITFLGGGNMAAALIGGLVERGFAAADLCAIDLDGATRERLAARFGVRTADAADDAALACDVLVLAVKPQQMKAALAPI
AGRLSAQLVVSIAAGLRVADLGRWLGEAGKPYARIVRCMPNTPALIGAGVTGLYAGAVVDAAGREAAERVLAAVGSTVWV
QDEAQIDAVTAVSGSGPAYVFHFIEALEAAGRALGFDEAVARKLALDTTLGAARLAAGSDEAPAVLRERVTSKGGTTAAA
LASLATAGWHDALGVAVAAAAARGRELGDELGRD
>Mature_274_residues
MKITFLGGGNMAAALIGGLVERGFAAADLCAIDLDGATRERLAARFGVRTADAADDAALACDVLVLAVKPQQMKAALAPI
AGRLSAQLVVSIAAGLRVADLGRWLGEAGKPYARIVRCMPNTPALIGAGVTGLYAGAVVDAAGREAAERVLAAVGSTVWV
QDEAQIDAVTAVSGSGPAYVFHFIEALEAAGRALGFDEAVARKLALDTTLGAARLAAGSDEAPAVLRERVTSKGGTTAAA
LASLATAGWHDALGVAVAAAAARGRELGDELGRD

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=271, Percent_Identity=35.0553505535055, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI24797097, Length=271, Percent_Identity=35.0553505535055, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI21361454, Length=275, Percent_Identity=33.0909090909091, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI198041662, Length=270, Percent_Identity=31.8518518518519, Blast_Score=115, Evalue=5e-26,
Organism=Escherichia coli, GI1786585, Length=270, Percent_Identity=35.9259259259259, Blast_Score=131, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17569021, Length=280, Percent_Identity=36.4285714285714, Blast_Score=134, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17540664, Length=293, Percent_Identity=28.6689419795222, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320861, Length=230, Percent_Identity=26.9565217391304, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=36.5671641791045, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24648116, Length=279, Percent_Identity=34.4086021505376, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24647700, Length=157, Percent_Identity=40.7643312101911, Blast_Score=107, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27526; Mature: 27526

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITFLGGGNMAAALIGGLVERGFAAADLCAIDLDGATRERLAARFGVRTADAADDAALA
CEEEEECCCCHHHHHHHHHHHCCCCHHHEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHH
CDVLVLAVKPQQMKAALAPIAGRLSAQLVVSIAAGLRVADLGRWLGEAGKPYARIVRCMP
HHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHCC
NTPALIGAGVTGLYAGAVVDAAGREAAERVLAAVGSTVWVQDEAQIDAVTAVSGSGPAYV
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEEECCCCHHHH
FHFIEALEAAGRALGFDEAVARKLALDTTLGAARLAAGSDEAPAVLRERVTSKGGTTAAA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHH
LASLATAGWHDALGVAVAAAAARGRELGDELGRD
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKITFLGGGNMAAALIGGLVERGFAAADLCAIDLDGATRERLAARFGVRTADAADDAALA
CEEEEECCCCHHHHHHHHHHHCCCCHHHEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHH
CDVLVLAVKPQQMKAALAPIAGRLSAQLVVSIAAGLRVADLGRWLGEAGKPYARIVRCMP
HHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHCC
NTPALIGAGVTGLYAGAVVDAAGREAAERVLAAVGSTVWVQDEAQIDAVTAVSGSGPAYV
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEEECCCCHHHH
FHFIEALEAAGRALGFDEAVARKLALDTTLGAARLAAGSDEAPAVLRERVTSKGGTTAAA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHH
LASLATAGWHDALGVAVAAAAARGRELGDELGRD
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]