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The map label for this gene is hisC2 [H]

Identifier: 119899637

GI number: 119899637

Start: 3685259

End: 3686347

Strand: Direct

Name: hisC2 [H]

Synonym: azo3348

Alternate gene names: 119899637

Gene position: 3685259-3686347 (Clockwise)

Preceding gene: 119899630

Following gene: 119899649

Centisome position: 84.21

GC content: 67.13

Gene sequence:

>1089_bases
ATGAGCCGCTACTGGAGCGCCGTCGTTCACGGCCTGACCCCTTATGTGCCGGGCGAACAGCCCAAGCTCGACAACCTGGT
CAAGCTCAACACCAACGAGCATCCGTACGGTCCGTCGCCGCGCGCGCTGGAGGCTATCCGCGCCGCCACATCGGATGCGC
TGCGGCTGTATCCGGACCCCAACGCCGACGCGCTCAAGCAGGCGCTCGCCGCGCGCTACCGGGTGAAGGCAGCGCAGATA
TTCGTCGGCAACGGCTCGGACGAAGTGCTGGCCCACGCTTTCATGGCCCTGCTCCGCCACGAGCGCCCGCTGTGGTTTCC
GGACATCAGTTACAGCTTCTACCCGGTGTATTGCGGCCTCTATGGCGTTCCGTCGCGCGTGGTGCCGCTCGACGCCGACT
TTGCGATCCGCGCCGACGACTACCTTCCCCGGGGCGAAGACCGCGCTGGCGCGATCATCTTCCCCAACCCCAACGCCCCC
ACCGGCCGCCTGCTGCCGCTCGCCGATATCGAGCGCATCGTCGCCGGCAATCCGGATGCAGTGGTTCTGGTCGACGAAGC
CTATGTCGATTTCGGCGGCGAAAGCGCGATCGCGCTGGTGGACCGCCACCCCAACCTGCTGGTAGTACAAACCTTTTCCA
AGAGCCGTTCGCTCGCCGGACTGCGCGTCGGCTTCGCTGTCGGCCACCCGGCACTGATCGAAGCCCTGGAGCGCGTGAAG
AACAGCTTCAACTCCTACCCGCTCGACCGCCTCGCCATCGCCGGTGCGGTCGCTTCGGTGGAAGACGAAGCGCACTTCTC
CGACAGCTGCGCGAAAGTGATCGCCACCCGCGAGCGCCTGACGGCCGCGCTGGCGGCACTGGGCTTCCAGGTCCTGCCGT
CAGCCGCCAACTTCGTCTTTGCGCGCCATCCTGCGCACGACGCCGGGCAACTCTCCGCGGCGCTACGCGAGCGCGCCATC
ATCGTGCGCCACTTCCGCCAGCCGCGCATCGACCAGTTCCTGCGCATTACCGTGGGCACGGATGCGCAGTGCGAGACGCT
GGTCGCCGGGTTGCGGGAAATCCTGGCGCGCGCAGGTACAGGCGGTTAA

Upstream 100 bases:

>100_bases
GCTGCAGAGAAAATCGAGGCCCATGATACCATCGCCGCACGATCCGGCCGCAAGCCGCGCCGCCCCCGCAAATCCCCCGT
TGCCAGCCGATACTGCAAGC

Downstream 100 bases:

>100_bases
CCGGGAAGAAGGGCTTCGCTGCCCCCGCGGCCGATTGGCAGTGACGGCAAGGCCGCACAGGCGGCCCGTGCCACCGCTCG
ATCAGACGTCGGCTTCACCC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSRYWSAVVHGLTPYVPGEQPKLDNLVKLNTNEHPYGPSPRALEAIRAATSDALRLYPDPNADALKQALAARYRVKAAQI
FVGNGSDEVLAHAFMALLRHERPLWFPDISYSFYPVYCGLYGVPSRVVPLDADFAIRADDYLPRGEDRAGAIIFPNPNAP
TGRLLPLADIERIVAGNPDAVVLVDEAYVDFGGESAIALVDRHPNLLVVQTFSKSRSLAGLRVGFAVGHPALIEALERVK
NSFNSYPLDRLAIAGAVASVEDEAHFSDSCAKVIATRERLTAALAALGFQVLPSAANFVFARHPAHDAGQLSAALRERAI
IVRHFRQPRIDQFLRITVGTDAQCETLVAGLREILARAGTGG

