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The map label for this gene is coxD

Identifier: 119899583

GI number: 119899583

Start: 3632697

End: 3633596

Strand: Reverse

Name: coxD

Synonym: azo3294

Alternate gene names: 119899583

Gene position: 3633596-3632697 (Counterclockwise)

Preceding gene: 119899584

Following gene: 119899582

Centisome position: 83.03

GC content: 66.56

Gene sequence:

>900_bases
ATGAAAACCCTGACCCTCGCACATCATGGTCTGGGGCGGCGGGCGCACGCCTTCTATGTGCTCACCAAACCCCGCGTCAA
TGCCTTGATCGTGTTCTGCGCCGTCATCGGCATGTTCCTGGCGGTGCCCGATGGCCTGCCGGATCCGCTGCGGGTATTCG
CTGCCACGGTCGGCATCGCGTGCGTGGCCGGCGCCGCCGCGGCGATGAACTGCCTGATCGAGCAGCAGCTGGATGCGCGC
ATGGCGCGTACCCGCAACCGCCCGCTGCCCCGCGGCGAACTGCATTCCGTGGAAGTGCTGGTGTTCGCGGGCGTGCTGGG
CGGATTCGGGCTGAGCGTGCTGTACCAGGCGGTGAATGCGCTGACGATGTGGCTGACGCTGGCGACCTTCGTGGGCTATG
CGGTGATCTACACCCTGCTGCTGAAGCCGCGGACGCCGCAGAACATCGTGATCGGCGGCGCCTCGGGCGCGATGCCGCCG
GTGCTGGGATGGGCGGCGGTGTCGGGCGAGGTCACCGCCGAGGCCTTGCTGCTGTTCCTGATCATCTTTGCGTGGACGCC
GCCGCATTTCTGGTCGCTGGCGCTGTATCGCACCGCCGACTATGCCCGCGCCGGACTGCCGATGTTGCCGGTGACCCACG
GCGCCGCCTACACGCGCTTGTCGGTGCTGCTGTACACCTGCGCGCTGTTCGGTGTGACGCTGCTGCCCTTCGCGATCCGC
ATGAGCGGCTGGATTTACCTCGTGGCCGCCGTGACACTGGGGCTGCGTTTCGTGCACTACGCGTGGCGCCTGTTGCGGGA
CTACAGTGACGCCTTGGCACGCCGCACTTTCCGCTTCTCCATCGTCTACCTATCATTGCTGTTCGCCGCGCTGCTCGCCG
ACCACTATCTGCGCTTATAG

Upstream 100 bases:

>100_bases
TGGTGTGGATCAACTGGCGGGCGGGCGGCGAGGCGGTGTCGCGCCGGTCGCCCGCGCTGCAGTTTGCGCCGCTGCGGCGC
GCAGAAAACGGGAGGCCATC

Downstream 100 bases:

>100_bases
AAGACCGCCTGACGATGCTCCGAGTCCTGCTTTGCGCGGCCGCACTGGCCGCAACCGTCCTCGCCGGGGGATGTTCAGAT
CCGGCTCCCGCCTTCCATTC

Product: protoheme IX farnesyltransferase

Products: heme O; pyrophosphate [C]

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKTLTLAHHGLGRRAHAFYVLTKPRVNALIVFCAVIGMFLAVPDGLPDPLRVFAATVGIACVAGAAAAMNCLIEQQLDAR
MARTRNRPLPRGELHSVEVLVFAGVLGGFGLSVLYQAVNALTMWLTLATFVGYAVIYTLLLKPRTPQNIVIGGASGAMPP
VLGWAAVSGEVTAEALLLFLIIFAWTPPHFWSLALYRTADYARAGLPMLPVTHGAAYTRLSVLLYTCALFGVTLLPFAIR
MSGWIYLVAAVTLGLRFVHYAWRLLRDYSDALARRTFRFSIVYLSLLFAALLADHYLRL

Sequences:

>Translated_299_residues
MKTLTLAHHGLGRRAHAFYVLTKPRVNALIVFCAVIGMFLAVPDGLPDPLRVFAATVGIACVAGAAAAMNCLIEQQLDAR
MARTRNRPLPRGELHSVEVLVFAGVLGGFGLSVLYQAVNALTMWLTLATFVGYAVIYTLLLKPRTPQNIVIGGASGAMPP
VLGWAAVSGEVTAEALLLFLIIFAWTPPHFWSLALYRTADYARAGLPMLPVTHGAAYTRLSVLLYTCALFGVTLLPFAIR
MSGWIYLVAAVTLGLRFVHYAWRLLRDYSDALARRTFRFSIVYLSLLFAALLADHYLRL
>Mature_299_residues
MKTLTLAHHGLGRRAHAFYVLTKPRVNALIVFCAVIGMFLAVPDGLPDPLRVFAATVGIACVAGAAAAMNCLIEQQLDAR
MARTRNRPLPRGELHSVEVLVFAGVLGGFGLSVLYQAVNALTMWLTLATFVGYAVIYTLLLKPRTPQNIVIGGASGAMPP
VLGWAAVSGEVTAEALLLFLIIFAWTPPHFWSLALYRTADYARAGLPMLPVTHGAAYTRLSVLLYTCALFGVTLLPFAIR
MSGWIYLVAAVTLGLRFVHYAWRLLRDYSDALARRTFRFSIVYLSLLFAALLADHYLRL

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=260, Percent_Identity=30.7692307692308, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI1786631, Length=279, Percent_Identity=33.6917562724014, Blast_Score=136, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71998235, Length=218, Percent_Identity=31.651376146789, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6325085, Length=287, Percent_Identity=28.5714285714286, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19921064, Length=284, Percent_Identity=30.6338028169014, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_AZOSB (A1KAQ4)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_934796.1
- STRING:   A1KAQ4
- GeneID:   4609864
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo3294
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   MALTEEW
- PhylomeDB:   A1KAQ4
- ProtClustDB:   PRK04375
- BioCyc:   ASP62928:AZO3294-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 32693; Mature: 32693

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1d9fb1a8)-; HASH(0x1ed9b090)-; HASH(0x1e691728)-; HASH(0x1dd9a558)-; HASH(0x1e9a1888)-; HASH(0x1ec6e414)-; HASH(0x1e2933ac)-; HASH(0x1f0c39a4)-; HASH(0x1f01dba0)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLTLAHHGLGRRAHAFYVLTKPRVNALIVFCAVIGMFLAVPDGLPDPLRVFAATVGIA
CCEEEEHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
CVAGAAAAMNCLIEQQLDARMARTRNRPLPRGELHSVEVLVFAGVLGGFGLSVLYQAVNA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LTMWLTLATFVGYAVIYTLLLKPRTPQNIVIGGASGAMPPVLGWAAVSGEVTAEALLLFL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHH
IIFAWTPPHFWSLALYRTADYARAGLPMLPVTHGAAYTRLSVLLYTCALFGVTLLPFAIR
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MSGWIYLVAAVTLGLRFVHYAWRLLRDYSDALARRTFRFSIVYLSLLFAALLADHYLRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MKTLTLAHHGLGRRAHAFYVLTKPRVNALIVFCAVIGMFLAVPDGLPDPLRVFAATVGIA
CCEEEEHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
CVAGAAAAMNCLIEQQLDARMARTRNRPLPRGELHSVEVLVFAGVLGGFGLSVLYQAVNA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LTMWLTLATFVGYAVIYTLLLKPRTPQNIVIGGASGAMPPVLGWAAVSGEVTAEALLLFL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHH
IIFAWTPPHFWSLALYRTADYARAGLPMLPVTHGAAYTRLSVLLYTCALFGVTLLPFAIR
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MSGWIYLVAAVTLGLRFVHYAWRLLRDYSDALARRTFRFSIVYLSLLFAALLADHYLRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protoheme; farnesyl-PP [C]

Specific reaction: protoheme + farnesyl-PP = heme O + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA