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The map label for this gene is lysA1 [H]

Identifier: 119899537

GI number: 119899537

Start: 3580380

End: 3581663

Strand: Direct

Name: lysA1 [H]

Synonym: azo3248

Alternate gene names: 119899537

Gene position: 3580380-3581663 (Clockwise)

Preceding gene: 119899536

Following gene: 119899542

Centisome position: 81.82

GC content: 66.59

Gene sequence:

>1284_bases
ATGCGCACGACGCCCCCATTCGCGGAAACCGAAGGCCCCGCCATGACCGAAGCCCGACCGACGCCCACCCATACGCCCAT
GACCCAGTTCCGCAGCGCGGAAGGCCAGTTGCTGGTGAATGGCGTCCCGCTCACCCGGCTAGCCGTGAGGGTGGGCCAGA
CCCCCTTCTATGCCTACGATCGCAGCCTGCTCGACGCCCGCGTGGCGCAGCTCCGCGCCGCGCTTCCATCGGAAATCAAG
CTGCACTATGCGATGAAGGCCAACCCGATGCCCGCACTGGTCGGCCACATGGTCCGACTGGTCGACGGTATCGACGTGGC
GTCCGCCGGGGAGCTGCAGGTGGCGCTCGACGCCGGGGCGGATCCCAAGGAAATCAGCTTCGCCGGGCCCGGCAAGCGCG
AACAGGAACTGCTGCAGGCGGTTGCCGCCGGCATCCTCATCAACGTGGAGTCGTTCCGCGAGTTGCCCATCCTGGCGGCC
GCACAAGATGCACTCGGGCTGCCCGCACGTGTGGCGGTGCGCGTCAATCCGGACTTTGAACTCAAGTCCTCGGGCATGAA
GATGGGGGGCGGACCCAAACAGTTCGGCGTCGACGCAGAGGACGTCCCCCGGCTTCTCGCGGAAATCGGCAACGCGGGCC
TGGCCTTCGAGGGTTTCCATCTCTTCGCGGGCTCTCAGAACCTGCGCCCGGAGGCCATCGTGGAGGCGCAGCAGAAAAGC
TATGCCCTGGCAGTGCGGCTGGCCGAGCATGCGCCCACCGCGGTGAGGTTCCTCAACCTGGGCGGCGGCTTCGGCATACC
CTATTTCCCGGGAGAAACGCCGCTGGACCTGGCGCCCATTGGAGACAACCTGGGCGCGATCGTCGCCGCAGCGAGGCAAC
AGCTTCCGGAAGCTGAGATCGTGATCGAACTGGGCCGTTACCTTGTGGGCGAGGCCGGCATCTACGTGGCGCGCGTCGTC
GACAAGAAGGTTTCCCGCGGCCAGATCTACCTGGTGACCGACGGCGGCCTGCACCATCACCTGTCGGCGTCGGGGAATTT
CGGCCAAGTCATTCGCAAGAACTACCCAGCGGCGATTGGCAACCGCATCGAGGGCTCCATGCGGGAAACCGTGTCGGTCG
TCGGCCCGCTGTGCACGCCACTGGACCTGCTCGCAGACAAGATGTCATTGCCCGCCGCGGAGCCCGGCGATCTGGTCGTG
GTCTATCAGTCGGGTGCCTACGGCGCCTCGGCCAGTCCGCAACGCTTTCTCGGCCACCCCGCCGTGGCCGAGGTGCTCGT
CTAA

Upstream 100 bases:

>100_bases
CAGCGCACCCCGGTTACTACGGCGAAATGGTATGGATCCTGATGATGCTGGAGTTCTGGCTGCGCGCCCACGACGGCAGC
ACCCTCTGACCCCGGGGACG

Downstream 100 bases:

>100_bases
CCGCGGGATCGAGCCGGCGTCTATTCCTTGCCGGCCTCGGCGCTGGCCGGCGCAGCCGCCGGCTCGGCGTCGACCGCCGG
CGACGCGGGCTCCGTCGTAT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MRTTPPFAETEGPAMTEARPTPTHTPMTQFRSAEGQLLVNGVPLTRLAVRVGQTPFYAYDRSLLDARVAQLRAALPSEIK
LHYAMKANPMPALVGHMVRLVDGIDVASAGELQVALDAGADPKEISFAGPGKREQELLQAVAAGILINVESFRELPILAA
AQDALGLPARVAVRVNPDFELKSSGMKMGGGPKQFGVDAEDVPRLLAEIGNAGLAFEGFHLFAGSQNLRPEAIVEAQQKS
YALAVRLAEHAPTAVRFLNLGGGFGIPYFPGETPLDLAPIGDNLGAIVAAARQQLPEAEIVIELGRYLVGEAGIYVARVV
DKKVSRGQIYLVTDGGLHHHLSASGNFGQVIRKNYPAAIGNRIEGSMRETVSVVGPLCTPLDLLADKMSLPAAEPGDLVV
VYQSGAYGASASPQRFLGHPAVAEVLV

Sequences:

>Translated_427_residues
MRTTPPFAETEGPAMTEARPTPTHTPMTQFRSAEGQLLVNGVPLTRLAVRVGQTPFYAYDRSLLDARVAQLRAALPSEIK
LHYAMKANPMPALVGHMVRLVDGIDVASAGELQVALDAGADPKEISFAGPGKREQELLQAVAAGILINVESFRELPILAA
AQDALGLPARVAVRVNPDFELKSSGMKMGGGPKQFGVDAEDVPRLLAEIGNAGLAFEGFHLFAGSQNLRPEAIVEAQQKS
YALAVRLAEHAPTAVRFLNLGGGFGIPYFPGETPLDLAPIGDNLGAIVAAARQQLPEAEIVIELGRYLVGEAGIYVARVV
DKKVSRGQIYLVTDGGLHHHLSASGNFGQVIRKNYPAAIGNRIEGSMRETVSVVGPLCTPLDLLADKMSLPAAEPGDLVV
VYQSGAYGASASPQRFLGHPAVAEVLV
>Mature_427_residues
MRTTPPFAETEGPAMTEARPTPTHTPMTQFRSAEGQLLVNGVPLTRLAVRVGQTPFYAYDRSLLDARVAQLRAALPSEIK
LHYAMKANPMPALVGHMVRLVDGIDVASAGELQVALDAGADPKEISFAGPGKREQELLQAVAAGILINVESFRELPILAA
AQDALGLPARVAVRVNPDFELKSSGMKMGGGPKQFGVDAEDVPRLLAEIGNAGLAFEGFHLFAGSQNLRPEAIVEAQQKS
YALAVRLAEHAPTAVRFLNLGGGFGIPYFPGETPLDLAPIGDNLGAIVAAARQQLPEAEIVIELGRYLVGEAGIYVARVV
DKKVSRGQIYLVTDGGLHHHLSASGNFGQVIRKNYPAAIGNRIEGSMRETVSVVGPLCTPLDLLADKMSLPAAEPGDLVV
VYQSGAYGASASPQRFLGHPAVAEVLV

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=379, Percent_Identity=22.9551451187335, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789203, Length=407, Percent_Identity=26.7813267813268, Blast_Score=92, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45165; Mature: 45165

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTTPPFAETEGPAMTEARPTPTHTPMTQFRSAEGQLLVNGVPLTRLAVRVGQTPFYAYD
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCHHHHHHHHCCCCHHHHH
RSLLDARVAQLRAALPSEIKLHYAMKANPMPALVGHMVRLVDGIDVASAGELQVALDAGA
HHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCC
DPKEISFAGPGKREQELLQAVAAGILINVESFRELPILAAAQDALGLPARVAVRVNPDFE
CCCEEEECCCCHHHHHHHHHHHHHHEEEHHHHHCCCHHEECHHHCCCCEEEEEEECCCCE
LKSSGMKMGGGPKQFGVDAEDVPRLLAEIGNAGLAFEGFHLFAGSQNLRPEAIVEAQQKS
ECCCCCCCCCCCHHCCCCHHHHHHHHHHHCCCCCEEECEEEEECCCCCCHHHHHHHHHHH
YALAVRLAEHAPTAVRFLNLGGGFGIPYFPGETPLDLAPIGDNLGAIVAAARQQLPEAEI
EEEEEEEHHCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCHHHH
VIELGRYLVGEAGIYVARVVDKKVSRGQIYLVTDGGLHHHLSASGNFGQVIRKNYPAAIG
HHHHHHHHHCCCCEEEHHHHHHHCCCCEEEEEECCCCEEEECCCCCHHHHHHHCCCHHHC
NRIEGSMRETVSVVGPLCTPLDLLADKMSLPAAEPGDLVVVYQSGAYGASASPQRFLGHP
CCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHCCH
AVAEVLV
HHHHHCC
>Mature Secondary Structure
MRTTPPFAETEGPAMTEARPTPTHTPMTQFRSAEGQLLVNGVPLTRLAVRVGQTPFYAYD
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCHHHHHHHHCCCCHHHHH
RSLLDARVAQLRAALPSEIKLHYAMKANPMPALVGHMVRLVDGIDVASAGELQVALDAGA
HHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCC
DPKEISFAGPGKREQELLQAVAAGILINVESFRELPILAAAQDALGLPARVAVRVNPDFE
CCCEEEECCCCHHHHHHHHHHHHHHEEEHHHHHCCCHHEECHHHCCCCEEEEEEECCCCE
LKSSGMKMGGGPKQFGVDAEDVPRLLAEIGNAGLAFEGFHLFAGSQNLRPEAIVEAQQKS
ECCCCCCCCCCCHHCCCCHHHHHHHHHHHCCCCCEEECEEEEECCCCCCHHHHHHHHHHH
YALAVRLAEHAPTAVRFLNLGGGFGIPYFPGETPLDLAPIGDNLGAIVAAARQQLPEAEI
EEEEEEEHHCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCHHHH
VIELGRYLVGEAGIYVARVVDKKVSRGQIYLVTDGGLHHHLSASGNFGQVIRKNYPAAIG
HHHHHHHHHCCCCEEEHHHHHHHCCCCEEEEEECCCCEEEECCCCCHHHHHHHCCCHHHC
NRIEGSMRETVSVVGPLCTPLDLLADKMSLPAAEPGDLVVVYQSGAYGASASPQRFLGHP
CCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHCCH
AVAEVLV
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]