Sequences:

>Translated_362_residues
MSRYWSAVVHGLTPYVPGEQPKLDNLVKLNTNEHPYGPSPRALEAIRAATSDALRLYPDPNADALKQALAARYRVKAAQI
FVGNGSDEVLAHAFMALLRHERPLWFPDISYSFYPVYCGLYGVPSRVVPLDADFAIRADDYLPRGEDRAGAIIFPNPNAP
TGRLLPLADIERIVAGNPDAVVLVDEAYVDFGGESAIALVDRHPNLLVVQTFSKSRSLAGLRVGFAVGHPALIEALERVK
NSFNSYPLDRLAIAGAVASVEDEAHFSDSCAKVIATRERLTAALAALGFQVLPSAANFVFARHPAHDAGQLSAALRERAI
IVRHFRQPRIDQFLRITVGTDAQCETLVAGLREILARAGTGG
>Mature_361_residues
SRYWSAVVHGLTPYVPGEQPKLDNLVKLNTNEHPYGPSPRALEAIRAATSDALRLYPDPNADALKQALAARYRVKAAQIF
VGNGSDEVLAHAFMALLRHERPLWFPDISYSFYPVYCGLYGVPSRVVPLDADFAIRADDYLPRGEDRAGAIIFPNPNAPT
GRLLPLADIERIVAGNPDAVVLVDEAYVDFGGESAIALVDRHPNLLVVQTFSKSRSLAGLRVGFAVGHPALIEALERVKN
SFNSYPLDRLAIAGAVASVEDEAHFSDSCAKVIATRERLTAALAALGFQVLPSAANFVFARHPAHDAGQLSAALRERAII
VRHFRQPRIDQFLRITVGTDAQCETLVAGLREILARAGTGG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=353, Percent_Identity=30.028328611898, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1788722, Length=293, Percent_Identity=27.3037542662116, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322075, Length=381, Percent_Identity=28.6089238845144, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39263; Mature: 39132

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRYWSAVVHGLTPYVPGEQPKLDNLVKLNTNEHPYGPSPRALEAIRAATSDALRLYPDP
CCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCEEECCCC
NADALKQALAARYRVKAAQIFVGNGSDEVLAHAFMALLRHERPLWFPDISYSFYPVYCGL
CHHHHHHHHHHHHHEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEHHH
YGVPSRVVPLDADFAIRADDYLPRGEDRAGAIIFPNPNAPTGRLLPLADIERIVAGNPDA
CCCCCCEEECCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCCE
VVLVDEAYVDFGGESAIALVDRHPNLLVVQTFSKSRSLAGLRVGFAVGHPALIEALERVK
EEEEEEHEECCCCCCEEEEEECCCCEEEEEECCCCCCCCEEEEEHHCCCHHHHHHHHHHH
NSFNSYPLDRLAIAGAVASVEDEAHFSDSCAKVIATRERLTAALAALGFQVLPSAANFVF
HHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCEEE
ARHPAHDAGQLSAALRERAIIVRHFRQPRIDQFLRITVGTDAQCETLVAGLREILARAGT
EECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCC
GG
CC
>Mature Secondary Structure 
SRYWSAVVHGLTPYVPGEQPKLDNLVKLNTNEHPYGPSPRALEAIRAATSDALRLYPDP
CHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCEEECCCC
NADALKQALAARYRVKAAQIFVGNGSDEVLAHAFMALLRHERPLWFPDISYSFYPVYCGL
CHHHHHHHHHHHHHEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEHHH
YGVPSRVVPLDADFAIRADDYLPRGEDRAGAIIFPNPNAPTGRLLPLADIERIVAGNPDA
CCCCCCEEECCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCCE
VVLVDEAYVDFGGESAIALVDRHPNLLVVQTFSKSRSLAGLRVGFAVGHPALIEALERVK
EEEEEEHEECCCCCCEEEEEECCCCEEEEEECCCCCCCCEEEEEHHCCCHHHHHHHHHHH
NSFNSYPLDRLAIAGAVASVEDEAHFSDSCAKVIATRERLTAALAALGFQVLPSAANFVF
HHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCEEE
ARHPAHDAGQLSAALRERAIIVRHFRQPRIDQFLRITVGTDAQCETLVAGLREILARAGT
EECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCC
GG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA