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The map label for this gene is proA

Identifier: 119899507

GI number: 119899507

Start: 3549209

End: 3550468

Strand: Direct

Name: proA

Synonym: azo3218

Alternate gene names: 119899507

Gene position: 3549209-3550468 (Clockwise)

Preceding gene: 119899506

Following gene: 119899508

Centisome position: 81.11

GC content: 67.54

Gene sequence:

>1260_bases
ATGCAGACCGTCGGCCGCGAAGCGCGCGCCGCCTCCCGCACGCTTGCGGCAGCCTCCACCGATGCCAAGAATTCCGCCCT
GGTGGCGATGGCGCAAGCCATCCGCGACAGTCGCGACGCGCTTCTGGCGGCCAACGCTGCCGACCTCGCCGAAGCGCGCG
CGGCCGGGCTGGACGAGGCCCTGATCGACCGCCTGACGCTGAGCGCCAAGGGCGTGGAAGGCATGGCCGCCGGGCTTGAA
CAGGTTGCGGCACTCCCCGACCCGGTGGGGGAAATCACCGACGTCAAGCGCCGCCCTTCCGGCATCCAGGTCGGCAAGAT
GCGTGTGCCGCTCGGCGTGGTCGGCATCATCTACGAGGCGCGGCCCAACGTCACCGCCGACGCGGCGGCCCTGTGCCTCA
AATCCGGCAACGCCGCGATCCTTCGCGGCGGCAAGGAAGCGCTGCGCTCGAATCAGGCAATTGCAAGCTGCGTGCGCACC
GGGCTTGCCGCCGCCGGCCTGCCGCAAACGGCCGTGCAGGTGCTGGAAACGACGGACCGGGCTGCGGTTGGCGCGCTCAT
CACGATGCCCGAATTCGTCGACGTGATCGTGCCGCGCGGCGGCAAAGGGCTGATCGAGCGAATCTCCAGCGAGGCACGCG
TCCCCGTCATCAAACACCTCGACGGCAACTGCCATGTGTACGTCGACGACCATGCCGACCCGGCGAAAGTGCTGCCCATC
GTAGAGAACGCCAAGACCCAGCGTTACGGCACCTGCAACACCACGGAATCGCTGCTCGTGGCCCGTGCCGTCGCCCCGCG
TTTCCTGTCCGACATCGGACGGATGCTGGCGGCGAGGAACGTCGAGATGCGAGCGTGCCCGGAAGCGCTCGCGCTGCTGC
GCGAAGCCGGAATCGAAGGTGCCCGGCTCAGCCCCGCCACCGAGCAGGACTGGCACGAGGAATACCTCGCGCCGATCATC
GCGATCCGCGTCGTGGCGGGCCTGGATGAAGCGATCGCACATATCAACACCTACAGCTCGGGCCACACCGAGGCGATCCT
TACCGAGCACTACACCCATGCGATGCGTTTCCTGCGCGAGGTGGATTCGGCATCCGTCATGGTGAACGCCTCCACGCGCT
TCGCCGACGGCTTCGAATACGGCCTCGGTGCCGAAATCGGGATTTCCACGGACAAGATCCACGCCCGCGGCCCGGTGGGG
CTGGAAGGGCTCACCAGCCAGAAATGGATCGTGTTCGGCAACGGCGAGATCCGCCGATAA

Upstream 100 bases:

>100_bases
TCCGCGGCGGATGTAGCGTGTGACCCACGGGCGCCGCGATCAGTGCTTTAATCCCTTTTTGGCTTTTCCGCCTGTGACTA
TGATGGATATCCAGCACTAC

Downstream 100 bases:

>100_bases
GCCGAAAGTCAGGATGGGGATCAACGCGAGGCGTGAGAAAATCCCCGCCCTTAAGGGTTTCTACGTAGACGAGGCAGACG
TCGGAATCCGACGTTCGTGG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MQTVGREARAASRTLAAASTDAKNSALVAMAQAIRDSRDALLAANAADLAEARAAGLDEALIDRLTLSAKGVEGMAAGLE
QVAALPDPVGEITDVKRRPSGIQVGKMRVPLGVVGIIYEARPNVTADAAALCLKSGNAAILRGGKEALRSNQAIASCVRT
GLAAAGLPQTAVQVLETTDRAAVGALITMPEFVDVIVPRGGKGLIERISSEARVPVIKHLDGNCHVYVDDHADPAKVLPI
VENAKTQRYGTCNTTESLLVARAVAPRFLSDIGRMLAARNVEMRACPEALALLREAGIEGARLSPATEQDWHEEYLAPII
AIRVVAGLDEAIAHINTYSSGHTEAILTEHYTHAMRFLREVDSASVMVNASTRFADGFEYGLGAEIGISTDKIHARGPVG
LEGLTSQKWIVFGNGEIRR

Sequences:

>Translated_419_residues
MQTVGREARAASRTLAAASTDAKNSALVAMAQAIRDSRDALLAANAADLAEARAAGLDEALIDRLTLSAKGVEGMAAGLE
QVAALPDPVGEITDVKRRPSGIQVGKMRVPLGVVGIIYEARPNVTADAAALCLKSGNAAILRGGKEALRSNQAIASCVRT
GLAAAGLPQTAVQVLETTDRAAVGALITMPEFVDVIVPRGGKGLIERISSEARVPVIKHLDGNCHVYVDDHADPAKVLPI
VENAKTQRYGTCNTTESLLVARAVAPRFLSDIGRMLAARNVEMRACPEALALLREAGIEGARLSPATEQDWHEEYLAPII
AIRVVAGLDEAIAHINTYSSGHTEAILTEHYTHAMRFLREVDSASVMVNASTRFADGFEYGLGAEIGISTDKIHARGPVG
LEGLTSQKWIVFGNGEIRR
>Mature_419_residues
MQTVGREARAASRTLAAASTDAKNSALVAMAQAIRDSRDALLAANAADLAEARAAGLDEALIDRLTLSAKGVEGMAAGLE
QVAALPDPVGEITDVKRRPSGIQVGKMRVPLGVVGIIYEARPNVTADAAALCLKSGNAAILRGGKEALRSNQAIASCVRT
GLAAAGLPQTAVQVLETTDRAAVGALITMPEFVDVIVPRGGKGLIERISSEARVPVIKHLDGNCHVYVDDHADPAKVLPI
VENAKTQRYGTCNTTESLLVARAVAPRFLSDIGRMLAARNVEMRACPEALALLREAGIEGARLSPATEQDWHEEYLAPII
AIRVVAGLDEAIAHINTYSSGHTEAILTEHYTHAMRFLREVDSASVMVNASTRFADGFEYGLGAEIGISTDKIHARGPVG
LEGLTSQKWIVFGNGEIRR

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=417, Percent_Identity=38.1294964028777, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI62912457, Length=417, Percent_Identity=38.1294964028777, Blast_Score=263, Evalue=3e-70,
Organism=Escherichia coli, GI1786438, Length=418, Percent_Identity=44.4976076555024, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17569969, Length=422, Percent_Identity=36.4928909952607, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17569967, Length=422, Percent_Identity=36.4928909952607, Blast_Score=275, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6324899, Length=434, Percent_Identity=38.4792626728111, Blast_Score=290, Evalue=2e-79,
Organism=Drosophila melanogaster, GI21357643, Length=417, Percent_Identity=38.3693045563549, Blast_Score=271, Evalue=7e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_AZOSB (A1KAH8)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_934720.1
- ProteinModelPortal:   A1KAH8
- SMR:   A1KAH8
- STRING:   A1KAH8
- GeneID:   4609012
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo3218
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   GICGAME
- PhylomeDB:   A1KAH8
- ProtClustDB:   PRK00197
- BioCyc:   ASP62928:AZO3218-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44257; Mature: 44257

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTVGREARAASRTLAAASTDAKNSALVAMAQAIRDSRDALLAANAADLAEARAAGLDEA
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHEEECCHHHHHHHHHCCCHHH
LIDRLTLSAKGVEGMAAGLEQVAALPDPVGEITDVKRRPSGIQVGKMRVPLGVVGIIYEA
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEECEEECCEEEEEEEEEC
RPNVTADAAALCLKSGNAAILRGGKEALRSNQAIASCVRTGLAAAGLPQTAVQVLETTDR
CCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCH
AAVGALITMPEFVDVIVPRGGKGLIERISSEARVPVIKHLDGNCHVYVDDHADPAKVLPI
HHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEECCCCEEEEECCCCCCHHHHHH
VENAKTQRYGTCNTTESLLVARAVAPRFLSDIGRMLAARNVEMRACPEALALLREAGIEG
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
ARLSPATEQDWHEEYLAPIIAIRVVAGLDEAIAHINTYSSGHTEAILTEHYTHAMRFLRE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
VDSASVMVNASTRFADGFEYGLGAEIGISTDKIHARGPVGLEGLTSQKWIVFGNGEIRR
CCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MQTVGREARAASRTLAAASTDAKNSALVAMAQAIRDSRDALLAANAADLAEARAAGLDEA
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHEEECCHHHHHHHHHCCCHHH
LIDRLTLSAKGVEGMAAGLEQVAALPDPVGEITDVKRRPSGIQVGKMRVPLGVVGIIYEA
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEECEEECCEEEEEEEEEC
RPNVTADAAALCLKSGNAAILRGGKEALRSNQAIASCVRTGLAAAGLPQTAVQVLETTDR
CCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCH
AAVGALITMPEFVDVIVPRGGKGLIERISSEARVPVIKHLDGNCHVYVDDHADPAKVLPI
HHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEECCCCEEEEECCCCCCHHHHHH
VENAKTQRYGTCNTTESLLVARAVAPRFLSDIGRMLAARNVEMRACPEALALLREAGIEG
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
ARLSPATEQDWHEEYLAPIIAIRVVAGLDEAIAHINTYSSGHTEAILTEHYTHAMRFLRE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
VDSASVMVNASTRFADGFEYGLGAEIGISTDKIHARGPVGLEGLTSQKWIVFGNGEIRR
CCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA