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The map label for this gene is msrA [H]

Identifier: 119899609

GI number: 119899609

Start: 3657267

End: 3657827

Strand: Reverse

Name: msrA [H]

Synonym: azo3320

Alternate gene names: 119899609

Gene position: 3657827-3657267 (Counterclockwise)

Preceding gene: 119899610

Following gene: 119899608

Centisome position: 83.59

GC content: 65.42

Gene sequence:

>561_bases
ATGACGAACACGACTGACACGTCGTTGCAGACTGCGCTGCTCGGCGGAGGATGTTTCTGGTGCCTCGAAGCCGTATTCCG
CGAAGTGGAAGGGGTGGAGCGGGTGGTTTCGGGTTATAGCGGCGGCCATGTAGAGGCGCCCACTTATCGCCAGGTGTGCG
CGGGCGGCACCGGGCATGTGGAGGTGGTGCAGATCCACTTCGACCCGGCGCGGGTGAGCTACCGCGACCTGCTGGAGATT
TTCTTCGTGATCCACGACCCGACCACGATGGACCGGCAGGGCAACGACATCGGCCCGCAGTACCGCTCGGTGATCTACGT
GAACGGCGACGAGCAGCTCCACACCGCGCTGGCGCTGATCGAGGAGCTGGGCGAGGCGCGCGTCTATCCGCGCGCCATCG
CCACCCGAGTCGAACGCGCCGGTACTTTCTGGCCGGCGGAGGTGGAGCACCAGGAGTACTACGCCCACAACAGCGACCAG
CCGTATTGCCAATACGTGGTGGCGCCCAAGGTGGCAAAGTTCCGCGAGAAGTTCGCGGCCCGGCGCAAGGGCGGACGCTG
A

Upstream 100 bases:

>100_bases
TCTTTCGATATGTGAGGCGGACTGTGAAAAATGGCGCGAATGATGTCGGGCCCCTGCTGTCTGATTTACGGGTGCCCAGT
GCGGCACATGAGGAACGATC

Downstream 100 bases:

>100_bases
CCGCGGGGCACGGCCGCGAGCGGGTAGAATCCCGGTTTTCAAACCCGGGGCGACCCGATCAGGAGAAGCGCATGACCCAG
ACCACCACCGCCAGCGGCCT

Product: putative peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MTNTTDTSLQTALLGGGCFWCLEAVFREVEGVERVVSGYSGGHVEAPTYRQVCAGGTGHVEVVQIHFDPARVSYRDLLEI
FFVIHDPTTMDRQGNDIGPQYRSVIYVNGDEQLHTALALIEELGEARVYPRAIATRVERAGTFWPAEVEHQEYYAHNSDQ
PYCQYVVAPKVAKFREKFAARRKGGR

Sequences:

>Translated_186_residues
MTNTTDTSLQTALLGGGCFWCLEAVFREVEGVERVVSGYSGGHVEAPTYRQVCAGGTGHVEVVQIHFDPARVSYRDLLEI
FFVIHDPTTMDRQGNDIGPQYRSVIYVNGDEQLHTALALIEELGEARVYPRAIATRVERAGTFWPAEVEHQEYYAHNSDQ
PYCQYVVAPKVAKFREKFAARRKGGR
>Mature_185_residues
TNTTDTSLQTALLGGGCFWCLEAVFREVEGVERVVSGYSGGHVEAPTYRQVCAGGTGHVEVVQIHFDPARVSYRDLLEIF
FVIHDPTTMDRQGNDIGPQYRSVIYVNGDEQLHTALALIEELGEARVYPRAIATRVERAGTFWPAEVEHQEYYAHNSDQP
YCQYVVAPKVAKFREKFAARRKGGR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=158, Percent_Identity=41.1392405063291, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI208609995, Length=158, Percent_Identity=41.1392405063291, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI208609993, Length=111, Percent_Identity=41.4414414414414, Blast_Score=78, Evalue=4e-15,
Organism=Escherichia coli, GI1790665, Length=160, Percent_Identity=43.125, Blast_Score=130, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=31.2925170068027, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320881, Length=153, Percent_Identity=37.2549019607843, Blast_Score=95, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24664627, Length=175, Percent_Identity=32, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI45553131, Length=157, Percent_Identity=32.484076433121, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24664631, Length=175, Percent_Identity=30.8571428571429, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20884; Mature: 20752

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTTDTSLQTALLGGGCFWCLEAVFREVEGVERVVSGYSGGHVEAPTYRQVCAGGTGHV
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCE
EVVQIHFDPARVSYRDLLEIFFVIHDPTTMDRQGNDIGPQYRSVIYVNGDEQLHTALALI
EEEEEEECCHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHH
EELGEARVYPRAIATRVERAGTFWPAEVEHQEYYAHNSDQPYCQYVVAPKVAKFREKFAA
HHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCEEEEECHHHHHHHHHHHH
RRKGGR
HHCCCC
>Mature Secondary Structure 
TNTTDTSLQTALLGGGCFWCLEAVFREVEGVERVVSGYSGGHVEAPTYRQVCAGGTGHV
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCE
EVVQIHFDPARVSYRDLLEIFFVIHDPTTMDRQGNDIGPQYRSVIYVNGDEQLHTALALI
EEEEEEECCHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHH
EELGEARVYPRAIATRVERAGTFWPAEVEHQEYYAHNSDQPYCQYVVAPKVAKFREKFAA
HHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCEEEEECHHHHHHHHHHHH
RRKGGR
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]