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The map label for this gene is hisI

Identifier: 119899632

GI number: 119899632

Start: 3681917

End: 3682312

Strand: Reverse

Name: hisI

Synonym: azo3343

Alternate gene names: 119899632

Gene position: 3682312-3681917 (Counterclockwise)

Preceding gene: 119899633

Following gene: 119899631

Centisome position: 84.15

GC content: 61.87

Gene sequence:

>396_bases
GTGAGTACGAGCACCAAGTGGCTCAACGAGGTGAAGTGGGACGAAAACGGCCTGGTGCCGGTGATCGCCCAGGAGGCCTC
CACGGGCGACGTGCTGATGTTCGCGTGGATGAACCGCGAAGCCCTGCAGCGCACGGCCGAAACCGGCAACGCCATCTACT
GGTCACGATCGCGCCGTAAGCTGTGGCACAAGGGCGAAGAGTCGGGGCACGTCCAGAAGGTGGTCGAGCTGCGGATTGAC
TGCGACAACGACGTGGTGCTGATGAAGGTGGAGCAGGTCGGGGGAATCGCCTGCCATACCGGGCGCCATAGCTGCTTTTT
CCAGAAGTATCTTGCCGACGGCCGCTGGGAGACCGTGGAGCCGGTCCTGAAGGATCCCAAGGACATCTATTCATGA

Upstream 100 bases:

>100_bases
GGGCGGACGCCGTGCTGGCTGCGAGCATCTTCCATTTCGGTCAGCACACGGTACGCGAGGCGAAGGAGTTGATGCGGACG
CGCGGGATCGAGGTGCGGCT

Downstream 100 bases:

>100_bases
TCGATATCGAAGTGCTGCACCGCGTGGCCGCCACGTTGGCCGAACGCAAGAAGGCGGATCCGGATTCGTCGTACGTGTCG
AGTCTGTACGCCAAGGGTAC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 131; Mature: 130

Protein sequence:

>131_residues
MSTSTKWLNEVKWDENGLVPVIAQEASTGDVLMFAWMNREALQRTAETGNAIYWSRSRRKLWHKGEESGHVQKVVELRID
CDNDVVLMKVEQVGGIACHTGRHSCFFQKYLADGRWETVEPVLKDPKDIYS

Sequences:

>Translated_131_residues
MSTSTKWLNEVKWDENGLVPVIAQEASTGDVLMFAWMNREALQRTAETGNAIYWSRSRRKLWHKGEESGHVQKVVELRID
CDNDVVLMKVEQVGGIACHTGRHSCFFQKYLADGRWETVEPVLKDPKDIYS
>Mature_130_residues
STSTKWLNEVKWDENGLVPVIAQEASTGDVLMFAWMNREALQRTAETGNAIYWSRSRRKLWHKGEESGHVQKVVELRIDC
DNDVVLMKVEQVGGIACHTGRHSCFFQKYLADGRWETVEPVLKDPKDIYS

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=98, Percent_Identity=45.9183673469388, Blast_Score=99, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6319819, Length=75, Percent_Identity=36, Blast_Score=64, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_AZOSB (A1KAV3)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_934845.1
- ProteinModelPortal:   A1KAV3
- SMR:   A1KAV3
- STRING:   A1KAV3
- GeneID:   4609004
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo3343
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- ProtClustDB:   PRK00051
- BioCyc:   ASP62928:AZO3343-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 15055; Mature: 14924

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSTKWLNEVKWDENGLVPVIAQEASTGDVLMFAWMNREALQRTAETGNAIYWSRSRRK
CCCCHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEECCHHHHHHHHHCCCEEEEECCHHH
LWHKGEESGHVQKVVELRIDCDNDVVLMKVEQVGGIACHTGRHSCFFQKYLADGRWETVE
HHCCCCCCCHHEEEEEEEECCCCCEEEEEECCCCCEEEECCCCHHHHHHHHCCCCCCCCC
PVLKDPKDIYS
HHHCCCHHHCC
>Mature Secondary Structure 
STSTKWLNEVKWDENGLVPVIAQEASTGDVLMFAWMNREALQRTAETGNAIYWSRSRRK
CCCHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEECCHHHHHHHHHCCCEEEEECCHHH
LWHKGEESGHVQKVVELRIDCDNDVVLMKVEQVGGIACHTGRHSCFFQKYLADGRWETVE
HHCCCCCCCHHEEEEEEEECCCCCEEEEEECCCCCEEEECCCCHHHHHHHHCCCCCCCCC
PVLKDPKDIYS
HHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA